Abstract：
:Patients with type 1 diabetes have lower bone mineral density and higher risk of fractures. The role of osteoblasts in diabetes-related osteoporosis is well acknowledged whereas the role of osteoclasts (OCLs) is still unclear. We hypothesize that OCLs participate in pathological bone remodeling. We conducted studies in animals (streptozotocin-induced type 1 diabetic mice) and cellular models to investigate canonical and non-canonical mechanisms underlying excessive OCL activation. Diabetic mice show an increased number of active OCLs. In vitro studies demonstrate the involvement of acidosis in OCL activation and the implication of transient receptor potential cation channel subfamily V member 1 (TRPV1). In vivo studies confirm the establishment of local acidosis in the diabetic bone marrow (BM) as well as the ineffectiveness of insulin in correcting the pH variation and osteoclast activation. Conversely, treatment with TRPV1 receptor antagonists re-establishes a physiological OCL availability. These data suggest that diabetes causes local acidosis in the BM that in turn increases osteoclast activation through the modulation of TRPV1. The use of clinically available TRPV1 antagonists may provide a new means to combat bone problems associated with diabetes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Reni C,Mangialardi G,Meloni M,Madeddu Pdoi
10.1038/srep30639subject
Has Abstractpub_date
2016-07-29 00:00:00pages
30639issn
2045-2322pii
srep30639journal_volume
6pub_type
杂志文章abstract：:During development, cell division often generates two daughters with different developmental fates. Distinct daughter identities can result from the physical polarity and size asymmetry itself, as well as the subsequent activation of distinct fate programmes in each daughter. Asymmetric divisions are a feature of the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01675-7
更新日期：2017-06-14 00:00:00
abstract：:Pancreatic cancer induces a substantial global burden. We examined its global incidence/mortality rates and their correlation with socioeconomic development (Human Development Index [HDI] and Gross Domestic Product [GDP] in 2000 as proxy measures). Data on age-standardized incidence/mortality rates in 2012 were retrie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02997-2
更新日期：2017-06-09 00:00:00
abstract：:Circular Dichroism data are often decomposed into their constituent spectra to quantify the secondary structure of peptides or proteins but the estimation of the secondary structure content fails when light scattering leads to spectral distortion. If peptide-induced liposome self-association occurs, subtracting contro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39450
更新日期：2016-12-22 00:00:00
abstract：:This study aimed to determine whether formyl peptide receptors (FPRs) regulated the differentiation of neural stem cells (NSCs). FPRs promote the migration of NSCs both in vitro and in vivo. However, the role of FPRs during differentiation of NSCs is unknown. Analysis by Western blot showed significantly increased exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00314-5
更新日期：2017-03-16 00:00:00
abstract：:Coincident climatic and human effects strongly influence water-quality properties in estuarine-coastal ecosystems around the world. Time-series data for a number of ecosystems reveal high spatio-temporal variability superimposed on secular trends traceable to nutrient over-enrichment. In this paper, we present new ana...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43036-6
更新日期：2019-04-30 00:00:00
abstract：:In the last years, great advances have been made in therapies based in cold atmospheric plasmas (CAP). CAP generate reactive oxygen and nitrogen species (RONS) which can be transferred to liquids. These CAP activated liquids display the same biological efficacy (i.e. on killing cancer cells) as CAP themselves, opening...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52673-w
更新日期：2019-11-06 00:00:00
abstract：:Precision medicine is continuously demanding for novel point of care systems, potentially exploitable also for in-vivo analysis. Biosensing probes based on Lab-On-Fiber Technology have been recently developed to meet these challenges. However, devices exploiting standard label-free approaches (based on ligand/target m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14852-5
更新日期：2017-10-31 00:00:00
abstract：:Annually averaged solar radiation in the McMurdo Dry Valleys, Antarctica has varied by over 20 W m-2 during the past three decades; however, the drivers of this variability are unknown. Because small differences in radiation are important to water availability and ecosystem functioning in polar deserts, determining th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23390-7
更新日期：2018-03-22 00:00:00
abstract：:Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan-, and cisplatin-eluting poly[(d,l)-lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 glioma-bearing rats in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30630
更新日期：2016-07-29 00:00:00
abstract：:Tradional antireflection coatings composed of dielectric layers usually require the thickness to be larger than quarter wavelength. Here, we demonstrate that materials with permittivity or permeability dominated by imaginary parts, i.e. lossy or gain media, can realize non-resonant antireflection coatings in deep sub-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28681
更新日期：2016-06-28 00:00:00
abstract：:Matrix metalloproteinases (MMPs) are a family of secreted endopeptidases expressed by neurons and glia. Regulated MMP activity contributes to physiological synaptic plasticity, while dysregulated activity can stimulate injury. Disentangling the role individual MMPs play in synaptic plasticity is difficult due to overl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35497
更新日期：2016-10-20 00:00:00
abstract：:Experimental evidence has shown that some of the human endogenous hormones significantly affect drug efficacy. Since hormone status varies with individual physiological states, it is essential to understand the interplay of hormones and drugs for precision medicine. Here, we developed an in silico method to predict in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16855-8
更新日期：2017-11-30 00:00:00
abstract：:Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 201...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36235
更新日期：2016-11-08 00:00:00
abstract：:The life-like fidelity of organisms captured in amber is unique among all kinds of fossilization and represents an invaluable source for different fields of palaeontological and biological research. One of the most challenging aspects in amber research is the study of traits related to behaviour. Here, indirect eviden...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34352
