Prognostic significance of distal subtotal gastrectomy with standard D2 and extended D2 lymphadenectomy for locally advanced gastric cancer.

Abstract:

:This study was conducted to investigate prognosis and survival of patients undergoing distal subtotal gastrectomy with D2 and D2+ lymphadenectomy for patients with locally advanced gastric cancer. Overall survival rates of 416 patients with locally advanced gastric cancer were compared between D2 and D2+ lymphadenectomy. Univariate analysis and multivariate analysis was used to identify significant prognostic factors correlated with LN metastasis and prognosis. Univariate analysis identified tumor size, lymphatic vessel invasion, pT stage, pN stage, TNM stage, locoregional recurrence, and distant recurrence, to significantly correlate with prognosis; Tumor size, LVI, and pT stage were identified as independent factors correlating with LN metastasis. Multivariate analysis demonstrated that tumor size, pT stage, pN stage, locoregional recurrence, and distant recurrence were independent prognostic factors; Tumor size and pT stage were independent prognostic factors predicting LN metastasis. When comparing 5-year survival rates of patients who underwent D2 and D2+ lymphadenectomy, as stratified by pT stage and pN stage, a significant difference was found in pN3 patients, but not for pT2-4 and pN0-2 patients, or the patient cohort as a whole. In conclusion, D2 lymphadenectomy for patients with locally advanced gastric cancer undergoing distal subtotal gastrectomy was recommended, especially in eastern Asia.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhang CD,Shen MY,Zhang JK,Ning FL,Zhou BS,Dai DQ

doi

10.1038/srep17273

subject

Has Abstract

pub_date

2015-11-25 00:00:00

pages

17273

issn

2045-2322

pii

srep17273

journal_volume

5

pub_type

杂志文章
  • Unravelling the gut bacteriome of Ips (Coleoptera: Curculionidae: Scolytinae): identifying core bacterial assemblage and their ecological relevance.

    abstract::Bark beetles often serve as forest damaging agents, causing landscape-level mortality. Understanding the biology and ecology of beetles are important for both, gathering knowledge about important forest insects and forest protection. Knowledge about the bark beetle gut-associated bacteria is one of the crucial yet sur...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75203-5

    authors: Chakraborty A,Ashraf MZ,Modlinger R,Synek J,Schlyter F,Roy A

    更新日期:2020-10-29 00:00:00

  • miR-30a acts as a tumor suppressor by double-targeting COX-2 and BCL9 in H. pylori gastric cancer models.

    abstract::Helicobacter pylori (H. pylori) is one of the most important factors that affect the development of gastric cancer, and its mechanism remains un-elucidated. Our present study found that, miR-30a is crucial for regulating the growth and migration of H. pylori infected gastric cancer in vitro by targeting COX-2 and BCL9...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07193-w

    authors: Liu X,Ji Q,Zhang C,Liu X,Liu Y,Liu N,Sui H,Zhou L,Wang S,Li Q

    更新日期:2017-08-02 00:00:00

  • Reformation of the Electron Internal Transport Barrier with the Appearance of a Magnetic Island.

    abstract::When realising future fusion reactors, their stationary burning must be maintained and the heat flux to the divertor must be reduced. This essentially requires a stationary internal transport barrier (ITB) plasma with a fast control system. However, the time scale for determining the position of the foot point of an I...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56492-x

    authors: Kenmochi N,Minami T,Mizuuchi T,Takahashi C,Weir GM,Nishioka K,Kobayashi S,Nakamura Y,Okada H,Kado S,Yamamoto S,Ohshima S,Konoshima S,Ohtani Y,Nagasaki K

    更新日期:2020-01-08 00:00:00

  • Genome wide association study of 5 agronomic traits in olive (Olea europaea L.).

    abstract::Olive (Olea europaea L.) is one of the most economically and historically important fruit crops worldwide. Genetic progress for valuable agronomic traits has been slow in olive despite its importance and benefits. Advances in next generation sequencing technologies provide inexpensive and highly reproducible genotypin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55338-w

    authors: Kaya HB,Akdemir D,Lozano R,Cetin O,Sozer Kaya H,Sahin M,Smith JL,Tanyolac B,Jannink JL

    更新日期:2019-12-10 00:00:00

  • PD-L1 predicts poor prognosis for nasopharyngeal carcinoma irrespective of PD-1 and EBV-DNA load.

    abstract::Programmed death-1 (PD-1) is an immunosuppressive receptor functionally bound with programmed death-ligand 1 (PD-L1), which has been reported in various malignancies. However, only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). In this study, we aim to invest...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43627

    authors: Zhou Y,Shi D,Miao J,Wu H,Chen J,Zhou X,Hu D,Zhao C,Deng W,Xie C

    更新日期:2017-03-03 00:00:00

  • Lineage diversification, homo- and heterologous reassortment and recombination shape the evolution of chicken orthoreoviruses.

