Abstract：
:Screening programs for lung cancer aim to allow diagnosis at the early stage, and therefore the decline in mortality rates. Thus, the aim of this retrospective cohort study was to the comparison of screened and non-screened lung cancer in terms of lung cancer characteristics, overdiagnosis and survival rate. A retrospective study in which 2883 patients with 2883 lung cancer diagnosed according to the hospital-based lung cancer register database between 2007 and 2017. A comparison was performed in term of clinical characteristics and outcomes of lung cancer between the screened and non-screening patient groups. 2883 subjects were identified (93 screened and 2790 non-screened). Screened group patients were younger (59.91 ± 8.14 versus 67.58 ± 12.95; p < 0.0001), and were more likely to be female than non-screened group (61.3% versus 36.8%; p < 0.0001). The screened group showed significantly better outcomes in overall mortality than the non-screened group (10.75% versus 79.06%; <0.0001). In a Cox proportional hazard model, lung cancer in the screened group proved to be an independent prognostic factor in lung cancer subjects. Our findings point to the improved survival outcome in the screened group and might underline the benefit of low-dose computed tomography (LDCT) screening program in Asian populations with the high prevalence of non-smoking-related lung cancer. Further study aimed at the LDCT mass screening program targeting at light smokers and non-smoker outside of existing screening criteria is warranted.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wu FZ,Kuo PL,Huang YL,Tang EK,Chen CS,Wu MT,Lin YPdoi
10.1038/s41598-019-56025-6subject
Has Abstractpub_date
2019-12-18 00:00:00pages
19386issue
1issn
2045-2322pii
10.1038/s41598-019-56025-6journal_volume
9pub_type
杂志文章abstract：:Proteasomes are a critical component of quality control that regulate turnover of short-lived, unfolded, and misfolded proteins. Proteasome activity has been therapeutically targeted and considered as a treatment option for several chronic lung disorders including pulmonary fibrosis. Although pharmacologic inhibition ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49020-4
更新日期：2019-08-29 00:00:00
abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been known as a promising agent for cancer therapy due to its specific apoptosis-inducing effect on tumor cells rather than most normal cells. However, systemically delivered TRAIL suffers from a rapid clearance from the body with an extremely short h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41904
更新日期：2017-02-22 00:00:00
abstract：:Channelrhodopsin-2 (ChR2)-based optogenetic technique has been increasingly applied to cardiovascular research. However, the potential effects of ChR2 protein overexpression on cardiomyocytes are not completely understood. The present work aimed to examine how the doxycycline-inducible lentiviral-mediated ChR2 express...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01723-2
更新日期：2017-05-08 00:00:00
abstract：:We report comparative indoor and outdoor stability testing of organic solar cells based on a blend between a donor-acceptor polyfluorene copolymer and a fullerene derivative. The outdoor testing was conducted for a period over 12,000 hours in Sheffield, England, with a Ts80 lifetime determined in excess of 10,000 hour...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01505-w
更新日期：2017-05-02 00:00:00
abstract：:Pantoea sp. IMH is the only bacterium found in genus Pantoea with a high As resistance capacity, but its molecular mechanism is unknown. Herein, the organization, function, and evolution of ars genes in IMH are studied starting with analysis of the whole genome. Two ars systems - ars1 (arsR1B1C1H1) and ars2 (arsR2B2C2...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39195
更新日期：2016-12-14 00:00:00
abstract：:Hirschsprung disease (HSCR) is a common cause of functional colonic obstruction in children. The currently available genetic testing is often inadequate as it mainly focuses on RET and several other genes, accounting for only 15-20% of cases. To identify novel, potentially pathogenic variants, we isolated a panel of g...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-14835-6
更新日期：2017-11-01 00:00:00
abstract：:Autophagy is a lysosomal degradation pathway that plays an essential role in neuronal homeostasis and is perturbed in many neurological diseases. Transcriptional downregulation of fat was previously observed in a Drosophila model of the polyglutamine disease Dentatorubral-pallidoluysian atrophy (DRPLA) and this was sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52684-7
