Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.

abstract：:We present a novel, non-invasive magnetic resonance imaging (MRI) technique to assess real-time dynamic vasomodulation of the microvascular bed. Unlike existing perfusion imaging techniques, our method is sensitive only to blood volume and not flow velocity. Using graded gas challenges and a long-life, blood-pool T 1-...

journal_title：Scientific reports

authors： Ganesh T,Estrada M,Yeger H,Duffin J,Cheng HL

更新日期：2017-08-07 00:00:00

abstract：:The effects of gradual vascular occlusion on the blood supply of perfused areas are poorly described. Information relating to the comparison of flap monitoring techniques is lacking. Varying stenotic conditions (0%, 25%, 50%, 75% and 100%) were generated on purpose at the A. and V. femoralis in the rat model. Analyses...

journal_title：Scientific reports

authors： Mücke T,Hapfelmeier A,Schmidt LH,Fichter AM,Kanatas A,Wolff KD,Ritschl LM

更新日期：2020-01-22 00:00:00

abstract：:The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons in the lateral hypothalamus and zona incerta. MCHergic neurons project throughout the central nervous system, indicating the involvements of many physiological functions, but the role in pain has yet to be determined. In thi...

journal_title：Scientific reports

authors： Jang JH,Park JY,Oh JY,Bae SJ,Jang H,Jeon S,Kim J,Park HJ

更新日期：2018-01-15 00:00:00

abstract：:Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the 'honey trap' during an economic exchange. Males tend to cooperate with physicall...

journal_title：Scientific reports

authors： Watabe M,Kato TA,Tsuboi S,Ishikawa K,Hashiya K,Monji A,Utsumi H,Kanba S

更新日期：2013-01-01 00:00:00

abstract：:The application of nitrogen (N) fertilizer deep in soil at the same time as mechanical transplanting of rice seedlings is an effective alternative to conventional broadcasting of fertilizer, but its effects on yields and profitability have not been analysed in detail. Here, we analysed the effects of a side deep appli...

journal_title：Scientific reports

authors： Zhu C,Xiang J,Zhang Y,Zhang Y,Zhu D,Chen H

更新日期：2019-04-04 00:00:00

abstract：:Inbred strains of mice are powerful models for understanding human pregnancy complications. For example, the exclusive mating of CBA/J females to DBA/2J males increases fetal resorption to 20-35% with an associated decline in placentation and maintenance of maternal Th1 immunity. More recently other complications of p...

journal_title：Scientific reports

authors： McKelvey KJ,Yenson VM,Ashton AW,Morris JM,McCracken SA

更新日期：2016-10-21 00:00:00

abstract：:Biosynthesis of sakuranetin, a flavonoid anti-fungal phytoalexin that occurs in rice, is highly dependent on jasmonic acid (JA) signalling and induced by a variety of environmental stimuli. We previously identified OsNOMT, which encodes naringenin 7-O-methyltransferase (NOMT); NOMT is a key enzyme for sakuranetin prod...

journal_title：Scientific reports

authors： Ogawa S,Miyamoto K,Nemoto K,Sawasaki T,Yamane H,Nojiri H,Okada K

更新日期：2017-01-09 00:00:00

abstract：:Numerical aberration of the centrosome results in chromosome missegregation, eventually leading to chromosomal instability, a hallmark of human tumor malignancy. Large tumor suppressors 1 and 2 (Lats1 and Lats2) are central kinases in the Hippo pathway and regulate development and tumorigenesis by coordinating the bal...

journal_title：Scientific reports

authors： Mukai S,Yabuta N,Yoshida K,Okamoto A,Miura D,Furuta Y,Abe T,Nojima H

更新日期：2015-11-04 00:00:00

abstract：:Amplicon based metabarcoding promises rapid and cost-efficient analyses of species composition. However, it is disputed whether abundance estimates can be derived from metabarcoding due to taxon specific PCR amplification biases. PCR-free approaches have been suggested to mitigate this problem, but come with considera...

journal_title：Scientific reports

authors： Krehenwinkel H,Wolf M,Lim JY,Rominger AJ,Simison WB,Gillespie RG

更新日期：2017-12-15 00:00:00

abstract：:The high failure strain of thermoplastic elastomers (TPEs) is a very desirable feature for rechargeable Li-ion batteries by improving the lifetime of high specific capacity anode materials that undergo mechanical fractures induced by large volume variations. In this work, poly(styrene-b-2-hydroxyethyl acrylate) called...

