Abstract：
:The involvement of the immune system, particularly the role of T-cells, in sarcoidosis is unclear. The existence of higher CD4+ T-cells and increased CD4/CD8 ratio may indicate a pathogenic role of T-cells in the disease. In this study, we quantified the contribution of T-cells associated variants and of CD4/CD8 ratio in sarcoidosis phenotypes, Löfgren's syndrome (LS) and non- Löfgren's syndrome (non-LS). We employed a polygenic-based approach using genome-wide association studies results on relative levels of T-cells in healthy individuals to measure the genetic contribution of T-cells in sarcoidosis entities. Results revealed that the genetic architecture of LS is highly influenced by genetic variants associated with CD8+ T-cells and CD4/CD8 ratio, explaining up to 7.94% and 6.49% of LS variation, respectively; whereas, the genetic architecture of non-LS is minimally influenced by T-cells, explaining a phenotypic variation of <1%. Moreover, pleiotropy assessment between T-cells and LS/non-LS associated-variants led to the discovery of highly scored pathway maps that shared common factors related to antigen presentation and T-cell regulatory mechanisms. Differences in significant polygenic scores, presence of pleiotropy, and distinct genetic factors provide further insights on how genetic variants and genes associated with relative levels of T-cell subtypes contribute differently to sarcoidosis phenotypes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rivera NV,Hagemann-Jensen M,Ferreira MAR,Kullberg S,Eklund A,Martin NG,Padyukov L,Grunewald Jdoi
10.1038/s41598-017-05754-7subject
Has Abstractpub_date
2017-07-17 00:00:00pages
5623issue
1issn
2045-2322pii
10.1038/s41598-017-05754-7journal_volume
7pub_type
杂志文章abstract：:Worldwide, Bartonella infections are known to inflict a wide range of mammals and, within rodents alone, more than 20 Bartonella species have been detected. There is, however, a lack of studies on the presence of Bartonella spp. in rodents in the Baltic region. We analysed 580 individuals belonging to eight small rode...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48715-y
更新日期：2019-08-26 00:00:00
abstract：:We show that the space in which scientific, technological and economic activities interplay with each other can be mathematically shaped using techniques from statistical physics of networks. We build a holistic view of the innovation system as the tri-layered network of interactions among these many activities (scien...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52767-5
更新日期：2019-11-11 00:00:00
abstract：:We have measured artificial radionuclides, such as 90Sr and 137Cs, in atmospheric depositions since 1957 in Japan. We observed the variations in 90Sr and 137Cs, which were emitted from atmospheric nuclear tests and nuclear power plant accidents, due to their diffusion, deposition, and resuspension. In March 2011, the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78312-3
更新日期：2020-12-10 00:00:00
abstract：:An individual's immune system is driven by both genetic and environmental factors that vary over time. To better understand the temporal and inter-individual variability of gene expression within distinct immune cell types, we developed a platform that leverages multiplexed single-cell sequencing and out-of-clinic cap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77073-3
更新日期：2020-11-25 00:00:00
abstract：:In response to infestation by herbivores, rice plants rapidly biosynthesize defense compounds by activating a series of defense-related pathways. However, which defensive compounds in rice are effective against herbivores remains largely unknown. We found that the infestation of white-backed planthopper (WBPH) Sogatel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62752-y
更新日期：2020-04-01 00:00:00
abstract：:The overuse of antibiotics results in the development of antibiotic resistance and limits the useful life of these drugs in fighting bacteria, including Aeromonas hydrophila, a well-known opportunistic pathogen that causes serious infections in fish and other animals. In this study, we investigated the adaptive resist...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39413
更新日期：2016-12-19 00:00:00
abstract：:Depressive disorder (DD) is a mental illness affecting more than 300 million people worldwide, whereas social stigma and subtle, variant symptoms impede diagnosis. Psychomotor retardation is a common component of DD with a negative impact on motor function, usually reflected on patients' routine activities, including,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50002-9
更新日期：2019-09-16 00:00:00
abstract：:In recent years, conservation biologists have raised awareness about the risk of ecological interference between massively introduced managed honeybees and the native wild bee fauna in protected natural areas. In this study, we surveyed wild bees and quantified their nectar and pollen foraging success in a rosemary Me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27591-y
更新日期：2018-06-18 00:00:00
abstract：:A three-dimensional multiscale modeling framework is developed to analyze the failure procedure of radially aligned zinc oxide (ZnO) enhanced single fiber composites (SFC) under tensile loading to understand the interfacial improvement between the fiber and the matrix. The model introduces four levels in the computati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56503-x
更新日期：2019-12-27 00:00:00
abstract：:Human milk delivers an array of bioactive components that safeguard infant growth and development and maintain healthy gut microbiota. Milk fat globule membrane (MFGM) is a biologically functional fraction of milk increasingly linked to beneficial outcomes in infants through protection from pathogens, modulation of th...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-47953-4
更新日期：2019-08-12 00:00:00
abstract：:Intriguing experimental results raised the question about the fundamental mechanisms governing the electron-hole coupling induced bipolar thermal conduction in semiconductors. Our combined theoretical analysis and experimental measurements show that in semiconductors bipolar thermal transport is in general a "conducti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10136
更新日期：2015-05-13 00:00:00
abstract：:A fundamental assumption in bioacoustics is that large animals tend to produce vocalizations with lower frequencies than small animals. This inverse relationship between body size and vocalization frequencies is widely considered to be foundational in animal communication, with prominent theories arguing that it playe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41070
更新日期：2017-01-24 00:00:00
