Multiple Sources of Infection and Potential Endemic Characteristics of the Large Outbreak of Dengue in Guangdong in 2014.

abstract：:Human milk delivers an array of bioactive components that safeguard infant growth and development and maintain healthy gut microbiota. Milk fat globule membrane (MFGM) is a biologically functional fraction of milk increasingly linked to beneficial outcomes in infants through protection from pathogens, modulation of th...

journal_title：Scientific reports

authors： He X,Parenti M,Grip T,Lönnerdal B,Timby N,Domellöf M,Hernell O,Slupsky CM

更新日期：2019-08-12 00:00:00

abstract：:PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...

journal_title：Scientific reports

authors： Caldwell RB,Braselmann H,Schoetz U,Heuer S,Scherthan H,Zitzelsberger H

更新日期：2016-07-04 00:00:00

abstract：:Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here w...

journal_title：Scientific reports

authors： Hansen J,Timmers S,Moonen-Kornips E,Duez H,Staels B,Hesselink MK,Schrauwen P

更新日期：2016-10-19 00:00:00

abstract：:Echovirus 11 (E-11) is one of the most frequently isolated enteroviruses causing meningitis and other diseases such as hand, foot, and mouth disease (HFMD) and acute flaccid paralysis (AFP). Fifty-nine newly determined E-11 VP1 sequences from the China AFP and HFMD surveillance network and 500 E-11 VP1 sequences obtai...

journal_title：Scientific reports

authors： Li J,Yan D,Chen L,Zhang Y,Song Y,Zhu S,Ji T,Zhou W,Gan F,Wang X,Hong M,Guan L,Shi Y,Wu G,Xu W

更新日期：2019-07-22 00:00:00

abstract：:The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the TARGT pipeline for...

journal_title：Scientific reports

authors： Pierini F,Nutsua M,Böhme L,Özer O,Bonczarowska J,Susat J,Franke A,Nebel A,Krause-Kyora B,Lenz TL

更新日期：2020-04-30 00:00:00

abstract：:Models on how perceptual and cognitive information on others' mental states are treated by the cognitive architecture are often framed as duplex models considering two independent systems. In the context of the neuroscience of empathy analogous systems have been described. Using event-related potentials (i.e., ERPs) t...

journal_title：Scientific reports

authors： Sessa P,Meconi F,Han S

更新日期：2014-12-11 00:00:00

abstract：:The manifestation of cognitive and physical impairment in stroke patients before the acute event suggests accumulating subclinical vascular pathology in the brain. We investigated whether impairments in cognitive and physical functioning were associated with an increased stroke risk. Between 2002 and 2008, 8,519 strok...

journal_title：Scientific reports

authors： Heshmatollah A,Mutlu U,Koudstaal PJ,Ikram MA,Ikram MK

更新日期：2020-04-14 00:00:00

abstract：:We performed a metabolomics study using liquid chromatography-mass spectrometry (LC-MS) combined with multivariate data analysis (MVDA) to discriminate global urine profiles in urine samples from esophageal squamous cell carcinoma (ESCC) patients and healthy controls (NC). Our work evaluated the feasibility of employi...

journal_title：Scientific reports

authors： Xu J,Chen Y,Zhang R,He J,Song Y,Wang J,Wang H,Wang L,Zhan Q,Abliz Z

更新日期：2016-10-11 00:00:00

abstract：:Term preeclampsia (tPE), ≥37 weeks, is the most common form of PE and the most difficult to predict. Little is known about its pathogenesis. This study aims to elucidate the pathogenesis and assess early prediction of tPE using serial integrated metabolomic and proteomic systems biology approaches. Serial first- (11-1...

journal_title：Scientific reports

authors： Bahado-Singh R,Poon LC,Yilmaz A,Syngelaki A,Turkoglu O,Kumar P,Kirma J,Allos M,Accurti V,Li J,Zhao P,Graham SF,Cool DR,Nicolaides K

更新日期：2017-11-23 00:00:00

abstract：:Graphene aerogels (GAs) with high mechanical strength, tunable density and volume have been prepared only via soaking graphene hydrogels (GHs) in ammonia solution. The density and volume of the obtained GAs are controlled by adjusting the concentration of ammonia solution. Although volume of the GAs decreases with inc...

journal_title：Scientific reports

authors： Han Z,Tang Z,Shen S,Zhao B,Zheng G,Yang J

更新日期：2014-05-22 00:00:00

abstract：:The overproduction of hydrogen peroxide is an inherent feature of some tumour cells and inflamed tissues. We took advantage of this peculiarity to eliminate cells using chemiluminescent peroxyoxalate reaction. We designed dispersions containing polyoxalate and tetramethylhematoporhyrin (TMHP) in dimethylphthalate drop...

