当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Chitosan grafted methoxy poly(ethylene glycol)-poly(ε-caprolactone) nanosuspension for ocular delivery of hydrophobic diclofenac.

Chitosan grafted methoxy poly(ethylene glycol)-poly(ε-caprolactone) nanosuspension for ocular delivery of hydrophobic diclofenac.

Abstract：

:This study aimed to develop a cationic nanosuspension of chitosan (CS) and methoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) for ocular delivery of diclofenac (DIC). MPEG-PCL-CS block polymer was synthesized by covalent coupling of MPEG-PCL with CS. The critical micelle concentration of the MPEG-PCL-CS block polymer was 0.000692 g/L. DIC/MPEG-PCL-CS nanosuspension (mean particle size = 105 nm, zeta potential = 8 mV) was prepared and characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry. The nanosuspension was very stable without apparent physical property changes after storage at 4 °C or 25 °C for 20 days, but it was unstable in the aqueous humor solution after 24 h incubation. Sustained release of the encapsulated DIC from the nanosuspension occurred over 8 h. Neither a blank MPEG-PCL-CS nanosuspension nor a 0.1% (mass fraction) DIC/MPEG-PCL-CS nanosuspension caused ocular irritation after 24 h of instillation. Enhanced penetration and retention in corneal tissue was achieved with a Nile red/MPEG-PCL-CS nanosuspension compared with a Nile red aqueous solution. In vivo pharmacokinetics studies showed enhanced pre-corneal retention and penetration of the DIC/MPEG-PCL-CS nanosuspension, which resulted in a higher concentration of DIC (Cmax) in the aqueous humor and better bioavailability compared with commercial DIC eye drops (P < 0.01).

journal_name

Sci Rep

journal_title

Scientific reports

authors

Shi S,Zhang Z,Luo Z,Yu J,Liang R,Li X,Chen H

doi

10.1038/srep11337

subject

Has Abstract

pub_date

2015-06-12 00:00:00

pages

11337

issn

2045-2322

pii

srep11337

journal_volume

5

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.

    abstract：:The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was to characterize the effects of spaceflight and reentry to 1 g on the structure and integrity of the retina and blood-retinal barrier (BRB) in the eye. To ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44696-0

    authors： Mao XW,Nishiyama NC,Byrum SD,Stanbouly S,Jones T,Drew A,Sridharan V,Boerma M,Tackett AJ,Zawieja D,Willey JS,Delp M,Pecaut MJ

    更新日期：2019-06-03 00:00:00

  • A selective autophagy cargo receptor NBR1 modulates abscisic acid signalling in Arabidopsis thaliana.

    abstract：:The plant selective autophagy cargo receptor neighbour of breast cancer 1 gene (NBR1) has been scarcely studied in the context of abiotic stress. We wanted to expand this knowledge by using Arabidopsis thaliana lines with constitutive ectopic overexpression of the AtNBR1 gene (OX lines) and the AtNBR1 Knock-Out (KO li...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64765-z

    authors： Tarnowski L,Rodriguez MC,Brzywczy J,Piecho-Kabacik M,Krčkova Z,Martinec J,Wawrzynska A,Sirko A

    更新日期：2020-05-08 00:00:00

  • Acoustic build-up in on-chip stimulated Brillouin scattering.

    abstract：:We investigate the role of the spatial evolution of the acoustic field in stimulated Brillouin scattering processes in short high-gain structures. When the gain is strong enough that the gain length becomes comparable to the acoustic wave decay length of order 100 microns, standard approximations treating the acoustic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13656

    authors： Wolff C,Steel MJ,Eggleton BJ,Poulton CG

    更新日期：2015-09-04 00:00:00

  • Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles.

    abstract：:Chemotherapy is widely used in cancer treatments. However, non-specific distribution of chemotherapeutic agents to healthy tissues and normal cells in the human body always leads to adverse side effects and disappointing therapeutic outcomes. Therefore, the main aim of this study was to develop a targeted drug deliver...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73967-4

    authors： Gan BK,Rullah K,Yong CY,Ho KL,Omar AR,Alitheen NB,Tan WS

    更新日期：2020-10-08 00:00:00

  • Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism.

