Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics.

abstract：:We describe a multiplexed RNA aptamer selection to 19 different targets simultaneously using a microcolumn-based device, MEDUSA (Microplate-based Enrichment Device Used for the Selection of Aptamers), as well as a modified selection process, that significantly reduce the time and reagents needed for selections. We exp...

journal_title：Scientific reports

authors： Reinholt SJ,Ozer A,Lis JT,Craighead HG

更新日期：2016-07-19 00:00:00

abstract：:Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the vacuole/lysosome in eukaryotic cells. MoAtg14 in M. oryzae, a hitherto uncharacterized protein, is the highly divergent homolog of the yeast Atg14 and the mammal BARKOR. The MoATG14 deletion muta...

journal_title：Scientific reports

authors： Liu XH,Zhao YH,Zhu XM,Zeng XQ,Huang LY,Dong B,Su ZZ,Wang Y,Lu JP,Lin FC

更新日期：2017-01-09 00:00:00

abstract：:Core-shell refractory plasmonic nanoparticles are used as excellent nanoantennas to improve the efficiency of lead-free perovskite solar cells (PSCs). SiO2 is used as the shell coating due to its high refractive index and low extinction coefficient, enabling the control over the sunlight directivity. An optoelectronic...

journal_title：Scientific reports

authors： Mohsen AA,Zahran M,Habib SED,Allam NK

更新日期：2020-04-21 00:00:00

abstract：:Patients with type 1 diabetes have lower bone mineral density and higher risk of fractures. The role of osteoblasts in diabetes-related osteoporosis is well acknowledged whereas the role of osteoclasts (OCLs) is still unclear. We hypothesize that OCLs participate in pathological bone remodeling. We conducted studies i...

journal_title：Scientific reports

authors： Reni C,Mangialardi G,Meloni M,Madeddu P

更新日期：2016-07-29 00:00:00

abstract：:Many reports have demonstrated that radiation stimulates reactive oxygen species (ROS) production by mitochondria for a few hours to a few days after irradiation. However, these studies were performed using cell lines, and there is a lack of information about redox homeostasis in irradiated animals and humans. Blood r...

journal_title：Scientific reports

authors： Sun L,Inaba Y,Sato K,Hirayama A,Tsuboi K,Okazaki R,Chida K,Moritake T

更新日期：2018-05-09 00:00:00

abstract：:The identification of enhancer-target gene (ETG) pairs is vital for the understanding of gene transcriptional regulation. Experimental approaches such as Hi-C have generated valuable resources of ETG pairs. Several computational methods have also been developed to successfully predict ETG interactions. Despite these p...

journal_title：Scientific reports

authors： Zhao C,Li X,Hu H

更新日期：2016-07-20 00:00:00

abstract：:Bast fibres are long extraxylary cells which mechanically support the phloem and they are divided into xylan- and gelatinous-type, depending on the composition of their secondary cell walls. The former, typical of jute/kenaf bast fibres, are characterized by the presence of xylan and a high degree of lignification, wh...

journal_title：Scientific reports

authors： Guerriero G,Behr M,Legay S,Mangeot-Peter L,Zorzan S,Ghoniem M,Hausman JF

更新日期：2017-07-10 00:00:00

abstract：:Chinese hamster ovary (CHO) cells are mainly used for recombinant protein production. However, the unstable transgene expression and lower transgene copy numbers are the major issues need to be resolved. Here, eleven internal ribosome entry site (IRES) elements from viral and cellular IRES were evaluated for foreign g...

journal_title：Scientific reports

authors： Chai YR,Ge MM,Wei TT,Jia YL,Guo X,Wang TY

更新日期：2018-04-27 00:00:00

abstract：:Most studies on ungulate reproduction have focused on the covariates of male reproductive success, while there is much less information on female tactics of mate choice. The aim of this work is to fill this gap and to assess condition-dependent variations in female tactics in a lekking fallow deer (Dama dama) populati...

journal_title：Scientific reports

authors： Imperio S,Lombardi S,De Marinis A,Ronchi F,Santini G,Focardi S

更新日期：2020-02-27 00:00:00

abstract：:A number of studies have reported that the digit ratio 2D:4D (length of the second finger divided by length of the fourth finger) is smaller (longer fourth digit) in autism spectrum disorder (ASD) than in typically developed (TD) controls. Because form and function are closely related in biological systems, we hypothe...

journal_title：Scientific reports

authors： Togo S,Itahashi T,Hashimoto R,Cai C,Kanai C,Kato N,Imamizu H

更新日期：2019-02-11 00:00:00

abstract：:The aim of this study was to identify the synergistic effect of microRNA expression with classical risk factors of coronary heart disease (CHD) and to explore their diagnostic value for coronary stenotic lesions in subjects with CHD. Plasma samples were obtained from 66 subjects with CHD and from 58 control individual...

