Hepatitis B virus X protein is capable of down-regulating protein level of host antiviral protein APOBEC3G.

abstract：:Centromeres usually contain large amounts of tandem repeat DNA. Alpha satellite DNA (AS) is the most abundant tandem repeat DNA found in the centromeres of simian primates. The AS of humans contains sequences organized into higher-order repeat (HOR) structures, which are tandem arrays of larger repeat units consisting...

journal_title：Scientific reports

authors： Sujiwattanarat P,Thapana W,Srikulnath K,Hirai Y,Hirai H,Koga A

更新日期：2015-05-14 00:00:00

abstract：:Age-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56...

journal_title：Scientific reports

authors： Cao P,Wong CM,Chan KH,Wang X,Chan KP,Peiris JS,Poon LL,Yang L

更新日期：2016-07-25 00:00:00

abstract：:Silicon is the second most common element on the Earth's crust and its oxide (SiO(2)) the most abundant mineral. Silica and silicates are widely used in medicine and industry as well as in micro- and nano-optics and electronics. However, the fabrication of glass fibres and components requires high temperature and non-...

journal_title：Scientific reports

authors： Polini A,Pagliara S,Camposeo A,Cingolani R,Wang X,Schröder HC,Müller WE,Pisignano D

更新日期：2012-01-01 00:00:00

abstract：:Sirtuins are NAD(+) dependent lysine deacylases involved in many regulatory processes such as control of metabolic pathways, DNA repair and stress response. Modulators of sirtuin activity are required as tools for uncovering the biological function of these enzymes and as potential therapeutic agents. Systematic disco...

journal_title：Scientific reports

authors： Schuster S,Roessler C,Meleshin M,Zimmermann P,Simic Z,Kambach C,Schiene-Fischer C,Steegborn C,Hottiger MO,Schutkowski M

更新日期：2016-03-04 00:00:00

abstract：:Identification of novel photosynthetic proteins is important for understanding and improving photosynthetic efficiency. Synergistically, genome neighborhood can provide additional useful information to identify photosynthetic proteins. We, therefore, expected that applying a computational approach, particularly machin...

journal_title：Scientific reports

authors： Sangphukieo A,Laomettachit T,Ruengjitchatchawalya M

更新日期：2020-04-28 00:00:00

abstract：:Supported by histological and genetic evidence implicating myelin, neuroinflammation and oligodendrocyte dysfunction in schizophrenia spectrum disorders (SZ), diffusion tensor imaging (DTI) studies have consistently shown white matter (WM) abnormalities when compared to healthy controls (HC). The diagnostic specificit...

journal_title：Scientific reports

authors： Tønnesen S,Kaufmann T,Doan NT,Alnæs D,Córdova-Palomera A,Meer DV,Rokicki J,Moberget T,Gurholt TP,Haukvik UK,Ueland T,Lagerberg TV,Agartz I,Andreassen OA,Westlye LT

更新日期：2018-09-20 00:00:00

abstract：:A unique combination of useful properties in boron-carbide, such as extreme hardness, excellent fracture toughness, a low density, a high melting point, thermoelectricity, semi-conducting behavior, catalytic activity and a remarkably good chemical stability, makes it an ideal material for a wide range of technological...

journal_title：Scientific reports

authors： Mondal S,Bykova E,Dey S,Ali SI,Dubrovinskaia N,Dubrovinsky L,Parakhonskiy G,van Smaalen S

更新日期：2016-01-18 00:00:00

abstract：:Oxidative stress and mitochondrial dysfunction are implicated in aging-related neurodegenerative disorders. 8-Oxoguanine (8-oxoG), a common oxidised base lesion, is often highly accumulated in brains from patients with neurodegenerative disorders. MTH1 hydrolyses 8-oxo-2'-deoxyguanosine triphosphate (8-oxo-dGTP) to 8-...

journal_title：Scientific reports

authors： Leon J,Sakumi K,Castillo E,Sheng Z,Oka S,Nakabeppu Y

更新日期：2016-02-25 00:00:00

abstract：:Culture medium of mesenchymal stromal cells (MSCs) is usually supplemented with either human platelet lysate (HPL) or fetal calf serum (FCS). Many studies have demonstrated that proliferation and cellular morphology are affected by these supplements - it is therefore important to determine if they favor outgrowth of d...

journal_title：Scientific reports

authors： Fernandez-Rebollo E,Mentrup B,Ebert R,Franzen J,Abagnale G,Sieben T,Ostrowska A,Hoffmann P,Roux PF,Rath B,Goodhardt M,Lemaitre JM,Bischof O,Jakob F,Wagner W

更新日期：2017-07-11 00:00:00

abstract：:Continuous solidification experiments were carried out with Cu-Bi-Sn alloys under the effects of Electric Current Pulses (ECPs). A model describing the microstructure evolution was developed. The formation of the microstructure in the continuously solidified alloys was calculated. The calculations demonstrated that EC...

