Noninvasive low-cycle fatigue characterization at high depth with photoacoustic eigen-spectrum analysis.

abstract：:Quality control of human induced pluripotent stem cells (iPSCs) can be performed by several methods. These methods are usually relatively labor-intensive, difficult to standardize, or they do not facilitate reliable quantification. Here, we describe a biomarker to distinguish between pluripotent and non-pluripotent ce...

journal_title：Scientific reports

authors： Lenz M,Goetzke R,Schenk A,Schubert C,Veeck J,Hemeda H,Koschmieder S,Zenke M,Schuppert A,Wagner W

更新日期：2015-03-10 00:00:00

abstract：:To relieve the environmental issues of sewage sludge (SS) disposal and greenhouse gas (GHG) emission in China, we proposed an integrated method for the first time to simultaneously deal with these two problems. The hot slags below 920 °C could act as a good heat carrier for sludge gasification and the increasing CO2 c...

journal_title：Scientific reports

authors： Sun Y,Nakano J,Liu L,Wang X,Zhang Z

更新日期：2015-06-15 00:00:00

abstract：:Plants are constantly exposed to pathogens and environmental stresses. To minimize damage caused by these potentially harmful factors, plants respond by massive transcriptional reprogramming of various stress-related genes via major transcription factor families. One of the transcription factor families, WRKY, plays a...

journal_title：Scientific reports

authors： Huh SU,Lee GJ,Jung JH,Kim Y,Kim YJ,Paek KH

更新日期：2015-01-23 00:00:00

abstract：:Microbial rhodopsin is a photoreceptor protein found in various bacteria and archaea, and it is considered to be a light-utilization device unique to heterotrophs. Recent studies have shown that several cyanobacterial genomes also include genes that encode rhodopsins, indicating that these auxiliary light-utilizing pr...

journal_title：Scientific reports

authors： Hasegawa M,Hosaka T,Kojima K,Nishimura Y,Nakajima Y,Kimura-Someya T,Shirouzu M,Sudo Y,Yoshizawa S

更新日期：2020-10-07 00:00:00

abstract：:Cytometric studies utilizing flow cytometry or multi-well culture plate fluorometry are often limited by a deficit in temporal resolution and a lack of single cell consideration. Unfortunately, many cellular processes, including signaling, motility, and molecular transport, occur transiently over relatively short peri...

journal_title：Scientific reports

authors： Byrd TF 4th,Hoang LT,Kim EG,Pfister ME,Werner EM,Arndt SE,Chamberlain JW,Hughey JJ,Nguyen BA,Schneibel EJ,Wertz LL,Whitfield JS,Wikswo JP,Seale KT

更新日期：2014-05-30 00:00:00

abstract：:Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) has a dimer of dimers quaternary structure with two independent allosteric sites in each monomer. Here, we reveal the different effects of nucleotide ligands on the quaternary structure regulation and functional role of the human m-NAD(P)-ME exosite. In ...

journal_title：Scientific reports

authors： Hsieh JY,Shih WT,Kuo YH,Liu GY,Hung HC

更新日期：2019-06-24 00:00:00

abstract：:Recent advances in fluorescent protein technology provide a wide variety of biological imaging applications; however current tools for bio-imaging in the Gram-positive bacterium Staphylococcus aureus has necessitated further developments for fluorescence intensity and for a multicolor palette of fluorescent proteins. ...

journal_title：Scientific reports

authors： Kato F,Nakamura M,Sugai M

更新日期：2017-06-06 00:00:00

abstract：:To date, analyses of individual targets have provided evidence of a miRNA targetome that extends beyond the boundaries of messenger RNAs (mRNAs) and can involve non-Watson-Crick base pairing in the miRNA seed region. Here we report our findings from analyzing 34 Argonaute HITS-CLIP datasets from several human and mous...

journal_title：Scientific reports

authors： Clark PM,Loher P,Quann K,Brody J,Londin ER,Rigoutsos I

更新日期：2014-08-08 00:00:00

abstract：:Drug-based treatments are the most widely used interventions for cancer management. Personalized drug response profiling remains inherently challenging with low cell count harvested from tumour sample. We present a 96well-formatted microfluidic plate with built-in micro-gap that preserves up to 99.2% of cells during m...

journal_title：Scientific reports

authors： Ma WY,Hsiung LC,Wang CH,Chiang CL,Lin CH,Huang CS,Wo AM

更新日期：2015-04-13 00:00:00

abstract：:A novel characterization technique using both in situ reflection high-energy electron diffraction (RHEED) transmission mode and transmission electron microscopy (TEM) has been developed to investigate the growth behaviour of semiconductor nanostructures. RHEED employed in transmission mode enables the acquisition of s...

