Abstract:
:The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala-centred functional connectivity (FC) affects anxiety and cortisol concentrations in everyday life. Here, we investigate the relationship between daily cortisol concentrations (dCOR) and amygdala-centred FC during emotional processing in forty-one healthy humans. FC analyses revealed that higher dCOR predicted strengthened amygdala-centred FC with the hippocampus and cerebellum, but inhibited FC with the supramarginal gyrus and a perigenual part of the ACC (pgACC) when processing fearful faces (vs. neutral faces). Notably, the strength of amygdala-hippocampus FC mediated the positive relationship between cortisol and anxiety, specifically when the effect of amygdala-pgACC FC, a presumptive neural indicator of emotional control, was taken into account. Individuals with diminished connectivity between the amygdala and pgACC during fear-related processing might be more vulnerable to anxiogenesis as it pertains to greater circulating cortisol levels in everyday life. Individual functional patterns of amygdala-hippocampal-pgACC connectivity might provide a key to understand the complicate link between cortisol and anxiety-related behaviors.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hakamata Y,Komi S,Moriguchi Y,Izawa S,Motomura Y,Sato E,Mizukami S,Kim Y,Hanakawa T,Inoue Y,Tagaya Hdoi
10.1038/s41598-017-08918-7subject
Has Abstractpub_date
2017-08-16 00:00:00pages
8313issue
1issn
2045-2322pii
10.1038/s41598-017-08918-7journal_volume
7pub_type
杂志文章abstract::Inner Mongolia cashmere goats, as an important part of animal husbandry production, play an important role in animal fiber industry. In recent years, scientific research has made a lot of explorations on the molecular regulation mechanism of hair follicle cycle growth, but few studies have been reported on the develop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60351-5
更新日期:2020-03-11 00:00:00
abstract::Hypoxia-induced retinal neovascularization is a major pathological condition in many vision-threatening diseases. In the present study, we determined whether interleukin (IL)-12, a cytokine that regulates angiogenesis, plays a role in the neovascularization in a mouse model of oxygen-induced retinopathy (OIR). We foun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28140
更新日期:2016-06-17 00:00:00
abstract::A weakening of the gut mucous barrier permits an increase in the access of intestinal luminal contents to the epithelial cells, which will trigger the inflammatory response. In inflammatory bowel diseases, there is an inappropriate and ongoing activation of the immune system, possibly because the intestinal mucus is l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09577
更新日期:2015-05-14 00:00:00
abstract::A growing bacterium typically divides into two genetically identical and morphologically similar sister cells and eventually gives rise to a clonal population. Nevertheless, significant phenotypic differentiation among isogenic cells frequently occurs, with the resulting heterogeneity in cellular behavior often ensuri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08660-0
更新日期:2017-08-16 00:00:00
abstract::Short-term prospective studies have suggested that pulmonary tuberculosis (TB) preludes permanent loss of lean tissue and fat mass even when TB treatment is effective. The aim of this study was to estimate the risk of sarcopenia and osteoporosis among Korean male TB survivors. Data of the population-based, Korea Natio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12419-y
更新日期:2017-10-13 00:00:00
abstract::Upregulated Wnt/β-catenin signaling is associated with increased cancer cell resistance and cancer cell-elicited immunosuppression. In non-neoplastic immune cells, upregulated Wnt/β-catenin is, however, associated with either immunosuppression or immunostimulation. Therefore, it is difficult to predict the therapeutic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41182-5
更新日期:2019-03-18 00:00:00
abstract::The emergence of metallic conduction in layered dichalcogenide semiconductor materials by chemical doping is one of key issues for two-dimensional (2D) materials engineering. At present, doping methods for layered dichalcogenide materials have been limited to an ion intercalation between layer units or electrostatic c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19733
更新日期:2016-01-21 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-21980-z
更新日期:2018-03-13 00:00:00
abstract::The objective of this study was to determine if Ihh is required for fracture healing. Fibular fracture was created in adult Col2a1-CreERT2; Ihhfl/fl mice. Ihhfl/fl mice received Tamoxifen (TM) to delete Ihh. WT mice received Cyclopamine to inhibit Hh pathway. Callus tissue properties and Ihh pathway were analyzed at 1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28657-7
更新日期:2018-07-09 00:00:00
abstract::We have studied photoinduced reduction of absorption and emission in p3ht, a semiconducting polymer, and found that the rate of photodegradation (destruction of the constituent thiophene rings) does not correlate with the luminescence intensity and, correspondingly, does not depend on the excited state concentration. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33238
更新日期:2016-09-15 00:00:00
abstract::The current study aimed to formulate Selenium-Chitosan-Mupirocin (M-SeNPs-CCH) complex. The nanohybrid system was prepared using chitosan-cetyltrimethylammonium bromide (CTAB)-based hydrogel (CCH) that entrapped mupirocin (M) and selenium nanoparticles (SeNPs). The in vitro studies were performed by evaluation of the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59510-5
更新日期:2020-02-18 00:00:00
abstract::First-generation adenovirus vectors (FG AdVs) are widely used in basic studies and gene therapy. However, virus-associated (VA) RNAs that act as small-interference RNAs are indeed transcribed from the vector genome. These VA RNAs can trigger the innate immune response. Moreover, VA RNAs are processed to functional vir...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01136
更新日期:2013-01-01 00:00:00
abstract::A fundamental challenge for behavioral neuroscientists is to accurately quantify (dis)similarities in animal behavior without excluding inherent variability present between individuals. We explored two new applications of curve and shape alignment techniques to address this issue. As a proof-of-concept we applied thes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52300-8
更新日期:2019-11-12 00:00:00
