Quantitating and dating recent gene flow between European and East Asian populations.

abstract：:Ultrasonic spray coating process (USCP) with high material -utilization, low manufacture costs and compatibility to streamline production has been attractive in researches on photoelectric devices. However, surface tension exists in the solvent is still a huge obstacle to realize smooth organic film for organic light ...

journal_title：Scientific reports

authors： Liu S,Zhang X,Zhang L,Xie W

更新日期：2016-11-22 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are highly prevalent inflammatory cells that play a key role in tumor development and are considered therapeutic targets. MDSCs promote tumor growth by blocking T-cell-mediated anti-tumoral immune response through depletion of arginine that is essential for T-cell proliferation...

journal_title：Scientific reports

authors： Najac C,Chaumeil MM,Kohanbash G,Guglielmetti C,Gordon JW,Okada H,Ronen SM

更新日期：2016-08-10 00:00:00

abstract：:Horizontal gene transfer (HGT) is a main mechanism of bacterial evolution endowing bacteria with new genetic traits. The transfer of mobile genetic elements such as plasmids (conjugation) requires the close proximity of cells. HGT between genetically distinct bacteria largely depends on cell movement in water films, w...

journal_title：Scientific reports

authors： Berthold T,Centler F,Hübschmann T,Remer R,Thullner M,Harms H,Wick LY

更新日期：2016-11-04 00:00:00

abstract：:The tumour suppressor p53 is mutated in cancer, including over 96% of high-grade serous ovarian cancer (HGSOC). Mutations cause loss of wild-type p53 function due to either gain of abnormal function of mutant p53 (mutp53), or absent to low mutp53. Massively parallel sequencing (MPS) enables increased accuracy of detec...

journal_title：Scientific reports

authors： Cole AJ,Dwight T,Gill AJ,Dickson KA,Zhu Y,Clarkson A,Gard GB,Maidens J,Valmadre S,Clifton-Bligh R,Marsh DJ

更新日期：2016-05-18 00:00:00

abstract：:In "classic" biomedical research, diseases have usually been studied individually. The pioneering human disease network (HDN) studies jointly consider a large number of diseases, analyse their interconnections, and provide a more comprehensive description of diseases. However, most of the existing HDN studies are base...

journal_title：Scientific reports

authors： Jiang Y,Ma S,Shia BC,Lee TS

更新日期：2018-03-14 00:00:00

abstract：:Transmembrane-4-L-six-family-1(TM4SF1), a four-transmembrane L6 family member, is highly expressed in various pancreatic cancer cell lines and promotes cancer cells metastasis. However, the TM4SF1-associated signaling network in metastasis remains unknown. In the present study, we found that TM4SF1 affected the format...

journal_title：Scientific reports

authors： Yang JC,Zhang Y,He SJ,Li MM,Cai XL,Wang H,Xu LM,Cao J

更新日期：2017-04-03 00:00:00

abstract：:We have developed a framework to convert an arbitrary integer factorization problem to an executable Ising model by first writing it as an optimization function then transforming the k-bit coupling (k ≥ 3) terms to quadratic terms using ancillary variables. Our resource-efficient method uses [Formula: see text] binary...

journal_title：Scientific reports

authors： Jiang S,Britt KA,McCaskey AJ,Humble TS,Kais S

更新日期：2018-12-05 00:00:00

abstract：:In order to screen out an effective bone loss protectant from natural plant polyphenol and to elucidate the mechanism of the plant polyphenols that alleviate bone loss under simulated microgravity, the proliferation activities of 9 total polyphenol extracts from natural product (TPENP) on osteoblasts were measured. Po...

journal_title：Scientific reports

authors： Diao Y,Chen B,Wei L,Wang Z

更新日期：2018-08-24 00:00:00

abstract：:Damage of enteric neurons and partial or total loss of selective neuronal populations are reported in intestinal disorders including inflammatory bowel diseases and necrotizing enterocolitis. To develop three-dimensional scaffolds for enteric neurons we propose the decoration of ionic-complementary self-assembling pep...

journal_title：Scientific reports

authors： Brun P,Zamuner A,Peretti A,Conti J,Messina GML,Marletta G,Dettin M

更新日期：2019-04-03 00:00:00

abstract：:Recent whooping cough (pertussis) outbreaks in many countries highlight the crucial need for a better understanding of the pathogenesis of Bordetella pertussis infection of the respiratory tract. The baboon is a recently described preclinical model for the study of B. pertussis infection and may be ideal for the evalu...

journal_title：Scientific reports

authors： Naninck T,Coutte L,Mayet C,Contreras V,Locht C,Le Grand R,Chapon C

更新日期：2018-08-16 00:00:00

abstract：:Oxaliplatin, a chemotherapy medication, causes severe peripheral neuropathy. Although oxaliplatin-induced peripheral neuropathy is a dose-limiting toxicity, a therapeutic strategy against its effects has not been established. We previously reported the involvement of N-methyl-D-aspartate receptors and their intracellu...