更新日期：2016-10-04 00:00:00
abstract：:We have developed a framework to convert an arbitrary integer factorization problem to an executable Ising model by first writing it as an optimization function then transforming the k-bit coupling (k ≥ 3) terms to quadratic terms using ancillary variables. Our resource-efficient method uses [Formula: see text] binary...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36058-z
更新日期：2018-12-05 00:00:00
abstract：:Two objects can be distinguished if they have different measurable properties. Thus, distinguishability depends on the Physics of the objects. In considering graphs, we revisit the Ising model as a framework to define physically meaningful spectral invariants. In this context, we introduce a family of refinements of t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05703
更新日期：2014-07-16 00:00:00
abstract：:It has been shown that bamboo leaf flavone (BLF) displays biological and pharmacological activities in mammals. However, the effects of BLF on broiler gut microbiota and related immune function have not been investigated. The aim of this study was to test our hypothesis that BLF can improve the health status of broile...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69010-1
更新日期：2020-07-23 00:00:00
abstract：:Recent studies suggest that spatial training can maintain associative memory capacity in Tg2576 mice, but it is not known whether the beneficial effects can be inherited from the trained fathers to their offspring. Here, we exposed male wild-type and male 3XTg Alzheimer disease (AD) mice (3-m old) respectively to spat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01811-3
更新日期：2017-05-08 00:00:00
abstract：:A method is proposed to drive an ultrafast non-adiabatic dynamics of an ultracold gas trapped in a time-dependent box potential. The resulting state is free from spurious excitations associated with the breakdown of adiabaticity, and preserves the quantum correlations of the initial state up to a scaling factor. The p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00648
更新日期：2012-01-01 00:00:00
abstract：:The mosquito, Aedes baisasi, which inhabits brackish mangrove swamps, is known to feed on fish. However, its host assemblage has not been investigated at the species level. We amplified and sequenced the cytochrome oxidase subunit I barcoding regions as well as some other regions from blood-fed females to identify hos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40509-6
更新日期：2019-03-08 00:00:00
abstract：:The pathophysiological mechanism involved in side effects of radiation therapy, and especially the role of the endothelium remains unclear. Previous results showed that plasminogen activator inhibitor-type 1 (PAI-1) contributes to radiation-induced intestinal injury and suggested that this role could be driven by an e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15738
更新日期：2015-10-29 00:00:00
abstract：:Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction mediated by the C-C loop of EDA activates pro-oncogenic signaling pathways leading to epithelial to mesenchymal transition (EMT) of tumor cells,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37151
更新日期：2016-11-16 00:00:00
abstract：:The present study was undertaken to determine the prevalence of endplate junction failure in a smaller cohort of Danish patients with lumbar disk herniation and compare this to the previously published data from India. Consecutive patients seen in a large regional hospital spine-care unit, with a clinical presentation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74690-w
更新日期：2020-10-19 00:00:00
abstract：:Children with chronic kidney disease suffer from excessive cardiovascular mortality and early alterations of the cardiovascular system. Tissue doppler imaging is a validated echocardiographic tool to assess early systolic and diastolic cardiac dysfunction. We hypothesized that tissue Doppler velocities would reveal re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46653-3
更新日期：2019-08-07 00:00:00
abstract：:Colon cancer stem cells have been attributed to poor prognosis, therapeutic resistance and aggressive nature of the malignancy. Recent reports associated CD44v6 expression with relapse, metastasis and reduced 5-year survival of colon cancer patients, thereby making it a potential therapeutic target. Thus, in this stud...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35069-0
更新日期：2018-11-19 00:00:00
abstract：:Ionizing radiation (IR)-induced intestinal damage is characterized by a loss of intestinal crypt cells, intestinal barrier disruption and translocation of intestinal microflora resulting in sepsis-mediated lethality. We have shown that mice lacking C/EBPδ display IR-induced intestinal and hematopoietic injury and leth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49437-x
更新日期：2019-09-27 00:00:00
abstract：:Music and language are complex hierarchical systems in which individual elements are systematically combined to form larger, syntactic structures. Suggestions that music and language share syntactic processing resources have relied on evidence that syntactic violations in music interfere with syntactic processing in l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36076-x
更新日期：2018-12-17 00:00:00
abstract：:Early fruit development is crucial for crop production in tomato. After fertilization, the ovary undergoes cell division and cell expansion before maturation. Although the roles of regulatory signals such as hormone and carbohydrate during early fruit development have been studied, the spatial distribution and the seq...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23173
更新日期：2016-03-18 00:00:00
abstract：:Alternate bearing (AB) refers to the tendency of trees to have an irregular crop load from 1 year (ON) to the next year (OFF). Despite its economic importance, it is not fully understood how gene networks and their related metabolic pathways may influence the irregular bearing in olive trees. To unravel molecular mech...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72895-7
更新日期：2020-09-25 00:00:00
abstract：:Loss of stromal Caveolin-1 (CAV1) expression is associated with poor prognosis in various cancers. We evaluated the prognostic value of CAV1 expression of both cancer cells and stromal cells in colorectal liver metastases (CRLM) in patients undergoing hepatectomy. In this retrospective study, 109 patients were enrolle...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02251-9
更新日期：2017-05-17 00:00:00
