A Targeted Quantitative Proteomic Method Revealed a Substantial Reprogramming of Kinome during Melanoma Metastasis.

abstract：:We investigated how skeletal muscle mass (SMM) affects spinal sagittal balance (radiographic parameters) in symptomatic spinal patients. The first purpose of this study was to evaluate the body composition and the spinal sagittal alignment in symptomatic spinal patients. The second purpose of this study was to compare...

journal_title：Scientific reports

authors： Hiyama A,Katoh H,Sakai D,Sato M,Tanaka M,Nukaga T,Watanabe M

更新日期：2018-10-19 00:00:00

abstract：:Clinical trials have recently demonstrated the effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV infection. Consequently, PrEP may soon be used for epidemic control. We model the dynamic interactions that will occur between treatment programs and potential PrEP interventions in resource-constrained co...

journal_title：Scientific reports

authors： Supervie V,Barrett M,Kahn JS,Musuka G,Moeti TL,Busang L,Blower S

更新日期：2011-01-01 00:00:00

abstract：:The current research on cellular heat stress management focuses on the roles of heat shock proteins (HSPs) and the proteostasis network under severe stress conditions. The mild, fever-type stress and the maintenance of membrane homeostasis are less well understood. Herein, we characterized the acute effect of mild, fe...

journal_title：Scientific reports

authors： Peksel B,Gombos I,Péter M,Vigh L Jr,Tiszlavicz Á,Brameshuber M,Balogh G,Schütz GJ,Horváth I,Vigh L,Török Z

更新日期：2017-11-15 00:00:00

abstract：:High-quality broadband ultrasound transducers yield superior imaging performance in biomedical ultrasonography. However, proper design to perfectly bridge the energy between the active piezoelectric material and the target medium over the operating spectrum is still lacking. Here, we demonstrate a new anisotropic cone...

journal_title：Scientific reports

authors： Li Z,Yang DQ,Liu SL,Yu SY,Lu MH,Zhu J,Zhang ST,Zhu MW,Guo XS,Wu HD,Wang XL,Chen YF

更新日期：2017-02-17 00:00:00

abstract：:Carbon-based nanomaterials such as single-walled carbon nanotubes and reduced graphene oxide are currently being evaluated for biomedical applications including in vivo drug delivery and tumor imaging. Several reports have studied the toxicity of carbon nanomaterials, but their effects on human male reproduction have ...

journal_title：Scientific reports

authors： Asghar W,Shafiee H,Velasco V,Sah VR,Guo S,El Assal R,Inci F,Rajagopalan A,Jahangir M,Anchan RM,Mutter GL,Ozkan M,Ozkan CS,Demirci U

更新日期：2016-08-19 00:00:00

abstract：:Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype. Genome-wide expression analysis revealed that only HIS4 in seven HIS genes for histidine biosynthesis was down-regulated in Kmmig1. Consistently, introduction of HIS4 ...

journal_title：Scientific reports

authors： Nurcholis M,Murata M,Limtong S,Kosaka T,Yamada M

更新日期：2019-07-09 00:00:00

abstract：:Experimental models that recapitulate mutational landscapes of human cancers are needed to decipher the rapidly expanding data on human somatic mutations. We demonstrate that mutation patterns in immortalised cell lines derived from primary murine embryonic fibroblasts (MEFs) exposed in vitro to carcinogens recapitula...

journal_title：Scientific reports

authors： Olivier M,Weninger A,Ardin M,Huskova H,Castells X,Vallée MP,McKay J,Nedelko T,Muehlbauer KR,Marusawa H,Alexander J,Hazelwood L,Byrnes G,Hollstein M,Zavadil J

更新日期：2014-03-27 00:00:00

abstract：:The dorsal striatum is a brain region involved in action control, with dorsomedial striatum (DMS) mediating goal-directed actions and dorsolateral striatum (DLS) mediating habitual actions. Presynaptic long-term synaptic depression (LTD) plasticity at glutamatergic inputs to dorsal striatum mediates many dorsal striat...

journal_title：Scientific reports

authors： Muñoz B,Haggerty DL,Atwood BK

更新日期：2020-04-29 00:00:00

abstract：:This work serves as a proof-of-concept for bacterially derived SimCells (Simple Cells), which contain the cell machinery from bacteria and designed DNA (or potentially a simplified genome) to instruct the cell to carry out novel, specific tasks. SimCells represent a reprogrammable chassis without a native chromosome, ...

journal_title：Scientific reports

authors： Rampley CPN,Davison PA,Qian P,Preston GM,Hunter CN,Thompson IP,Wu LJ,Huang WE