journal_title：Scientific reports

authors： Romanyuk AV,Grozdova ID,Ezhov AA,Melik-Nubarov NS

更新日期：2017-06-13 00:00:00

abstract：:No consensus currently exist on the optimal treatment of patients with high-risk nonmuscle invasive (HGT1) micropapillary variant of bladder cancer (MPBC). Transcripsome analysis may allow stratification of MPBC-HGT1 enabling prediction of recurrence and guide therapeutic management for individual patients. Whole tran...

journal_title：Scientific reports

authors： Bowden M,Nadal R,Zhou CW,Werner L,Barletta J,Juanpere N,Lloreta J,Hernandez-Llodrà S,Morote J,de Torres I,Orsola A,Cejas P,Long H,Bellmunt J

更新日期：2020-11-18 00:00:00

abstract：:Biomaterial injection is a novel therapy to treat ischemic heart failure (HF) that has shown to reduce remodeling and restore cardiac function in recent preclinical studies. While the effect of biomaterial injection in reducing mechanical wall stress has been recently demonstrated, the influence of biomaterials on the...

journal_title：Scientific reports

authors： Ramírez WA,Gizzi A,Sack KL,Guccione JM,Hurtado DE

更新日期：2020-07-31 00:00:00

abstract：:Male infertility due to spermatogenesis defects affects millions of men worldwide. However, the genetic etiology of the vast majority remains unclear. Here we describe three men with primary infertility due to multiple morphological abnormalities of the sperm flagella (MMAF) from two unrelated Han Chinese families. We...

journal_title：Scientific reports

authors： Tu C,Nie H,Meng L,Yuan S,He W,Luo A,Li H,Li W,Du J,Lu G,Lin G,Tan YQ

更新日期：2019-11-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors are among the most prescribed antidepressants. Fluoxetine is the lead molecule which exerts its therapeutic effects, at least in part, by promoting neuroplasticity through increased brain-derived neurotrophic factor (BDNF)/tropomyosin-related receptor kinase B (TrkB) signalling....

journal_title：Scientific reports

authors： Levy MJF,Boulle F,Emerit MB,Poilbout C,Steinbusch HWM,Van den Hove DLA,Kenis G,Lanfumey L

更新日期：2019-04-19 00:00:00

abstract：:Hydrogels are being extensively used for three-dimensional immobilization and culture of cells in fundamental biological studies, biochemical processes, and clinical treatments. However, it is still a challenge to support viability and regulate phenotypic activities of cells in a structurally stable gel, because the g...

journal_title：Scientific reports

authors： Lee MK,Rich MH,Baek K,Lee J,Kong H

更新日期：2015-03-10 00:00:00

abstract：:For the application of formic acid as a liquid organic hydrogen carrier, development of efficient catalysts for dehydrogenation of formic acid is a challenging topic, and most studies have so far focused on the composition of metals and supports, the size effect of metal nanoparticles, and surface chemistry of support...

journal_title：Scientific reports

authors： Jin MH,Oh D,Park JH,Lee CB,Lee SW,Park JS,Lee KY,Lee DW

更新日期：2016-09-26 00:00:00

abstract：:Insulin secretion from pancreatic beta-cells is dependent on zinc ions as essential components of insulin crystals, zinc transporters are thus involved in the insulin secretory process. Zip14 (SLC39a14) is a zinc importing protein that has an important role in glucose homeostasis. Zip14 knockout mice display hyperinsu...

journal_title：Scientific reports

authors： Maxel T,Smidt K,Petersen CC,Honoré B,Christensen AK,Jeppesen PB,Brock B,Rungby J,Palmfeldt J,Larsen A

更新日期：2019-06-13 00:00:00

abstract：:Sorafenib is a multikinase inhibitor used as a first-line treatment for advanced hepatocellular carcinoma (HCC), but it has shown modest to low response rates. The characteristic tumour hypoxia of advanced HCC maybe a major factor underlying hypoxia-mediated treatment failure. Thus, it is urgent to elucidate the mecha...

journal_title：Scientific reports

authors： Zhou TY,Zhuang LH,Hu Y,Zhou YL,Lin WK,Wang DD,Wan ZQ,Chang LL,Chen Y,Ying MD,Chen ZB,Ye S,Lou JS,He QJ,Zhu H,Yang B

更新日期：2016-08-01 00:00:00

abstract：:Tumor genetic heterogeneity may underlie poor clinical outcomes because diverse subclones could be comprised of metastatic and drug resistant cells. Targeted deep sequencing has been used widely as a diagnostic tool to identify actionable mutations in cancer patients. In this study, we evaluated the clinical utility o...

journal_title：Scientific reports

authors： Oh BY,Shin HT,Yun JW,Kim KT,Kim J,Bae JS,Cho YB,Lee WY,Yun SH,Park YA,Park YH,Im YH,Lee J,Joung JG,Kim HC,Park WY

