Mesenchymal stem cells of Systemic Sclerosis patients, derived from different sources, show a profibrotic microRNA profiling.

abstract：:Src family of kinases (SFKs) has been found to play an important role in the regulation of nociception. However, how each member of this family acts in the central nervous system (CNS) structures involved in the relay and/or modulation of nociceptive signals, and thereby contributes to the formation and maintenance of...

journal_title：Scientific reports

authors： Ma H,Yao C,Ma P,Zhou J,Gong S,Tao J,Yu XM,Jiang X

更新日期：2019-03-07 00:00:00

abstract：:Extracellular vesicles are selectively enriched in RNA that has potential as disease biomarkers. To systemically characterize circulating extracellular RNA (exRNA) profiles, we performed RNA sequencing analysis on plasma extracellular vesicles derived from 50 healthy individuals and 142 cancer patients. Of ~12.6 milli...

journal_title：Scientific reports

authors： Yuan T,Huang X,Woodcock M,Du M,Dittmar R,Wang Y,Tsai S,Kohli M,Boardman L,Patel T,Wang L

更新日期：2016-01-20 00:00:00

abstract：:After injury to the mature central nervous system (CNS), myelin-derived inhibitory ligands bind to the Nogo-66 tripartite receptor complex expressed on axonal growth cones, comprised of LINGO-1 and p75NTR/TROY and induce growth cone collapse through the RhoA pathway. We have also shown that amphoterin-induced gene and...

journal_title：Scientific reports

authors： Almutiri S,Berry M,Logan A,Ahmed Z

更新日期：2018-07-16 00:00:00

abstract：:Bacteria belonging to the genus Acinetobacter have become of clinical importance over the last decade due to the development of a multi-resistant phenotype and their ability to survive under multiple environmental conditions. The development of these traits among Acinetobacter strains occurs frequently as a result of ...

journal_title：Scientific reports

authors： Salto IP,Torres Tejerizo G,Wibberg D,Pühler A,Schlüter A,Pistorio M

更新日期：2018-05-17 00:00:00

abstract：:Cross-linked protein crystals (CLPCs) are very useful materials in applications such as biosensors, catalysis, and X-ray crystallography. Hence, preparation of CLPCs is an important research direction. During the preparation of CLPCs, an often encountered problem is that cracks may appear in the crystals, which may fi...

journal_title：Scientific reports

authors： Yan EK,Lu QQ,Zhang CY,Liu YL,He J,Chen D,Wang B,Zhou RB,Wu P,Yin DC

更新日期：2016-10-05 00:00:00

abstract：:The concept of parity-time (PT) symmetry in SPPs is proposed and confirmed for the first time in this work. By introducing periodic modulation of the effective refractive index in SPP system, the asymmetric propagation is theoretically predicted and numerically demonstrated. After validation of this concept, we apply ...

journal_title：Scientific reports

authors： Yang F,Lei Mei Z

更新日期：2015-10-08 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a...

journal_title：Scientific reports

authors： Yu Z,Chen X,Han F,Qin S,Li M,Wu Y,Su Y,Ge J

更新日期：2017-03-10 00:00:00

abstract：:Ants are a dominant insect group in terrestrial ecosystems and many myrmecophilous species evolve to associate with ants to gain benefits. One iconic example is myrmecophilous butterflies that often produce ant-mimicking vibrational calls to modulate ant behaviors. Despite its popularity, empirical exploration of how ...

journal_title：Scientific reports

authors： Lin YH,Liao YC,Yang CS,Billen J,Yang MM,Hsu YF

更新日期：2019-12-06 00:00:00

abstract：:The development of human induced pluripotent stem cell (iPSC) technology has revolutionized the regenerative medicine field. This technology provides a powerful tool for disease modeling and drug screening approaches. To circumvent the risk of random integration into the host genome caused by retroviruses, non-integra...

journal_title：Scientific reports

authors： Diecke S,Lu J,Lee J,Termglinchan V,Kooreman NG,Burridge PW,Ebert AD,Churko JM,Sharma A,Kay MA,Wu JC

更新日期：2015-01-28 00:00:00

abstract：:Cell adhesion molecule 1 (CADM1), a member of the immunoglobulin superfamily, is identified as a novel cell surface marker for human T-cell leukemia virus (HTLV-1)-infected T cells. Adult T-cell leukemia/lymphoma (ATLL) is developed in HTLV-1-infected T-cells after a long infection period. To examine the mechanism of ...

