Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport.

abstract：:This paper presents an ultracompact tunable device for power splitting and switching by tuning the Fermi energy level of monolayer patternless graphene underneath a slotted multimode interference (MMI) coupler operating in the mid-infrared, λ = 9-11 μm. By introducing a high-index silicon slot in the central region of...

journal_title：Scientific reports

authors： Huang CC,Sun TC

更新日期：2019-09-04 00:00:00

abstract：:Accumulating evidences have suggested the potential association between Int7G24A (rs334354) polymorphism and cancer risk. However, results from epidemiological studies are controversial. We thus conducted this meta-analysis to clarify the association. Relevant studies were identified on electronic databases according ...

journal_title：Scientific reports

authors： Wu W,Tong Y,Wei X,Zhao Q,Pan X,Yu G,Lu Q

更新日期：2015-06-15 00:00:00

abstract：:Ancestral stress can program stress sensitivity and health trajectories across multiple generations. While ancestral stress is uncontrollable to the filial generations, it is critical to identify therapies that overcome transgenerational programming. Here we report that prenatal stress in rats generates a transgenerat...

journal_title：Scientific reports

authors： McCreary JK,Erickson ZT,Hao Y,Ilnytskyy Y,Kovalchuk I,Metz GA

更新日期：2016-11-24 00:00:00

abstract：:DNA methylation on CpG sites is the most common epigenetic modification. Recently, methylation in a non-CpG context was found to occur widely on genomic DNA. Moreover, methylation of non-CpG sites is a highly controlled process, and its level may vary during cellular development. To study non-CpG methylation effects o...

journal_title：Scientific reports

authors： Jin J,Lian T,Gu C,Yu K,Gao YQ,Su XD

更新日期：2016-07-07 00:00:00

abstract：:Biomodels made of poly(vinyl alcohol) (PVA) are demanded because they can represent the geometries and mechanical properties of human tissues realistically. Injecting and molding, commonly used in three-dimensional (3D) modeling, help to represent the blood vessels accurately. However, these techniques sometimes requi...

journal_title：Scientific reports

authors： Shimizu Y,Tanabe T,Yoshida H,Kasuya M,Matsunaga T,Haga Y,Kurihara K,Ohta M

更新日期：2018-11-08 00:00:00

abstract：:New vaccine production technologies can significantly shorten the timelines for availability of a strain-specific vaccine in the event of an influenza pandemic. We sought to evaluate the potential benefits of early vaccination in reducing the clinical attack rate (CAR), taking into account the timing and speed of vacc...

journal_title：Scientific reports

authors： Champredon D,Laskowski M,Charland N,Moghadas SM

更新日期：2018-04-24 00:00:00

abstract：:Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially expressed genes (DEGs) were ann...

journal_title：Scientific reports

authors： Pérez-Valencia JA,Prosdocimi F,Cesari IM,da Costa IR,Furtado C,Agostini M,Rumjanek FD

更新日期：2018-01-31 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ashokkumar M,Sonawane A,Sperk M,Tripathy SP,Neogi U,Hanna LE

更新日期：2020-08-10 00:00:00

abstract：:The Hurst effect plays an important role in many areas such as physics, climate and finance. It describes the anomalous growth of range and constrains the behavior and predictability of these systems. The Hurst effect is frequently taken to be synonymous with Long-Range Dependence (LRD) and is typically assumed to be ...

journal_title：Scientific reports

authors： Franzke CL,Osprey SM,Davini P,Watkins NW

更新日期：2015-03-13 00:00:00

abstract：:Cellular therapies for liver diseases and in vitro models for drug testing both require functional human hepatocytes (Hum-H), which have unfortunately been limited due to the paucity of donor liver tissues. Human pluripotent stem cells (hPSCs) represent a promising and potentially unlimited cell source to derive Hum-H...