journal_title：Scientific reports

authors： Ding XQ,Ge PC,Liu Z,Jia H,Chen X,An FH,Li LH,Chen ZH,Mao HW,Li ZY,Gu Y,Zhu TB,Li CJ,Wang LS,Ma WZ,Yang ZJ,Jia EZ

更新日期：2015-10-08 00:00:00

abstract：:Porous three-dimensional (3D) polyurethane-based biocomposites were produced utilizing diatomite and hydroxyapatite as fillers. Diatomite and Hydroxyapatite (HA) were utilized to reinforce the morphological, chemical, mechanical, and thermal properties of polyurethane foam (PUF). Diatomite and Hydroxyapatite were adde...

journal_title：Scientific reports

authors： Mustafov SD,Sen F,Seydibeyoglu MO

更新日期：2020-08-06 00:00:00

abstract：:We report a three dimensional (3D) quantitative visualization of a mammalian mitochondrion by coherent x-ray diffractive imaging (CXDI) using synchrotron radiation. The internal structures of a mitochondrion from a mouse embryonic fibroblast cell line (NIH3T3) were visualized by tomographic imaging at approximately 60...

journal_title：Scientific reports

authors： Kim Y,Kim C,Kwon OY,Nam D,Kim SS,Park JH,Kim S,Gallagher-Jones M,Kohmura Y,Ishikawa T,Song C,Tae G,Noh DY

更新日期：2017-05-12 00:00:00

abstract：:Fossils of the sponge Angulosuspongia sinensis from calcareous mudstones of the middle and upper part of the Kaili Formation (Cambrian Stage 5) in the Jianhe area of Guizhou province, South China, exhibit an apparently reticulate pattern, characteristic of the Vauxiidae. Energy Dispersive X-Ray Spectrometry (EDS) and ...

journal_title：Scientific reports

authors： Yang XL,Zhao YL,Babcock LE,Peng J

更新日期：2017-02-21 00:00:00

abstract：:The nutritional alarmones ppGpp and pppGpp (collectively: (p)ppGpp) are nucleotide-based second messengers enabling bacteria to respond to environmental and stress conditions. Several bacterial species contain two highly homologous (p)ppGpp synthetases named RelP (SAS2, YwaC) and RelQ (SAS1, YjbM). It is established t...

journal_title：Scientific reports

authors： Steinchen W,Vogt MS,Altegoer F,Giammarinaro PI,Horvatek P,Wolz C,Bange G

更新日期：2018-02-01 00:00:00

abstract：:Atrial fibrillation (AF) is known to cause adverse remodeling of left atrium (LA). Radiofrequency catheter ablation (RFCA) of AF is associated with decrease in LA volume. However, the impact of RFCA on left atrial appendage (LAA) volume and hemodynamic function is not fully understood. We analyzed 123 patients who und...

journal_title：Scientific reports

authors： Kim YG,Shim J,Oh SK,Park HS,Lee KN,Hwang SH,Choi JI,Kim YH

更新日期：2018-05-18 00:00:00

abstract：:Patients who undergo orthotopic liver transplantation often sustain acute kidney injury(AKI). The toll-like receptor 4(TLR4)/Nuclear factor-кB(NF-кB) pathway plays a role in AKI. Dexmedetomidine(Dex) has been shown to attenuate AKI. The current study aimed to determine whether liver transplantation-induced AKI is asso...

journal_title：Scientific reports

authors： Yao H,Chi X,Jin Y,Wang Y,Huang P,Wu S,Xia Z,Cai J

更新日期：2015-11-20 00:00:00

abstract：:The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required. In order to identify new candidates as potential drug targets, we combined large-scale transposon mutagenesis data analysis and bioinforma...

journal_title：Scientific reports

authors： Fernández-Piñar R,Lo Sciuto A,Rossi A,Ranucci S,Bragonzi A,Imperi F

更新日期：2015-12-01 00:00:00

abstract：:Diabetes is a globally prevalent disease that can cause visible microvascular complications such as diabetic retinopathy and macular edema in the human eye retina, the images of which are today used for manual disease screening and diagnosis. This labor-intensive task could greatly benefit from automatic detection usi...

journal_title：Scientific reports

authors： Sahlsten J,Jaskari J,Kivinen J,Turunen L,Jaanio E,Hietala K,Kaski K

更新日期：2019-07-24 00:00:00

abstract：:Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set enrichment analysis using summary statistics from a large-scale ...

journal_title：Scientific reports

authors： Horgusluoglu-Moloch E,Risacher SL,Crane PK,Hibar D,Thompson PM,Saykin AJ,Nho K,Alzheimer’s Disease Neuroimaging Initiative (ADNI).