journal_title：Scientific reports

authors： Jo J,Tchoe Y,Yi GC,Kim M

更新日期：2018-01-26 00:00:00

abstract：:Chromatin remodeling has been newly established as an important cancer genome characterization and recent exome and whole-genome sequencing studies of hepatocellular carcinoma (HCC) showed that recurrent inactivating mutations in SWI/SNF subunits involved in the molecular basis of hepatocarcinogenesis. To test the hyp...

journal_title：Scientific reports

authors： Zhong R,Liu L,Tian Y,Wang Y,Tian J,Zhu BB,Chen W,Qian JM,Zou L,Xiao M,Shen N,Yang H,Lou J,Qiu Q,Ke JT,Lu XH,Wang ZL,Song W,Zhang T,Li H,Wang L,Miao XP

更新日期：2014-02-21 00:00:00

abstract：:Contemporary improvements in the type II clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system offer a convenient way for genome editing in zebrafish. However, the low efficiencies of genome editing and germline transmission require a time-intensive and laborious sc...

journal_title：Scientific reports

authors： Xie SL,Bian WP,Wang C,Junaid M,Zou JX,Pei DS

更新日期：2016-09-29 00:00:00

abstract：:Pantoea sp. IMH is the only bacterium found in genus Pantoea with a high As resistance capacity, but its molecular mechanism is unknown. Herein, the organization, function, and evolution of ars genes in IMH are studied starting with analysis of the whole genome. Two ars systems - ars1 (arsR1B1C1H1) and ars2 (arsR2B2C2...

journal_title：Scientific reports

authors： Wang L,Zhuang X,Zhuang G,Jing C

更新日期：2016-12-14 00:00:00

abstract：:Previously, we cloned a new gene termed 'tongue cancer resistance-associated protein 1' (TCRP1), which modulates tumorigenesis, enhances cisplatin (cDDP) resistance in cancers, and may be a potential target for reversing drug resistance. However, the mechanisms for regulating TCRP1 expression remain unclear. Herein, w...

journal_title：Scientific reports

authors： Jia X,Zhang Z,Luo K,Zheng G,Lu M,Song Y,Liu H,Qiu H,He Z

更新日期：2017-06-16 00:00:00

abstract：:The Ah receptor (AhR) is a ligand-dependent transcription factor belonging to the basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) superfamily. Binding to and activation of the AhR by a variety of chemicals results in the induction of expression of diverse genes and production of a broad spectrum of biological and toxic...

journal_title：Scientific reports

authors： Giani Tagliabue S,Faber SC,Motta S,Denison MS,Bonati L

更新日期：2019-07-23 00:00:00

abstract：:Plastic represents 60-80% of litter in the ocean. Degradation of plastic to small fragments leads to the formation of microplastics (MPs <5 mm) and nanoplastics (NPs <1 µm). One of the most widely used and representative plastics found in the ocean is polystyrene (PS). Among marine organisms, the immune system of biva...

journal_title：Scientific reports

authors： Sendra M,Carrasco-Braganza MI,Yeste PM,Vila M,Blasco J

更新日期：2020-05-25 00:00:00

abstract：:Accumulating evidence indicates the association between obesity and lung function. However, no previous study has examined whether obesity affects lung function in normal weight participants with high body fat. We hypothesized that subjects with normal weight obesity (NWO) were inversely associated with lung function ...

journal_title：Scientific reports

authors： Chen YY,Kao TW,Fang WH,Wang CC,Chang YW,Yang HF,Wu CJ,Sun YS,Chen WL

更新日期：2019-06-20 00:00:00

abstract：:Spirometry is required to confirm a chronic obstructive pulmonary disease (COPD) diagnosis, but it is difficult to perform in resource-limited settings. This study aimed to evaluate symptom-based questions for screening of individuals with COPD among Chinese populations. We recruited 3969 adult subjects from the First...

journal_title：Scientific reports

authors： Zhang Q,Wang M,Li X,Wang H,Wang J

更新日期：2016-07-26 00:00:00

abstract：:The endosymbiotic bacterium Wolbachia spreads rapidly through populations of Aedes aegypti mosquitoes, and strongly inhibits infection with key human pathogens including the dengue and Zika viruses. Mosquito control programs aimed at limiting transmission of these viruses are ongoing in multiple countries, yet there i...

journal_title：Scientific reports

authors： Dutra HLC,Rodrigues SL,Mansur SB,de Oliveira SP,Caragata EP,Moreira LA

更新日期：2017-11-16 00:00:00

abstract：:Discrimination of species and geographical origins of traditional Chinese medicine (TCM) is essential to prevent adulteration and inferior problems. We studied Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A.Mey. and Ephedra przewalskii Bge. to investigate the relationship between inorganic element content and...

