Abstract：
:Malaria-associated acute lung injury (ALI) is a frequent complication of severe malaria that is often caused by "excessive" immune responses. To better understand the mechanism of ALI in malaria infection, here we investigated the roles of galectin (Gal)-1, 3, 8, 9 and the receptors of Gal-9 (Tim-3, CD44, CD137, and PDI) in malaria-induced ALI. We injected alpha (α)-lactose into mice-infected with Plasmodium berghei ANKA (PbANKA) to block galectins and found significantly elevated total proteins in bronchoalveolar lavage fluid, higher parasitemia and tissue parasite burden, and increased numbers of CD68(+) alveolar macrophages as well as apoptotic cells in the lungs after blockage. Additionally, mRNA levels of Gal-9, Tim-3, CD44, CD137, and PDI were significantly increased in the lungs at day 5 after infection, and the levels of CD137, IFN-α, IFN-β, IFN-γ, IL-4, and IL-10 in the lungs were also increased after α-lactose treatment. Similarly, the levels of Gal-9, Tim-3, IFN-α, IFN-β, IFN-γ, and IL-10 were all significantly increased in murine peritoneal macrophages co-cultured with PbANKA-infected red blood cells in vitro; but only IFN-α and IFN-β were significantly increased after α-lactose treatment. Our data indicate that Gal-9 interaction with its multiple receptors play an important role in murine malaria-associated ALI.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu J,Huang S,Su XZ,Song J,Lu Fdoi
10.1038/srep32024subject
Has Abstractpub_date
2016-08-24 00:00:00pages
32024issn
2045-2322pii
srep32024journal_volume
6pub_type
杂志文章abstract：:Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19658-7
更新日期：2018-02-05 00:00:00
abstract：:In species richness studies, citizen-science surveys where participants make individual decisions regarding sampling strategies provide a cost-effective approach to collect a large amount of data. However, it is unclear to what extent the bias inherent to opportunistically collected samples may invalidate our inferenc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55593-x
更新日期：2019-12-13 00:00:00
abstract：:The first-ever study of nickel selenide materials as efficient anode materials for Na-ion rechargeable batteries is conducted using the electrospinning process. NiSe2-reduced graphene oxide (rGO)-C composite nanofibers are successfully prepared via electrospinning and a subsequent selenization process. The electrospun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23338
更新日期：2016-03-21 00:00:00
abstract：:Rapid integration of high-quality functional devices in microchannels is in highly demand for miniature lab-on-a-chip applications. This paper demonstrates the embellishment of existing microfluidic devices with integrated micropatterns via femtosecond laser MRAF-based holographic patterning (MHP) microfabrication, wh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33281
更新日期：2016-09-13 00:00:00
abstract：:The formation of proper sensory afferent connections during development is essential for brain function. Activity-based competition is believed to drive ocular dominance columns (ODC) in mammals and in experimentally-generated three-eyed frogs. ODC formation is thus a compromise of activity differences between two eye...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08338
更新日期：2015-02-09 00:00:00
abstract：:Plant seed germination is a crucial developmental event that has significant effects on seedling establishment and yield production. This process is controlled by multiple intrinsic signals, particularly phytohormones. The gaseous hormone ethylene stimulates seed germination; however, the genetic basis of ethylene pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58607-1
更新日期：2020-02-03 00:00:00
abstract：:Recent studies showed that anomalous dry conditions and limited moisture supply roughly between 1998 and 2008, especially in the Southern Hemisphere, led to reduced vegetation productivity and ceased growth in land evapotranspiration (ET). However, natural variability of Earth's climate system can degrade capabilities...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15956
更新日期：2015-10-30 00:00:00
abstract：:Synapses are an early pathological target in many neurodegenerative diseases ranging from well-known adult onset conditions such as Alzheimer and Parkinson disease to neurodegenerative conditions of childhood such as spinal muscular atrophy (SMA) and neuronal ceroid lipofuscinosis (NCLs). However, the reasons why syna...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12603-0
更新日期：2017-09-29 00:00:00
abstract：:Gut dysbiosis contributes to the development of a dysfunctional gut barrier, facilitating the translocation of bacteria and inflammagens, and is implicated in colorectal cancer (CRC) pathogenesis. Such 'leaky gut' conditions result in systemic inflammation, of which a hallmark is increased hypercoagulability. Fluoresc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65324-2
更新日期：2020-05-29 00:00:00
abstract：:The South American Monsoon System (SAMS) is generally considered to be highly sensitive to Northern Hemisphere (NH) temperature variations on multi-centennial timescales. The direct influence of solar forcing on moisture convergence in global monsoon systems on the other hand, while well explored in modeling studies, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24762
更新日期：2016-04-21 00:00:00
abstract：:The human β-defensin-1 (HBD1) is an antimicrobial peptide constitutively expressed by epithelial cells at mucosal surfaces. In addition to its microbicidal properties, the loss of HBD1 expression in several cancers suggests that it may also have an anti-tumor activity. Here, we investigated the link between HBD1 expre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36387-z
更新日期：2018-12-21 00:00:00
abstract：:Strenuous exercise increases circulating cell free DNA (cfDNA) and stimulates blood phagocytes to generate reactive oxygen species (ROS) which may induce DNA strand breaks. We tested whether: (A) elevated cfDNA in response to three repeated bouts of exhaustive exercise has decreased integrity; (B) each bout of exercis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52409-w
更新日期：2019-11-04 00:00:00
abstract：:Common genetic risk variants for colorectal cancer (CRC) have been identified at approximately 40 loci by genome-wide association studies (GWAS). We investigated the association of these risk variants by age at onset of CRC using case-only and case-control analysis. A total of 1,962 CRC cases and 2,668 controls from t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40644
更新日期：2017-01-13 00:00:00
