Abstract:
:Desert locusts (Schistocerca gregaria) show a dramatic form of socially induced phenotypic plasticity known as phase polyphenism. In the absence of conspecifics, locusts occur in a shy and cryptic solitarious phase. Crowding with conspecifics drives a behavioural transformation towards gregariousness that occurs within hours and is followed by changes in physiology, colouration and morphology, resulting in the full gregarious phase syndrome. We analysed methylation-sensitive amplified fragment length polymorphisms (MS-AFLP) to compare the effect of acute and chronic crowding on DNA methylation in the central nervous system. We find that crowd-reared and solitary-reared locusts show markedly different neural MS-AFLP fingerprints. However, crowding for a day resulted in neural MS-AFLP fingerprints that were clearly distinct from both crowd-reared and uncrowded solitary-reared locusts. Our results indicate that changes in DNA methylation associated with behavioural gregarisation proceed through intermediate states that are not simply partial realisations of the endpoint states.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mallon EB,Amarasinghe HE,Ott SRdoi
10.1038/srep35608subject
Has Abstractpub_date
2016-10-18 00:00:00pages
35608issn
2045-2322pii
srep35608journal_volume
6pub_type
杂志文章abstract::Alcohol and nicotine are the most widely co-abused drugs. Both modify the activity of dopaminergic (DA) neurons of the Ventral Tegmental Area (VTA) and lead to an increase in DA release in the Nucleus Accumbens, thereby affecting the reward system. Evidences support the hypothesis that distinct nicotinic acetylcholine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45116
更新日期:2017-03-23 00:00:00
abstract::Nano-sized hydroxyapatite (n-HA) is considered as a bio-active material, which is often mixed into bone implant material, polyetheretherketone (PEEK). To reveal the global protein expression modulations of osteoblast in response to direct contact with the PEEK composite containing high level (40%) nano-sized hydroxyap...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22832
更新日期:2016-03-09 00:00:00
abstract::Immune checkpoint inhibitors (ICIs) elicit antitumour effects by activating the host immunity and cause immune-related adverse events (irAEs). ICI-related interstitial lung disease (ICI-ILD) is a fatal irAE that is difficult to treat; moreover, its incidence is relatively higher in patients with lung cancer. Therefore...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70743-2
更新日期:2020-08-13 00:00:00
abstract::In situ measurements by the Curiosity rover provide a unique opportunity for studying the effects of dust on assets placed at the surface of Mars. Here we use in situ measurements of solar UV radiation to quantify the seasonal and interannual variability of dust accumulation on the sensor on the rover deck. We show th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35946-8
更新日期:2018-12-04 00:00:00
abstract::A five-year swine manure application trial and a study of nitrate leaching losses have been conducted. There were three treatments: traditional without manure (CK), traditional matched manure 4500 kg ha-2 (T1) and traditional matched manure 9000 kg ha-2 (T2). Nitrate nitrogen leaching losses at the 30-, 60-, and 90-cm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12953-9
更新日期:2017-10-20 00:00:00
abstract::Challenges in social communication and interaction are core features of autism spectrum disorder (ASD) for which social skills group training (SSGT) is a commonly used intervention. SSGT has shown modest and heterogeneous effects. One of the major genetic risk factors in ASD is rare copy number variation (CNV). Howeve...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/s41598-019-46396-1
更新日期:2019-07-08 00:00:00
abstract::NLRP3 inflammasomes recognize non-microbial danger signals and induce release of proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular disease. Because sterile inflammation is involved in doxorubicin (Dox)-induced cardiotoxicity, we investigated the role of NLRP3 inflammasomes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26489
更新日期:2016-05-26 00:00:00
abstract::Electrohydrodynamic (EHD) jet printing has a variety of benefits compared to conventional inkjet techniques, such as high resolution and the ability to work with high-viscosity pastes. In this work, Ag nanoparticles with 4000 cPs were chosen because they are printable on various substrates for electronic devices. The ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45504-5
更新日期:2019-06-24 00:00:00
abstract::Rheumatoid Arthritis (RA) causes chronic inflammation of joints. The cytokines TNFα and IFNγ are central players in RA, however their source has not been fully elucidated. Natural Killer (NK) cells are best known for their role in elimination of viral-infected and transformed cells, and they secrete pro-inflammatory c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37448-z
更新日期:2019-02-04 00:00:00
abstract::Deep venous thrombosis (DVT) is a common complication of orthopedic surgery. Genetic risk factors and high heritability carried a substantial risk of DVT. In this study, we aimed to investigate the potential association in the Han Chinese population between the polymorphisms of BDKRB2 and KNG1 and DVT after orthopedic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34868-9
更新日期:2018-11-26 00:00:00
abstract::Duchenne muscular dystrophy (DMD) is a common and severe X-linked myopathy, characterized by muscle degeneration due to altered or absent dystrophin. DMD has no effective cure, and the underlying molecular mechanisms remain incompletely understood. The aim of this study is to investigate the metabolic changes in DMD u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81090-1
更新日期:2021-01-21 00:00:00
abstract::Leishmaniases are an ensemble of diseases caused by the protozoan parasite of the genus Leishmania. Current antileishmanial treatments are limited and present main issues of toxicity and drug resistance emergence. Therefore, the generation of new inhibitors specifically directed against a leishmanial target is an attr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00848-8
更新日期:2017-04-07 00:00:00
abstract::Volatile organic compounds (VOCs) represent a broad class of chemicals, many of which can be found in indoor air including residential indoor air. VOCs derive from a variety of sources including cleaning products, cooking practices, fragrances and fresheners, hobbies and at-home work behaviors. This study examined res...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78756-7
更新日期:2020-12-10 00:00:00