journal_title：Scientific reports

authors： Tesfaye AT,Dumur F,Gigmes D,Maria S,Monconduit L,Djenizian T

更新日期：2019-03-13 00:00:00

abstract：:A number of human and animal in vitro or in vivo studies have investigated the relationship between dietary choline and betaine and cancer risk, suggesting that choline and betaine consumption may be protective for cancer. There are also a few epidemiologic studies exploring this relationship, however, with inconsiste...

journal_title：Scientific reports

authors： Sun S,Li X,Ren A,Du M,Du H,Shu Y,Zhu L,Wang W

更新日期：2016-10-19 00:00:00

abstract：:Negative hemodynamic response has been widely reported in blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging studies, however its origin is still controversial. Optical intrinsic signal (OIS) imaging can be used to study brain activity by simultaneously recording hemodynamic signals at diff...

journal_title：Scientific reports

authors： Ma Z,Cao P,Sun P,Zhao L,Li L,Tong S,Lu Y,Yan Y,Chen Y,Chai X

更新日期：2016-02-10 00:00:00

abstract：:In large random networks, each eigenvector of the Laplacian matrix tends to localize on a subset of network nodes having similar numbers of edges, namely, the components of each Laplacian eigenvector take relatively large values only on a particular subset of nodes whose degrees are close. Although this localization p...

journal_title：Scientific reports

authors： Hata S,Nakao H

更新日期：2017-04-25 00:00:00

abstract：:The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated. The results showed that Ac-MPS have potential ability to relieve the hypertriglyceridemia and preventing oxidative...

journal_title：Scientific reports

authors： Gao Z,Lai Q,Yang Q,Xu N,Liu W,Zhao F,Liu X,Zhang C,Zhang J,Jia L

更新日期：2018-11-30 00:00:00

abstract：:Despite dedicated research has been carried out to adequately map the distribution of the sperm whale in the Mediterranean Sea, unlike other regions of the world, the species population status is still presently uncertain. The analysis of two years of continuous acoustic data provided by the ANTARES neutrino telescope...

journal_title：Scientific reports

authors： André M,Caballé A,van der Schaar M,Solsona A,Houégnigan L,Zaugg S,Sánchez AM,Castell JV,Solé M,Vila F,Djokic D,Adrián-Martínez S,Albert A,Anghinolfi M,Anton G,Ardid M,Aubert JJ,Avgitas T,Baret B,Barrios-Martí J,Ba

更新日期：2017-04-12 00:00:00

abstract：:Transition Metal Dichalcogenides (TMDs) are one of the most studied two-dimensional materials in the last 5-10 years due to their extremely interesting layer dependent properties. Despite the presence of vast research work on TMDs, the complex relation between the electro-chemical and physical properties make them the...

journal_title：Scientific reports

authors： Ghatak K,Kang KN,Yang EH,Datta D

更新日期：2020-02-03 00:00:00

abstract：:Anopheles gambiae and Aedes aegypti are perhaps the best studied mosquito species and important carriers of human malaria and arbovirus, respectively. Mosquitoes have daily rhythms in behaviors and show a wide range of activity patterns. Although Anopheles is known to be principally nocturnal and Aedes principally diu...

journal_title：Scientific reports

authors： Araujo MDS,Guo F,Rosbash M

更新日期：2020-03-19 00:00:00

abstract：:Night shift work can associate with an increased risk for depression. As night workers experience a 'misalignment' between their circadian system and daily sleep-wake behaviors, with negative health consequences, we investigated whether exposure to circadian misalignment underpins mood vulnerability in simulated shift...

journal_title：Scientific reports

authors： Chellappa SL,Morris CJ,Scheer FAJL

更新日期：2020-10-29 00:00:00

abstract：:Multi-junction (MJ) solar cells are one of the most promising technologies achieving high sunlight to electricity conversion efficiency. Resistive losses constitute one of the main underlying mechanisms limiting their efficiency under high illumination. In this paper, we study, by numerical modeling, the extent to whi...

journal_title：Scientific reports

authors： Zeitouny J,Katz EA,Dollet A,Vossier A

更新日期：2017-05-11 00:00:00

abstract：:Accurate estimation of carrier probabilities of cancer susceptibility gene mutations is an important part of pre-test genetic counselling. Many predictive models are available but their applicability in the Asian population is uncertain. We evaluated the performance of five BRCA mutation risk predictive models in a Ch...

journal_title：Scientific reports

authors： Hung FH,Wang YA,Jian JW,Peng HP,Hsieh LL,Hung CF,Yang MM,Yang AS

更新日期：2019-07-15 00:00:00

abstract：:Multi-stranded helices are widespread in nature. The interplay of polymeric properties with biological function is seldom discussed. This study probes analogies between structural and mechanical properties of collagen and DNA. We modeled collagen with Eulerian rotational and translational parameters of adjacent rungs ...