journal_title：Scientific reports

authors： Hongxiang J,Jie H,Jiuzhou Z

更新日期：2015-07-31 00:00:00

abstract：:Natural sensory signals have nonlinear structures dynamically composed of the carrier frequencies and the variation of the amplitude (i.e., envelope). How the human brain processes the envelope information is still poorly understood, largely due to the conventional analysis failing to quantify it directly. Here, we us...

journal_title：Scientific reports

authors： Nguyen KT,Liang WK,Lee V,Chang WS,Muggleton NG,Yeh JR,Huang NE,Juan CH

更新日期：2019-11-15 00:00:00

abstract：:Photonic integrated circuits for photonic computing open up the possibility for the realization of ultrahigh-speed and ultra wide-band signal processing with compact size and low power consumption. Differential equations model and govern fundamental physical phenomena and engineering systems in virtually any field of ...

journal_title：Scientific reports

authors： Yang T,Dong J,Lu L,Zhou L,Zheng A,Zhang X,Chen J

更新日期：2014-07-04 00:00:00

abstract：:Biological control mechanisms of plant diseases have been intensively studied. However, how plant pathogens respond to and resist or alleviate biocontrol agents remains largely unknown. In this study, a comparative transcriptome analysis was performed to elucidate how the pathogen of sclerotinia stem rot, Sclerotinia ...

journal_title：Scientific reports

authors： Yang X,Zhang L,Xiang Y,Du L,Huang X,Liu Y

更新日期：2020-07-28 00:00:00

abstract：:Due to the increasing concern of using smallpox virus as biological weapons for terrorist attack, there is renewed interest in studying the pathogenesis of human smallpox and development of new therapies. Animal models are highly demanded for efficacy and safety examination of new vaccines and therapeutic drugs. Here,...

journal_title：Scientific reports

authors： Liu Q,Fan C,Zhou S,Guo Y,Zuo Q,Ma J,Liu S,Wu X,Peng Z,Fan T,Guo C,Shen Y,Huang W,Li B,He Z,Wang Y

更新日期：2015-08-03 00:00:00

abstract：:Rare individuals remain cognitively intact despite the presence of neuropathology usually associated with fully symptomatic Alzheimer's disease (AD), which we refer to as Non-Demented with Alzheimer's disease Neuropathology (NDAN). Understanding the involved mechanism(s) of their cognitive resistance may reveal novel ...

journal_title：Scientific reports

authors： Briley D,Ghirardi V,Woltjer R,Renck A,Zolochevska O,Taglialatela G,Micci MA

更新日期：2016-06-14 00:00:00

abstract：:Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of growth retardation associated with the KBD have been carried out by now. In this study, we conducted a two-stage bivariate genome-wide association study (BGWAS) of the KBD...

journal_title：Scientific reports

authors： Hao J,Wang W,Wen Y,Xiao X,He A,Guo X,Yang T,Liu X,Shen H,Chen X,Tian Q,Deng HW,Zhang F

更新日期：2016-08-22 00:00:00

abstract：:As an important method for building blocks synthesis, whole cell biocatalysis is hindered by some shortcomings such as unpredictability of reactions, utilization of opportunistic pathogen, and side reactions. Due to its biological and extensively studied genetic background, Pseudomonas putida KT2440 is viewed as a pro...

journal_title：Scientific reports

authors： Wang Y,Lv M,Zhang Y,Xiao X,Jiang T,Zhang W,Hu C,Gao C,Ma C,Xu P

更新日期：2014-11-06 00:00:00

abstract：:Multi-modal three dimensional (3D) optical imaging combining both structural sensitivity and molecular specificity is highly desirable in biomedical research. In this paper, we present a method termed oblique scanning laser microscopy (OSLM) to combine optical coherence tomography (OCT), for simultaneously volumetric ...

journal_title：Scientific reports

authors： Zhang L,Capilla A,Song W,Mostoslavsky G,Yi J

更新日期：2017-08-17 00:00:00

abstract：:Five selected carbazole derivatives, namely carbazole, 3,6-dibromocarbazole, 2-hydroxycarbazole, 1,2,3,4-tetrahydrocarbazole and 9-(2-ethylhexyl)carbazole-3,6-dicarboxaldehyde were investigated for their inhibitive effects on Desulfovibrio vulgaris (D. vulgaris) induced corrosion of mild steel and in 1 M HCl medium us...

journal_title：Scientific reports

authors： Nwankwo HU,Olasunkanmi LO,Ebenso EE

更新日期：2017-05-26 00:00:00

abstract：:The bulk-insulating topological insulators with tunable surface states are necessary for applications in spintronics and quantum computation. Here we present theoretical evidence for modulating the topological surface states and achieving the insulating bulk states in solid-solution (Bi(1-x)Sb(x))(2)Te(3). Our results...

journal_title：Scientific reports

authors： Niu C,Dai Y,Zhu Y,Ma Y,Yu L,Han S,Huang B

更新日期：2012-01-01 00:00:00

abstract：:Boiling histotripsy (BH) is a High Intensity Focused Ultrasound (HIFU) method for precise mechanical disintegration of target tissue using millisecond-long pulses containing shocks. BH treatments with real-time ultrasound (US) guidance allowed by BH-generated bubbles were previously demonstrated ex vivo and in vivo in...