journal_title：Scientific reports

authors： Song W,Lu YC,Frankel AS,An D,Schwartz RE,Ma M

更新日期：2015-11-23 00:00:00

abstract：:The emergence of metallic conduction in layered dichalcogenide semiconductor materials by chemical doping is one of key issues for two-dimensional (2D) materials engineering. At present, doping methods for layered dichalcogenide materials have been limited to an ion intercalation between layer units or electrostatic c...

journal_title：Scientific reports

authors： Kim SI,Hwang S,Kim SY,Lee WJ,Jung DW,Moon KS,Park HJ,Cho YJ,Cho YH,Kim JH,Yun DJ,Lee KH,Han IT,Lee K,Sohn Y

更新日期：2016-01-21 00:00:00

abstract：:An important safety concern on cell-based gene therapy is that few methods have been available to control the proliferation and functioning of therapeutic protein-expressing cells after transplantation. We previously reported that the proliferation and functioning of the cells transfected with herpes simplex virus thy...

journal_title：Scientific reports

authors： Tsujimura M,Kusamori K,Katsumi H,Sakane T,Yamamoto A,Nishikawa M

更新日期：2019-12-11 00:00:00

abstract：:Particle shape plays a crucial role in determining packing characteristics. Real particles in nature usually have rounded corners. In this work, we systematically investigate the rounded corner effect on the dense packings of spherotetrahedral particles. The evolution of dense packing structure as the particle shape c...

journal_title：Scientific reports

authors： Jin W,Lu P,Li S

更新日期：2015-10-22 00:00:00

abstract：:Deep venous thrombosis (DVT) is a common complication of orthopedic surgery. Genetic risk factors and high heritability carried a substantial risk of DVT. In this study, we aimed to investigate the potential association in the Han Chinese population between the polymorphisms of BDKRB2 and KNG1 and DVT after orthopedic...

journal_title：Scientific reports

authors： Wang Q,Cheng G,Wang X,Wang D,Yang Y,Chen K,Ye J,Qing Z

更新日期：2018-11-26 00:00:00

abstract：:Tin selenide has attracted much research interest due to its unprecedentedly high thermoelectric figure of merit (ZT). For real applications, it is desirable to increase the ZT value in the lower-temperature range, as the peak ZT value currently exists near the melting point. It is shown in this paper that the structu...

journal_title：Scientific reports

authors： Yu H,Dai S,Chen Y

更新日期：2016-05-19 00:00:00

abstract：:We quantitatively evaluated breast tumor movement and volume changes between magnetic resonance imaging (MRI) scans in prone and supine positions. Twenty-seven breast tumor patients who received neoadjuvant systemic therapy (NST) for breast-conserving surgery were studied. Before and after NST, MRI scans in prone and ...

journal_title：Scientific reports

authors： Wang CB,Lee S,Kim T,Hong D,Kim GB,Yoon GY,Kim HH,Kim N,Ko B

更新日期：2020-03-17 00:00:00

abstract：:Many studies have now consistently reported that the phase angle of ongoing oscillatory activity (measured using EEG/MEG), at time of stimulus presentation influences detection when stimuli are near-threshold. However, studies examining whether the adjustment of the phase angle of oscillations is under top-down attent...

journal_title：Scientific reports

authors： van Diepen RM,Mazaheri A

更新日期：2018-02-14 00:00:00

abstract：:Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encoura...

journal_title：Scientific reports

authors： Mangraviti A,Raghavan T,Volpin F,Skuli N,Gullotti D,Zhou J,Asnaghi L,Sankey E,Liu A,Wang Y,Lee DH,Gorelick N,Serra R,Peters M,Schriefer D,Delaspre F,Rodriguez FJ,Eberhart CG,Brem H,Olivi A,Tyler B

更新日期：2017-11-02 00:00:00

abstract：:Although pneumococcal infection is a serious problem worldwide and has a high mortality rate, the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive. Here, we show that BLT2, a G protein-coupled receptor for leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid (12-HHT), protects mice...