更新日期：2019-03-14 00:00:00

abstract：:We propose a novel injection scheme for laser-driven wakefield acceleration in which controllable localized electron injection is obtained by inserting nanoparticles into a plasma medium. The nanoparticles provide a very confined electric field that triggers localized electron injection where nonlinear plasma waves ar...

journal_title：Scientific reports

authors： Cho MH,Pathak VB,Kim HT,Nam CH

更新日期：2018-11-16 00:00:00

abstract：:The application of metabolic phenotyping in clinical and epidemiological studies is limited by a poor understanding of inter-individual, intra-individual and temporal variability in metabolic phenotypes. Using 1H NMR spectroscopy we characterised short-term variability in urinary metabolites measured from 20 children ...

journal_title：Scientific reports

authors： Maitre L,Lau CE,Vizcaino E,Robinson O,Casas M,Siskos AP,Want EJ,Athersuch T,Slama R,Vrijheid M,Keun HC,Coen M

更新日期：2017-04-19 00:00:00

abstract：:Chemotherapy is widely used in cancer treatments. However, non-specific distribution of chemotherapeutic agents to healthy tissues and normal cells in the human body always leads to adverse side effects and disappointing therapeutic outcomes. Therefore, the main aim of this study was to develop a targeted drug deliver...

journal_title：Scientific reports

authors： Gan BK,Rullah K,Yong CY,Ho KL,Omar AR,Alitheen NB,Tan WS

更新日期：2020-10-08 00:00:00

abstract：:It is known that a developing avian embryo resorbs micronutrients (calcium and other chemical elements) from the inner layer of the eggshell, inducing thinning and overall changes in the shell's chemical composition. However, an aspect yet to be explored relates to the local changes in the multi-elemental composition ...

journal_title：Scientific reports

authors： Orłowski G,Niedzielski P,Merta D,Pokorny P,Proch J

更新日期：2020-12-17 00:00:00

abstract：:Fusarium head blight (FHB) is a devastating disease of wheat worldwide. Fhb1 is the most consistently reported quantitative trait locus (QTL) for FHB resistance breeding. A pore-forming toxin-like (PFT) gene at Fhb1 was first cloned by map-based cloning and found to confer FHB resistance in wheat. Proteins often inter...

journal_title：Scientific reports

authors： He Y,Wu L,Liu X,Zhang X,Jiang P,Ma H

更新日期：2019-10-29 00:00:00

abstract：:Methylated non-CpGs (mCpH; H means A, C, and T) have emerged as key epigenetic marks in mammalian embryonic stem cells (ESCs) and neurons, regulating cell type-specific functions. In these two cell types, mCpHs show distinct motifs and correlations to transcription that could be a key in understanding the cell type-sp...

journal_title：Scientific reports

authors： Lee JH,Park SJ,Nakai K

更新日期：2017-09-12 00:00:00

abstract：:One of the health hazards of PM2.5 exposure is to induce pulmonary inflammatory responses. In our previous study, we demonstrated that exposing both the immortalized and primary human bronchial epithelial cells to PM2.5 results in a significant upregulation of VEGF production, a typical signaling event to trigger chro...

journal_title：Scientific reports

authors： Xu H,Xu X,Wang H,Qimuge A,Liu S,Chen Y,Zhang C,Hu M,Song L

更新日期：2019-11-12 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations are commonly found in the skeletal muscle of patients with mitochondrial disease, inflammatory myopathies and sarcopenia. The majority of these mutations are mtDNA deletions, which accumulate to high levels in individual muscle fibres causing a respiratory defect. Most mtDNA deletio...

journal_title：Scientific reports

authors： Rygiel KA,Grady JP,Taylor RW,Tuppen HA,Turnbull DM

更新日期：2015-05-19 00:00:00

abstract：:The same copper phosphate catalysts were synthesized by obtaining the methods involving solid state as well as liquid state reactions in this work. And then the optimised p-n hybrid junction photocatalysts have been synthesized following the same solid/liquid reaction pathways. The synthesized copper phosphate photoca...

journal_title：Scientific reports

authors： Samal A,Das DP,Madras G

更新日期：2018-02-13 00:00:00

abstract：:TMEM230 mutations have been recently reported to cause autosomal dominant Parkinson's disease (PD). However, there are limited studies from different ethnic populations to support the role of TMEM230 in sporadic PD. In this study, we performed a comprehensive TMEM230 mutation screening in 550 sporadic PD patients and ...

journal_title：Scientific reports

authors： Shi CH,Li F,Shi MM,Yang ZH,Mao CY,Zhang SY,Wang H,Cheng Y,Yang J,Wu J,Xu YM

更新日期：2017-04-26 00:00:00