Abstract：
:Chronic inflammation-associated bone destruction, which is observed in rheumatoid arthritis (RA) and periodontitis, is mediated by excessive osteoclastogenesis. We showed previously that γ-glutamyltranspeptidase (GGT), an enzyme involved in glutathione metabolism, acts as an endogenous activator of such pathological osteoclastogenesis, independent of its enzymatic activity. GGT accumulation is clinically observed in the joints of RA patients, and, in animals, the administration of recombinant GGT to the gingival sulcus as an in vivo periodontitis model induces an increase in the number of osteoclasts. However, the underlying mechanisms of this process remain unclear. Here, we report that Toll-like receptor 4 (TLR4) recognizes GGT to activate inflammation-associated osteoclastogenesis. Unlike lipopolysaccharide, GGT is sensitive to proteinase K treatment and insensitive to polymyxin B treatment. TLR4 deficiency abrogates GGT-induced osteoclastogenesis and activation of NF-κB and MAPK signaling in precursor cells. Additionally, GGT does not induce osteoclastogenesis in cells lacking the signaling adaptor MyD88. The administration of GGT to the gingival sulcus induces increased osteoclastogenesis in wild-type mice, but does not induce it in TLR4-deficient mice. Our findings elucidate a novel mechanism of inflammation-associated osteoclastogenesis, which involves TLR4 recognition of GGT and subsequent activation of MyD88-dependent signaling.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Moriwaki S,Into T,Suzuki K,Miyauchi M,Takata T,Shibayama K,Niida Sdoi
10.1038/srep35930subject
Has Abstractpub_date
2016-10-24 00:00:00pages
35930issn
2045-2322pii
srep35930journal_volume
6pub_type
杂志文章abstract：:Since the world population is ageing, dementia is going to be a growing concern. Alzheimer's disease is the most common form of dementia. The pathogenesis of Alzheimer's disease is extensively studied, yet unknown remains. Therefore, we aimed to extract new knowledge from existing data. We analysed about 2700 upregula...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-64452-z
更新日期：2020-05-20 00:00:00
abstract：:Studies of morphological integration and modularity, and of anatomical complexity in human evolution typically focus on skeletal tissues. Here we provide the first network analysis of the musculoskeletal anatomy of both the fore- and hindlimbs of the two species of chimpanzee and humans. Contra long-accepted ideas, ne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25262-6
更新日期：2018-05-02 00:00:00
abstract：:Without any root contact with the soil, epiphytic bryophytes must experience and explore poor, patchy, and heterogeneous habitats; while, the nitrogen (N) uptake and use strategies of these organisms remain uncharacterized, which obscures their roles in the N cycle. To investigate the N sources, N preferences, and res...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30408
更新日期：2016-07-27 00:00:00
abstract：:Articular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally correct cartilage tissue when cultured. Thus, culture conditions, which enhance the maintenance of chondrocyte phenotype would be very useful for cartilage research...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03958-5
更新日期：2017-06-16 00:00:00
abstract：:The concept of remission for patients with inflammatory bowel diseases has recently evolved, and should also include histological healing of the mucosa, difficult to evaluate since there is no agreement on pathological scores and those available are quite complex to use in the daily routine. We evaluated the possible ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07338-x
更新日期：2017-07-28 00:00:00
abstract：:Traumatic brain injury (TBI) causes brain edema that induces increased intracranial pressure and decreased cerebral perfusion. Decompressive craniectomy has been recommended as a surgical procedure for the management of swollen brain and intracranial hypertension. Proper location and size of a decompressive craniectom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75479-7
更新日期：2020-10-29 00:00:00
abstract：:Upper lip scars are at risk of hypertrophy. Our center therefore uses microporous tape and silicone sheeting for postoperative scar care following cleft lip repair. However, some babies have previously ingested their silicone sheeting, which has the potential for respiratory compromise or gastrointestinal obstruction....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25697-x
更新日期：2018-05-09 00:00:00
abstract：:Loss of anorectal resting pressure due to internal anal sphincter (IAS) dysfunctionality causes uncontrolled fecal soiling and leads to passive fecal incontinence (FI). The study is focused on immediate and long-term safety and potential efficacy of bioengineered IAS BioSphincters to treat passive FI in a clinically r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54440-3
更新日期：2019-12-02 00:00:00
abstract：:The considerable range of genetic variation in human populations may partly reflect distinctive processes of adaptation to variable environmental conditions. However, the adaptive genomic signatures remain to be completely elucidated. This research explores candidate loci under selection at the population level by cha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22468
更新日期：2016-03-02 00:00:00
abstract：:Prion-like behaviour is attracting much attention due to the growing evidences that amyloid-like self-assembly may reach beyond neurodegeneration and be a conserved functional mechanism. The best characterized functional prions correspond to a subset of yeast proteins involved in translation or transcription. Their co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09714-z
更新日期：2017-09-21 00:00:00
abstract：:Auxetic mechanical metamaterials are engineered systems that exhibit the unusual macroscopic property of a negative Poisson's ratio due to sub-unit structure rather than chemical composition. Although their unique behaviour makes them superior to conventional materials in many practical applications, they are limited ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08395
更新日期：2015-02-11 00:00:00
abstract：:Electron- or X-ray-induced characteristic X-ray analysis has been widely used to determine chemical compositions of materials in vast research fields. In recent years, analysis of characteristic X-rays from muonic atoms, in which a muon is captured, has attracted attention because both a muon beam and a muon-induced c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15719-5
更新日期：2017-11-13 00:00:00