abstract::The villous cytotrophoblastic cells have the ability to fuse and differentiate, forming the syncytiotrophoblast (STB). The syncytialisation process is essential for placentation. Nevertheless, the mechanisms involved in cell fusion and differentiation are yet to be fully elucidated. It has been suggested that cell sur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66554-0
更新日期:2020-06-15 00:00:00
abstract::To investigate the role of the circadian clock in the development of alcohol-induced fatty liver disease we examined livers of mice chronically alcohol-fed over 4-weeks that resulted in steatosis. Here we show time-of-day specific changes in expression of clock genes and clock-controlled genes, including those associa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03725
更新日期:2014-01-16 00:00:00
abstract::This study investigates the efficacy of systemic growth hormone (GH) therapy in ameliorating the deleterious effects of chronic denervation (CD) injury on nerve regeneration and resulting motor function. Using a forelimb CD model, 4 groups of Lewis rats were examined (n = 8 per group): Group-1 (negative control) 8 wee...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39738-6
更新日期:2019-02-28 00:00:00
abstract::Chromosomal polymorphism is widespread in the Drosophila genus, with extensive evidence supporting its adaptive character in diverse species. Moreover, inversions are the major contributors to the genus chromosomal evolution. The molecular characterization of a reduced number of polymorphic inversion breakpoints in Dr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36248
更新日期:2016-10-26 00:00:00
abstract::A metal-free three component cyclization reaction with amidation is devised for direct synthesis of DFT-designed amido-phenazine derivative bearing noncovalent gluing interactions to fabricate organic nanomaterials. Composition-dependent organic nanoelectronics for nonvolatile memory devices are discovered using mixed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13754-w
更新日期:2017-10-17 00:00:00
abstract::A highly sensitive microwave near-field sensor based on electrically-small planar resonators is proposed for highly accurate characterization of dielectric materials. The proposed sensor was developed in a robust complete-cycle topology optimization procedure wherein first the sensing area was pixelated. By maximizing...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49767-w
更新日期:2019-09-16 00:00:00
abstract::In the jejunum, PepT1 is particularly enriched in the well-differentiated absorptive epithelial cells in the villi. Studies of expression and function of PepT1 along the crypt-villus axis demonstrated that this protein is crucial to the process of di/tripeptide absorption. We recently exhibited that PepT1 plays an imp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27119
更新日期:2016-06-01 00:00:00
abstract::The origin of (ferro)magnetic ordering in transition metal doped ZnO is a still open question. For applications it is fundamental to establish if it arises from magnetically ordered impurity clusters embedded into the semiconducting matrix or if it originates from ordering of magnetic ions dilute into the host lattice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36336-w
更新日期:2019-01-16 00:00:00
abstract::Prenylated indole diketopiperazine (DKP) alkaloids are important bioactive molecules or their precursors. In the context of synthetic biology, efficient means for their biological production would increase their chemical diversification and the discovery of novel bioactive compounds. Here, we prove the suitability of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45519-y
更新日期:2019-06-25 00:00:00
abstract::Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40869-z
更新日期:2019-03-13 00:00:00
abstract::At the center of a collapsing hole lies a singularity, a point of infinite curvature where the governing equations break down. It is a topic of fundamental physical interest to clarify the dynamics of fluids approaching such singularities. Here, we use scaling arguments supported by high-fidelity simulations to analyz...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50956-w
更新日期:2019-10-10 00:00:00
abstract::Global climate change is predicted to alter precipitation and temperature patterns across the world, affecting a range of infectious diseases and particularly foodborne infections such as Campylobacter. In this study, we used national surveillance data to analyse the relationship between climate and campylobacteriosis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70593-y
更新日期:2020-08-17 00:00:00
abstract::Haloarchaea are unique microorganism's resistant to environmental and osmotic stresses and thrive in their habitats despite extreme fluctuating salinities. In the present study, haloarchaea were isolated from hypersaline thalossohaline salterns of Bhandup, Mumbai, India and were identified as Haloferax prahovense, Hal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25642
更新日期:2016-05-27 00:00:00
abstract::At the regional scale, although environmental factors are known to shape the distributions of belowground communities in terrestrial ecosystems, these environmental factors account for relatively low percentages of the variation in belowground communities. More of this variation might be explained by considering ecosy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07517-w
更新日期:2017-08-04 00:00:00
abstract::Secreted Protein Acidic and Rich in Cysteine (SPARC)-related modular calcium-binding protein-2 (SMOC2), a secreted matricellular protein, is reported to be involved in various processes related to cancer progression such as regulating the cell cycle, angiogenesis, and invasion. However, its expression and prognostic s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61828-z
更新日期:2020-03-17 00:00:00
abstract::Multisensory integration provides continuous and stable perception from separate sensory inputs. Here, we investigated the functional role of temporal binding between the visual and the tactile senses. To this end we used the paradigm of compression that induces shifts in time when probe stimuli are degraded, e.g., by...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25843
更新日期:2016-05-16 00:00:00
abstract::It has been an old unsolved puzzle to evolutionary theorists on which mechanisms would increase large-scale cooperation in human societies. Thus, how such mechanisms operate in a biological network is still not well understood. This study addresses these questions with empirical evidence from agent-based models design...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17481-0
更新日期:2017-12-11 00:00:00