Enlarged perivascular spaces are associated with the disease activity in systemic lupus erythematosus.

abstract：:One strategy to address new potential dangers is to generate defensive responses to stimuli that remind learned threats, a phenomenon called fear generalization. During a threatening experience, the brain encodes implicit and explicit memory traces. Nevertheless, there is a lack of studies comparing implicit and expli...

journal_title：Scientific reports

authors： Manassero E,Mana L,Concina G,Renna A,Sacchetti B

更新日期：2019-09-16 00:00:00

abstract：:Combining strong magnetic anisotropy with strong exchange interaction is a long standing goal in the design of quantum magnets. The lanthanide complexes, while exhibiting a very strong ionic anisotropy, usually display a weak exchange coupling, amounting to only a few wavenumbers. Recently, an isostructural series of ...

journal_title：Scientific reports

authors： Vieru V,Iwahara N,Ungur L,Chibotaru LF

更新日期：2016-04-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Whittington CM,O'Meally D,Laird MK,Belov K,Thompson MB,McAllan BM

更新日期：2020-07-22 00:00:00

abstract：:We conducted two online surveys about antibiotics targeted at the Japanese general population in March 2017 and February 2018. In total, 6,982 participants completed the questionnaire. Factors associated with knowledge of antibiotics, knowledge of antimicrobial resistance (AMR) and appropriate behavioural changes were...

journal_title：Scientific reports

authors： Tsuzuki S,Fujitsuka N,Horiuchi K,Ijichi S,Gu Y,Fujitomo Y,Takahashi R,Ohmagari N

更新日期：2020-02-26 00:00:00

abstract：:Plant resistance can provide effective, economical, and sustainable pest control. Tolerance to the soybean aphid has been identified and confirmed in the soybean KS4202. Although its resistance mechanisms are not fully understood, evidence suggests that enhanced detoxification of reactive oxygen species (ROS) is an ac...

journal_title：Scientific reports

authors： Chapman KM,Marchi-Werle L,Hunt TE,Heng-Moss TM,Louis J

更新日期：2018-10-11 00:00:00

abstract：:Despite recent advances in melanoma treatment, metastasis and resistance to therapy remain serious clinical challenges. NME1 is a metastasis suppressor, a class of proteins which inhibits metastatic spread of cancer cells without impact on growth of the primary tumor. We have identified a rare subpopulation of cells w...

journal_title：Scientific reports

authors： Snyder D,Wang Y,Kaetzel DM

更新日期：2020-02-06 00:00:00

abstract：:Knowledge of brain correlates of postural control is limited by the technical difficulties in performing controlled experiments with currently available neuroimaging methods. Here we present a system that allows the measurement of anticipatory postural adjustment of human legs to be synchronized with the acquisition o...

journal_title：Scientific reports

authors： de Lima-Pardini AC,de Azevedo Neto RM,Coelho DB,Boffino CC,Shergill SS,de Oliveira Souza C,Brant R,Barbosa ER,Cardoso EF,Teixeira LA,Cohen RG,Horak FB,Amaro E Jr

更新日期：2017-02-23 00:00:00

abstract：:We assessed the Chinese version of the Drug Abuse Screening Test (DAST-10) for identifying illicit drug use during pregnancy among Chinese population. Chinese pregnant women attending their first antenatal visit or their first unbooked visit to the maternity ward were recruited during a 4-month study period in 2011. T...

journal_title：Scientific reports

authors： Lam LP,Leung WC,Ip P,Chow CB,Chan MF,Ng JW,Sing C,Lam YH,Mak WL,Chow KM,Chin RK

更新日期：2015-06-19 00:00:00

abstract：:Most biodiesel currently in use consists of fatty acid methyl esters (FAMEs) produced by transesterification of plant oils with methanol. To reduce competition with food supplies, it would be desirable to directly produce biodiesel in microorganisms. To date, the most effective pathway for the production of biodiesel ...

journal_title：Scientific reports

authors： Sherkhanov S,Korman TP,Clarke SG,Bowie JU

更新日期：2016-04-07 00:00:00

abstract：:MCR-1 is a phosphoethanolamine (pEtN) transferase that modifies the pEtN moiety of lipid A, conferring resistance to colistin, which is an antibiotic belonging to the class of polypeptide antibiotics known as polymyxins and is the last-line antibiotic used to treat multidrug resistant bacterial infections. Here we det...

journal_title：Scientific reports

authors： Hu M,Guo J,Cheng Q,Yang Z,Chan EWC,Chen S,Hao Q

更新日期：2016-12-13 00:00:00

abstract：:This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apoptosis. MTT activity was only significantly reduced by FG4592 or Baye...