abstract：:The establishment of a healthy gastrointestinal milieu may not only offer an opportunity to reduce swine production costs but could also open the way for a lifetime of human health improvement. This study investigates the effects of feeding soluble fibre from flaxseed meal-containing diet (FM) and insoluble fibre from...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24043-5
更新日期：2018-04-12 00:00:00
abstract：:There is a pressing need for novel and innovative therapeutic strategies to address infections caused by intracellular pathogens. Peptide nucleic acids (PNAs) present a novel method to target intracellular pathogens due to their unique mechanism of action and their ability to be conjugated to cell penetrating peptides...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20832
更新日期：2016-02-10 00:00:00
abstract：:The International Institute of Tropical Agriculture maintains the world's largest collection of cowpea germplasm of over 15,000 accessions. A sub-set of 298 lines from the loosely composed mini core collection of 370 landraces were genotyped based on genotyping by sequencing (GBS). Ward's minimum variance hierarchical...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34555-9
更新日期：2018-10-30 00:00:00
abstract：:Given the prevalence of poor adherence to therapy and the biases of self-reporting across healthcare, we hypothesized that an engaging, personalized therapy may improve adherence and treatment outcomes in the home. We tested this hypothesis in the initial indication of amblyopia, a neurodevelopmental disorder for whic...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-65234-3
更新日期：2020-05-20 00:00:00
abstract：:We show that filamentous fungi can emit green or red light after the accumulation of particulate lanthanide metal-organic frameworks over the cell wall. These new biohybrids present photoluminescence properties that are unaffected by the components of the cell wall. In addition, the fungal cells internalise lanthanide...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43835-x
更新日期：2019-05-13 00:00:00
abstract：:Carbon uptake by terrestrial ecosystems is increasing along with the rising of atmospheric CO2 concentration. Embedded in this trend, recent studies suggested that the interannual variability (IAV) of global carbon fluxes may be dominated by semi-arid ecosystems, but the underlying mechanisms of this high variability ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39748
更新日期：2016-12-23 00:00:00
abstract：:Immunoproteasomes are known for their involvement in antigen presentation. However, their broad tissue presence and other evidence are indicative of nonimmune functions. We examined a role for immunoproteasomes in cellular responses to the endogenous and environmental carcinogen formaldehyde (FA) that binds to cytosol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00757-w
更新日期：2017-04-05 00:00:00
abstract：:Bisphenol A (BPA) is widely used in the manufacture of plastics and epoxy resins and is prevalent in the aquatic environment. BPA disrupts endocrine pathways in fish, but the long-term developmental implications are unknown. We demonstrate that BPA deposition in the eggs of rainbow trout (Oncorhynchus mykiss), an ecol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13301-7
更新日期：2017-10-26 00:00:00
abstract：:Relying on an exact time evolution scheme, we identify a novel transient energy transfer phenomenon in an exactly-solvable quantum microscopic model consisting of a three-level system coupled to two non-Markovian zero-temperature bosonic baths through two separable quantum channels. The dynamics of this model can be s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15332
更新日期：2015-10-19 00:00:00
abstract：:Autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and restricted/repetitive behavior patterns or interests. Antagonists targeting histamine H3 receptor (H3R) are considered potential therapeutic agents for the therapeutic management of different brain...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31385-7
更新日期：2018-08-30 00:00:00
abstract：:Oral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects. The aim of this study was to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58548-9
更新日期：2020-02-03 00:00:00
abstract：:We aimed to investigate the association of smoking and physical exercise on ventricular function and structure, determined by cardiac magnetic resonance imaging (CMR), in subjects without known cardiovascular diseases. A total of 381 participants (median age 57 years) of the Cooperative Health Research in the Region o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54956-8
更新日期：2019-12-09 00:00:00
abstract：:Afforestation is an important approach to mitigate global warming. Its complex interactions with the climate system, however, makes it controversial. Afforestation is expected to be effective in the tropics where biogeochemical and biogeophysical effects act in concert; however, its potential in the large semi-arid re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19265-6
更新日期：2018-01-17 00:00:00
abstract：:Systems of closely-spaced resonators can be strongly coupled by interactions mediated by scattered electromagnetic fields. In large systems the resulting response has been shown to be more sensitive to these collective interactions than to the detailed structure of individual resonators. Attempts to describe such syst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41327-6
更新日期：2019-04-05 00:00:00
abstract：:Circadian clocks keep time via ~ 24 h transcriptional feedback loops. In Drosophila, CLOCK-CYCLE (CLK-CYC) activators and PERIOD-TIMELESS (PER-TIM) repressors are feedback loop components whose transcriptional status varies over a circadian cycle. Although changes in the state of activators and repressors has been cha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75009-5
更新日期：2020-10-21 00:00:00
abstract：:Acute leukemia (AL) patients undergoing intensive induction chemotherapy develop severe gut dysbiosis, placing them at heightened risk for infectious complications. Some AL patients will undergo "repeat therapy" (re-induction or salvage) due to persistent or relapsed disease. We hypothesized that prior injury to the m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42652-6
更新日期：2019-04-15 00:00:00
abstract：:The annotation of genomic ranges of interest represents a recurring task for bioinformatics analyses. These ranges can originate from various sources, including peaks called for transcription factor binding sites (TFBS) or histone modification ChIP-seq experiments, chromatin structure and accessibility experiments (su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02464-y
更新日期：2017-06-01 00:00:00
