Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population.

Abstract:

:Toll-like receptors (TLRs), as innate immunity sensors, play critical roles in immune responses. Six SNPs of TLR3, TLR7, and TLR8 were genotyped to determine their associations with systemic lupus erythematosus (SLE) and clinical manifestations of SLE. TLR7 SNP rs3853839 was independently associated with SLE susceptibility in females (G vs. C: p = 0.0051). TLR7 rs3853839-G (G vs. C: p = 0.0100) and TLR8 rs3764880-G (recessive model: p = 0.0173; additive model: p = 0.0161) were associated with pericardial effusion in females relative to healthy females. Anti-SSA positive cases were more likely to have the dominant TLR7 rs179010-T allele than normal controls (p = 0.0435). TLR3 rs3775296-T was associated with photosensitivity (p = 0.0020) and anemia (p = 0.0082). The "G-G" haplotype of TLR7 rs3853839 and TLR8 rs3764880 increased risk of SLE in females (age adjusted p = 0.0032). These findings suggest that TLR variations that modify gene expression affect risk for SLE susceptibility, clinical phenotype development, and production of autoantibodies.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang CM,Chang SW,Wu YJ,Lin JC,Ho HH,Chou TC,Yang B,Wu J,Chen JY

doi

10.1038/srep03792

subject

Has Abstract

pub_date

2014-01-21 00:00:00

pages

3792

issn

2045-2322

pii

srep03792

journal_volume

4

pub_type

杂志文章
  • The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity.

    abstract::Resistance to 157 different herbicides and 88% of known sites of action has been observed, with many weeds resistant to two or more modes. Coupled with tighter environmental regulation, this demonstrates the need to identify new modes of action and novel herbicides. The plant sphingolipid biosynthetic enzyme, inositol...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44544-1

    authors: Pinneh EC,Mina JG,Stark MJR,Lindell SD,Luemmen P,Knight MR,Steel PG,Denny PW

    更新日期:2019-05-30 00:00:00

  • Responses of crop yield growth to global temperature and socioeconomic changes.

    abstract::Although biophysical yield responses to local warming have been studied, we know little about how crop yield growth-a function of climate and technology-responds to global temperature and socioeconomic changes. Here, we present the yield growth of major crops under warming conditions from preindustrial levels as simul...

    journal_title:Scientific reports

    pub_type: 历史文章,杂志文章

    doi:10.1038/s41598-017-08214-4

    authors: Iizumi T,Furuya J,Shen Z,Kim W,Okada M,Fujimori S,Hasegawa T,Nishimori M

    更新日期:2017-08-10 00:00:00

  • Exploration of phase structure evolution induced by alloying elements in Ti alloys via a chemical-short-range-order cluster model.

    abstract::The prominent comprehensive properties of solid-solution- and intermetallic-based Ti alloys are derived from their diverse microstructures induced by multi-component alloying, which results in a chemical composition complexity. A cluster-plus-glue-atom model, characterizing the chemical short-range orders, was introdu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40302-5

    authors: Jiang B,Wang Q,Dong C,Liaw PK

    更新日期:2019-03-04 00:00:00

  • Anti-tumor efficacy of fulvestrant in estrogen receptor positive gastric cancer.

    abstract::To investigate the prognostic role of the estrogen receptor (ER) in gastric cancer (GC) patients, tumor tissues from 932 patients with advanced GC were assessed for ER expression using immunohistochemistry, and their clinicopathologic features were evaluated. Forty patients (4.3%) had ER expression and they were more ...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/srep07592

    authors: Yi JH,Do IG,Jang J,Kim ST,Kim KM,Park SH,Park JO,Park YS,Lim HY,Kang WK,Lee J

    更新日期:2014-12-23 00:00:00

  • Effect of surface and porosity of biochar on water holding capacity aiming indirectly at preservation of the Amazon biome.

    abstract::As part of efforts to reduce pressure on the Amazon and other biomes, one approach considered by Brazilian authorities and scientists is more intensive use of the soils of the interior of the northeast of the country, which are generally sandy, with low contents of organic matter and low water holding capacity and are...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28794-z

    authors: Batista EMCC,Shultz J,Matos TTS,Fornari MR,Ferreira TM,Szpoganicz B,de Freitas RA,Mangrich AS

    更新日期:2018-07-16 00:00:00

  • Recombinant Adeno-Associated Virus-Mediated Expression of Methamphetamine Antibody Attenuates Methamphetamine-Induced Hyperactivity in Mice.