    abstract：:Once assumed only to be a waste product of anaerobe glycolytic activity, lactate is now recognized as an energy source in skeletal muscles. While lactate metabolism has been extensively studied in vivo, underlying cellular processes are poorly described. This study aimed to examine lactate metabolism in cultured human...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28249-5

    authors： Lund J,Aas V,Tingstad RH,Van Hees A,Nikolić N

    更新日期：2018-06-29 00:00:00

  • Implicit Theory of Mind under realistic social circumstances measured with mobile eye-tracking.

    abstract：:Recently, there has been a debate whether implicit Theory of Mind can be reliably measured using anticipatory looking tasks. Previous anticipatory looking paradigms used video stimuli to measure implicit Theory of Mind; however, numerous replications of these paradigms were unsuccessful. This lack of replications may ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80614-5

    authors： Kulke L,Hinrichs MAB

    更新日期：2021-01-13 00:00:00

  • Contralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo: implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas.

    abstract：:Cerebellar involvement in cognition, as well as in sensorimotor control, is increasingly recognized and is thought to depend on connections with the cerebral cortex. Anatomical investigations in animals and post-mortem humans have established that cerebro-cerebellar connections are contralateral to each other and incl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13079-8

    authors： Palesi F,De Rinaldis A,Castellazzi G,Calamante F,Muhlert N,Chard D,Tournier JD,Magenes G,D'Angelo E,Gandini Wheeler-Kingshott CAM

    更新日期：2017-10-09 00:00:00

  • Scaling in vitro activity of CYP3A7 suggests human fetal livers do not clear retinoic acid entering from maternal circulation.

    abstract：:All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is a critical signaling molecule during embryonic and fetal development and is necessary for maternal health. Fetal exposure to endogenous atRA is tightly regulated during gestation in a tissue specific manner and maternal exposure to exogenous retino...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40995-8

    authors： Topletz AR,Zhong G,Isoherranen N

    更新日期：2019-03-15 00:00:00

  • Author Correction: Node property of weighted networks considering connectability to nodes within two degrees of separation.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-30955-z

    authors： Amano SI,Ogawa KI,Miyake Y

    更新日期：2018-08-20 00:00:00

  • Cytogenetic and agronomic characterization of intergeneric hybrids between Saccharum spp. hybrid and Erianthus arundinaceus.

    abstract：:In sugarcane (Saccharum spp. hybrid) breeding, introgression of useful genes via intergeneric hybridization is a powerful strategy for improving the crop productivity. Erianthus arundinaceus shows great potential in terms of useful traits; however, little is known about the cytogenetic and agronomic characteristics of...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-38316-6

    authors： Pachakkil B,Terajima Y,Ohmido N,Ebina M,Irei S,Hayashi H,Takagi H

    更新日期：2019-02-11 00:00:00

  • Higher Order Architecture of Designer Peptides Forms Bioinspired 10 nm siRNA Delivery System.

    abstract：:The higher-order architecture observed in biological systems, like viruses, is very effective in nucleic acid transport. The replications of this system has been attempted with both synthetic and naturally occurring polymers with mixed results. Here we describe a peptide/siRNA quaternary complex that functions as an s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53462-1

    authors： Gamboa A,Urfano SF,Hernandez K,Fraser DA,Ayalew L,Slowinska K

    更新日期：2019-11-14 00:00:00

  • In-situ fabrication of macroporous films for dye-sensitised solar cells: formation of the scattering layer and the gelation of electrolytes.

    abstract：:Dye-sensitised solar cells (DSCs) are a promising substitute for conventional silicon solar cells. A scattering layer of submicrometer pores or particles has been widely introduced to achieve a high light-harvesting efficiency. However, many such fabrication processes require high temperatures and multiple steps to pr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05375

    authors： Ha SJ,Moon JH

    更新日期：2014-07-09 00:00:00

  • Author Correction: Potential damaging mutation in LRP5 from genome sequencing of the first reported chimpanzee with the Chiari malformation.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-24993-w

    authors： Solis-Moruno M,de Manuel M,Hernandez-Rodriguez J,Fontsere C,Gomara-Castaño A,Valsera-Naranjo C,Crailsheim D,Navarro A,Llorente M,Riera L,Feliu-Olleta O,Marques-Bonet T

    更新日期：2018-05-04 00:00:00

  • Hexane-Isopropanolic Extract of Tungrymbai, a North-East Indian fermented soybean food prevents hepatic steatosis via regulating AMPK-mediated SREBP/FAS/ACC/HMGCR and PPARα/CPT1A/UCP2 pathways.