更新日期：2019-11-06 00:00:00
abstract：:Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tumour cells (CTCs)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20608-6
更新日期：2018-02-13 00:00:00
abstract：:Nitric oxide (NO), a vascular signaling molecule, is primarily produced by endothelial NO synthase. Recently, a functional endothelial NO synthase (eNOS) was described in red blood cells (RBC). The RBC-eNOS contributes to the intravascular NO pool and regulates physiological functions. However the regulatory mechanism...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26935
更新日期：2016-06-27 00:00:00
abstract：:Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated nuclear receptor which controls lipid and glucose metabolism. It is also the master regulator of adipogenesis. In adipocytes, ligand-dependent PPARγ activation is associated with proteasomal degradation; therefore, regulation of PPARγ degradati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38550
更新日期：2016-12-05 00:00:00
abstract：:Fatal Familial Insomnia (FFI) is a genetic prion disease caused by a point mutation in the prion protein gene (PRNP) characterized by prominent thalamic atrophy, diffuse astrogliosis and moderate deposition of PrPSc in the brain. Here, for the first time, we demonstrate that the olfactory mucosa (OM) of patients with ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46269
更新日期：2017-04-07 00:00:00
abstract：:Salmonella spp. and thermotolerant Campylobacter spp. are the most important causes of human bacterial diarrheal infections worldwide. These bacterial species are influenced by several factors like behaviour of the host, shedding, environment incl. directly or indirectly through ambient temperature, and the infections...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28442
更新日期：2016-06-21 00:00:00
abstract：:The development of bulk, three-dimensional (3D), macroporous polymers with high permeability, large surface area and large volume is highly desirable for a range of applications in the biomedical, biotechnological and environmental areas. The experimental techniques currently used are limited to the production of smal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21154
更新日期：2016-02-17 00:00:00
abstract：:Fusarium head blight (FHB) is a devastating disease of wheat worldwide. Fhb1 is the most consistently reported quantitative trait locus (QTL) for FHB resistance breeding. A pore-forming toxin-like (PFT) gene at Fhb1 was first cloned by map-based cloning and found to confer FHB resistance in wheat. Proteins often inter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52030-x
更新日期：2019-10-29 00:00:00
abstract：:Medium chain fatty acids can activate the pro-inflammatory receptor GPR84 but so also can molecules related to 3,3'-diindolylmethane. 3,3'-Diindolylmethane and decanoic acid acted as strong positive allosteric modulators of the function of each other and analysis showed the affinity of 3,3'-diindolylmethane to be at l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18159-3
更新日期：2017-12-20 00:00:00
abstract：:This paper aims to eliminate the disharmony between simulation and experiment, and takes the mechanical properties of 6082-T6 Al alloy as an example. In order to obtain the equivalent distribution of material properties after considering the randomicity of materials, a new inversion method combining with stochastic fi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54046-9
更新日期：2019-11-28 00:00:00
abstract：:Lattice dynamics and elasticity for the high-temperature ε phase (body-centered cubic; bcc) of plutonium is predicted utilizing first-principles electronic structure coupled with a self-consistent phonon method that takes phonon-phonon interaction and strong anharmonicity into account. These predictions establish the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01034-6
更新日期：2017-04-25 00:00:00
abstract：:We report the molecular basis of the largest Tunisian cohort with inherited retinal dystrophies (IRD) reported to date, identify disease-causing pathogenic variants and describe genotype-phenotype correlations. A subset of 26 families from a cohort of 73 families with clinical diagnosis of autosomal recessive IRD (AR-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67792-y
更新日期：2020-07-08 00:00:00
abstract：:We demonstrate the surface-plasmon-induced enhancement of Förster resonance energy transfer (FRET)using a model multilayer core-shell nanostructure consisting of an Au core and surrounding FRET pairs, i.e., CdSe quantum dot donors and S101 dye acceptors. The multilayer configuration was demonstrated to exhibit synergi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04735