更新日期：2019-10-10 00:00:00

abstract：:All-inorganic visibly-transparent energy-harvesting clear laminated glass windows are the most practical solution to boosting building-integrated photovoltaics (BIPV) energy outputs significantly while reducing cooling- and heating-related energy consumption in buildings. By incorporating luminophore materials into la...

journal_title：Scientific reports

authors： Alghamedi R,Vasiliev M,Nur-E-Alam M,Alameh K

更新日期：2014-10-16 00:00:00

abstract：:Downstream analysis of genomic and transcriptomic sequence data is often executed by functional annotation that can be performed by various bioinformatics tools and biological databases. However, a full fast integrated tool is not available for such analysis. Besides, the current available software is not able to prod...

journal_title：Scientific reports

authors： Araujo FA,Barh D,Silva A,Guimarães L,Ramos RTJ

更新日期：2018-01-29 00:00:00

abstract：:Solar-driven photoelectrochemical water splitting (PEC-WS) using semiconductor photoelectrodes is considered a promising solution for sustainable, renewable, clean, safe and alternative energy sources such as hydrogen. Here, we report the synthesis and characterization of a novel heterostructure MoS2/GaN to be used as...

journal_title：Scientific reports

authors： Hassan MA,Kim MW,Johar MA,Waseem A,Kwon MK,Ryu SW

更新日期：2019-12-27 00:00:00

abstract：:Huntington's disease (HD) is a progressive, dominantly inherited neurological disorder caused by an abnormal expansion of polyglutamine (polyQ) repeat within the Huntingtin (Htt) protein with no disease modifying treatments. In a Drosophila model of HD, expression of mutant Huntingtin (Htt) protein with expanded polyQ...

journal_title：Scientific reports

authors： Chongtham A,Agrawal N

更新日期：2016-01-05 00:00:00

abstract：:Air pollution has aroused significant public concern in China, therefore, long-term air-quality data with high temporal and spatial resolution are needed to understand the variations of air pollution in China. However, the yearly variations with high spatial resolution of air quality and six air pollutants are still u...

journal_title：Scientific reports

authors： Guo H,Gu X,Ma G,Shi S,Wang W,Zuo X,Zhang X

更新日期：2019-10-23 00:00:00

abstract：:Soil microorganisms have important influences on plant growth and health. In this study, four black pepper fields consecutively monocultured for 12, 18, 28 and 38 years were selected for investigating the effect of planting age on rhizosphere and non-rhizosphere soil microbial communities and soil physicochemical prop...

journal_title：Scientific reports

authors： Li Z,Zu C,Wang C,Yang J,Yu H,Wu H

更新日期：2016-10-24 00:00:00

abstract：:Fibrolamellar carcinoma (FLC) is a unique liver cancer primarily affecting young adults and characterized by a fusion event between DNAJB1 and PRKACA. By analyzing RNA-sequencing data from The Cancer Genome Atlas (TCGA) for >9,100 tumors across ~30 cancer types, we show that the DNAJB1-PRKACA fusion is specific to FLC...

journal_title：Scientific reports

authors： Dinh TA,Vitucci EC,Wauthier E,Graham RP,Pitman WA,Oikawa T,Chen M,Silva GO,Greene KG,Torbenson MS,Reid LM,Sethupathy P

更新日期：2017-03-17 00:00:00

abstract：:Plant resistance can provide effective, economical, and sustainable pest control. Tolerance to the soybean aphid has been identified and confirmed in the soybean KS4202. Although its resistance mechanisms are not fully understood, evidence suggests that enhanced detoxification of reactive oxygen species (ROS) is an ac...

journal_title：Scientific reports

authors： Chapman KM,Marchi-Werle L,Hunt TE,Heng-Moss TM,Louis J

更新日期：2018-10-11 00:00:00

abstract：:Invasive Salmonella diseases, both typhoid and invasive non-typhoidal Salmonella (iNTS), are seasonal bloodstream infections causing important morbidity and mortality globally in Africa. The reservoirs and transmission of both are not fully understood. We hypothesised that differences in the time-lagged relationships ...

journal_title：Scientific reports

authors： Thindwa D,Chipeta MG,Henrion MYR,Gordon MA

更新日期：2019-12-30 00:00:00

abstract：:To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their pe...

journal_title：Scientific reports

authors： Zhang Q,Ma J,Liu H,He D,Chen L,Wu H,Jiang H,Lu Q,Bai S

更新日期：2018-01-09 00:00:00