Abstract：
:Tumor tissue mutational burden (TMB) has emerged as a promising predictive biomarker for immune checkpoint therapy. Measuring TMB from circulating tumor DNA (ctDNA) found in plasma is attractive in tissue-constrained indications. We compared the performance of two plasma-based commercial TMB assays including the effect of two different collection methods. Our findings suggest that the two plasma based TMB assays are highly correlated and they are also both correlated with a tissue-based TMB assay for relatively high TMB samples. The two collection methods are also found to be very comparable. Plasma-based TMB assays may be mature enough to be clinically useful in mCRPC and potentially other indications.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Qiu P,Poehlein CH,Marton MJ,Laterza OF,Levitan Ddoi
10.1038/s41598-018-37128-ysubject
Has Abstractpub_date
2019-01-14 00:00:00pages
114issue
1issn
2045-2322pii
10.1038/s41598-018-37128-yjournal_volume
9pub_type
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pub_type： 杂志文章,多中心研究,随机对照试验
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