journal_title：Scientific reports

authors： Xu F,Zheng H,Clauvelin N,Lu XJ,Olson WK,Nanda V

更新日期：2017-10-16 00:00:00

abstract：:Following retinal degeneration, retinal remodeling can cause neuronal microcircuits to undergo structural alterations, which particularly affect the dendrites of bipolar cells. However, the mechanisms and functional consequences of such changes remain unclear. Here, we used Royal College of Surgeon (RCS) rats as a mod...

journal_title：Scientific reports

authors： Fu Y,Hou B,Weng C,Liu W,Dai J,Zhao C,Yin ZQ

更新日期：2017-04-21 00:00:00

abstract：:Although the initial formulation of modern concepts of adaptive radiation arose from consideration of the fossil data, rigorous attempts to identify this phenomenon in the fossil record are largely uncommon. Here I focus on direct evidence of the diet (through tooth-wear patterns) and ecologically-relevant traits of o...

journal_title：Scientific reports

authors： DeMiguel D

更新日期：2016-07-13 00:00:00

abstract：:Seven new formyl phloroglucinol meroterpenoids (FPMs), namely eucalrobusones J-P (1-7), as well as three known ones (8-10) were isolated from the leaves of Eucalyptus robusta. Their structures were elucidated by spectroscopic data analysis, and their absolute configurations were determined by applications of the Snatz...

journal_title：Scientific reports

authors： Shang ZC,Yang MH,Liu RH,Wang XB,Kong LY

更新日期：2016-12-22 00:00:00

abstract：:During the last decades, atmospheric nitrogen loading in mountain ranges of the Northern Hemisphere has increased substantially, resulting in high nitrate concentrations in many lakes. Yet, how increased nitrogen has affected denitrification, a key process for nitrogen removal, is poorly understood. We measured actual...

journal_title：Scientific reports

authors： Palacin-Lizarbe C,Camarero L,Hallin S,Jones CM,Catalan J

更新日期：2020-02-20 00:00:00

abstract：:The recombination is one of the most frequently identified drivers of double-stranded DNA viruses evolution. However, the recombination events in African swine fever virus (ASFV) genomes have been poorly annotated. We hypothesize that the genetic determinants of ASFV variability are potential hot-spots for recombinati...

journal_title：Scientific reports

authors： Nefedeva M,Titov I,Tsybanov S,Malogolovkin A

更新日期：2020-10-28 00:00:00

abstract：:Breast cancer is a heterogeneous disease with differences in its clinical, molecular and biological features. Traditionally, immunohistochemical markers together with clinicopathologic parameters are used to classify breast cancer and to predict disease outcome. Triple-negative breast cancer (TNBC) is a particular typ...

journal_title：Scientific reports

authors： Manica GC,Ribeiro CF,Oliveira MA,Pereira IT,Chequin A,Ramos EA,Klassen LM,Sebastião AP,Alvarenga LM,Zanata SM,Noronha L,Rabinovich I,Costa FF,Souza EM,Klassen G

更新日期：2017-03-15 00:00:00

abstract：:M2BP (also called 90K) is an interferon-stimulated gene product that is upregulated in HIV-1 infection. A recent study revealed that M2BP reduces the infectivity of HIV-1 by inhibiting the processing of the viral envelope protein. Here we report that in addition to reducing viral infectivity, M2BP inhibits HIV-1 virio...

journal_title：Scientific reports

authors： Wang Q,Zhang X,Han Y,Wang X,Gao G

更新日期：2016-09-08 00:00:00

abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...

journal_title：Scientific reports

authors： Lopes-Marques M,Serrano C,Cardoso AR,Salazar R,Seixas S,Amorim A,Azevedo L,Prata MJ

更新日期：2020-07-14 00:00:00

abstract：:Meteorite impacts have caused catastrophic perturbations to the global environment and mass extinctions throughout the Earth's history. Here, we present petrographic and geochemical evidence of a possible impact ejecta layer, dating from about 11 Ma, in deep-sea clayey sediment in the Northwest Pacific. This clay laye...

journal_title：Scientific reports

authors： Nozaki T,Ohta J,Noguchi T,Sato H,Ishikawa A,Takaya Y,Kimura JI,Chang Q,Shimada K,Ishibashi JI,Yasukawa K,Kimoto K,Iijima K,Kato Y

更新日期：2019-11-20 00:00:00