abstract::We focus on the impacts of technological spillovers and environmental awareness in a two-echelon supply chain with one-single supplier and one-single manufacturer to reduce carbon emission. In this supply chain, carbon abatement investment becomes one of key factors of cutting costs and improving profits, which is red...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03270-2
更新日期:2017-06-08 00:00:00
abstract::The rapid urbanization in China has been associated with a growing hunger for energy consumption and steadily-increasing CO2 emissions. In this paper, an integrated system dynamics model composed of four sub-models is developed to simulate the urbanization and energy consumption in China from 1998 to 2050. Three scena...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66125-3
更新日期:2020-06-19 00:00:00
abstract::Understanding the genetic basis of phenotypic diversity is a challenge in contemporary biology. Domestication provides a model for unravelling aspects of the genetic basis of stress sensitivity. The ancestral Red Junglefowl (RJF) exhibits greater fear-related behaviour and a more pronounced HPA-axis reactivity than it...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15345
更新日期:2015-10-16 00:00:00
abstract::Estrogen-related receptor alpha (ESRRa) regulates a number of cellular processes including development of bone and muscles. However, direct evidence regarding its involvement in cartilage development remains elusive. In this report, we establish an in vivo role of Esrra in cartilage development during embryogenesis in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18011
更新日期:2015-12-10 00:00:00
abstract::Haze is a serious issue in China with increasing concerns, and understanding the factors driving decadal-scale variations in haze occurrence is relevant for government policymaking. Using a comprehensive observational haze dataset, we demonstrate notable decadal fluctuations in the number of haze days (HD) during wint...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27424
更新日期:2016-06-10 00:00:00
abstract::This paper has been retracted at the request of the authors. ...
journal_title:Scientific reports
pub_type: 撤回出版物
doi:10.1038/s41598-018-29892-8
更新日期:2018-08-02 00:00:00
abstract::Silicene is an exciting two-dimensional material that shares many of graphene's electronic properties, but differs in its structural buckling. This buckling allows opening a bandgap in silicene through the application of a perpendicular electric field. Here we show that this buckling also enables highly effective modu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14815
更新日期:2015-10-06 00:00:00
abstract::Human iPS cells hold great promise for disease modeling and treatment of degenerative disorders including muscular dystrophies. Although a few research groups have used them for skeletal muscle differentiation, most were based on gene over-expression or long-term mesenchymal differentiation and retrospective identific...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18759
更新日期:2016-01-05 00:00:00
abstract::Aneurysmal subarachnoid hemorrhage (aSAH)-induced cerebral vasospasm and delayed ischemic neurological deficit (DIND) are the major causes of morbidity and mortality in patients with aSAH. The effects of statins-use for patients with aSAH remain controversial. Here,a total of 249 patients from six randomized controlle...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep04573
更新日期:2014-04-25 00:00:00
abstract::The preferential degeneration of Substantia nigra dopamine midbrain neurons (SN DA) causes the motor-symptoms of Parkinson's disease (PD). Voltage-gated L-type calcium channels (LTCCs), especially the Cav1.3-subtype, generate an activity-related oscillatory Ca(2+) burden in SN DA neurons, contributing to their degener...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13688
更新日期:2015-09-18 00:00:00
abstract::In this work we study the entropy of the Gibbs state corresponding to a graph. The Gibbs state is obtained from the Laplacian, normalized Laplacian or adjacency matrices associated with a graph. We calculated the entropy of the Gibbs state for a few classes of graphs and studied their behavior with changing graph orde...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78626-2
更新日期:2021-01-11 00:00:00
abstract::Programmed cell death 5 (PDCD5) is believed to play a crucial role in p53 activation; however, the underlying mechanism of how PDCD5 function is regulated during apoptosis remains obscure. Here, we report that the serine/threonine phosphatase PPEF-1 interacts with and dephosphorylates PDCD5 at Ser-119, which leads to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39222
更新日期:2017-01-04 00:00:00
abstract::The dispersal of animals from their birth place has profound effects on the immediate survival and longer-term persistence of populations. Molecular studies have estimated that bumblebee colonies can be established many kilometers from their queens' natal nest site. However, little is known about when and how queens d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40355-6
更新日期:2019-03-20 00:00:00
abstract::Double-strand breaks (DSBs) are the most lethal DNA damages induced by ionising radiation (IR) and their efficient repair is crucial to limit genomic instability. The cellular DSB response after low IR doses is of particular interest but its examination requires the analysis of high cell numbers. Here, we present an a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35660-5
更新日期:2018-11-23 00:00:00
abstract::People with normal hearing thresholds can nonetheless have difficulty with understanding speech in noisy backgrounds. The origins of such supra-threshold hearing deficits remain largely unclear. Previously we showed that the auditory brainstem response to running speech is modulated by selective attention, evidencing ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50773-1
更新日期:2019-10-01 00:00:00
abstract::In this paper, we demonstrate and thoroughly analyze the activation volumetric properties of selected liquid crystals in the nematic and crystalline E phases in comparison with those reported for glass-forming liquids. In the analysis, we have employed and evaluated two entropic models (based on either total or config...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42174
更新日期:2017-02-09 00:00:00
abstract::Elevated levels of Creatine Kinase-MB (CK-MB) Isoenzyme are a common phenomenon among rotavirus (RV) diarrhea. However, few studies have addressed this issue using large sample size. In current study, 1,118 children (age <5 years) hospitalized with diarrhea in Guangzhou Women and Children's Medical Center from 2012 to...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-017-07636-4
更新日期:2017-08-09 00:00:00