Abstract:
:Water is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics upon mixing with water, which in glass-forming systems implies a lower glass transition temperature (T g ), is considered a universal result of hydration. In fact, even in the cases where hydration or humidification of an organic glass-forming sample result in stiffer mechanical properties, the molecular mobility of the sample almost always increases with increasing water content, and its T g decreases correspondingly. Here, we present an experimental report of a genuine antiplasticizing effect of water on the molecular dynamics of a small-molecule glass former. In detail, we show that addition of water to prilocaine, an active pharmaceutical ingredient, has the same effect as that of an applied pressure, namely, a decrease in mobility and an increase of T g . We assign the antiplasticizing effect to the formation of prilocaine-H 2 O dimers or complexes with enhanced hydrogen bonding interactions.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ruiz GN,Romanini M,Hauptmann A,Loerting T,Shalaev E,Tamarit JL,Pardo LC,Macovez Rdoi
10.1038/s41598-017-07643-5subject
Has Abstractpub_date
2017-08-07 00:00:00pages
7470issue
1issn
2045-2322pii
10.1038/s41598-017-07643-5journal_volume
7pub_type
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