    abstract::The near complete genome sequences of ten field avian orthoreovirus (ARV) strains collected from young chicken between 2002 and 2011 in Hungary have been determined in order to explore the genetic diversity and evolutionary mechanisms affecting ARVs in this region. Sequence analyses and phylogenetic calculations revea...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36960

    authors: Farkas SL,Marton S,Dandár E,Kugler R,Gál B,Jakab F,Bálint Á,Kecskeméti S,Bányai K

    更新日期:2016-11-10 00:00:00

  • Meta-analysis of the changes of peripheral blood regulatory T cell to CD4+ T cell ratio in patients with systemic sclerosis.

    abstract::Current reports on the changes in peripheral blood regulatory T cell (Tregs) to CD4+ T cell ratio in systemic sclerosis (SSc) patients are varied in their conclusions. We therefore performed a meta-analysis to identify the actual change in the proportion of peripheral Tregs in SSc. Three databases, namely EMBASE, ISI ...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/srep43532

    authors: Deng C,Li W,Chen S,Li Y

    更新日期:2017-03-02 00:00:00

  • Pushing the limit: examining factors that affect anoxia tolerance in a single genotype of adult D. melanogaster.

    abstract::Drosophila melanogaster is a promiscuous species that inhabits a large range of harsh environments including flooded habitats and varying temperature changes. To survive these environments, fruit flies have adapted mechanisms of tolerance that allow them to thrive. During exposure to anoxic stress, fruit flies and oth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09204

    authors: Benasayag-Meszaros R,Risley MG,Hernandez P,Fendrich M,Dawson-Scully K

    更新日期:2015-03-17 00:00:00

  • The chorioallantoic membrane (CAM) assay for the study of human bone regeneration: a refinement animal model for tissue engineering.

    abstract::Biomaterial development for tissue engineering applications is rapidly increasing but necessitates efficacy and safety testing prior to clinical application. Current in vitro and in vivo models hold a number of limitations, including expense, lack of correlation between animal models and human outcomes and the need to...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32168

    authors: Moreno-Jiménez I,Hulsart-Billstrom G,Lanham SA,Janeczek AA,Kontouli N,Kanczler JM,Evans ND,Oreffo RO

    更新日期:2016-08-31 00:00:00

  • Increase in predation risk and trophic level induced by nocturnal visits of piscivorous fishes in a temperate seagrass bed.

    abstract::The majority of surveys on food webs of aquatic ecosystems have been conducted during the day owning to difficulties in sampling animals at night. In this study, to examine diurnal changes in predator-prey interactions in a temperate seagrass Zostera marina bed, a quantitative day/night survey of fish, the dominant an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04217-3

    authors: Shoji J,Mitamura H,Ichikawa K,Kinoshita H,Arai N

    更新日期:2017-06-20 00:00:00

  • Permafrost Degradation and Subsidence Observations during a Controlled Warming Experiment.

    abstract::Global climate change has resulted in a warmer Arctic, with projections indicating accelerated modifications to permafrost in the near future. The thermal, hydrological, and mechanical physics of permafrost thaw have been hypothesized to couple in a complex fashion but data collection efforts to study these feedbacks ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29292-y

    authors: Wagner AM,Lindsey NJ,Dou S,Gelvin A,Saari S,Williams C,Ekblaw I,Ulrich C,Borglin S,Morales A,Ajo-Franklin J

    更新日期:2018-07-19 00:00:00

  • Simultaneous high-speed imaging and optogenetic inhibition in the intact mouse brain.

    abstract::Genetically encoded calcium indicators and optogenetic actuators can report and manipulate the activity of specific neuronal populations. However, applying imaging and optogenetics simultaneously has been difficult to establish in the mammalian brain, even though combining the techniques would provide a powerful appro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40041

    authors: Bovetti S,Moretti C,Zucca S,Dal Maschio M,Bonifazi P,Fellin T

    更新日期:2017-01-05 00:00:00

  • Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts.

    abstract::Screening programs for lung cancer aim to allow diagnosis at the early stage, and therefore the decline in mortality rates. Thus, the aim of this retrospective cohort study was to the comparison of screened and non-screened lung cancer in terms of lung cancer characteristics, overdiagnosis and survival rate. A retrosp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56025-6

    authors: Wu FZ,Kuo PL,Huang YL,Tang EK,Chen CS,Wu MT,Lin YP

    更新日期:2019-12-18 00:00:00

  • Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.

