Abstract：
:When trying to conceive 1% of couples have recurrent miscarriages, defined as three or more consecutive pregnancy losses. This is not accounted for by the known incidence of chromosomal aneuploidy in miscarriage, and it has been suggested that there is an immunological aetiology. The endometrial mucosa is populated by a variety of immune cells which in addition to providing host pathogen immunity must facilitate pregnancy. Here we characterise the endometrial CD8-T cell population during the embryonic window of implantation and find that the majority of cells are tissue resident memory T cells with high levels of CD69 and CD103 expression, proteins that prevent cells egress. We demonstrate that unexplained recurrent miscarriage is associated with significantly decreased expression of the T-cell co-receptor CD8 and tissue residency marker CD69. These cells differ from those found in control women, with less expression of CD127 indicating a lack of homeostatic cell control through IL-7 signalling. Nevertheless this population is resident in the endometrium of women who have RM, more than three months after the last miscarriage, indicating that the memory CD8-T cell population is altered in RM patients. This is the first evidence of a differing pre-pregnancy phenotype in endometrial immune cells in RM.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Southcombe JH,Mounce G,McGee K,Elghajiji A,Brosens J,Quenby S,Child T,Granne Idoi
10.1038/srep41335subject
Has Abstractpub_date
2017-01-23 00:00:00pages
41335issn
2045-2322pii
srep41335journal_volume
7pub_type
杂志文章abstract：:Comparable taxonomic ranks within clades can facilitate more consistent classifications and objective comparisons among taxa. Here we use a temporal approach to identify taxonomic ranks. This is an extension of the temporal banding approach including a Temporal Error Score that finds an objective cut-off for each taxo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02477-7
更新日期：2017-05-23 00:00:00
abstract：:Breast cancer is a heterogeneous disease with differences in its clinical, molecular and biological features. Traditionally, immunohistochemical markers together with clinicopathologic parameters are used to classify breast cancer and to predict disease outcome. Triple-negative breast cancer (TNBC) is a particular typ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44414
更新日期：2017-03-15 00:00:00
abstract：:Antiretroviral therapy-naive HIV-1 infected infants experience poor viral containment and rapid disease progression compared to adults. Viral factors (e.g. transmitted cytotoxic T- lymphocyte (CTL) escape mutations) or infant factors (e.g. reduced CTL functional capacity) may explain this observation. We assessed CTL ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29536
更新日期：2016-07-12 00:00:00
abstract：:The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the TARGT pipeline for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64312-w
更新日期：2020-04-30 00:00:00
abstract：:Cardiac damage associated with iron overload is the most common cause of morbidity and mortality in patients with hereditary hemochromatosis, but the precise mechanisms leading to disease progression are largely unexplored. Here we investigated the effects of iron overload and age on cardiac hypertrophy using 1-, 5- a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05810-2
更新日期：2017-07-18 00:00:00
abstract：:Nitrogen metabolism in gut systems remains poorly studied in spite of its importance for microbial growth and its implications for the metabolism of the host. Prevotella spp. are the most predominant bacteria detected in the rumen, but their presence has also been related to health and disease states in the human gut ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08463-3
更新日期：2017-08-10 00:00:00
abstract：:Emergence of DS-1-like-G1P[8] rotavirus in Asia have been recently reported. We report for the first time the detection and the whole genome phylogenetic analysis of DS-1-like-G1P[8] strains in America. From 2013 to 2017, a total of 4226 fecal samples were screened for rotavirus by ELISA, PAGE, RT-PCR and sequencing. ...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-019-38703-7
更新日期：2019-02-18 00:00:00
abstract：:To determine whether any brain MR abnormalities, including enlarged perivascular spaces (EPVS), were associated with disease activity in systemic lupus erythematosus (SLE) as an inflammatory activity. One hundred and thirty SLE patients with normal MR findings were assessed. With regard to MRI abnormalities, patients ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12966-4
更新日期：2017-10-03 00:00:00
abstract：:The process, how lipids are removed from the circulation and transferred from high density lipoprotein (HDL) - a main carrier of cholesterol in the blood stream - to cells, is highly complex. HDL particles are captured from the blood stream by the scavenger receptor, class B, type I (SR-BI), the so-called HDL receptor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15949-7
更新日期：2017-11-21 00:00:00
abstract：:A common spinning toy, called "buzzer", consists of a perforated disk and flexible threads. Despite of its simple construction, a buzzer can effectively transfer translational motions into high-speed rotations. In the present work, we find that the disk can be spun by hand at an extremely high rotational speed, e.g., ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13137-1
更新日期：2017-10-13 00:00:00
abstract：:Eucalyptus globulus is an aromatic medicinal plant which known for its 1,8-cineole main pharmacological constituent exhibits as natural analgesic agent. Eucalyptus globulus-loaded micellar nanoparticle was developed via spontaneous emulsification technique and further evaluation for its analgesic efficacy study, in vi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50134-y
更新日期：2019-09-23 00:00:00
abstract：:Flavivirus-mediated inflammation causes neuronal death, but whether the infected neurons can evoke an innate immune response to elicit their own protection, is unknown. In an earlier study we have shown that neuronal RIG-I, play a significant role in inducing production and release of molecules that are related to inf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00347
更新日期：2012-01-01 00:00:00
abstract：:Estrogen deprivation aggravates cardiac injury after myocardial ischemia and reperfusion (I/R) injury. Although either estrogen or the dipeptidyl peptidase-4 (DPP-4) inhibitor, vildagliptin, reduces myocardial damage following cardiac I/R, their effects on the heart in obese-insulin resistant and estrogen deprived con...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44306
