Abstract:
:Specialized processing in the brain is performed by multiple groups of brain regions organized as functional modules. Although, in vivo studies of brain functional modules involve multiple functional Magnetic Resonance Imaging (fMRI) scans, the methods used to derive functional modules from functional networks of the brain ignore individual differences in the functional architecture and use incomplete functional connectivity information. To correct this, we propose an Iterative Consensus Spectral Clustering (ICSC) algorithm that detects the most representative modules from individual dense weighted connectivity matrices derived from multiple scans. The ICSC algorithm derives group-level modules from modules of multiple individuals by iteratively minimizing the consensus-cost between the two. We demonstrate that the ICSC algorithm can be used to derive biologically plausible group-level (for multiple subjects) and subject-level (for multiple subject scans) brain modules, using resting-state fMRI scans of 589 subjects from the Human Connectome Project. We employed a multipronged strategy to show the validity of the modularizations obtained from the ICSC algorithm. We show a heterogeneous variability in the modular structure across subjects where modules involved in visual and motor processing were highly stable across subjects. Conversely, we found a lower variability across scans of the same subject. The performance of our algorithm was compared with existing functional brain modularization methods and we show that our method detects group-level modules that are more representative of the modules of multiple individuals. Finally, the experiments on synthetic images quantitatively demonstrate that the ICSC algorithm detects group-level and subject-level modules accurately under varied conditions. Therefore, besides identifying functional modules for a population of subjects, the proposed method can be used for applications in personalized neuroscience. The ICSC implementation is available at https://github.com/SCSE-Biomedical-Computing-Group/ICSC.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gupta S,Rajapakse JCdoi
10.1038/s41598-020-63552-0subject
Has Abstractpub_date
2020-05-05 00:00:00pages
7590issue
1issn
2045-2322pii
10.1038/s41598-020-63552-0journal_volume
10pub_type
杂志文章abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62766-6
更新日期:2020-04-06 00:00:00
abstract::Neonatal animal models are increasingly employed in order to unravel age-specific disease mechanisms. Appropriate tools objectifying the clinical condition of murine neonates are lacking. In this study, we tested a scoring system specifically designed for newborn mice that relies on clinical observation and examinatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42414-4
更新日期:2019-04-11 00:00:00
abstract::The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development. PIM1 levels are regulated mainly through cytokine-induced transcription and prote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03775-w
更新日期:2017-06-15 00:00:00
abstract::The colon can have an absorptive function similar to that of the small intestine after the massive resection of the small bowel. To improve colonic absorptive function, we created a valve in the colon (artificial colonic valve, ACV). ACVs were created in 20 rats that had 80 percent of their small intestine resected, w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57865-3
更新日期:2020-01-21 00:00:00
abstract::The General Unified Threshold model for Survival (GUTS) integrates previously published toxicokinetic-toxicodynamic models and estimates survival with explicitly defined assumptions. Importantly, GUTS accounts for time-variable exposure to the stressor. We performed three studies to test the ability of GUTS to predict...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29178
更新日期:2016-07-06 00:00:00
abstract::The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce the variance in the Aβ CL unit between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 partici...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70978-z
更新日期:2020-09-11 00:00:00
abstract::Abnormal expression of microRNAs (miRNAs) contributes to glioma initiation. However, the expression of miRNAs in tumour tissue or blood of spinal cord glioma (SCG) patients, particularly in high-grade spinal gliomas (Grade IV) known as glioblastoma (GBM), remains largely unknown. In this study we aimed to determine di...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42364-x
更新日期:2019-06-24 00:00:00
abstract::Norfloxacin (NOF) is an environmentally harmful and ubiquitous aquatic pollutant with extensive production and application. In this study, a novel composition named carbon-based composite photocatalytic material of zinc oxide and zinc sulphide (ZnO/ZnS@BC) was successfully obtained by the impregnation-roasting method ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68517-x
更新日期:2020-07-17 00:00:00
abstract::Geothermal waters from the Semi, Dagejia and Kawu hot springs in the Shiquanhe-Yarlung Zangbo geothermal field of southern Tibet (China) are highly enriched in rare alkali metals (RAM). However, the enrichment mechanism is still hotly debated. Here, we report the first silicon isotope data of these geothermal waters t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44249-5
更新日期:2019-05-27 00:00:00
abstract::Both attraction and repulsion from linearly polarized light have been observed in zooplankton. A dichotomous choice experiment, consisting of plankton light traps deployed in natural waters at a depth of 30 m that projected either polarized or unpolarized light of the same intensity, was used to test the hypothesis th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35891
更新日期:2016-10-20 00:00:00
abstract::The precise clinicopathologic significance of myeloid differentiation primary response gene (MYD88) L265P mutation in diffuse large B-cell lymphomas (DLBCLs) remains elusive. To investigate the frequency and clinicopathologic significance of the MYD88 L265P mutation in DLBCLs, we conducted a meta-analysis of 40 publis...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-01998-5
更新日期:2017-05-11 00:00:00
abstract::Controlled ovarian stimulation by exogenous gonadotrophins is a key procedure during the in vitro fertilization cycle to obtain a sufficient number of oocytes in humans. Previous studies demonstrated that repeated superovulation had deleterious effects on the ovaries. However, whether repeated superovulation adversely...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31368
更新日期:2016-10-04 00:00:00