    abstract：:This study for the first time examined the prophylactic role of Tungrymbai, a well-known fermented soybean food of North-East India, against hepatic steatosis. Treatment with hexane-isopropanolic (2:1, HIET) but not hydro-alcoholic (70% ethanol, HAET) extract dose-dependently (0.1, 0.2, or 0.3 µg/mL) reduced the intra...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27607-7

    authors： Dihingia A,Bordoloi J,Dutta P,Kalita J,Manna P

    更新日期：2018-07-03 00:00:00

  • Fluid flow facilitates inward rectifier K+ current by convectively restoring [K+] at the cell membrane surface.

    abstract：:The inward rectifier Kir2.1 current (IKir2.1) was reported to be facilitated by fluid flow. However, the mechanism underlying this facilitation remains uncertain. We hypothesized that during K+ influx or efflux, [K+] adjacent to the outer mouth of the Kir2.1 channel might decrease or increase, respectively, compared w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39585

    authors： Kim JG,Park SW,Byun D,Choi WS,Sung DJ,Shin KC,Kim HJ,Leem YE,Kang JS,Cho H,Kim B,Cho SI,Bae YM

    更新日期：2016-12-22 00:00:00

  • The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer.

    abstract：:The serum macrophage inhibitory cytokine-1 (MIC-1) levels are elevated in some inflammatory conditions and cancers. We thus compared the levels of biliary and serum MIC-1 and conventional tumour markers between 23 biliary tract cancer (BTC) patients (malignant group) and 29 benign biliary disease patients (benign grou...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09740-x

    authors： Sugimoto M,Takagi T,Konno N,Suzuki R,Asama H,Watanabe K,Nakamura J,Waragai Y,Kikuchi H,Takasumi M,Sato Y,Hikichi T,Ohira H

    更新日期：2017-08-23 00:00:00

  • Environment-based preference selection promotes cooperation in spatial prisoner's dilemma game.

    abstract：:The impact of environment on individuals is particularly critical. In evolutionary games, adopting the strategy of the neighbor who performs better is nontrivial for the survival and maintenance of cooperation, in that such an action may help the agents to obtain higher benefit and more obvious evolutionary advantages...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34116-0

    authors： Wu Y,Zhang S,Zhang Z

    更新日期：2018-10-23 00:00:00

  • Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers.

    abstract：:Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vivo. In this study, a small-d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03851-1

    authors： Pan Y,Zhou X,Wei Y,Zhang Q,Wang T,Zhu M,Li W,Huang R,Liu R,Chen J,Fan G,Wang K,Kong D,Zhao Q

    更新日期：2017-06-15 00:00:00

  • Population expansions dominate demographic histories of endemic and widespread Pacific reef fishes.

    abstract：:Despite the unique nature of endemic species, their origin and population history remain poorly studied. We investigated the population history of 28 coral reef fish species, close related, from the Gambier and Marquesas Islands, from five families, with range size varying from widespread to small-range endemic. We an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40519

    authors： Delrieu-Trottin E,Mona S,Maynard J,Neglia V,Veuille M,Planes S

    更新日期：2017-01-16 00:00:00

  • Publisher Correction: Social Closure and the Evolution of Cooperation via Indirect Reciprocity.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-43810-6

    authors： Righi S,Takács K

    更新日期：2019-10-30 00:00:00

  • Fisheries-independent surveys identify critical habitats for young scalloped hammerhead sharks (Sphyrna lewini) in the Rewa Delta, Fiji.

    abstract：:Sharp declines in numerous shark populations around the world have generated considerable interest in better understanding and characterising their biology, ecology and critical habitats. The scalloped hammerhead shark (SHS, Sphyrna lewini) is subject to a multitude of natural and anthropogenic threats that are often ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17152-0

    authors： Marie AD,Miller C,Cawich C,Piovano S,Rico C

    更新日期：2017-12-08 00:00:00

  • Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex.

    abstract：:A physically active lifestyle is associated with better health in body and mind, and it is urgent that supporting agents for such lifestyles be developed. In rodents, voluntary locomotor activity as an active physical behavior may be mediated by dopaminergic neurons (DNs). Thiamine phosphate esters can stimulate DNs, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28462-2

    authors： Saiki M,Matsui T,Soya M,Kashibe T,Shima T,Shimizu T,Naruto T,Kitayoshi T,Akimoto K,Ninomiya S,Soya H