更新日期：2017-03-10 00:00:00
abstract：:Understanding adipose tissue cellular heterogeneity and homeostasis is essential to comprehend the cell type dynamics in metabolic diseases. Cellular subpopulations in the adipose tissue have been related to disease development, but efforts towards characterizing the adipose tissue cell type composition are limited. H...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67177-1
更新日期：2020-06-26 00:00:00
abstract：:Blueberry juice is a healthy and nutritious food that has become increasingly popular worldwide. However, little is known about the microbial groups of this juice that can cause its spoilage. This study aimed to identify the main spoilage microorganisms in blueberry juice and explore whether a microchip pulsed electri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26513-2
更新日期：2018-05-25 00:00:00
abstract：:In this study we introduce the starch-recognising carbohydrate binding module family 20 (CBM20) from Aspergillus niger for screening biological variations in starch molecular structure using high throughput carbohydrate microarray technology. Defined linear, branched and phosphorylated maltooligosaccharides, pure star...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30551
更新日期：2016-07-29 00:00:00
abstract：:The population of hepatitis B combined with a number of metabolic disorders is increasing significantly. Resveratrol (RSV) has been used as a preclinical drug for the treatment of the metabolic disorders. However, the impact of RSV on HBV replication remains unknown. In this study, the HBV-expressing hepatocelluar car...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24744
更新日期：2016-04-21 00:00:00
abstract：:Recognising an object involves rapid visual processing and activation of semantic knowledge about the object, but how visual processing activates and interacts with semantic representations remains unclear. Cognitive neuroscience research has shown that while visual processing involves posterior regions along the vent...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28865-1
更新日期：2018-07-13 00:00:00
abstract：:Desert locusts (Schistocerca gregaria) show a dramatic form of socially induced phenotypic plasticity known as phase polyphenism. In the absence of conspecifics, locusts occur in a shy and cryptic solitarious phase. Crowding with conspecifics drives a behavioural transformation towards gregariousness that occurs withi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35608
更新日期：2016-10-18 00:00:00
abstract：:Bloodstain Pattern Analysis is a forensic discipline in which, among others, the position of victims can be determined at crime scenes on which blood has been shed. To determine where the blood source was investigators use a straight-line approximation for the trajectory, ignoring effects of gravity and drag and thus ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11461
更新日期：2015-06-22 00:00:00
abstract：:Neonatal hypoxic-ischaemic (HI) encephalopathy is among the most serious complications in neonatology. In the present study, we studied the immediate (0 hour), subacute (36 hours) and late (144 hours) responses of the neonatal brain to experimental HI insult in laboratory rats. At the striatal level, the mass spectrom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25088-2
更新日期：2018-05-03 00:00:00
abstract：:One of the factors that has increased the incidence and worse prognosis of breast cancer is obesity. In this condition, high amounts of leptin are secreted, which have proliferative, mitogenic, antiapoptotic, and proinflammatory activity that may be antagonistic to treatment with tamoxifen, considered the first choice...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55674-x
更新日期：2019-12-16 00:00:00
abstract：:Magnetic refrigeration is of great interest due to its high energy efficiency, environmental friendliness and low cost. However, undesired hysteresis losses, concentrated working temperature interval (WTI) and poor mechanical stability are vital drawbacks that hinder its practical application. Off-stoichiometric Ni-Mn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35028-9
更新日期：2018-11-08 00:00:00
abstract：:Dengue virus (DENV) infects 400 million people worldwide annually. Infection of more than one serotype of DENV highly corresponds to dengue hemorrhagic fever and dengue shock syndrome, which are the leading causes of high mortality. Due to lack of effective vaccines and unavailable therapies against DENV, discovery of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45171
更新日期：2017-03-24 00:00:00
abstract：:Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10382-2
更新日期：2017-09-11 00:00:00
abstract：:Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make attractive targets for new drugs. Here, by genome-wide phenotypic profiling, we identify and cat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47905-y
更新日期：2019-08-06 00:00:00
abstract：:The purpose of this study was to investigate changes in peripapillary microvasculature using optical coherence tomography angiography (OCTA) in systemic hypertension (HTN) patients. This was a cross-sectional study. Based on the duration of HTN, seventy-eight HTN patients were divided into two groups. (HTN group 1: <1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63603-6
更新日期：2020-04-16 00:00:00
abstract：:Boron carbide (B4C) coating on diamond particle is synthesized by heating diamond particles in a powder mix of H3BO3 and B in Ar atmosphere. The composition, bond state and coverage fraction of boron carbide coating on diamond particles are investigated. The boron carbide coating favors to grow on diamond (100) surfac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11142-y
更新日期：2017-09-06 00:00:00
abstract：:The purpose of the study was to assess both anatomic and functional outcomes between short-pulse continuous wavelength and infrared micropulse lasers in the treatment of DME. This was a prospective interventional study from tertiary care eye hospital-King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia). Patients...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79699-9
更新日期：2021-01-08 00:00:00
abstract：:The midline thalamus is reciprocally connected with the medial temporal lobe, where neural circuitry essential for spatial navigation and memory formation resides. Yet, little information is available on the dynamic relationship between activity patterns in the midline thalamus and medial temporal lobe. Here, we repor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29807
更新日期：2016-07-14 00:00:00