更新日期：2014-04-22 00:00:00
abstract：:The toxicological mechanisms of liver injury caused by most traditional Chinese medicine (TCM) remain largely unknown. Due to the unique features, exosomal microRNAs (miRNAs) are currently attracting major interests to provide further insights into toxicological mechanisms. Thus, taking Fructus Meliae Toosendan as an ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21113-6
更新日期：2018-02-12 00:00:00
abstract：:The elastic modulus of ZnO nanowires was measured using a resonance method based on laser Doppler effect and their fracture strains were determined via two-point bending with the aid of optical nanomanipulation. The elastic moduli of ZnO nanowires with diameters of 78 to 310 nm vary from 123 to 154 GPa, which are clos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09843-5
更新日期：2017-08-25 00:00:00
abstract：:Tumour tracking is an advanced radiotherapy technique for precise treatment of tumours subject to organ motion. In this work, we addressed crucial aspects of dose delivery for its realisation in pencil beam scanning proton therapy, exploring the momentum acceptance and global achromaticity of a Gantry beamline to perf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71821-1
更新日期：2020-09-18 00:00:00
abstract：:Obstacles to widespread deployments of direct air capture of CO2 (DAC) lie in high material and energy costs. By grafting quaternary ammonium (QA) functional group to mesoporous polymers with high surface area, a unique DAC adsorbent with moisture swing adsorption (MSA) ability and ultra-high kinetics was developed in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77477-1
更新日期：2020-12-08 00:00:00
abstract：:Pigment organelles known as melanosomes disperse or aggregate in a melanophore in response to hormones. These movements are mediated by the microtubule motors kinesin-2 and cytoplasmic dynein. However, the force generation mechanism of dynein, unlike that of kinesin, is not well understood. In this study, to address t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41458-w
更新日期：2019-03-25 00:00:00
abstract：:This work aimed to investigate the co-grinding effects of β-cyclodextrin (β-CD) and cucurbit[7]uril (CB[7]) on crystalline zaltoprofen (ZPF) in tablet formulation. Crystalline ZPF was prepared through anti-solvent recrystallization and fully analyzed through single-crystal X-ray diffraction. Co-ground dispersions and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45984
更新日期：2017-04-03 00:00:00
abstract：:Associations between cognitive decline and cerebral microbleeds (CMBs) have received increasing attention. An association between CMB distribution (deep or lobar) and cognitive decline has been reported, but these findings are controversial. We investigated the association between magnetic resonance imaging (MRI) find...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73404-6
更新日期：2020-10-02 00:00:00
abstract：:Gene expression profiles reflect the biologically diverse activities of cells under specific cell environments. Using the transcriptional response of cultured cells to blood composition, we developed a litmus gene assay to discriminate blood samples reflecting different sample qualities or disease conditions. This cel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17293-2
更新日期：2017-12-04 00:00:00
abstract：:Cortical gyrification of the brain represents the folding characteristic of the cerebral cortex. How the brain cortical gyrification changes from childhood to old age in healthy human subjects is still unclear. Additionally, studies have shown regional gyrification alterations in patients with major psychiatric disord...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00582-1
更新日期：2017-03-30 00:00:00
abstract：:In this paper, we demonstrate a novel dual-pump approach to generate robust optical frequency comb with varying free spectral range (FSR) spacing in a CMOS-compatible high-Q micro-ring resonator (MRR). The frequency spacing of the comb can be tuned by an integer number FSR of the MRR freely in our dual-pump scheme. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28501
更新日期：2016-06-24 00:00:00
abstract：:Powdered activated carbon (AC) is commonly used as an effective additive to enhance anaerobic digestion (AD), but little is known about how the metabolic pathways resulting from adding AC change the microbial association network and enhance food waste treatment. In this work, the use of AC in an anaerobic digestion sy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11826-5
更新日期：2017-09-12 00:00:00