journal_title：Scientific reports

authors： Singh A,Wilson JW,Schofield CJ,Chen R

更新日期：2020-01-31 00:00:00

abstract：:Even though a number of different in vitro fusion assays have been developed to analyze protein mediated fusion, they still only partially capture the essential features of the in vivo situation. Here we established an in vitro fusion assay that mimics the fluidity and planar geometry of the cellular plasma membrane t...

journal_title：Scientific reports

authors： Schwenen LL,Hubrich R,Milovanovic D,Geil B,Yang J,Kros A,Jahn R,Steinem C

更新日期：2015-07-13 00:00:00

abstract：:Diamond attracts considerable attention as a versatile and technologically useful material. For many demanding applications, such as recently emerged quantum optics and sensing, it is important to develop new routes for fabrication of diamond containing defects with specific optical, electronic and magnetic properties...

journal_title：Scientific reports

authors： Palyanov YN,Kupriyanov IN,Borzdov YM,Surovtsev NV

更新日期：2015-10-05 00:00:00

abstract：:The UCSC Cancer Genomics Browser (https://genome-cancer.ucsc.edu) offers interactive visualization and exploration of TCGA genomic, phenotypic, and clinical data, as produced by the Cancer Genome Atlas Research Network. Researchers can explore the impact of genomic alterations on phenotypes by visualizing gene and pro...

journal_title：Scientific reports

authors： Cline MS,Craft B,Swatloski T,Goldman M,Ma S,Haussler D,Zhu J

更新日期：2013-10-02 00:00:00

abstract：:In this paper, large area and deep sub-wavelength interference patterns are realized experimentally by using odd surface plasmon modes in the metal/insulator/metal structure. Theoretical investigation shows that the odd modes possesses much higher transversal wave vector and great inhibition of tangential electric fie...

journal_title：Scientific reports

authors： Liu L,Luo Y,Zhao Z,Zhang W,Gao G,Zeng B,Wang C,Luo X

更新日期：2016-07-28 00:00:00

abstract：:The human brain has evolved specialised mechanisms to enable the rapid detection of threat cues, including emotional face expressions (e.g., fear and anger). However, contextual cues - such as gaze direction - influence the ability to recognise emotional expressions. For instance, anger paired with direct gaze, and fe...

journal_title：Scientific reports

authors： Caruana N,Inkley C,Zein ME,Seymour K

更新日期：2019-11-07 00:00:00

abstract：:The success of filamentous fungi in colonizing most natural environments can be largely attributed to their ability to form an expanding interconnected network, the mycelium, or thallus, constituted by a collection of hyphal apexes in motion producing hyphae and subject to branching and fusion. In this work, we charac...

journal_title：Scientific reports

authors： Dikec J,Olivier A,Bobée C,D'Angelo Y,Catellier R,David P,Filaine F,Herbert S,Lalanne C,Lalucque H,Monasse L,Rieu M,Ruprich-Robert G,Véber A,Chapeland-Leclerc F,Herbert E

更新日期：2020-02-21 00:00:00

abstract：:A polarized macrophage response into inflammatory (M1) or regenerative/anti-inflammatory (M2) phenotypes is critical in host response to multiple intracellular bacterial infections. Ehrlichia is an obligate Gram-negative intracellular bacterium that causes human monocytic ehrlichiosis (HME): a febrile illness that may...

journal_title：Scientific reports

authors： Haloul M,Oliveira ERA,Kader M,Wells JZ,Tominello TR,El Andaloussi A,Yates CC,Ismail N

更新日期：2019-10-01 00:00:00

abstract：:Propofol sedation has been applied during esophagogastroduodenoscopy procedures, but whether topical pharyngeal anesthesia should be administered at the same time has rarely been reported. Our study examined the role of topical pharyngeal anesthesia in sedated endoscopies in a randomized controlled double-blinded clin...

journal_title：Scientific reports

authors： Sun X,Xu Y,Zhang X,Li A,Zhang H,Yang T,Liu Y

更新日期：2018-04-27 00:00:00

abstract：:We present a comprehensive study of a magnetic sensor system that benefits from a new technique to substantially increase the magnetoelastic coupling of surface acoustic waves (SAW). The device uses shear horizontal acoustic surface waves that are guided by a fused silica layer with an amorphous magnetostrictive FeCoS...

journal_title：Scientific reports

authors： Kittmann A,Durdaut P,Zabel S,Reermann J,Schmalz J,Spetzler B,Meyners D,Sun NX,McCord J,Gerken M,Schmidt G,Höft M,Knöchel R,Faupel F,Quandt E