更新日期：2017-08-03 00:00:00

abstract：:Stem cell therapy that can restore function to damaged tissue, avoid host rejection and reduce inflammation throughout body without use of immunosuppressive drugs. The established methods were used to identify and to isolate specific stem cell markers by FACS or by immunomagnetic cell separation. The procedures for di...

journal_title：Scientific reports

authors： Kim MS,Lee MH,Kwon BJ,Kim D,Koo MA,Seon GM,Park JC

更新日期：2017-08-29 00:00:00

abstract：:The psychrophilic (cold-loving) fungus Pseudogymnoascus destructans was discovered more than a decade ago to be the pathogen responsible for white-nose syndrome, an emerging disease of North American bats causing unprecedented population declines. The same species of fungus is found in Europe but without associated mo...

journal_title：Scientific reports

authors： Ren P,Rajkumar SS,Zhang T,Sui H,Masters PS,Martinkova N,Kubátová A,Pikula J,Chaturvedi S,Chaturvedi V

更新日期：2020-08-17 00:00:00

abstract：:Local mRNA translation occurs in growing axons enabling precise control of the proteome in response to signals. To measure quantitatively the spatiotemporal dynamics of protein synthesis in growth cones, we further developed a technique for single molecule translation imaging (SMTI). We report that Netrin-1 triggers a...

journal_title：Scientific reports

authors： Ströhl F,Lin JQ,Laine RF,Wong HH,Urbančič V,Cagnetta R,Holt CE,Kaminski CF

更新日期：2017-04-06 00:00:00

abstract：:The precision and efficiency of the registration of megavolt-level electronic portal imaging devices (EPID) images with the naked eye in the orthogonal window are reduced. This study aims to develop a new registration algorithm with enhanced accuracy and efficiency. Ten setup errors with different translation and rota...

journal_title：Scientific reports

authors： Chen C,Wu C,Zhong Y,Xie C,Zhou Y,Liu H,Zhang J,Sheng J,Jiang D,Zhao H,Yu H

更新日期：2020-06-24 00:00:00

abstract：:By using silver nanoplatelets with a widely tunable localized surface plasmon resonance (LSPR), and their corresponding local field enhancement, here we show large manipulation of plasmonic enhanced upconversion in NaYF4:Yb(3+)/Er(3+) nanocrystals at the single particle level. In particular, we show that when the plas...

journal_title：Scientific reports

authors： Wang YL,Mohammadi Estakhri N,Johnson A,Li HY,Xu LX,Zhang Z,Alù A,Wang QQ,Shih CK

更新日期：2015-05-15 00:00:00

abstract：:Adolescence is a critical period for the development of higher-order cognitive functions. Unlike in humans, very limited tools are available to assess such cognitive abilities in adolescent rodents. We implemented a modified 5-Choice Serial Reaction Time Task (5CSRTT) to selectively measure attentiveness, impulsivity,...

journal_title：Scientific reports

authors： Ciampoli M,Contarini G,Mereu M,Papaleo F

更新日期：2017-08-30 00:00:00

abstract：:The purpose of this study is to probe the peristaltic propulsion of a non-Newtonian fluid model with suspended gold nanoparticles. The base fluid is considered to simulate blood using the Carreau fluid model. We model a small annulus as a tube with a peristaltic wave containing a clot propagating towards the tube wall...

journal_title：Scientific reports

authors： Abdelsalam SI,Bhatti MM

更新日期：2019-01-22 00:00:00

abstract：:The effects of antithrombotic drugs on random and free flap survival have been investigated in the past, but the experimental and clinical results are not in agreement. A perforator-based critical ischaemia model was used to evaluate the effects of different perioperatively administered pharmaceutical agents on tissue...

journal_title：Scientific reports

authors： Fichter AM,Ritschl LM,Robitzky LK,Wagenpfeil S,Mitchell DA,Wolff KD,Mücke T

更新日期：2016-10-21 00:00:00

abstract：:Alternations in the p53 regulatory network may render cancer cells resistant to the radiation-induced apoptosis. In this theoretical study we search for the best protocols combining targeted therapy with radiation to treat cancers with wild-type p53, but having downregulated expression of PTEN or overexpression of Wip...

journal_title：Scientific reports

authors： Hat B,Jaruszewicz-Błońska J,Lipniacki T

更新日期：2020-07-28 00:00:00

abstract：:Nano-sized hydroxyapatite (n-HA) is considered as a bio-active material, which is often mixed into bone implant material, polyetheretherketone (PEEK). To reveal the global protein expression modulations of osteoblast in response to direct contact with the PEEK composite containing high level (40%) nano-sized hydroxyap...

journal_title：Scientific reports

authors： Zhao M,Li H,Liu X,Wei J,Ji J,Yang S,Hu Z,Wei S

更新日期：2016-03-09 00:00:00

abstract：:Glucocorticoid receptor (GR) is a hormone-activated transcription regulatory protein involved in metabolism as well as adrenocortical responses to psychosocial stress. Ligand-activated GR localizes to the nucleus, where GR homodimers regulate gene transcription via direct binding to glucocorticoid response elements (G...

