Abstract：
:A number of human and animal in vitro or in vivo studies have investigated the relationship between dietary choline and betaine and cancer risk, suggesting that choline and betaine consumption may be protective for cancer. There are also a few epidemiologic studies exploring this relationship, however, with inconsistent conclusions. The PubMed and Embase were searched, from their inception to March 2016, to identify relevant studies and we brought 11 articles into this meta-analysis eventually. The pooled relative risks (RRs) of cancer for the highest versus the lowest range were 0.82 (95% CI, 0.70 to 0.97) for choline consumption only, 0.86 (95%CI, 0.76 to 0.97) for betaine consumption only and 0.60 (95%CI, 0.40 to 0.90) for choline plus betaine consumption, respectively. Significant protective effect of dietary choline and betaine for cancer was observed when stratified by study design, location, cancer type, publication year, sex and quality score of study. An increment of 100 mg/day of choline plus betaine intake helped reduce cancer incidence by 11% (0.89, 95% CI, 0.87 to 0.92) through a dose-response analysis. To conclude, choline and betaine consumption lowers cancer incidence in this meta-analysis, but further studies are warranted to verify the results.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sun S,Li X,Ren A,Du M,Du H,Shu Y,Zhu L,Wang Wdoi
10.1038/srep35547subject
Has Abstractpub_date
2016-10-19 00:00:00pages
35547issn
2045-2322pii
srep35547journal_volume
6pub_type
杂志文章,meta分析abstract：:To determine whether p16 INK4a deletion ameliorated renal tubulointerstitial injury by inhibiting a senescence-associated secretory phenotype (SASP) in Bmi-1-deficient (Bmi-1 -/-) mice, renal phenotypes were compared among 5-week-old Bmi-1 and p16 INK4a double-knockout, and Bmi-1 -/- and wild-type mice. Fifth-passage ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06868-8
更新日期：2017-08-08 00:00:00
abstract：:MicroRNAs (miRNAs) have been reported to be involved in DNA damage response induced by ionizing radiation (IR). c-Myc is reduced when cells treated with IR or other DNA damaging agents. It is unknown whether miRNAs participate in c-Myc downregulation in response to IR. In the present study, we found that miR-449a enha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27346
更新日期：2016-06-02 00:00:00
abstract：:Environmental Enteric Dysfunction (EED), a syndrome characterized by chronic gut inflammation, contributes towards stunting and poor response to enteric vaccines in children in developing countries. In this study, we evaluated major putative biomarkers of EED using growth faltering as its clinical proxy. Newborns (n =...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21319-8
更新日期：2018-02-14 00:00:00
abstract：:Cytochrome P450 monooxygenases are present in almost all organisms and can play vital roles in hormone regulation, metabolism of xenobiotics and in biosynthesis or inactivation of endogenous compounds. In the present study, a genome-wide approach was used to identify and analyze the P450 gene family of diamondback mot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08952
更新日期：2015-03-10 00:00:00
abstract：:Automatically detecting and grading cancerous regions on radical prostatectomy (RP) sections facilitates graphical and quantitative pathology reporting, potentially benefitting post-surgery prognosis, recurrence prediction, and treatment planning after RP. Promising results for detecting and grading prostate cancer on...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66849-2
更新日期：2020-06-18 00:00:00
abstract：:Terminally misfolded proteins are selectively recognized and cleared by the endoplasmic reticulum-associated degradation (ERAD) pathway. SEL1L, a component of the ERAD machinery, plays an important role in selecting and transporting ERAD substrates for degradation. We have determined the crystal structure of the mouse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20261
更新日期：2016-02-09 00:00:00
abstract：:Food thickening agents are used to aid the administration of medicine to elderly patients with dysphagia. Magnesium oxide tablets are sometimes administered with food thickening agents. Non-disintegration and disintegration delay of these tablets in the body are problems associated with food thickening agent use. Howe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73135-8
更新日期：2020-09-30 00:00:00
abstract：:Listeria monocytogenes is well known for having the ability to cross the placental barrier, leading to fetal infections and abortion. However, the mechanisms leading to infectious abortion are poorly understood. In this study, we demonstrate that interferon γ-induced GTPase (IGTP) contributes to the invasion of L. mon...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08195
更新日期：2015-02-03 00:00:00
abstract：:Cells grown in three-dimensional (3D) cultures are more likely to have native cell-cell and cell-matrix interactions than in 2D cultures that impose mechanical constraints to cells. However, most 3D cultures utilise gel matrix which, while serving as a scaffold, limits application due to its solid and opaque nature an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21950-5
更新日期：2018-02-26 00:00:00
abstract：:The uncertainty relation is a fundamental limit in quantum mechanics and is of great importance to quantum information processing as it relates to quantum precision measurement. Due to interactions with the surrounding environment, a quantum system will unavoidably suffer from decoherence. Here, we investigate the dyn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01094-8
更新日期：2017-04-21 00:00:00
abstract：:Oil spills represent an overwhelming carbon input to the marine environment that immediately impacts the sea surface ecosystem. Microbial communities degrading the oil fraction that eventually sinks to the seafloor must also deal with hydrostatic pressure, which linearly increases with depth. Piezosensitive hydrocarbo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23526
更新日期：2016-03-29 00:00:00
abstract：:Aluminum-based quasicrystals typically form across narrow composition ranges within binary to quaternary alloys, which makes their fabrication and characterization challenging. Here, we use combinatorial approaches together with fast characterization techniques to study a wide compositional range including known quasi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43666-w
更新日期：2019-05-09 00:00:00
