Abstract：
:The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated. The results showed that Ac-MPS have potential ability to relieve the hypertriglyceridemia and preventing oxidative stress by decreasing levels of TG, TC LDL-C, elevating contents of HDL-C in serum, increasing the activities of SOD, GSH-Px, CAT and T-AOC, and the down regulating MDA and LPO contents in liver, heart, kidney and spleen. And the histopathological observations also displayed that Ac-MPS could alleviate organ damage. Moreover, the GC, HPGPC, FT-IR and AFM analyses revealed the Ac-MPS possessed the typical polysaccharides structure with the molecular weights (Mw) of 2.712 × 105 Da. These conclusions indicated that the Ac-MPS had the potential to develop new drugs for hypertriglyceridemia-induced multiple organ failure.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gao Z,Lai Q,Yang Q,Xu N,Liu W,Zhao F,Liu X,Zhang C,Zhang J,Jia Ldoi
10.1038/s41598-018-35706-8subject
Has Abstractpub_date
2018-11-30 00:00:00pages
17500issue
1issn
2045-2322pii
10.1038/s41598-018-35706-8journal_volume
8pub_type
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