abstract：:Kefir peptides, generated by kefir grain fermentation of milk proteins, showed positive antioxidant effects, lowered blood pressure and modulated the immune response. In this study, kefir peptide was evaluated regarding their anti-inflammatory effects on particulate matter <4 μm (PM4.0)-induced lung inflammation in NF...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47872-4
更新日期：2019-08-08 00:00:00
abstract：:The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80812-1
更新日期：2021-01-14 00:00:00
abstract：:Stroke is a leading cause of death and the leading cause of long-term disability, but its electrophysiological basis is poorly understood. Characterizing acute ischemic neuronal activity dynamics is important for understanding the temporal and spatial development of ischemic pathophysiology and determining neuronal ac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78179-4
更新日期：2020-12-08 00:00:00
abstract：:Rapid diagnostic tests (RDTs) have been widely deployed in low-resource settings. These tests are typically read by visual inspection, and accurate record keeping and data aggregation remains a substantial challenge. A successful malaria elimination campaign will require new strategies that maximize the sensitivity of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28645
更新日期：2016-06-27 00:00:00
abstract：:The FGF receptor signaling pathway is recurrently involved in the leukemogenic processes. Oncogenic fusions of FGFR1 with various fusion partners were described in myeloid proliferative neoplasms, and overexpression and mutations of FGFR3 are common in multiple myeloma. In addition, fibroblast growth factors are abund...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38169-z
更新日期：2019-02-12 00:00:00
abstract：:Visualization of morphological dynamics of live cells with nanometer resolution under physiological conditions is highly desired, but challenging. It has been demonstrated that high-speed atomic force microscopy is a powerful technique for visualizing dynamics of biomolecules under physiological conditions. However, a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08724
更新日期：2015-03-04 00:00:00
abstract：:N-α-acetyltransferase 10 (Naa10) displays alpha (N-terminal) acetyltransferase activity. It functions as a major modulator of cell growth and differentiation. Until now, a few downstream targets were found, but no studies have concerned about which gene is the early event of Naa10 downstream target. As we know, the ea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38508
更新日期：2016-12-02 00:00:00
abstract：:Oil repellent surface have lots of practical applications in many fields. Current oil repellent coating may suffer from limited liquid repellency to oils or environmental risks. In this work, we report an eco-friendly 'green' processes for preparing oil-repellent surface using a renewable and environmentally benign bi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38016
更新日期：2016-11-29 00:00:00
abstract：:Coronary plaque distribution, frequency and cut-off value of percent stenosis for developing vasospasm are uncertain in patients with vasospastic angina (VA). We enrolled 2960 patients who received coronary angiography (CAG) and ergonovine provocation test prospectively in 11 university hospitals in Korea. A total of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62670-z
更新日期：2020-03-31 00:00:00
abstract：:The arbitrary control of the polarization states of light has attracted the interest of the scientific community because of the wide range of modern optical applications that such control can afford. However, conventional polarization control setups are bulky and very often operate only within a narrow wavelength rang...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18106
更新日期：2015-12-15 00:00:00
abstract：:This study aims to evaluate the diagnostic accuracy of digital breast tomosynthesis-guided vacuum assisted breast biopsy (DBT-VABB) of screening detected suspicious mammographic abnormalities comprising of calcifications, asymmetric densities, architectural distortions and spiculated masses. In this institutionally ap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80124-4
更新日期：2021-01-08 00:00:00
abstract：:Upon illumination, a dielectric microsphere (μS) can generate a photonic nanojet (PNJ), which plays a role in the super-resolution imaging of a sample placed in the μS's immediate proximity. Recent microscopy implementations pioneered this concept but, despite the experimental characterization and theoretical modeling...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33604-7
更新日期：2018-10-12 00:00:00
abstract：:Up to 30% of all breast cancer cases may be inherited and up to 85% of those may be due to segregation of susceptibility genes with low and moderate risk [odds ratios (OR) ≤ 3] for (mostly peri- and post-menopausal) breast cancer. The majority of low/moderate-risk genes, particularly those with minor allele frequencie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77037-7
更新日期：2020-12-04 00:00:00
abstract：:We propose a novel injection scheme for laser-driven wakefield acceleration in which controllable localized electron injection is obtained by inserting nanoparticles into a plasma medium. The nanoparticles provide a very confined electric field that triggers localized electron injection where nonlinear plasma waves ar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34998-0
更新日期：2018-11-16 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-75176-5
更新日期：2020-10-28 00:00:00
abstract：:The Xanthomonadaceae family consists of species of non-pathogenic and pathogenic γ-proteobacteria that infect different hosts, including humans and plants. In this study, we performed a comparative analysis using 69 fully sequenced genomes belonging to this family, with a focus on identifying proteins enriched in phyt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16325-1
更新日期：2017-11-23 00:00:00
abstract：:In this work, we address the ubiquitous phenomenon of Fano resonances in bilayer graphene. We consider that this phenomenon is as exotic as other phenomena in graphene because it can arise without an external extended states source or elaborate nano designs. However, there are not theoretical and/or experimental studi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16838-9
更新日期：2017-12-01 00:00:00
abstract：:The morbidity and mortality rates of human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfection are higher than that of either infection alone. Outcomes and the virological response to antiretrovirals (combination antiretroviral therapy, cART) were explored in HIV/HBV subjects in a cohort of Italian patien...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46976-1
更新日期：2019-08-16 00:00:00
