Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases.

abstract：:Dysregulation of dopaminergic system induced by HIV-1 Tat protein-mediated direct inhibition of the dopamine transporter (DAT) has been implicated as a mediating factor of HIV-1 associated neurocognitive disorders. We have reported that single point mutations on human DAT (hDAT) at tyrosine88 (Y88F), lysine92 (K92M), ...

journal_title：Scientific reports

authors： Sun WL,Quizon PM,Yuan Y,Strauss MJ,McCain R Jr,Zhan CG,Zhu J

更新日期：2019-03-07 00:00:00

abstract：:Mycobacterium spp. are renowned for being the causative agent of diseases like leprosy, Buruli ulcer and tuberculosis in human beings. With more and more mycobacterial genomes being sequenced, any knowledge generated from comparative genomic analysis would provide better insights into the biology, evolution, phylogeny...

journal_title：Scientific reports

authors： Choo SW,Ang MY,Dutta A,Tan SY,Siow CC,Heydari H,Mutha NV,Wee WY,Wong GJ

更新日期：2015-12-15 00:00:00

abstract：:A cDNA library from a pool of all the seven silk glands from a tropical spider species was constructed. More than 1000 expressed sequence tag (EST) clones were created. Almost 65% of the EST clones were identified and around 50% were annotated. The cellular and functional distribution of the EST clones indicated high ...

journal_title：Scientific reports

authors： Huang W,Zhang Y,Chen Y,Wang Y,Yuan W,Zhang N,Lam TJ,Gong Z,Yang D,Lin Z

更新日期：2017-10-17 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Nik ME,Malaekeh-Nikouei B,Amin M,Hatamipour M,Teymouri M,Sadeghnia HR,Iranshahi M,Jaafari MR

更新日期：2020-02-27 00:00:00

abstract：:Two-photon polymerization (TPP) is capable of fabricating 3D structures with dimensions from sub-µm to a few hundred µm. As a direct laser writing (DLW) process, fabrication time of 3D TPP structures scale with the third order, limiting its use in large volume fabrication. Here, we report on a scalable fabrication met...

journal_title：Scientific reports

authors： Maibohm C,Silvestre OF,Borme J,Sinou M,Heggarty K,Nieder JB

更新日期：2020-05-26 00:00:00

abstract：:Oxalate decarboxylase (OXDC) enzyme has immense biotechnological applications due to its ability to decompose anti-nutrient oxalic acid. Flammulina velutipes, an edible wood rotting fungus responds to oxalic acid by induction of OXDC to maintain steady levels of pH and oxalate anions outside the fungal hyphae. Here, w...

journal_title：Scientific reports

authors： Kamthan A,Kamthan M,Kumar A,Sharma P,Ansari S,Thakur SS,Chaudhuri A,Datta A

更新日期：2015-10-12 00:00:00

abstract：:Magic clusters have attracted significant interest to explore the dynamics of quantum dot (QD) nucleation and growth. At the same time, CdSe magic-sized QDs reveal broadband emission in the visible wavelength region, which advantageously offer simple integration of a single-type of nanomaterial and high color renderin...

journal_title：Scientific reports

authors： Sadeghi S,Khabbaz Abkenar S,Ow-Yang CW,Nizamoglu S

更新日期：2019-07-11 00:00:00

abstract：:Decreasing coral cover on the Great Barrier Reef (GBR) may provide opportunities for rapid growth and expansion of other taxa. The bioeroding sponges Cliona spp. are strong competitors for space and may take advantage of coral bleaching, damage, and mortality. Benthic surveys of the inshore GBR (2005-2014) revealed th...

journal_title：Scientific reports

authors： Ramsby BD,Hoogenboom MO,Whalan S,Webster NS,Thompson A

更新日期：2017-06-02 00:00:00

abstract：:Recent longitudinal neuroimaging and neurophysiological studies have shown that tracking relative age-related changes in neural signals, rather than a static snapshot of a neural measure, could offer higher sensitivity for discriminating typically developing (TD) individuals from those with autism spectrum disorder (A...

journal_title：Scientific reports

authors： Nunes AS,Vakorin VA,Kozhemiako N,Peatfield N,Ribary U,Doesburg SM

更新日期：2020-07-06 00:00:00

abstract：:For people suffering from severe paralysis, communication can be difficult or nearly impossible. Technology systems called brain-computer interfaces (BCIs) are being developed to assist these people with communication by using their brain activity to control a computer without any muscle activity. To benefit the devel...