journal_title：Scientific reports

authors： Oasa S,Mikuni S,Yamamoto J,Kurosaki T,Yamashita D,Kinjo M

更新日期：2018-05-10 00:00:00

abstract：:This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Two multiple logistic regression models ...

journal_title：Scientific reports

authors： Cherubini V,Skrami E,Ferrito L,Zucchini S,Scaramuzza A,Bonfanti R,Buono P,Cardella F,Cauvin V,Chiari G,D Annunzio G,Frongia AP,Iafusco D,Patera IP,Toni S,Tumini S,Rabbone I,Lombardo F,Carle F,Gesuita R,Diabetes St

更新日期：2016-12-19 00:00:00

abstract：:From the viewpoint of networks, a ranking system for players or teams in sports is equivalent to a centrality measure for sports networks, whereby a directed link represents the result of a single game. Previously proposed network-based ranking systems are derived from static networks, i.e., aggregation of the results...

journal_title：Scientific reports

authors： Motegi S,Masuda N

更新日期：2012-01-01 00:00:00

abstract：:In bacteria, the SecA ATPase provides the driving force for protein secretion via the SecYEG translocon. While the dynamic interplay between SecA and SecYEG in translocation is widely appreciated, it is not clear how SecA associates with the translocon in the crowded cellular environment. We use super-resolution micro...

journal_title：Scientific reports

authors： Seinen AB,Spakman D,van Oijen AM,Driessen AJM

更新日期：2021-01-14 00:00:00

abstract：:Accumulation of advanced glycation end products (AGEs) is linked with development or aggravation of many degenerative processes or disorders, including aging and atherosclerosis. AGEs production in skin cells is known to promote stiffness and loss of elasticity through their buildup in connective tissue. However, the ...

journal_title：Scientific reports

authors： Lee EJ,Kim JY,Oh SH

更新日期：2016-06-13 00:00:00

abstract：:In this paper, we investigate the possibility of improving efficiency in non-radiative wireless power transfer (WPT) using metasurfaces embedded between two current varying coils and present a complete theoretical analysis of this system. We use a point-dipole approximation to calculate the fields of the coils. Based ...

journal_title：Scientific reports

authors： Younesiraad H,Bemani M

更新日期：2018-10-05 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) is a biopharmaceutical drug given to patients who have a low hemoglobin related to chronic kidney disease, cancer or anemia. However, some patients repeatedly receiving rHuEPO develop anti-rHuEPO neutralizing antibodies leading to the development of pure red cell aplasia (PRCA...

journal_title：Scientific reports

authors： Susantad T,Fuangthong M,Tharakaraman K,Tit-Oon P,Ruchirawat M,Sasisekharan R

更新日期：2021-01-15 00:00:00

abstract：:Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity. NFAT1 knock out (KO) mice spontaneously developed CHS-like skin inflammation in old age. ...

journal_title：Scientific reports

authors： Kwon HK,Kim GC,Hwang JS,Kim Y,Chae CS,Nam JH,Jun CD,Rudra D,Surh CD,Im SH

更新日期：2016-01-18 00:00:00

abstract：:Motion sensitivity impairment in Alzheimer's disease (AD) is often characterized as elevated coherence threshold. An alternative way to measure motion sensitivity is the direction threshold, i.e., the minimal angle of motion direction that can be discriminated. So far, it is less clear whether and how the direction th...

journal_title：Scientific reports

authors： Liu Y,Feng D,Wang H

更新日期：2019-09-10 00:00:00

abstract：:Toll-like receptors (TLRs), as innate immunity sensors, play critical roles in immune responses. Six SNPs of TLR3, TLR7, and TLR8 were genotyped to determine their associations with systemic lupus erythematosus (SLE) and clinical manifestations of SLE. TLR7 SNP rs3853839 was independently associated with SLE susceptib...

journal_title：Scientific reports

authors： Wang CM,Chang SW,Wu YJ,Lin JC,Ho HH,Chou TC,Yang B,Wu J,Chen JY

更新日期：2014-01-21 00:00:00

abstract：:Bed bugs are pests of public health importance due to their relentless biting habits that can lead to allergies, secondary infections and mental health issues. When not feeding on human blood bed bugs aggregate in refuges close to human hosts. This aggregation behaviour could be exploited to lure bed bugs into traps f...

journal_title：Scientific reports

authors： Weeks ENI,Logan JG,Birkett MA,Caulfield JC,Gezan SA,Welham SJ,Brugman VA,Pickett JA,Cameron MM

更新日期：2020-03-12 00:00:00