abstract：:Enhanced oil recovery using low-salinity solutions to sweep sandstone reservoirs is a widely-practiced strategy. The mechanisms governing this remain unresolved. Here, we elucidate the role of Ca2+ by combining chemical force microscopy (CFM) and molecular dynamics (MD) simulations. We probe the influence of electroly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10327-9
更新日期：2017-09-08 00:00:00
abstract：:Recent experimental work in the field of synthetic protocell biology has shown that prebiotic vesicles are able to 'steal' lipids from each other. This phenomenon is driven purely by asymmetries in the physical state or composition of the vesicle membranes, and, when lipid resource is limited, translates directly into...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05675
更新日期：2014-07-14 00:00:00
abstract：:We compared the cranial base of newborn Pax7-deficient and wildtype mice using a computational shape modeling technology called particle-based modeling (PBM). We found systematic differences in the morphology of the basiooccipital bone, including a broadening of the basioccipital bone and an antero-inferior inflection...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18199-9
更新日期：2017-12-20 00:00:00
abstract：:Mesenchymal stem cells (MSCs) aid the regeneration of tissues damaged by treatment with cisplatin. However, the effects of this cytotoxic drug on the stem cells have been largely unknown. Here we demonstrate that human bone marrow-derived MSCs are relatively resistant to cisplatin treatment and show resistance levels ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20035
更新日期：2016-01-25 00:00:00
abstract：:Generation of multiple mRNAs by alternative splicing is well known in the group of cytokines and has recently been reported for the human erythropoietin (EPO) gene. Here, we focus on the alternatively spliced EPO transcript characterized by deletion of exon 3 (hEPOΔ3). We show co-regulation of EPO and hEPOΔ3 in human ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03167-0
更新日期：2017-06-16 00:00:00
abstract：:Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37313-z
更新日期：2019-01-29 00:00:00
abstract：:Ceramide (Cer) release from glucosylceramides (GlcCer) is critical for the formation of the skin permeability barrier. Changes in β-glucocerebrosidase (GlcCer'ase) activity lead to diminished Cer, GlcCer accumulation and structural defects in SC lipid lamellae; however, the molecular basis for this impairment is not c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06990-7
更新日期：2017-07-25 00:00:00
abstract：:Intermediate level radioactive waste (ILW) generally contains a heterogeneous range of organic and inorganic materials, of which some are encapsulated in cement. Of particular concern are cellulosic waste items, which will chemically degrade under the conditions predicted during waste disposal, forming significant qua...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26963-8
更新日期：2018-06-08 00:00:00
abstract：:Humans interact with the oceans in diverse and profound ways. The scope, magnitude, footprint and ultimate cumulative impacts of human activities can threaten ocean ecosystems and have changed over time, resulting in new challenges and threats to marine ecosystems. A fundamental gap in understanding how humanity is af...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47201-9
更新日期：2019-08-12 00:00:00
abstract：:Night-workers, transcontinental travelers and individuals that regularly shift their sleep timing, suffer from circadian desynchrony and are at risk to develop metabolic disease, cancer, and mood disorders, among others. Experimental and clinical studies provide evidence that food intake restricted to the normal activ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63227-w
更新日期：2020-04-10 00:00:00
abstract：:Supercapacitors with aqueous electrolytes and nanostructured composite electrodes are attractive because of their high charging-discharging speed, long cycle life, low environmental impact and wide commercial affordability. However, the energy capacity of aqueous supercapacitors is limited by the electrochemical windo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09854
更新日期：2015-04-21 00:00:00
abstract：:Dengue virus infection is a global threat for which no specific treatment has not been established. Previous reports suggested chrysin and flavanone derivatives were potential flaviviral inhibitors. Here, we reported two halogenated chrysins, abbreviated FV13 and FV14, were highly potent against DENV1-4 and ZIKV infec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14121-5
更新日期：2017-10-20 00:00:00
abstract：:The mechanical behavior of a single phase (fcc) Al0.3CoCrFeNi high-entropy alloy (HEA) was studied in the low and high strain-rate regimes. The combination of multiple strengthening mechanisms such as solid solution hardening, forest dislocation hardening, as well as mechanical twinning leads to a high work hardening ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42742
更新日期：2017-02-17 00:00:00
abstract：:The formation of proper sensory afferent connections during development is essential for brain function. Activity-based competition is believed to drive ocular dominance columns (ODC) in mammals and in experimentally-generated three-eyed frogs. ODC formation is thus a compromise of activity differences between two eye...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08338
更新日期：2015-02-09 00:00:00
abstract：:Nontuberculous mycobacteria (NTM) are environmental bacteria increasingly associated to public health problems. In water systems, free-living amoebae (FLA) feed on bacteria by phagocytosis, but several bacteria, including many NTM, are resistant to this predation. Thus, FLA can be seen as a training ground for pathoge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46270
更新日期：2017-04-10 00:00:00
abstract：:The intrauterine environment is particularly vulnerable to environmental exposures. We previously established a mouse model that provided evidence for pregnancy complications and placental anti-angiogenesis in response to Aroclor 1254 (A-1254), a mixture of polychlorinated biphenyls (PCBs). Importantly, these effects ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39885
更新日期：2017-01-10 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep37196. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep47002
更新日期：2018-07-04 00:00:00
abstract：:No study to date has prospectively evaluated the association between pre-diagnostic cruciferous vegetables intake and lung cancer survival among women. This analysis included 547 incident lung cancer cases identified from the Shanghai Women's Health Study (SWHS) during the follow-up period of 1997-2011. Dietary intake...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10306
更新日期：2015-05-19 00:00:00