journal_title：Scientific reports

authors： Salari E,Freudenburg ZV,Branco MP,Aarnoutse EJ,Vansteensel MJ,Ramsey NF

更新日期：2019-10-02 00:00:00

abstract：:Listeria monocytogenes is an intracellular pathogen that causes listeriosis. Due to its intracellular niche, L. monocytogenes has evolved to limit immune recognition and response to infection. Antibodies that are slightly induced by listerial infection are completely unable to protect re-infection of L. monocytogenes....

journal_title：Scientific reports

authors： Asano K,Sashinami H,Osanai A,Hirose S,Ono HK,Narita K,Hu DL,Nakane A

更新日期：2016-12-22 00:00:00

abstract：:During interpersonal interactions, people perform actions with different forms of vitality, communicating their positive or negative attitude toward others. For example, a handshake can be "soft" or "vigorous", a caress can be 'kind' or 'rushed'. While previous studies have shown that the dorso-central insula is a key...

journal_title：Scientific reports

authors： Di Cesare G,Vannucci F,Rea F,Sciutti A,Sandini G

更新日期：2020-10-09 00:00:00

abstract：:Angelica gigas Nakai (AGN) is an oriental traditional medicine to treat anemia, dysmenorrhea, and migraine. However, its anti-lymphoma effect is yet to be tested. Here, we demonstrated that AGN and its major component decursin target Myc to suppress lymphomagenesis in vitro and in vivo. AGN inhibited cell viability in...

journal_title：Scientific reports

authors： Kim E,Nam J,Chang W,Zulfugarov IS,Okhlopkova ZM,Olennikov D,Chirikova NK,Kim SW

更新日期：2018-07-12 00:00:00

abstract：:Climate change is the greatest threat to coral reef ecosystems. In particular, increasing ocean temperatures are causing severe and widespread coral bleaching, contributing to extensive coral loss and degradation of coral reef habitats globally. Effects of coral bleaching are not however, equally apportioned among dif...

journal_title：Scientific reports

authors： Pisapia C,Burn D,Pratchett MS

更新日期：2019-06-10 00:00:00

abstract：:Numerous studies have reported cold atmospheric plasma cytotoxic activities in various cancer cell lines, either by direct exposure to non-thermal plasma or indirectly by activating a medium (plasma-activated medium, PAM) prior to cell treatment. We suggested the use of in vitro 3D tumor model spheroids to determine t...

journal_title：Scientific reports

authors： Chauvin J,Gibot L,Griseti E,Golzio M,Rols MP,Merbahi N,Vicendo P

更新日期：2019-03-19 00:00:00

abstract：:Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit its clinical application and efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that...

journal_title：Scientific reports

authors： Jin H,Pi J,Yang F,Jiang J,Wang X,Bai H,Shao M,Huang L,Zhu H,Yang P,Li L,Li T,Cai J,Chen ZW

更新日期：2016-07-29 00:00:00

abstract：:Major overturn within a magma chamber can bring together felsic and mafic magmas, prompting de-volatilisation and acting as the driver for Plinian eruptions. Until now identification of mixing has been limited to analysis of lavas or individual crystals ejected during eruptions. We have recovered partially developed c...

journal_title：Scientific reports

authors： Stock MJ,Taylor RN,Gernon TM

更新日期：2012-01-01 00:00:00

abstract：:Monochamus beetles are the dispersing vectors of the nematode Bursaphelenchus xylophilus, the causative agent of pine wilt disease (PWD). PWD inflicts significant damages in Eurasian pine forests. Symbiotic microorganisms have a large influence in insect survival. The aim of this study was to characterize the bacteria...

journal_title：Scientific reports

authors： Alves M,Pereira A,Matos P,Henriques J,Vicente C,Aikawa T,Hasegawa K,Nascimento F,Mota M,Correia A,Henriques I

更新日期：2016-04-05 00:00:00

abstract：:Magnesium has been shown to effectively prevent vascular calcification associated with chronic kidney disease. Magnesium has been hypothesized to prevent the upregulation of osteoblastic genes that potentially drives calcification. However, extracellular effects of magnesium on hydroxyapatite formation are largely neg...

journal_title：Scientific reports

authors： Ter Braake AD,Tinnemans PT,Shanahan CM,Hoenderop JGJ,de Baaij JHF

更新日期：2018-02-01 00:00:00

abstract：:The ability of the cerebellar cortex to learn from experience ensures the accuracy of movements and reflex adaptation, processes which require long-term plasticity at granule cell (GC) to Purkinje neuron (PN) excitatory synapses. PNs also receive GABAergic inhibitory inputs via GCs activation of interneurons; despite ...

journal_title：Scientific reports

authors： Binda F,Dorgans K,Reibel S,Sakimura K,Kano M,Poulain B,Isope P

更新日期：2016-09-19 00:00:00

abstract：:In this paper, for the first time, the switchable two-color quantum dot laser has been realized considering solution process technology, which has both simultaneous and lonely lasing capability exploiting selective energy contacts. Furthermore, both channels can be modulated independently, which is a significant featu...