journal_title：Scientific reports

authors： Khokhlova TD,Schade GR,Wang YN,Buravkov SV,Chernikov VP,Simon JC,Starr F,Maxwell AD,Bailey MR,Kreider W,Khokhlova VA

更新日期：2019-12-27 00:00:00

abstract：:Rapid vertebrate diversity evaluation is invaluable for monitoring changing ecosystems worldwide. Wild blow flies naturally recover DNA and chemical signatures from animal carcasses and feces. We demonstrate the power of blow flies as biodiversity monitors through sampling of flies in three environments with varying h...

journal_title：Scientific reports

authors： Owings CG,Banerjee A,Asher TMD,Gilhooly WP 3rd,Tuceryan A,Huffine M,Skaggs CL,Adebowale IM,Manicke NE,Picard CJ

更新日期：2019-07-22 00:00:00

abstract：:Mayaro virus (MAYV) is endemic in South American countries where it is responsible for sporadic outbreaks of acute febrile illness. The hallmark of MAYV infection is a highly debilitating and chronic arthralgia. Although MAYV emergence is a potential threat, there are no specific therapies or licensed vaccine. In this...

journal_title：Scientific reports

authors： Mota MTO,Costa VV,Sugimoto MA,Guimarães GF,Queiroz-Junior CM,Moreira TP,de Sousa CD,Santos FM,Queiroz VF,Passos I,Hubner J,Souza DG,Weaver SC,Teixeira MM,Nogueira ML

更新日期：2020-03-24 00:00:00

abstract：:Arterial stiffness index (ASI) is a non-invasive measure of arterial stiffness using infra-red finger sensors (photoplethysmography). It is a well-suited measure for large populations as it is relatively inexpensive to perform, and data can be acquired within seconds. These features raise interest in using ASI as a to...

journal_title：Scientific reports

authors： Fung K,Ramírez J,Warren HR,Aung N,Lee AM,Tzanis E,Petersen SE,Munroe PB

更新日期：2019-06-24 00:00:00

abstract：:Agriculture, forestry and other land uses are currently the second highest source of anthropogenic greenhouse gases (GHGs) emissions. In soil, these gases derive from microbial activity, during carbon (C) and nitrogen (N) cycling. To investigate how Eucalyptus land use and growth period impact the microbial community,...

journal_title：Scientific reports

authors： Monteiro DA,Fonseca EDS,Rodrigues RAR,da Silva JJN,da Silva EP,Balieiro FC,Alves BJR,Rachid CTCDC

更新日期：2020-06-03 00:00:00

abstract：:Staphylococcus aureus colonizes the skin of atopic dermatitis (AD) individuals, but the impact of its enterotoxins on the chronic activation of CD4+ T cells demands further analysis. We aimed to analyze the CD4+ T cell anergy profile and their phenotypic and functional features through differential expression of cellu...

journal_title：Scientific reports

authors： Orfali RL,Yoshikawa FSY,Oliveira LMDS,Pereira NZ,de Lima JF,Ramos YÁL,Duarte AJDS,Sato MN,Aoki V

更新日期：2019-09-11 00:00:00

abstract：:Heterostructures consisting of two-dimensional materials have shown new physical phenomena, novel electronic and optical properties, and new device concepts not observed in bulk material systems or purely three dimensional heterostructures. These new effects originated mostly from the van der Waals interaction between...

journal_title：Scientific reports

authors： Park J,Back T,Mitchel WC,Kim SS,Elhamri S,Boeckl J,Fairchild SB,Naik R,Voevodin AA

更新日期：2015-09-23 00:00:00

abstract：:Mequindox (MEQ) is a synthetic antimicrobial agent of quinoxaline-1,4-dioxide group (QdNOs). The liver is regarded as the toxicity target of QdNOs, and the role of N → O group-associated various toxicities mediated by QdNOs is well recognized. However, the mechanism underlying the in vivo effects of MEQ on the liver, ...

journal_title：Scientific reports

authors： Liu Q,Lei Z,Huang A,Wu Q,Xie S,Awais I,Dai M,Wang X,Yuan Z

更新日期：2017-02-03 00:00:00

abstract：:Early detection of cancer is essential for effective intervention. Urine has been used to reflect early changes in various tumor-bearing models. However, urine has not been used to predict whether tumors will form in animal models. In this study, a cancer model was established by tail vein injection of 2 million NuTu-...

journal_title：Scientific reports

authors： Wei J,Ni N,Meng W,Huan Y,Gao Y

更新日期：2020-07-16 00:00:00

abstract：:The degree of tumor removal at surgery is a major factor in predicting outcome for ovarian cancer. A single multimodality agent that can be used with magnetic resonance (MR) for staging and pre-surgical planning, and with optical imaging to aid surgical removal of tumors, would present a new paradigm for ovarian cance...

journal_title：Scientific reports

authors： Ravoori MK,Singh S,Bhavane R,Sood AK,Anvari B,Bankson J,Annapragada A,Kundra V

更新日期：2016-12-22 00:00:00