journal_title：Scientific reports

authors： Sarkar B,Nishikata I,Nakahata S,Ichikawa T,Shiraga T,Saha HR,Fujii M,Tanaka Y,Shimoda K,Morishita K

更新日期：2019-03-05 00:00:00

abstract：:Viral upper respiratory tract infection (URTI) predisposes to bacterial pneumonia possibly by facilitating growth of bacteria such as Streptococcus pneumoniae colonising the nasopharynx. We investigated whether viral URTI is temporally associated with an increase in nasopharyngeal pneumococcal concentration. Episodes ...

journal_title：Scientific reports

authors： Morpeth SC,Munywoki P,Hammitt LL,Bett A,Bottomley C,Onyango CO,Murdoch DR,Nokes DJ,Scott JAG

更新日期：2018-07-23 00:00:00

abstract：:The precise clinicopathologic significance of myeloid differentiation primary response gene (MYD88) L265P mutation in diffuse large B-cell lymphomas (DLBCLs) remains elusive. To investigate the frequency and clinicopathologic significance of the MYD88 L265P mutation in DLBCLs, we conducted a meta-analysis of 40 publis...

journal_title：Scientific reports

authors： Lee JH,Jeong H,Choi JW,Oh H,Kim YS

更新日期：2017-05-11 00:00:00

abstract：:RNA protein interactions (RPI) play a pivotal role in the regulation of various biological processes. Experimental validation of RPI has been time-consuming, paving the way for computational prediction methods. The major limiting factor of these methods has been the accuracy and confidence of the predictions, and our ...

journal_title：Scientific reports

authors： Jain DS,Gupte SR,Aduri R

更新日期：2018-06-22 00:00:00

abstract：:Although the power conversion efficiency (PCE) of perovskite solar cells (PSCs) reached up to 23%, their short lifetime and fast degradation still remain as the main challenges. In this work, a new facile optical method based on the high power UV-irradiation is presented for the recovery of the degraded PSCs. Addition...

journal_title：Scientific reports

authors： Arabpour Roghabadi F,Mansour Rezaei Fumani N,Alidaei M,Ahmadi V,Sadrameli SM

更新日期：2019-07-01 00:00:00

abstract：:Cassava is an important staple crop in tropical and sub-tropical areas. As a common farming practice, cassava is usually cultivated intercropping with other crops and subjected to various degrees of shading, which causes reduced productivity. Herein, a comparative transcriptomic analysis was performed on a series of d...

journal_title：Scientific reports

authors： Ding Z,Zhang Y,Xiao Y,Liu F,Wang M,Zhu X,Liu P,Sun Q,Wang W,Peng M,Brutnell T,Li P

更新日期：2016-08-19 00:00:00

abstract：:Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by many loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, including N1303K. We previously introduced the concept of 'co-potentiators' (combination-potentiators) to rescu...

journal_title：Scientific reports

authors： Phuan PW,Tan JA,Rivera AA,Zlock L,Nielson DW,Finkbeiner WE,Haggie PM,Verkman AS

更新日期：2019-11-27 00:00:00

abstract：:Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana. The molecular bases for low affinity transport however remained unknown. Since IRT1 and NRAMP1 have a broad range of subst...

journal_title：Scientific reports

authors： Castaings L,Caquot A,Loubet S,Curie C

更新日期：2016-11-16 00:00:00

abstract：:A new bicentennial series of the Australian monsoon strength based on historical wind observations has allowed for the assessment of the variability of this system since the early 19th century. Our series covers a period in which the scarcity of meteorological observations in the area had precluded the evaluation of l...

journal_title：Scientific reports

authors： Gallego D,García-Herrera R,Peña-Ortiz C,Ribera P

更新日期：2017-11-23 00:00:00

abstract：:Sesame is prized for its oil. Genetic improvement of sesame can be enhanced through marker-assisted breeding. However, few simple sequence repeat (SSR) markers and SSR-based genetic maps were available in sesame. In this study, 7,357 SSR markers were developed from the sesame genome and transcriptomes, and a genetic m...

journal_title：Scientific reports

authors： Wang L,Zhang Y,Zhu X,Zhu X,Li D,Zhang X,Gao Y,Xiao G,Wei X,Zhang X

更新日期：2017-08-21 00:00:00

abstract：:The Coronavirus Disease 2019 (COVID-19) pandemic continues to have a devastating effect on the health and well-being of the global population. A critical step in the fight against COVID-19 is effective screening of infected patients, with one of the key screening approaches being radiology examination using chest radi...