journal_title：Scientific reports

authors： Matloub S,Amini P,Rostami A

更新日期：2020-03-24 00:00:00

abstract：:Galectin-3 is a biomarker of fibrosis, inflammation and oxidative stress, and its role in heart remodelling and exercise intolerance has not been conclusively proven in heart failure (HF) patients with reduced ejection fraction (rEF). We prospectively assessed 67 consecutive patients with symptomatic HF and left ventr...

journal_title：Scientific reports

authors： Zaborska B,Sygitowicz G,Smarż K,Pilichowska-Paszkiet E,Budaj A

更新日期：2020-10-07 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Tsuchiya K,Suzuki Y,Yoshimura K,Yasui H,Karayama M,Hozumi H,Furuhashi K,Enomoto N,Fujisawa T,Nakamura Y,Inui N,Yokomura K,Suda T

更新日期：2020-02-19 00:00:00

abstract：:Systemic Sclerosis (SSc) is a disease with limited therapeutic possibilities. Mesenchymal stem cells (MSCs)-therapy could be a promising therapeutic option, however the ideal MSCs source has not yet been found. To address this problem, we perform comparison between bone marrow (BM)-MSCs and adipose (A)-MSCs, by the mi...

journal_title：Scientific reports

authors： Di Benedetto P,Panzera N,Cipriani P,Mastroiaco V,Tessitore A,Liakouli V,Ruscitti P,Berardicurti O,Carubbi F,Guggino G,Bianchi A,Di Marco A,Ciccia F,Alesse E,Giacomelli R

更新日期：2019-05-09 00:00:00

abstract：:Paedomorphosis and metamorphosis are two major developmental processes that characterize the evolution of complex life cycles in many lineages. Whereas these processes were fixed in some taxa, they remained facultative in others, with alternative phenotypes expressed in the same populations. From a genetic perspective...

journal_title：Scientific reports

authors： Oromi N,Michaux J,Denoël M

更新日期：2016-08-18 00:00:00

abstract：:A pancreatic β-cell line MIN6 was previously established in our lab from an insulinoma developed in an IT6 transgenic mouse expressing the SV40 T antigen in β-cells. This cell line has been widely used for in vitro analysis of β-cell function, but tends to lose the mature β-cell features, including glucose-stimulated ...

journal_title：Scientific reports

authors： Miyazaki S,Tashiro F,Tsuchiya T,Sasaki K,Miyazaki JI

更新日期：2021-01-12 00:00:00

abstract：:An in vitro-transcribed RNA aptamer (trans-RA16) that targets non-small cell lung cancer (NSCLC) was previously identified through in vivo SELEX. Trans-RA16 can specifically target and inhibit human NCI-H460 cells in vitro and xenograft tumors in vivo. Here, in a follow-up study, we obtained a chemically-synthesized v...

journal_title：Scientific reports

authors： Wang H,Qin M,Liu R,Ding X,Chen ISY,Jiang Y

更新日期：2019-12-11 00:00:00

abstract：:This study analyses spatially resolved estimates of mass budget and surface velocity of glaciers in the Zanskar Basin of Western Himalaya in the context of varying debris cover, glacier hypsometry and orientation. The regional glacier mass budget for the period of 1999-2014 is -0.38 ± 0.09 m w.e./a. Individual mass bu...

journal_title：Scientific reports

authors： Bhushan S,Syed TH,Arendt AA,Kulkarni AV,Sinha D

更新日期：2018-06-11 00:00:00

abstract：:PDA is a major cause of US cancer-related deaths. Oncogenic Kras presents in 90% of human PDAs. Kras mutations occur early in pre-neoplastic lesions but are insufficient to cause PDA. Other contributing factors early in disease progression include chronic pancreatitis, alterations in epigenetic regulators, and tumor s...

journal_title：Scientific reports

authors： Layeghi-Ghalehsoukhteh S,Pal Choudhuri S,Ocal O,Zolghadri Y,Pashkov V,Niederstrasser H,Posner BA,Kantheti HS,Azevedo-Pouly AC,Huang H,Girard L,MacDonald RJ,Brekken RA,Wilkie TM

更新日期：2020-11-26 00:00:00

abstract：:DNA N6-methyldeoxyadenosine (6 mA) modifications were first found more than 60 years ago but were thought to be only widespread in prokaryotes and unicellular eukaryotes. With the development of high-throughput sequencing technology, 6 mA modifications were found in different multicellular eukaryotes by using experime...

journal_title：Scientific reports

authors： Liu Z,Dong W,Jiang W,He Z

更新日期：2019-09-11 00:00:00