journal_title：Scientific reports

authors： Yamamoto S,Ushio S,Egashira N,Kawashiri T,Mitsuyasu S,Higuchi H,Ozawa N,Masuguchi K,Ono Y,Masuda S

更新日期：2017-08-29 00:00:00

abstract：:Neural crest cells (NCC) are stem cells that generate different lineages, including neuroendocrine, melanocytic, cartilage, and bone. The differentiation potential of NCC varies according to the level from which cells emerge along the neural tube. For example, only anterior "cranial" NCC form craniofacial bone, wherea...

journal_title：Scientific reports

authors： Huang M,Miller ML,McHenry LK,Zheng T,Zhen Q,Ilkhanizadeh S,Conklin BR,Bronner ME,Weiss WA

更新日期：2016-01-27 00:00:00

abstract：:The Cancer/Testes (CT) Antigen HORMAD1 is germ cell-restricted and plays developmental roles in generation and processing of meiotic DNA Double Strand Breaks (DSB). Many tumors aberrantly overexpress HORMAD1 yet the potential impact of this CT antigen on cancer biology is unclear. We tested a potential role of HORMAD1...

journal_title：Scientific reports

authors： Gao Y,Kardos J,Yang Y,Tamir TY,Mutter-Rottmayer E,Weissman B,Major MB,Kim WY,Vaziri C

更新日期：2018-10-17 00:00:00

abstract：:Nanocrystals of Ln3+ (Ln = Yb, Tm and Ho) doped β-NaLuF4 with average diameter about 200 nm are dispersed in silica-based microtube (MT) by a simple flame heating method. The fabricated microtube has a diameter range from 2 μm to 30 μm and lengths up to hundreds microns. The fluorescence of upconversion nanocrystals (...

journal_title：Scientific reports

authors： Li H,Wang Y,Li H,Zhang Y,Yang J

更新日期：2016-10-25 00:00:00

abstract：:Recognition of the potential for vegetated coastal ecosystems to store and sequester carbon has led to their increasing inclusion into global carbon budgets and carbon offset schemes. However, kelp forests have been overlooked in evaluations of this 'blue carbon', which have been limited to tidal marshes, mangrove for...

journal_title：Scientific reports

authors： Filbee-Dexter K,Wernberg T

更新日期：2020-07-23 00:00:00

abstract：:To evaluate crop rotation effects on maize seedling performance and its associated microbiome, maize plants were grown in the greenhouse in soils preceded by either maize, pea, soybean or sunflower. Soils originated from a replicated field experiment evaluating different four-year rotation combinations. In the greenho...

journal_title：Scientific reports

authors： Benitez MS,Osborne SL,Lehman RM

更新日期：2017-11-16 00:00:00

abstract：:Close contacts between the endoplasmic reticulum membrane and the mitochondrial outer membrane facilitate efficient transfer of lipids between the organelles and coordinate Ca2+ signalling and stress responses. Changes to this coupling is associated with a number of metabolic disorders and neurodegenerative diseases i...

journal_title：Scientific reports

authors： Harmon M,Larkman P,Hardingham G,Jackson M,Skehel P

更新日期：2017-12-12 00:00:00

abstract：:The Fanconi anemia pathway in coordination with homologous recombination is essential to repair interstrand crosslinks (ICLs) caused by cisplatin. TIP60 belongs to the MYST family of acetyltransferases and is involved in DNA repair and regulation of gene transcription. Although the physical interaction between the TIP...

journal_title：Scientific reports

authors： Su WP,Ho YC,Wu CK,Hsu SH,Shiu JL,Huang JC,Chang SB,Chiu WT,Hung JJ,Liu TL,Wu WS,Wu PY,Su WC,Chang JY,Liaw H

更新日期：2017-06-20 00:00:00

abstract：:Stress-induced sensitization represents a process whereby prior exposure to severe stressors leaves animals or humans in a hyper-responsive state to further stressors. Indeed, this phenomenon is assumed to be the basis of certain stress-associated pathologies, including post-traumatic stress disorder and psychosis. On...

journal_title：Scientific reports

authors： Belda X,Nadal R,Armario A

更新日期：2016-08-11 00:00:00

abstract：:Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumor carrying poor prognosis and needing new treatment options. The aim of this study was to identify actionable gene mutations that can guide new personalized target-specific therapies in ITAC patients. A series of 48 tumor and 27 corresponding germline DNA s...

journal_title：Scientific reports

authors： Sánchez-Fernández P,Riobello C,Costales M,Vivanco B,Cabal VN,García-Marín R,Suárez-Fernández L,López F,Cabanillas R,Hermsen MA,Llorente JL

