Abstract：
:The identification of enhancer-target gene (ETG) pairs is vital for the understanding of gene transcriptional regulation. Experimental approaches such as Hi-C have generated valuable resources of ETG pairs. Several computational methods have also been developed to successfully predict ETG interactions. Despite these progresses, high-throughput experimental approaches are still costly and existing computational approaches are still suboptimal and not easy to apply. Here we developed a motif module based approach called PETModule that predicts ETG pairs. Tested on eight human cell types and two mouse cell types, we showed that a large number of our predictions were supported by Hi-C and/or ChIA-PET experiments. Compared with two recently developed approaches for ETG pair prediction, we shown that PETModule had a much better recall, a similar or better F1 score, and a larger area under the receiver operating characteristic curve. The PETModule tool is freely available at http://hulab.ucf.edu/research/projects/PETModule/.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhao C,Li X,Hu Hdoi
10.1038/srep30043subject
Has Abstractpub_date
2016-07-20 00:00:00pages
30043issn
2045-2322pii
srep30043journal_volume
6pub_type
杂志文章abstract：:Can humans produce well-timed blink responses to a neutral stimulus voluntarily, without receiving any blink-eliciting, unconditional, stimulus? And if they can, to what degree does classical eyeblink conditioning depend on volition? Here we show that voluntary blink responses learned in two paradigms that did not inv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03343-2
更新日期：2017-06-13 00:00:00
abstract：:Restenosis remains a significant problem after angioplasty of hemodialysis vascular access. Both experimental and clinical studies have shown a protective effect of antioxidants against post-angioplasty restenosis. A prospective, randomized, feasibility study was conducted to investigate the effect of ascorbic acid to...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
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abstract：:Whether age has any impact on the risk of lymph node (LN) metastasis in patients with early-stage non-small cell lung cancer (NSCLC) remains controversial. Therefore, we aimed to objectively compare the risk of LN metastasis between elderly and young patients so as to justify for age-different extent of surgical resec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66509-5
更新日期：2020-06-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-07-29 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2019-06-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-03-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67043-0
更新日期：2020-06-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58730-z
更新日期：2020-02-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-06-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80925-7
更新日期：2021-01-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2014-04-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20286
更新日期：2016-02-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-08-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03264
更新日期：2013-11-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-07-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-01-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-01-11 00:00:00
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journal_title：Scientific reports
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-03-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-06-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-10-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-02-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69484-z
更新日期：2020-07-28 00:00:00
abstract：:Huntington's disease (HD) is a progressive, dominantly inherited neurological disorder caused by an abnormal expansion of polyglutamine (polyQ) repeat within the Huntingtin (Htt) protein with no disease modifying treatments. In a Drosophila model of HD, expression of mutant Huntingtin (Htt) protein with expanded polyQ...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-01-05 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2020-05-20 00:00:00
abstract：:Many studies have now consistently reported that the phase angle of ongoing oscillatory activity (measured using EEG/MEG), at time of stimulus presentation influences detection when stimuli are near-threshold. However, studies examining whether the adjustment of the phase angle of oscillations is under top-down attent...
journal_title：Scientific reports
pub_type： 杂志文章
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