更新日期：2018-01-10 00:00:00

abstract：:The present study examined different types of neurological signs in patients with first-episode schizophrenia and their relationships with neurocognitive functions. Both cross-sectional and longitudinal designs were adopted with the use of the abridged Cambridge Neurological Inventory which comprises items capturing m...

journal_title：Scientific reports

authors： Chan RCK,Dai S,Lui SSY,Ho KKY,Hung KSY,Wang Y,Geng FL,Li Z,Cheung EFC

更新日期：2015-07-02 00:00:00

abstract：:Water is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics upon mixing with water, which in glass-forming systems implies a lower glass transition temperat...

journal_title：Scientific reports

authors： Ruiz GN,Romanini M,Hauptmann A,Loerting T,Shalaev E,Tamarit JL,Pardo LC,Macovez R

更新日期：2017-08-07 00:00:00

abstract：:Epilepsy is a chronic neurological disease with a variable therapeutic response. To design effective treatment strategies for epilepsy, it is important to understand treatment responses and predictive factors. However, limited data are available in Africa, including Ethiopia. The aim of this study was therefore to ass...

journal_title：Scientific reports

authors： Gidey K,Chelkeba L,Gemechu TD,Daba FB

更新日期：2019-11-07 00:00:00

abstract：:L-selectin on T-cells is best known as an adhesion molecule that supports recruitment of blood-borne naïve and central memory cells into lymph nodes. Proteolytic shedding of the ectodomain is thought to redirect activated T-cells from lymph nodes to sites of infection. However, we have shown that activated T-cells re-...

journal_title：Scientific reports

authors： Mohammed RN,Wehenkel SC,Galkina EV,Yates EK,Preece G,Newman A,Watson HA,Ohme J,Bridgeman JS,Durairaj RRP,Moon OR,Ladell K,Miners KL,Dolton G,Troeberg L,Kashiwagi M,Murphy G,Nagase H,Price DA,Matthews RJ,Knäuper V

更新日期：2019-04-02 00:00:00

abstract：:Nanopore-based sensing has emerged as a promising candidate for affordable and powerful DNA sequencing technologies. Herein, we demonstrate that nanopores can be successfully fabricated in Mg alloys via focused electron beam (e-beam) technology. Employing in situ high-resolution transmission electron microscopy techni...

journal_title：Scientific reports

authors： Zheng H,Liu Y,Cao F,Wu S,Jia S,Cao A,Zhao D,Wang J

更新日期：2013-01-01 00:00:00

abstract：:Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painful syndromes TRPM8 a...

journal_title：Scientific reports

authors： Beccari AR,Gemei M,Lo Monte M,Menegatti N,Fanton M,Pedretti A,Bovolenta S,Nucci C,Molteni A,Rossignoli A,Brandolini L,Taddei A,Za L,Liberati C,Vistoli G

更新日期：2017-09-08 00:00:00

abstract：:Histone lysine acetyltransferase (KAT)-catalyzed acetylation of lysine residues in histone tails plays a key role in regulating gene expression in eukaryotes. Here, we examined the role of lysine side chain length in the catalytic activity of human KATs by incorporating shorter and longer lysine analogs into synthetic...

journal_title：Scientific reports

authors： Proietti G,Wang Y,Rainone G,Mecinović J

更新日期：2020-08-03 00:00:00

abstract：:The natural ligand 17β-estradiol (E2) is so far believed to induce a unique agonist-bound active conformation in the ligand binding domain (LBD) of the estrogen receptors (ERs). Both subtypes, ERα and ERβ, are transcriptionally activated in the presence of E2 with ERβ being somewhat less active than ERα under similar ...

journal_title：Scientific reports

authors： Souza PCT,Textor LC,Melo DC,Nascimento AS,Skaf MS,Polikarpov I

更新日期：2017-06-14 00:00:00

abstract：:Experimental evidence has shown that some of the human endogenous hormones significantly affect drug efficacy. Since hormone status varies with individual physiological states, it is essential to understand the interplay of hormones and drugs for precision medicine. Here, we developed an in silico method to predict in...

journal_title：Scientific reports

authors： Kwon M,Jung J,Yu H,Lee D

更新日期：2017-11-30 00:00:00

abstract：:Integrins coupled with other proteins form protein complexes named focal adhesions (FA) which are considered as the primary sites for cellular forces transduction during cell stable adhesion. Cell traction forces transmitted by FAs and integrin tensions inside FAs have been extensively studied. However, it remains unk...

journal_title：Scientific reports

authors： Wang Y,Wang X

更新日期：2016-11-15 00:00:00