更新日期：2021-01-26 00:00:00

abstract：:Without any root contact with the soil, epiphytic bryophytes must experience and explore poor, patchy, and heterogeneous habitats; while, the nitrogen (N) uptake and use strategies of these organisms remain uncharacterized, which obscures their roles in the N cycle. To investigate the N sources, N preferences, and res...

journal_title：Scientific reports

authors： Song L,Lu HZ,Xu XL,Li S,Shi XM,Chen X,Wu Y,Huang JB,Chen Q,Liu S,Wu CS,Liu WY

更新日期：2016-07-27 00:00:00

abstract：:Intrasynovial tendon injuries are among the most challenging in orthopedics. Despite significant improvements in operative and rehabilitation methods, functional outcomes continue to be limited by adhesions, gap formation, and rupture. Adhesions result from excessive inflammation, whereas tendon gapping and rupture re...

journal_title：Scientific reports

authors： Shen H,Jayaram R,Yoneda S,Linderman SW,Sakiyama-Elbert SE,Xia Y,Gelberman RH,Thomopoulos S

更新日期：2018-07-23 00:00:00

abstract：:Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We ...

journal_title：Scientific reports

authors： Moilanen JM,Löffek S,Kokkonen N,Salo S,Väyrynen JP,Hurskainen T,Manninen A,Riihilä P,Heljasvaara R,Franzke CW,Kähäri VM,Salo T,Mäkinen MJ,Tasanen K

更新日期：2017-03-22 00:00:00

abstract：:This study provides a pore-scale investigation of two-phase flow dynamics during primary drainage in a realistic heterogeneous rock sample. Using the lattice Boltzmann (LB) method, a series of three-dimensional (3D) immiscible displacement simulations are conducted and three typical flow patterns are identified and ma...

journal_title：Scientific reports

authors： Bakhshian S,Hosseini SA,Shokri N

更新日期：2019-03-04 00:00:00

abstract：:Neuropathic pain is a complex, chronic pain state that often accompanies tissue damage, inflammation or injury of the nervous system. However the underlying molecular mechanisms still remain unclear. Here, we showed that CXCL12 and CXCR4 were upregulated in the dorsal root ganglion (DRG) after chronic compression of D...

journal_title：Scientific reports

authors： Yu Y,Huang X,Di Y,Qu L,Fan N

更新日期：2017-07-18 00:00:00

abstract：:In this study, we reported a new technique based on laser speckle flowgraphy to record the ocular blood flow in rabbits under deep anesthesia, and proposed parameters to characterize retinal ischemia. We applied the proposed technique to study the correlation of blood flow between the eyes of normal non-anesthetized a...

journal_title：Scientific reports

authors： Bhatti MS,Tang TB,Chen HC

更新日期：2018-04-09 00:00:00

abstract：:Most bacterial cells are stressed, and as a result, some become tolerant to antibiotics by entering a dormant state known as persistence. The key intracellular metabolite that has been linked to this persister state is guanosine tetraphosphate (ppGpp), the alarmone that was first linked to nutrient stress. In Escheric...

journal_title：Scientific reports

authors： Chowdhury N,Kwan BW,Wood TK

更新日期：2016-02-03 00:00:00

abstract：:This study was conducted to investigate prognosis and survival of patients undergoing distal subtotal gastrectomy with D2 and D2+ lymphadenectomy for patients with locally advanced gastric cancer. Overall survival rates of 416 patients with locally advanced gastric cancer were compared between D2 and D2+ lymphadenecto...

journal_title：Scientific reports

authors： Zhang CD,Shen MY,Zhang JK,Ning FL,Zhou BS,Dai DQ

更新日期：2015-11-25 00:00:00

abstract：:The growth dynamics of Ga(In)N semiconductors by Plasma-Assisted Molecular Beam Epitaxy (PAMBE) at low temperatures (T = 450 °C) is here investigated. The presence of droplets at the growth surface strongly affects the adatom incorporation dynamics, making the growth rate a decreasing function of the metal flux imping...

journal_title：Scientific reports

authors： Azadmand M,Barabani L,Bietti S,Chrastina D,Bonera E,Acciarri M,Fedorov A,Tsukamoto S,Nötzel R,Sanguinetti S

更新日期：2018-07-26 00:00:00

abstract：:Remote photoplethysmography (PPG) is an optical measurement technique with established applications in vital signs monitoring. Recently, the consensual understanding of blood volume variations (BVVs) as the origin of PPG signals was challenged, raising validity concerns about the remote SpO2 methodology. Recognizing t...

journal_title：Scientific reports

authors： Moço AV,Stuijk S,de Haan G

更新日期：2018-05-31 00:00:00