    abstract::The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was to characterize the effects of spaceflight and reentry to 1 g on the structure and integrity of the retina and blood-retinal barrier (BRB) in the eye. To ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44696-0

    authors: Mao XW,Nishiyama NC,Byrum SD,Stanbouly S,Jones T,Drew A,Sridharan V,Boerma M,Tackett AJ,Zawieja D,Willey JS,Delp M,Pecaut MJ

    更新日期:2019-06-03 00:00:00

  • On the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells.

    abstract::Learning rules by which cell shape impacts cell function would enable control of cell physiology and fate in medical applications, particularly, on the interface of cells and material of the implants. We defined the phenotypic response of human bone marrow-derived mesenchymal stem cells (hMSCs) to 2176 randomly genera...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76019-z

    authors: Vasilevich AS,Vermeulen S,Kamphuis M,Roumans N,Eroumé S,Hebels DGAJ,van de Peppel J,Reihs R,Beijer NRM,Carlier A,Carpenter AE,Singh S,de Boer J

    更新日期:2020-11-04 00:00:00

  • Enhanced Capacitance of Hybrid Layered Graphene/Nickel Nanocomposite for Supercapacitors.

    abstract::In this work, Ni nanoparticles were directly decorated on graphene (G) nanosheets via mechanical ball milling. Based on transmission electron microscopy observations, the Ni nanoparticles were well dispersed and attached to the G nanosheet without any agglomerations. Electrochemical results showed that the capacitance...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32082

    authors: Mohd Zaid NA,Idris NH

    更新日期:2016-08-24 00:00:00

  • Wheat growth, applied water use efficiency and flag leaf metabolome under continuous and pulsed deficit irrigation.

    abstract::The intensity and frequency of precipitation events are predicted to change over the coming decades. For many areas, longer periods without rainfall are expected. We investigated the importance of irrigation frequency under water deficit conditions for growth, physiology and chemistry of wheat (Triticum aestivum). Dro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66812-1

    authors: Stallmann J,Schweiger R,Pons CAA,Müller C

    更新日期:2020-06-22 00:00:00

  • Quantitative image analysis for evaluating the abrasion resistance of nanoporous silica films on glass.

    abstract::The abrasion resistance of coated glass surfaces is an important parameter for judging lifetime performance, but practical testing procedures remain overly simplistic and do often not allow for direct conclusions on real-world degradation. Here, we combine quantitative two-dimensional image analysis and mechanical abr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17708

    authors: Nielsen KH,Karlsson S,Limbach R,Wondraczek L

    更新日期:2015-12-10 00:00:00

  • Publisher Correction: A Computational Method to Quantify the Effects of Slipped Strand Mispairing on Bacterial Tetranucleotide Repeats.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-58622-2

    authors: Harhay GP,Harhay DM,Bono JL,Capik SF,DeDonder KD,Apley MD,Lubbers BV,White BJ,Larson RL,Smith TPL

    更新日期:2020-01-28 00:00:00

  • Pressure-induced spin transition and site-selective metallization in CoCl2.

    abstract::The interplay between spin states and metallization in compressed CoCl2 is investigated by combining diffraction, resistivity and spectroscopy techniques under high-pressure conditions and ab-initio calculations. A pressure-induced metallization along with a Co2+ high-spin (S = 3/2) to low-spin (S = 1/2) crossover tra...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41337-4

    authors: Barreda-Argüeso JA,Nataf L,Aguado F,Hernández I,González J,Otero-de-la-Roza A,Luaña V,Jia Y,Jin C,Kim B,Kim K,Min BI,Heribert W,Jephcoat AP,Rodríguez F

    更新日期:2019-04-01 00:00:00

  • Inkjet-Printed Graphene/PEDOT:PSS Temperature Sensors on a Skin-Conformable Polyurethane Substrate.

    abstract::Epidermal electronic systems (EESs) are skin-like electronic systems, which can be used to measure several physiological parameters from the skin. This paper presents materials and a simple, straightforward fabrication process for skin-conformable inkjet-printed temperature sensors. Epidermal temperature sensors are a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35289

    authors: Vuorinen T,Niittynen J,Kankkunen T,Kraft TM,Mäntysalo M

    更新日期:2016-10-18 00:00:00

  • Wells provide a distorted view of life in the aquifer: implications for sampling, monitoring and assessment of groundwater ecosystems.

    abstract::When compared to surface ecosystems, groundwater sampling has unique constraints, including limited access to ecosystems through wells. In order to monitor groundwater, a detailed understanding of groundwater biota and what biological sampling of wells truly reflects, is paramount. This study aims to address this unce...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40702

    authors: Korbel K,Chariton A,Stephenson S,Greenfield P,Hose GC

    更新日期:2017-01-19 00:00:00

  • Co-immunization with DNA and protein mixture: a safe and efficacious immunotherapeutic strategy for Alzheimer's disease in PDAPP mice.