abstract::Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here, we found that expression of miR-155 was up regulated in lesional skin tissue from patients with either systemic or localized scleroderma, and correlated with f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20314
更新日期:2016-02-01 00:00:00
abstract::PP2A is a master controller of multiple inflammatory signaling pathways. It is a target in asthma; however the molecular mechanisms by which PP2A controls inflammation warrant further investigation. In A549 lung epithelial cells in vitro we show that inhibition of basal PP2A activity by okadaic acid (OA) releases rest...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10063
更新日期:2015-05-18 00:00:00
abstract::Congenital ptosis may be associated with abnormalities of visual development and function, including amblyopia, strabismus and refractive errors. However, the prevalence estimates of these abnormalities vary widely. We performed a systematic review and meta-analysis to estimate the prevalence of amblyopia, strabismus ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-26671-3
更新日期:2018-05-29 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis, which urgently demanding new drugs for treating infection. Two homologous insect CSαβ peptides-DLP2 and DLP4 from Hermetia illucens were firstly expressed in Pichia pastoris, with the yields of 873.5 and 801.3 mg/l, respectively...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10839-4
更新日期:2017-09-21 00:00:00
abstract::Since its recent foundation, phase-coherent caloritronics has sparkled continuous interest giving rise to numerous concrete applications. This research field deals with the coherent manipulation of heat currents in mesoscopic superconducting devices by mastering the Josephson phase difference. Here, we introduce a new...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30268-1
更新日期:2018-08-16 00:00:00
abstract::Due to their small dimensions, electrophysiology on thin and intricate axonal branches in support of understanding their role in normal and diseased brain function poses experimental challenges. To reduce experimental complexity, we coupled microelectrode arrays (MEAs) to bi-level microchannel devices for the long-ter...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09033-3
更新日期:2017-08-17 00:00:00
abstract::Sacroiliac (SI) screw loosening may indicate persistent instability, non-union and contribute to pain. Yet, there is no reliable objective measurement technique to detect and monitor SI screw loosening. In 9 cadaveric pelvises one of two SI screw was turned back approximately 20 mm and subsequently assessed by optical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40052-4
更新日期:2019-02-28 00:00:00
abstract::Metal nitrides have been proposed to replace noble metals in plasmonics for some specific applications. In particular, while titanium nitride (TiN) and zirconium nitride (ZrN) possess localized plasmon resonances very similar to gold in magnitude and wavelength, they benefit from a much higher sustainability to temper...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38647
更新日期:2016-12-09 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-44354-5
更新日期:2019-05-23 00:00:00
abstract::Agricultural soil is often subjected to waterlogging after heavy rainfalls, resulting in sharp and explosive increases in the emission of nitrous oxide (N2O), an important greenhouse gas primarily released from agricultural soil ecosystems. Previous studies on waterlogged soil examined the abundance of denitrifiers bu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00953-8
更新日期:2017-04-11 00:00:00
abstract::There has been a significant increase in autism spectrum disorder (ASD) in the last decades that cannot be exclusively attributed to better diagnosis and an increase in the communication of new cases. Patients with ASD often show dysregulation of proteins associated with synaptic plasticity, notably brain-derived neur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74239-x
更新日期:2020-10-15 00:00:00
abstract::We explore the spectral dependence of fluorescence enhancement and the associated lifetime modification of fluorescent molecules coupled to single metal nanoparticles. Fluorescence lifetime imaging microscopy and single-particle dark-field spectroscopy are combined to correlate the dependence of fluorescence lifetime ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21349
更新日期:2016-02-15 00:00:00
abstract::The phenomenon of cation ordering is closely related to certain physical properties of complex oxides, which necessitates the search of underlying structure-property relationship at atomic resolution. Here we study the superlattices within reduced calcium titanate single crystal micro-pillars, which are unexpected fro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15120-2
更新日期:2017-11-03 00:00:00
abstract::A large outbreak of dengue, with the most documented cases, occurred in Guangdong China in 2014. Epidemiological studies and phylogenetic analysis of the isolated dengue virus (DENV) showed this outbreak was attributed to multiple sources and caused by at least two genotypes of DENV-1 (Genotypes I and III) and two gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16913
更新日期:2015-11-23 00:00:00
abstract::This meta-analysis aims to evaluate whether the extant literature justifies any definitive conclusions about whether and how SITBs may be associated with brain differences. A total of 77 papers (N = 4,903) published through January 1, 2019 that compared individuals with and without SITBs were included, resulting in 88...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-020-59490-6
更新日期:2020-02-12 00:00:00
abstract::Heme catabolism exerts physiological functions that impact health through depressing inflammation. Upon reactive pathway progression, as in Gilbert's Syndrome (GS; UGT1A1*28 polymorphism), aggravated health effects have been determined. Based on lower inflammation and improved metabolic health reported for GS, inter-g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00933-y
更新日期:2017-04-07 00:00:00
abstract::We developed a simple, scalable and high-throughput method for fabrication of large-area three-dimensional rose-like microflowers with controlled size, shape and density on graphene films by femtosecond laser micromachining. The novel biomimetic microflower that composed of numerous turnup graphene nanoflakes can be f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17557
更新日期:2015-11-30 00:00:00
abstract::The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26822
更新日期:2016-05-31 00:00:00