Abstract：
:The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons in the lateral hypothalamus and zona incerta. MCHergic neurons project throughout the central nervous system, indicating the involvements of many physiological functions, but the role in pain has yet to be determined. In this study, we found that pMCH-/- mice showed lower baseline pain thresholds to mechanical and thermal stimuli than did pMCH+/+ mice, and the time to reach the maximum hyperalgesic response was also significantly earlier in both inflammatory and neuropathic pain. To examine its pharmacological properties, MCH was administered intranasally into mice, and results indicated that MCH treatment significantly increased mechanical and thermal pain thresholds in both pain models. Antagonist challenges with naltrexone (opioid receptor antagonist) and AM251 (cannabinoid 1 receptor antagonist) reversed the analgesic effects of MCH in both pain models, suggesting the involvement of opioid and cannabinoid systems. MCH treatment also increased the expression and activation of CB1R in the medial prefrontal cortex and dorsolateral- and ventrolateral periaqueductal grey. The MCH1R antagonist abolished the effects induced by MCH. This is the first study to suggest novel analgesic actions of MCH, which holds great promise for the application of MCH in the therapy of pain-related diseases.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jang JH,Park JY,Oh JY,Bae SJ,Jang H,Jeon S,Kim J,Park HJdoi
10.1038/s41598-018-19145-zsubject
Has Abstractpub_date
2018-01-15 00:00:00pages
707issue
1issn
2045-2322pii
10.1038/s41598-018-19145-zjournal_volume
8pub_type
杂志文章abstract：:Choosing an option increases a person's preference for that option. This phenomenon, called choice-based learning (CBL), has been investigated separately in the contexts of internally guided decision-making (IDM, e.g., preference judgment), for which no objectively correct answer exists, and externally guided decision...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32477
更新日期：2016-08-31 00:00:00
abstract：:It has been postulated that there is a link between age related degenerative diseases and cancer. The TNF-related apoptosis-inducing ligand (TRAIL) has been shown to selectively kill tumor cells by binding to pro-apoptotic and anti-apoptotic receptors. Our aim was to study the levels of anti-apoptotic receptor (DcR1) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04114
更新日期：2014-02-18 00:00:00
abstract：:Pancreatic cancer is predominantly lethal, and is primarily treated using gemcitabine, with increasing resistance. Therefore, novel agents that increase tumor sensitivity to gemcitabine are needed. Histone deacetylase (HDAC) inhibitors are emerging therapeutic agents, since HDAC plays an important role in cancer initi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41615
更新日期：2017-01-30 00:00:00
abstract：:Terahertz (THz) technology has emerged recently as a potential novel imaging modality in biomedical fields, including ophthalmology. However, the ocular biological responses after THz electromagnetic exposure have not been investigated. We conducted a rabbit study to evaluate the safety profiles of THz scanning on eye...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82103-9
更新日期：2021-01-28 00:00:00
abstract：:A dual mode rare-earth based vanadate material (YVO4: Ho3+/Yb3+), prepared through ethylene glycol assisted hydrothermal method, demonstrating both downconversion and upconversion, along with systematic investigation of the luminescence spectroscopy within 12-300 K is presented herein. The energy transfer processes ha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36342
更新日期：2016-11-02 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-54609-w
更新日期：2019-11-27 00:00:00
abstract：:Plant microbiota is a key determinant of plant health and productivity. The composition and structure of plant microbiota varies according to plant tissue and compartment, which are specific habitats for microbial colonization. To investigate the structural composition of the microbiome associated with tomato roots un...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45660-8
更新日期：2019-06-26 00:00:00
abstract：:Diet composition impacts metabolic and cardiovascular health with high caloric diets contributing to obesity related disorders. Dietary interventions such as caloric restriction exert beneficial effects in the cardiovascular system, but alteration of which specific nutrient is responsible is less clear. This study inv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51654-3
更新日期：2019-10-22 00:00:00
abstract：:Seeded polymerisation of proteins forming amyloid fibres and their spread in tissues has been implicated in the pathogenesis of multiple neurodegenerative diseases: so called "prion-like" mechanisms. While ex vivo mammalian prions, composed of multichain assemblies of misfolded host-encoded prion protein (PrP), act as...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36700-w
更新日期：2019-01-23 00:00:00
abstract：:High Refractive Index (HRI) dielectric nanoparticles have been proposed as an alternative to metallic ones due to their low absorption and magnetodielectric response in the VIS and NIR ranges. For the latter, important scattering directionality effects can be obtained. Also, systems constituted by dimers of HRI dielec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11401-y
更新日期：2017-09-11 00:00:00
abstract：:In this study, the effects of different feeding frequencies on the growth and the expression of genes in the GH/IGF axis were assessed in juvenile Chinese sturgeon. The newly hatched Chinese sturgeons were bred for 38 days at three different feeding frequencies groups (feeding frequency of two times a day, TWD; three ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74120-x
更新日期：2020-10-15 00:00:00
abstract：:Burgeoning availability of genome-wide association study (GWAS) results and national biobank data has led to growing interest in performing multi-trait genetic analyses. Numerous multi-trait GWAS methods that exploit either summary statistics or individual-level data have been developed, but their relative performance...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38837
更新日期：2017-03-13 00:00:00
abstract：:Periodontal ligament stem cells (PDLSCs) are a major source of mesenchymal stem cells (MSCs) in adults and are effective for tissue engineering, like promoting angiogenesis and bone regeneration. CXCL12 has been reported to be involved in the recruitment and engraftment of MSCs in wound sites. However, whether CXCL12 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10971-1