journal_title：Scientific reports

authors： Ma X,Fan L,Mao F,Zhao Y,Yan Y,Tian H,Xu R,Peng Y,Sui H

更新日期：2018-07-06 00:00:00

abstract：:Hysteresis, which is the history dependence of physical systems, is one of the most important topics in physics. Interestingly, bi-stability of plasma with a huge hysteresis loop has been observed in inductive plasma discharges. Despite long plasma research, how this plasma hysteresis occurs remains an unresolved ques...

journal_title：Scientific reports

authors： Lee HC,Chung CW

更新日期：2015-10-20 00:00:00

abstract：:HIV-exposed uninfected (HEU) infants are disproportionately at a higher risk of morbidity and mortality, as compared to HIV-unexposed uninfected (HUU) infants. Here, we used transcriptional profiling of peripheral blood mononuclear cells to determine immunological signatures of in utero HIV exposure. We identified 262...

journal_title：Scientific reports

authors： Musimbi ZD,Rono MK,Otieno JR,Kibinge N,Ochola-Oyier LI,de Villiers EP,Nduati EW

更新日期：2019-12-02 00:00:00

abstract：:Protein colocalisation is often studied using pixel intensity-based coefficients such as Pearson, Manders, Li or Costes. However, these methods cannot be used to study object-based colocalisations in biological systems. Therefore, a novel method is required to automatically identify regions of fluorescent signal in tw...

journal_title：Scientific reports

authors： Khushi M,Napier CE,Smyth CM,Reddel RR,Arthur JW

更新日期：2017-08-21 00:00:00

abstract：:The role of orbital differentiation on the emergence of superconductivity in the Fe-based superconductors remains an open question to the scientific community. In this investigation, we employ a suitable microscopic spin probe technique, namely Electron Spin Resonance (ESR), to investigate this issue on selected chemi...

journal_title：Scientific reports

authors： Rosa PF,Adriano C,Garitezi TM,Grant T,Fisk Z,Urbano RR,Pagliuso PG

更新日期：2014-10-08 00:00:00

abstract：:Macroautophagy, the degradation of cytoplasmic content by lysosomal fusion, is an evolutionary conserved process promoting homeostasis and intracellular defence. Macroautophagy is initiated primarily by a complex containing ULK1 or ULK2 (two paralogs of the yeast Atg1 protein). To understand the differences between UL...

journal_title：Scientific reports

authors： Demeter A,Romero-Mulero MC,Csabai L,Ölbei M,Sudhakar P,Haerty W,Korcsmáros T

更新日期：2020-07-02 00:00:00

abstract：:Transition metal dichalcogenides (TMDCs) are promising materials for sensing applications, due to their exceptional high performance in nano-electronics. Inherentely, the chemical and thermal responses of TMDCs are highly stable, hence, they pave way for real time sensor applications. This article proposes inceptively...

journal_title：Scientific reports

authors： Awais M,Khan MU,Hassan A,Bae J,Chattha TE

更新日期：2020-03-26 00:00:00

abstract：:In East Greenland, a dramatic increase of tuberculosis (TB) incidence has been observed in recent years. Classical genotyping suggests a genetically similar Mycobacterium tuberculosis (Mtb) strain population as cause, however, precise transmission patterns are unclear. We performed whole genome sequencing (WGS) of Mtb...

journal_title：Scientific reports

authors： Bjorn-Mortensen K,Soborg B,Koch A,Ladefoged K,Merker M,Lillebaek T,Andersen AB,Niemann S,Kohl TA

更新日期：2016-09-12 00:00:00

abstract：:GABA is a key regulator of adult-born dentate granule cell (abDGC) maturation so mapping the functional connectivity between abDGCs and local interneurons is required to understand their development and integration into the hippocampal circuit. We recorded from birthdated abDGCs in mice and photoactivated parvalbumin ...

journal_title：Scientific reports

authors： Remmers CL,Castillon CCM,Armstrong JN,Contractor A

更新日期：2020-10-16 00:00:00

abstract：:Chronic hepatitis viral infection, alcoholic intoxication, and obesity cause liver fibrosis, which progresses to decompensated liver cirrhosis, a disease for which medical demands cannot be met. Since there are currently no approved anti-fibrotic therapies for established liver fibrosis, the development of novel modal...

journal_title：Scientific reports

authors： Itaba N,Kono Y,Watanabe K,Yokobata T,Oka H,Osaki M,Kakuta H,Morimoto M,Shiota G

更新日期：2019-05-02 00:00:00

abstract：:Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed anti-inflammatory and anti-oxidant properties. We evaluated the effects of liraglutide on HSC phenotype and hepatic microvascular function using diverse pre-clinical ...

journal_title：Scientific reports

authors： de Mesquita FC,Guixé-Muntet S,Fernández-Iglesias A,Maeso-Díaz R,Vila S,Hide D,Ortega-Ribera M,Rosa JL,García-Pagán JC,Bosch J,de Oliveira JR,Gracia-Sancho J

更新日期：2017-06-12 00:00:00