    abstract::Methamphetamine (Meth) is one of the most frequently abused drugs worldwide. Recent studies have indicated that antibodies with high affinity for Meth reduce its pharmacological effects. The purpose of this study was to develop a technique for virus-based passive immunization against Meth effects. We generated a recom...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46301

    authors: Chen YH,Wu KJ,Wu KL,Wu KL,Tsai HM,Chen ML,Chen YW,Hsieh W,Lin CM,Wang Y

    更新日期:2017-04-07 00:00:00

  • Surface ocean carbon dioxide variability in South Pacific boundary currents and Subantarctic waters.

    abstract::To improve estimates of the long-term response of the marine carbon system to climate change a better understanding of the seasonal and interannual variability is needed. We use high-frequency multi-year data at three locations identified as climate change hotspots: two sites located close to South Pacific boundary cu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44109-2

    authors: C Pardo P,Tilbrook B,van Ooijen E,Passmore A,Neill C,Jansen P,Sutton AJ,Trull TW

    更新日期:2019-05-20 00:00:00

  • P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis.

    abstract::P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains relatively unexplored. We charac...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71753-w

    authors: Wisniewski L,French V,Lockwood N,Valdivia LE,Frankel P

    更新日期:2020-09-24 00:00:00

  • Microenvironment-triggered dual-activation of a photosensitizer- fluorophore conjugate for tumor specific imaging and photodynamic therapy.

    abstract::Photodynamic therapy is attracting increasing attention, but how to increase its tumor-specificity remains a daunting challenge. Herein we report a theranostic probe (azo-PDT) that integrates pyropheophorbide α as a photosensitizer and a NIR fluorophore for tumor imaging. The two functionalities are linked with a hypo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68847-w

    authors: Wang C,Wang S,Wang Y,Wu H,Bao K,Sheng R,Li X

    更新日期:2020-07-22 00:00:00

  • Entropic uncertainty relations for Markovian and non-Markovian processes under a structured bosonic reservoir.

    abstract::The uncertainty relation is a fundamental limit in quantum mechanics and is of great importance to quantum information processing as it relates to quantum precision measurement. Due to interactions with the surrounding environment, a quantum system will unavoidably suffer from decoherence. Here, we investigate the dyn...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01094-8

    authors: Wang D,Huang AJ,Hoehn RD,Ming F,Sun WY,Shi JD,Ye L,Kais S

    更新日期:2017-04-21 00:00:00

  • Hidden treasure of the Gobi: understanding how water limits range use of khulan in the Mongolian Gobi.

    abstract::Most large herbivores in arid landscapes need to drink which constrains their movements and makes them vulnerable to disturbance. Asiatic wild ass or khulan (Equus hemionus) were widespread and abundant throughout the arid landscapes of Central Asia and Mongolia, but have undergone dramatic population declines and ran...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59969-2

    authors: Payne JC,Buuveibaatar B,Bowler DE,Olson KA,Walzer C,Kaczensky P

    更新日期:2020-02-19 00:00:00

  • Orientation toward humans predicts cognitive performance in orang-utans.

    abstract::Non-human animals sometimes show marked intraspecific variation in their cognitive abilities that may reflect variation in external inputs and experience during the developmental period. We examined variation in exploration and cognitive performance on a problem-solving task in a large sample of captive orang-utans (P...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40052

    authors: Damerius LA,Forss SI,Kosonen ZK,Willems EP,Burkart JM,Call J,Galdikas BM,Liebal K,Haun DB,van Schaik CP

    更新日期:2017-01-09 00:00:00

  • Spred2-deficiecy Protects Mice from Polymicrobial Septic Peritonitis by Enhancing Inflammation and Bacterial Clearance.

    abstract::Sepsis is an infection-induced systemic inflammatory syndrome and a major cause of death for critically ill patients. Here, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences host defense against polymicrobial s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13204-7

    authors: Itakura J,Sato M,Ito T,Mino M,Fushimi S,Takahashi S,Yoshimura T,Matsukawa A

    更新日期:2017-10-09 00:00:00

  • Establishing next-generation pest control services in rice fields: eco-agriculture.