更新日期：2017-08-31 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-42196-9
更新日期：2019-04-12 00:00:00
abstract：:In this paper, α-Fe2O3 nanoparticles (NPs)-reduced graphene oxide (RGO), α-FeOOH nanorods (NRs)-RGO and porous α-Fe2O3 NRs-RGO could be selectively synthesized by hydrothermal method. The investigations indicated that the obtained α-Fe2O3 NPs, α-FeOOH NRs and porous α-Fe2O3 NRs were either attached on the surface of R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11131-1
更新日期：2017-09-11 00:00:00
abstract：:Immune parameters show characteristic normal baseline levels and variance in the population. We characterised the degree of inter-individual and within-individual variation over one-year time period in 33 immune cell subsets by flow cytometry in peripheral blood mononuclear cells from 43 healthy young adult volunteers...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51294-7
更新日期：2019-10-14 00:00:00
abstract：:In primary Sjögren's syndrome (pSS) the exocrine glands become infiltrated with lymphocytes instigating severe damage to the salivary and lacrimal glands causing dry eyes and dry mouth. Previous investigations have suggested that dysregulated localized and systemic inflammation contributes to the development and patho...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-64422-5
更新日期：2020-05-04 00:00:00
abstract：:Monoclonal antibodies (mAbs) are attractive therapeutics for treating a wide range of human disorders, and bind to the antigen through their complementarity-determining regions (CDRs). Small stable proteins containing structurally retained CDRs are promising alternatives to mAbs. In this report, we present a method to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57713-4
更新日期：2020-01-21 00:00:00
abstract：:Little is known about the effect of long-term diet patterns on the composition and functional potential of the human salivary microbiota. In the present study, we sought to contribute to the ongoing elucidation of dietary effects on the oral microbial community by examining the diversity, composition and functional po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24207-3
更新日期：2018-04-11 00:00:00
abstract：:Substance P (SP) has been implicated in major depressive disorder (MDD), with SP antagonists being studied as potential antidepressants. Although impaired neural plasticity is considered a key mechanism in MDD pathophysiology, the association between SP and brain structural changes in depression has not been investiga...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10100-y
更新日期：2017-08-29 00:00:00
abstract：:Bee-pollinated plants face a dilemma in that bees both passively transport pollen grains among conspecific flowers and actively collect pollen to feed their larvae. Therefore, mechanisms that reduce pollen collection by bees have evolved in melittophilous plants. Malvaceae pollen is uncollectable for corbiculate bees ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41262-6
更新日期：2019-03-18 00:00:00
abstract：:The prevalence of patients on automated peritoneal dialysis (APD) is increasing worldwide and may be guided by clinical characteristics, financial issues and patient option. Whether socioeconomic factors at the patient level may influence the decision for the initial peritoneal dialysis (PD) modality is unknown. This ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05544-1
更新日期：2017-07-12 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23598-7
更新日期：2018-04-11 00:00:00
abstract：:Pond-dwelling cyclic parthenogens are often proposed to be highly vagile. However, the Holarctic biogeography of parthenogens has been hampered by very limited sampling in the eastern Palearctic. Here we examine the geographic boundaries, diversity, and connectivity across the Palearctic for the Daphnia curvirostris c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43281-9
更新日期：2019-05-02 00:00:00
abstract：:Posttraumatic growth (PTG) is defined as positive psychological change in the wake of highly challenging circumstances. Healthcare workers in particular are more vulnerable to stressors and trauma than the general population. The current study examined the use and effectiveness of a novel positive psychological interv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39189
更新日期：2016-12-20 00:00:00
abstract：:Many basic properties of the T-cell receptor (TCR) repertoire require clarification, and the changes occurring in the TCR repertoire during carcinogenesis, especially during precancerous stages, remain unclear. This study used deep sequencing analyses to examine 41 gastric tissue samples at different pathological stag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08289-z
更新日期：2017-08-10 00:00:00
abstract：:Antibody based bio-molecular drugs are an exciting, new avenue of drug development as an alternative to the more traditional small chemical compounds. However, the binding mechanism and the effect on the conformational ensembles of a therapeutic antibody to its peptide or protein antigen have not yet been well studied...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58320-z
更新日期：2020-01-29 00:00:00
abstract：:The intravenous, intramuscular or intraperitoneal administration of water solubilized graphene nanoparticles for biomedical applications will result in their interaction with the hematological components and vasculature. Herein, we have investigated the effects of dextran functionalized graphene nanoplatelets (GNP-Dex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02584
更新日期：2013-01-01 00:00:00
abstract：:We propose a scheme for generating an entangled state for two atoms trapped in two separate cavities coupled to each other. The scheme is based on the competition between the unitary dynamics induced by the classical fields and the collective decays induced by the dissipation of two non-local bosonic modes. In this sc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17933-7
更新日期：2017-12-15 00:00:00
abstract：:Male Wistar rats were exposed to herbicide, pendimethalin (PND) at varying oral doses of 62.5, 125 and 250 mg/kg b.w. for 14 days. Toxiological effects were assessed in terms of oxidative stress, DNA damage, histopathological alterations and induction of anti-inflammatory and apoptotic responses linked Bax, Bcl-2, IFN...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35484-3
更新日期：2018-11-20 00:00:00