abstract：:The aim of this study was to assess the systemic and analgesic effects of epidural dexmedetomidine in thoracic epidural anaesthesia (TEA) combined with total intravenous anaesthesia during thoracic surgery. Seventy-one patients undergoing open thoracotomy were included in this study and randomly divided into three gro...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-017-04382-5
更新日期：2017-06-21 00:00:00
abstract：:Enterobacter aerogenes LU2 was isolated from cow rumen and recognized as a potential succinic acid producer in our previous study. Here, we present the first complete genome sequence of this new, wild strain and report its basic genetic features from a biotechnological perspective. The MinION single-molecule nanopore ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58929-0
更新日期：2020-02-06 00:00:00
abstract：:Long-term daylight deprivation such as during the Antarctic winter has been shown to lead to delayed sleep timing and sleep fragmentation. We aimed at testing whether retinal sensitivity, sleep and circadian rest-activity will change during long-term daylight deprivation on two Antarctic bases (Concordia and Halley VI...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33450-7
更新日期：2018-11-01 00:00:00
abstract：:Through a geomorphological study relying on statistically assessed classes of hilltop elevations, we reconstruct a suite of paleo-surfaces along the Tiber River Valley north of Rome that we identify as fluvial terraces formed by interplay between global sea-level fluctuations and regional upift. Using biostratigraphic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02437-1
更新日期：2017-05-31 00:00:00
abstract：:Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been geographical, although cultural and linguistic differences still exist between some of the districts/prefectures, especially between Okinawa and th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17855
更新日期：2015-12-09 00:00:00
abstract：:Accurately establishing the state of large-scale quantum systems is an important tool in quantum information science; however, the large number of unknown parameters hinders the rapid characterisation of such states, and reconstruction procedures can become prohibitively time-consuming. Compressive sensing, a procedur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06542
更新日期：2014-10-13 00:00:00
abstract：:Coastal protection design heights typically consider the superimposed effects of tides, surges, waves, and relative sea-level rise (SLR), neglecting non-linear feedbacks between these forcing factors. Here, we use hydrodynamic modelling and multivariate statistics to show that shallow coastal areas are extremely sensi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40171
更新日期：2017-01-06 00:00:00
abstract：:Loss of cardiomyocyte proliferative capacity after birth is a major obstacle for therapeutic heart regeneration in adult mammals. We and others have recently shown the importance of hypoxic in utero environments for active foetal cardiomyocyte proliferation. Here, we report the unexpected expression of novex-3, the sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30886-9
更新日期：2018-08-17 00:00:00
abstract：:Approximately 300,000 men around the globe self-identify as Ashkenazi Levites, of whom two thirds were previously shown to descend from a single male. The paucity of whole Y-chromosome sequences precluded conclusive identification of this ancestor's age, geographic origin and migration patterns. Here, we report the va...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14761-7
更新日期：2017-11-02 00:00:00
abstract：:Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44009
更新日期：2017-03-10 00:00:00
abstract：:A wide-band and tunable Q-switched erbium-doped fiber (EDF) laser operating at 1560.5 nm with a tungsten ditelluride (WTe2) saturable absorber (SA) is demonstrated. The semi-metallic nature of WTe2 as well as its small band gap and excellent nonlinear optical properties make it an excellent SA material. The laser cavi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66664-9
更新日期：2020-06-17 00:00:00
abstract：:The gut microbiota (GM) is related to obesity and other metabolic diseases. To detect GM markers for obesity in patients with different metabolic abnormalities and investigate their relationships with clinical indicators, 1,914 Chinese adults were enrolled for 16S rRNA gene sequencing in this retrospective study. Base...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-49462-w
更新日期：2019-09-17 00:00:00
abstract：:Human protein tyrosine phosphatase non-receptor type 4 (PTPN4) has been shown to prevent cell death. The active form of human PTPN4 consists of two globular domains, a PDZ (PSD-95/Dlg/ZO-1) domain and a phosphatase domain, tethered by a flexible linker. Targeting its PDZ domain abrogates this protection and triggers a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08193-6
更新日期：2017-08-11 00:00:00
abstract：:The intricate molecular processes underlying photosynthesis have long been studied using various analytic approaches. However, the three-dimensional (3D) dynamics of such photosynthetic processes remain unexplored due to technological limitations related to investigating intraorganellar mechanisms in vivo. By developi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29940
更新日期：2016-07-15 00:00:00
abstract：:Polymer-supported nanozero-valent iron composites (D001-nZVI) were fabricated for the removal of lead ions from aqueous solutions by embedding nZVI into the porous polystyrene anion exchanger D001. Humic acid (HA) was selected as a model species because of its ubiquitous existence to gain insight into the influencing ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76362-1
更新日期：2020-11-12 00:00:00
abstract：:Climate change and human activity are dooming species at an unprecedented rate via a plethora of direct and indirect, often synergic, mechanisms. Among these, primary extinctions driven by environmental change could be just the tip of an enormous extinction iceberg. As our understanding of the importance of ecological...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35068-1
更新日期：2018-11-13 00:00:00
abstract：:We collected Solidago altissima clones to explore their leaf damage resistance, and as a result identified five accessions that exhibited variable defense abilities against the generalist herbivore Spodoptera litura. In order to characterize molecules involved in such natural variation, we focused on ethylene response...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62142-4
更新日期：2020-03-24 00:00:00
abstract：:In recent years, there has been an impressively fast technological progress in the development of highly efficient lead halide perovskite solar cells. However, the stability of perovskite films and respective solar cells is still an open point of concern and calls for advanced characterization methods. In this work, w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35973
更新日期：2016-10-27 00:00:00
