Abstract：
:Breast cancer is a heterogeneous disease with differences in its clinical, molecular and biological features. Traditionally, immunohistochemical markers together with clinicopathologic parameters are used to classify breast cancer and to predict disease outcome. Triple-negative breast cancer (TNBC) is a particular type of breast cancer that is defined by a lack of expression of hormonal receptors and the HER2 gene. Most cases of TNBC also have a basal-like phenotype (BLBC) with expression of cytokeratin 5/6 and/or EGFR. A basal marker alone is insufficient for a better understanding of the tumor biology of TNBC. In that regard, the ADAM33 gene is silenced by DNA hypermethylation in breast cancer, which suggests that ADAM33 might be useful as a molecular marker. In the present study, we have produced monoclonal antibodies against the ADAM33 protein and have investigated the role of ADAM33 protein in breast cancer. We used 212 breast tumor samples and lower levels of ADAM33 were correlated with TNBC and basal-like markers. A lower level of ADAM33 was also correlated with shorter overall survival and metastasis-free survival and was considered an independent prognostic factor suggesting that ADAM33 is a novel molecular biomarker of TNBC and BLBC that might be useful as a prognostic factor.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Manica GC,Ribeiro CF,Oliveira MA,Pereira IT,Chequin A,Ramos EA,Klassen LM,Sebastião AP,Alvarenga LM,Zanata SM,Noronha L,Rabinovich I,Costa FF,Souza EM,Klassen Gdoi
10.1038/srep44414subject
Has Abstractpub_date
2017-03-15 00:00:00pages
44414issn
2045-2322pii
srep44414journal_volume
7pub_type
杂志文章abstract：:Although it is clear that lipids are responsible for insulin resistance, it is poorly understood what types of lipids are involved. In this study, we verified the characteristic lipid species in skeletal muscle of a chronic exercise training model and a high-fat induced-obesity model. Three different lipidomics analys...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2013-11-20 00:00:00
abstract：:New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-11-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14675
更新日期：2015-09-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-01-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-06-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-11-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析
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更新日期：2018-10-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13463
更新日期：2015-08-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11003
更新日期：2015-07-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35872
更新日期：2016-10-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27630
更新日期：2016-06-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57772-7
更新日期：2020-01-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57345-3
更新日期：2020-01-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-08-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08316
更新日期：2015-02-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-08-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-11-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2014-07-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-02-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36035
更新日期：2016-10-31 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-05-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49701-0
更新日期：2019-09-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-02-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56723-1
更新日期：2019-12-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-03-13 00:00:00
abstract：:SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid development of dru...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-03-09 00:00:00
abstract：:Domoic acid (DA, 1), a potent neurotoxin that causes amnesic shellfish poisoning, has been found in diatoms and red algae. While biosynthetic pathway towards DA from geranyl diphosphate and L-glutamate has been previously proposed, its late stage is still unclear. Here, six novel DA related compounds, 7'-methyl-isodom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18651-w
更新日期：2018-01-10 00:00:00