    abstract::Pesticides are commonly used in food crop production systems to control crop pests and diseases and ensure maximum yield with high market value. However, the accumulation of these chemical inputs in crop fields increases risks to biodiversity and human health. In addition, people are increasingly seeking foods in whic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46688-6

    authors: Ali MP,Bari MN,Haque SS,Kabir MMM,Afrin S,Nowrin F,Islam MS,Landis DA

    更新日期:2019-07-15 00:00:00

  • All semiconductor enhanced high-harmonic generation from a single nanostructured cone.

    abstract::The enhancement and control of non-linear phenomena at a nanometer scale has a wide range of applications in science and in industry. Among these phenomena, high-harmonic generation in solids is a recent focus of research to realize next generation petahertz optoelectronic devices or compact all solid state EUV source...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41642-y

    authors: Franz D,Kaassamani S,Gauthier D,Nicolas R,Kholodtsova M,Douillard L,Gomes JT,Lavoute L,Gaponov D,Ducros N,Février S,Biegert J,Shi L,Kovacev M,Boutu W,Merdji H

    更新日期:2019-04-05 00:00:00

  • Feasibility and accuracy of a robotic guidance system for navigated spine surgery in a hybrid operating room: a cadaver study.

    abstract::The combination of navigation and robotics in spine surgery has the potential to accurately identify and maintain bone entry position and planned trajectory. The goal of this study was to examine the feasibility, accuracy and efficacy of a new robot-guided system for semi-automated, minimally invasive, pedicle screw p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64462-x

    authors: Burström G,Balicki M,Patriciu A,Kyne S,Popovic A,Holthuizen R,Homan R,Skulason H,Persson O,Edström E,Elmi-Terander A

    更新日期:2020-05-05 00:00:00

  • Liposome-mediated delivery of challenging chemicals to aid environmental assessment of Bioaccumulative (B) and Toxic (T) properties.

    abstract::Standard aquatic toxicity tests of chemicals are often limited by the chemicals' water solubility. Liposomes have been widely used in the pharmaceutical industry to overcome poor pharmacokinetics and biodistribution. In this work, liposomes were synthesized and used in an ecotoxicological context, as a tool to assure ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66694-3

    authors: Castro M,Lindqvist D

    更新日期:2020-06-16 00:00:00

  • Diversity begets diversity in mammal species and human cultures.

    abstract::Across the planet the biogeographic distribution of human cultural diversity tends to correlate positively with biodiversity. In this paper we focus on the biogeographic distribution of mammal species and human cultural diversity. We show that not only are these forms of diversity similarly distributed in space, but t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76658-2

    authors: Hamilton MJ,Walker RS,Kempes CP

    更新日期:2020-11-12 00:00:00

  • Multi-band MIM refractive index biosensor based on Ag-air grating with equivalent circuit and T-matrix methods in near-infrared region.

    abstract::In this paper, a multi-band metal-insulator-metal (MIM) perfect absorber with refractive index sensing capability has been investigated in near-infrared region. The proposed structure has been studied for biomedical applications such as detection of solution of glucose in water, diagnosis of different stages of malari...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63459-w

    authors: Nejat M,Nozhat N

    更新日期:2020-04-14 00:00:00

  • Anticipation of guilt for everyday moral transgressions: The role of the anterior insula and the influence of interpersonal psychopathic traits.

    abstract::Psychopathy is a personality disorder characterised by atypical moral behaviour likely rooted in atypical affective/motivational processing, as opposed to an inability to judge the wrongness of an action. Guilt is a moral emotion believed to play a crucial role in adherence to moral and social norms, but the mechanism...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36273

    authors: Seara-Cardoso A,Sebastian CL,McCrory E,Foulkes L,Buon M,Roiser JP,Viding E

    更新日期:2016-11-03 00:00:00

  • Obstructive Sleep Apnea and the Subsequent Risk of Chronic Rhinosinusitis: A Population-Based Study.

    abstract::The relationship between obstructive sleep apnea (OSA) and chronic rhinosinusitis (CRS) still remains unclear. This retrospective cohort study aimed to investigate the relationship between OSA and subsequent CRS using a population-based dataset. The study used data from the Taiwan Longitudinal Health Insurance Databas...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20786

    authors: Kao LT,Hung SH,Lin HC,Liu CK,Huang HM,Wu CS

    更新日期:2016-02-10 00:00:00

  • L-proline: a highly effective cryoprotectant for mouse oocyte vitrification.