    abstract::Active immunotherapy targeting β-amyloid (Aβ) is the most promising strategy to prevent or treat Alzheimer's disease (AD). Based on pre-clinical studies and clinical trials, a safe and effective AD vaccine requires a delicate balance between providing therapeutically adequate anti-Aβ antibodies and eliminating or supp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07771

    authors: Liu S,Shi D,Wang HC,Yu YZ,Xu Q,Sun ZW

    更新日期:2015-01-14 00:00:00

  • Mechanical properties and microstructural change of W-Y2O3 alloy under helium irradiation.

    abstract::A wet-chemical method combined with spark plasma sintering was used to prepare a W-Y2O3 alloy. High-temperature tensile tests and nano-indentation microhardness tests were used to characterize the mechanical properties of the alloy. After He-ion irradiation, fuzz and He bubbles were observed on the irradiated surface....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12755

    authors: Tan X,Luo L,Chen H,Zhu X,Zan X,Luo G,Chen J,Li P,Cheng J,Liu D,Wu Y

    更新日期:2015-07-31 00:00:00

  • Conformational Ensemble of hIAPP Dimer: Insight into the Molecular Mechanism by which a Green Tea Extract inhibits hIAPP Aggregation.

    abstract::Small oligomers formed early along human islet amyloid polypeptide (hIAPP) aggregation is responsible for the cell death in Type II diabetes. The epigallocatechin gallate (EGCG), a green tea extract, was found to inhibit hIAPP fibrillation. However, the inhibition mechanism and the conformational distribution of the s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33076

    authors: Mo Y,Lei J,Sun Y,Zhang Q,Wei G

    更新日期:2016-09-13 00:00:00

  • Biomimetic cellular vectors for enhancing drug delivery to the lungs.

    abstract::Despite recent advances in drug delivery, the targeted treatment of unhealthy cells or tissues continues to remain a priority. In cancer (much like other pathologies), delivery vectors are designed to exploit physical and biological features of unhealthy tissues that are not always homogenous across the disease. In so...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55909-x

    authors: Evangelopoulos M,Yazdi IK,Acciardo S,Palomba R,Giordano F,Pasto A,Sushnitha M,Martinez JO,Basu N,Torres A,Hmaidan S,Parodi A,Tasciotti E

    更新日期:2020-01-13 00:00:00

  • Organism-like formation of Schistosoma hemozoin and its function suggest a mechanism for anti-malarial action of artemisinin.

    abstract::The current theories of antimalarial mechanism of artemisinin are inadequate to fully explain the observed effects. In our study, "organism-like" formation of Schistosoma hemozoin granules by attaching to and utilizing erythrocytes to form new ones was observed. This indicates that heme iron is transferred from erythr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34463

    authors: Sun J,Li C,Wang S

    更新日期:2016-10-03 00:00:00

  • Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive- and anxiety-like behaviour, and gut microbiome composition.

    abstract::Converging evidence supports the involvement of pro-inflammatory pathways and the gut microbiome in major depressive disorder (MDD). Pre-clinical and clinical studies suggest that decreasing pro-inflammatory signaling may provide clinical benefit in MDD. In this study, we used the chronic unpredictable stress (CUS) pa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-38055-8

    authors: Inserra A,Choo JM,Lewis MD,Rogers GB,Wong ML,Licinio J

    更新日期:2019-04-23 00:00:00

  • Part 1: profiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets.

    abstract::Intervertebral disc degeneration is accompanied by a loss of Extra-cellular matrix (ECM) due to an imbalance in anabolic and catabolic pathways. Identifying ECM proteins with anabolic and/or regenerative potential could be the key to developing regenerative therapies. Since human fetal discs grow and develop rapidly, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72859-x

    authors: Rajasekaran S,Tangavel C,Djuric N,Raveendran M,Soundararajan DCR,Nayagam SM,Matchado MS,Anand KSSV

    更新日期:2020-09-24 00:00:00

  • Ethylene and hydrogen peroxide are involved in brassinosteroid-induced salt tolerance in tomato.

    abstract::Crosstalk between phytohormone pathways is essential in plant growth, development and stress responses. Brassinosteroids (BRs) and ethylene are both pivotal plant growth regulators, and the interaction between these two phytohormones in the tomato response to salt stress is still unclear. Here, we explored the mechani...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35392

    authors: Zhu T,Deng X,Zhou X,Zhu L,Zou L,Li P,Zhang D,Lin H

    更新日期:2016-10-14 00:00:00