    更新日期：2018-07-11 00:00:00

  • Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment.

    abstract：:Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patients. Therefore, companion diagnostics are needed in order to identify patients for whom these therapies are eff...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39345-5

    authors： Iwahori K,Shintani Y,Funaki S,Yamamoto Y,Matsumoto M,Yoshida T,Morimoto-Okazawa A,Kawashima A,Sato E,Gottschalk S,Okumura M,Kumanogoh A,Wada H

    更新日期：2019-02-22 00:00:00

  • Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach.

    abstract：:The prevalence of tobacco use in people with schizophrenia is much higher than in general population, which indicates a close relationship between nicotine addiction and schizophrenia. However, the molecular mechanism underlying the high comorbidity of tobacco smoking and schizophrenia remains largely unclear. In this...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21297-x

    authors： Hu Y,Fang Z,Yang Y,Rohlsen-Neal D,Cheng F,Wang J

    更新日期：2018-02-13 00:00:00

  • Comparative Transcriptional Profiling and Physiological Responses of Two Contrasting Oat Genotypes under Salt Stress.

    abstract：:Salinity is one of the major abiotic factors that affect productivity in oat. Here, we report a comparison of the transcriptomes of two hexaploid oat cultivars, 'Hanyou-5' and 'Huazao-2', which differ with respect to salt tolerance, in seedlings exposed to salt stress. Analysis of the assembled unigenes from the osmot...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34505-5

    authors： Wu B,Munkhtuya Y,Li J,Hu Y,Zhang Q,Zhang Z

    更新日期：2018-11-02 00:00:00

  • Magnetic Resonance Imaging for tracking cellular patterns obtained by Laser-Assisted Bioprinting.

    abstract：:Recent advances in the field of Tissue Engineering allowed to control the three-dimensional organization of engineered constructs. Cell pattern imaging and in vivo follow-up remain a major hurdle in in situ bioprinting onto deep tissues. Magnetic Resonance Imaging (MRI) associated with Micron-sized superParamagnetic I...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34226-9

    authors： Kérourédan O,Ribot EJ,Fricain JC,Devillard R,Miraux S

    更新日期：2018-10-25 00:00:00

  • Deciphering the secretome of leukocyte-platelet rich fibrin: towards a better understanding of its wound healing properties.

    abstract：:Leukocyte-platelet rich fibrin (L-PRF) is extensively used in the dentistry field and other clinical scenarios due to its regeneration properties. The goal of the present study was to depict the L-PRF secretome and how it changes over time. We obtained L-PRF membranes and cultured them in DMEM. The secretome was colle...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71419-7

    authors： Hermida-Nogueira L,Barrachina MN,Morán LA,Bravo S,Diz P,García Á,Blanco J

    更新日期：2020-09-03 00:00:00

  • ARC6-mediated Z ring-like structure formation of prokaryote-descended chloroplast FtsZ in Escherichia coli.

    abstract：:Plant chloroplasts proliferate through binary fission, and the stromal-side molecules that are involved in chloroplast division are bacterial derivatives. As in bacteria, the prokaryotic tubulin homolog FtsZ assembles into a ring-like structure (Z ring) at mid-chloroplast, and this process is followed by constriction....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03698-6

    authors： Irieda H,Shiomi D

    更新日期：2017-06-14 00:00:00

  • Male Antarctic fur seals: neglected food competitors of bioindicator species in the context of an increasing Antarctic krill fishery.

    abstract：:The fishery for Antarctic krill is currently managed using a precautionary, ecosystem-based approach to limiting catch, with performance indices from a long-term monitoring program focused on several krill-dependent predators that are used to track ecosystem health. Concerns over increased fishing in concentrated area...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75148-9

    authors： Lowther AD,Staniland I,Lydersen C,Kovacs KM

    更新日期：2020-10-28 00:00:00

  • Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer.

    abstract：:Tunneling nanotubes (TNTs) are actin-based membranous structures bridging distant cells for intercellular communication. We define roles for TNTs in stress adaptation and treatment resistance in prostate cancer (PCa). Androgen receptor (AR) blockade and metabolic stress induce TNTs, but not in normal prostatic epithel...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44346-5

    authors： Kretschmer A,Zhang F,Somasekharan SP,Tse C,Leachman L,Gleave A,Li B,Asmaro I,Huang T,Kotula L,Sorensen PH,Gleave ME

    更新日期：2019-05-24 00:00:00