    abstract::Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian ooc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26326

    authors: Zhang L,Xue X,Yan J,Yan LY,Jin XH,Zhu XH,He ZZ,Liu J,Li R,Qiao J

    更新日期:2016-07-14 00:00:00

  • Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects.

    abstract::A wide network of interconnected areas was previously found in neuroimaging studies involving normal as well as pathological subjects; however literature seems to suffer from a lack of investigation in glucose metabolism behaviour under olfactory condition. Thus, the present work describe for the first time a pure olf...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05146

    authors: Alessandrini M,Micarelli A,Chiaravalloti A,Candidi M,Bruno E,Di Pietro B,Schillaci O,Pagani M

    更新日期:2014-06-03 00:00:00

  • Quantifying greenhouse gas emissions from global aquaculture.

    abstract::Global aquaculture makes an important contribution to food security directly (by increasing food availability and accessibility) and indirectly (as a driver of economic development). In order to enable sustainable expansion of aquaculture, we need to understand aquaculture's contribution to global greenhouse gas (GHG)...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68231-8

    authors: MacLeod MJ,Hasan MR,Robb DHF,Mamun-Ur-Rashid M

    更新日期:2020-07-15 00:00:00

  • RNA sequencing reveals a transcriptomic portrait of human mesenchymal stem cells from bone marrow, adipose tissue, and palatine tonsils.

    abstract::Human mesenchymal stem cells (MSCs) are adult multipotent cells that have plasticity and inhabit the stroma of diverse tissues. The potential utility of MSCs has been heavily investigated in the fields of regenerative medicine and cell therapy. However, MSCs represent diverse populations that may depend on the tissue ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16788-2

    authors: Cho KA,Park M,Kim YH,Woo SY,Ryu KH

    更新日期:2017-12-07 00:00:00

  • Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations.

    abstract::The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the TARGT pipeline for...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64312-w

    authors: Pierini F,Nutsua M,Böhme L,Özer O,Bonczarowska J,Susat J,Franke A,Nebel A,Krause-Kyora B,Lenz TL

    更新日期:2020-04-30 00:00:00

  • Impairment of microbial and meiofaunal ecosystem functions linked to algal forest loss.

    abstract::Habitat loss is jeopardizing marine biodiversity. In the Mediterranean Sea, the algal forests of Cystoseira spp. form one of the most complex, productive and vulnerable shallow-water habitats. These forests are rapidly regressing with negative impact on the associated biodiversity, and potential consequences in terms ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76817-5

    authors: Bianchelli S,Danovaro R

    更新日期:2020-11-17 00:00:00

  • Human T-lymphotropic virus 1 and 2 among people who used illicit drugs in the state of Pará, northern Brazil.

    abstract::People who used illicit drugs (PWUDs) represent an important population group for acquisition and viral dispersion. In Brazil, high rates of the human T lymphotropic virus 1 (HTLV-1) and 2 (HTLV-2) have been reported in epidemiological studies. However, the epidemiological scenario of HTLV-1/2 infections in PWUDs is s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51383-7

    authors: Oliveira-Filho AB,Araújo APS,Souza APC,Gomes CM,Silva-Oliveira GC,Martins LC,Fischer B,Machado LFA,Vallinoto ACR,Ishak R,Lemos JAR,Kupek E

    更新日期:2019-10-14 00:00:00

  • Bivariate genomic analysis identifies a hidden locus associated with bacteria hypersensitive response in Arabidopsis thaliana.

    abstract::Multi-phenotype analysis has drawn increasing attention to high-throughput genomic studies, whereas only a few applications have justified the use of multivariate techniques. We applied a recently developed multi-trait analysis method on a small set of bacteria hypersensitive response phenotypes and identified a singl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45281

    authors: Wang B,Li Z,Xu W,Feng X,Wan Q,Zan Y,Sheng S,Shen X

    更新日期:2017-03-24 00:00:00

  • Analysis of Differentially Expressed Genes in Tissues of Camellia sinensis during Dedifferentiation and Root Redifferentiation.

    abstract::Tissue culture is very important for identifying the gene function of Camellia sinensis (L.) and exploiting novel germplasm through transgenic technology. Regeneration system of tea plant has been explored but not been well established since the molecular mechanism of tea plant regeneration is not clear yet. In this s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39264-5

    authors: Gao Y,Zhao M,Wu XH,Li D,Borthakur D,Ye JH,Zheng XQ,Lu JL

    更新日期:2019-02-27 00:00:00