journal_title：Scientific reports

authors： Wang L,Lin ZQ,Wong A

更新日期：2020-11-11 00:00:00

abstract：:Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy storing tendons are more elastic and extensible than positional tendons; behaviour provided by specialisation of the IFM to enable repeated interfascicular sliding and recoil. With ageing, the IFM becomes stiffer and less fatigu...

journal_title：Scientific reports

authors： Godinho MSC,Thorpe CT,Greenwald SE,Screen HRC

更新日期：2017-08-30 00:00:00

abstract：:We have previously demonstrated that the Thymus algeriensis and Thymus fontanesii extracts have powerful anti-inflammatory, antipyretic, and analgesic effects against acute pain models. We profiled their chemical composition and found many phenolic acids, flavonoids, and phenolic diterpenes. In this work, we investiga...

journal_title：Scientific reports

authors： Rezq S,Alsemeh AE,D'Elia L,El-Shazly AM,Monti DM,Sobeh M,Mahmoud MF

更新日期：2020-11-25 00:00:00

abstract：:Valproic acid (VPA) is a drug commonly used for epileptic seizure control. Recently, it has been shown that VPA alters the activation of several immune cells, including Natural Killer (NK) cells, which play an important role in the containment of viruses and intracellular bacteria. Although VPA can increase susceptibi...

journal_title：Scientific reports

authors： Soria-Castro R,Chávez-Blanco AD,García-Pérez BE,Wong-Baeza I,Flores-Mejía R,Flores-Borja F,Estrada-Parra S,Estrada-García I,Serafín-López J,Chacón-Salinas R

更新日期：2020-10-20 00:00:00

abstract：:Conventional solid lubricants such as MoS2, graphite, or diamond-like carbon films demonstrate excellent tribological performance but only in specific environments due to their inherent materials properties. This limitation prohibits using these solid lubricants in environments that change dynamically. This study pres...

journal_title：Scientific reports

authors： Ayyagari AV,Mutyala KC,Sumant AV

更新日期：2020-09-21 00:00:00

abstract：:Lon is an essential, multitasking AAA(+) protease regulating many cellular processes in species across all kingdoms of life. Altered expression levels of the human mitochondrial Lon protease (hLon) are linked to serious diseases including myopathies, paraplegia, and cancer. Here, we present the first 3D structure of f...

journal_title：Scientific reports

authors： Kereïche S,Kováčik L,Bednár J,Pevala V,Kunová N,Ondrovičová G,Bauer J,Ambro Ľ,Bellová J,Kutejová E,Raška I

更新日期：2016-09-16 00:00:00

abstract：:Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghrelin and related hypothalamic...

journal_title：Scientific reports

authors： Assadi MH,Shknevsky E,Segev Y,Tarasiuk A

更新日期：2017-06-02 00:00:00

abstract：:A synergetic approach of employing smooth mesoporous TiO2 microsphere (SμS-TiO2)-nanoparticulate TiO2 (np-TiO2) composite photoanode, and size and defect controlled CdSe quantum dots (QD) to achieve high efficiency (η) in a modified Grätzel solar cell, quantum dot sensitized whisperonic solar cells (QDSWSC), is report...

journal_title：Scientific reports

authors： Das TK,Ilaiyaraja P,Sudakar C

更新日期：2018-06-26 00:00:00

abstract：:All electronic, optoelectronic or photovoltaic applications of silicon depend on controlling majority charge carriers via doping with impurity atoms. Nanoscale silicon is omnipresent in fundamental research (quantum dots, nanowires) but also approached in future technology nodes of the microelectronics industry. In ge...

journal_title：Scientific reports

authors： König D,Hiller D,Gutsch S,Zacharias M,Smith S

更新日期：2017-04-20 00:00:00

abstract：:Quantum information technologies harness the intrinsic nature of quantum theory to beat the limitations of the classical methods for information processing and communication. Recently, the application of quantum features to metrology has attracted much attention. Quantum optical coherence tomography (QOCT), which util...

journal_title：Scientific reports

authors： Okano M,Lim HH,Okamoto R,Nishizawa N,Kurimura S,Takeuchi S

更新日期：2015-12-14 00:00:00

abstract：:microRNAs (miRNAs) are small double stranded RNA molecules consisting of two complementary strands called the 5p and 3p arms. Following imprecise processing and/or addition of nucleotides at the ends, miRNA biogenesis can give rise to variants called isomiRs. Exosomes are small vesicles released by cells. They have at...

journal_title：Scientific reports

authors： Karlsen TA,Aae TF,Brinchmann JE

更新日期：2019-12-27 00:00:00