journal_title：Scientific reports

authors： Shigematsu M,Koga T,Ishimori A,Saeki K,Ishii Y,Taketomi Y,Ohba M,Jo-Watanabe A,Okuno T,Harada N,Harayama T,Shindou H,Li JD,Murakami M,Hoka S,Yokomizo T

更新日期：2016-10-05 00:00:00

abstract：:Nuclear factor κB (NF-κB) plays an essential role in regulation of innate immunity. In mammals, NF-κB factors can form homodimers and heterodimers to activate gene expression. In insects, three NF-κB factors, Dorsal, Dif and Relish, have been identified to activate antimicrobial peptide (AMP) gene expression. However,...

journal_title：Scientific reports

authors： Zhong X,Rao XJ,Yi HY,Lin XY,Huang XH,Yu XQ

更新日期：2016-02-05 00:00:00

abstract：:Cell competition is a cell-cell interaction by which a cell compares its fitness to that of neighboring cells. The cell with the relatively lower fitness level is the "loser" and actively eliminated, while the cell with the relatively higher fitness level is the "winner" and survives. Recent studies have shown that ce...

journal_title：Scientific reports

authors： Chiba T,Ishihara E,Miyamura N,Narumi R,Kajita M,Fujita Y,Suzuki A,Ogawa Y,Nishina H

更新日期：2016-06-21 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common liver cancer, with a very poor prognosis. There is an urgent need for an effective therapy for HCC. Ginsenoside Rh2 (GRh2) has been shown to significantly inhibit growth of some types of cancer, whereas its effects on HCC have not been examined. Here, we treated human ...

journal_title：Scientific reports

authors： Yang Z,Zhao T,Liu H,Zhang L

更新日期：2016-01-19 00:00:00

abstract：:Obesity is a major cause of type 2 diabetes mellitus (T2DM) in mammals. We have previously established a zebrafish model of diet-induced obesity (DIO zebrafish) by overfeeding Artemia. Here we created DIO zebrafish using a different method to induce T2DM. Zebrafish were overfed a commercially available fish food using...

journal_title：Scientific reports

authors： Zang L,Shimada Y,Nishimura N

更新日期：2017-05-03 00:00:00

abstract：:Neuropsychological assessment of human visual processing capabilities strongly depends on visual testing conditions including room lighting, stimuli, and viewing-distance. This limits standardization, threatens reliability, and prevents the assessment of core visual functions such as visual processing speed. Increasin...

journal_title：Scientific reports

authors： Foerster RM,Poth CH,Behler C,Botsch M,Schneider WX

更新日期：2016-11-21 00:00:00

abstract：:YPEL3 that induces cellular senescence in both normal and tumour cells of humans may show altered expression under the influence of incidental mutations. In this study, we proposed the first structure of Native YPEL3 protein and its five possible deleterious mutants-V40M, C61Y, G98R, G108S, and A131T and predicted the...

journal_title：Scientific reports

authors： Singh A,Thakur M,Singh SK,Sharma LK,Chandra K

更新日期：2020-09-17 00:00:00

abstract：:Fiber lasers with flexible spectral manipulation property could provide a flexible tool for scenes where the temporal coherence property accounts, for example, coherent sensing/communication and nonlinear frequency conversion. Due to the good laser performance and relative simplicity of implementation, random fiber la...

journal_title：Scientific reports

authors： Ye J,Xu J,Song J,Wu H,Zhang H,Wu J,Zhou P

更新日期：2018-02-01 00:00:00

abstract：:Although there is evidence that non-steroidal anti-inflammatory drugs (NSAIDs) might be able to prevent pancreatic cancer, the findings from epidemiological studies have been inconsistent. In this paper, we conducted a meta-analysis of observational studies to examine this possibility. We searched PubMed and Embase fo...

journal_title：Scientific reports

authors： Zhang YP,Wan YD,Sun YL,Li J,Zhu RT

更新日期：2015-10-21 00:00:00

abstract：:This study for the first time examined the prophylactic role of Tungrymbai, a well-known fermented soybean food of North-East India, against hepatic steatosis. Treatment with hexane-isopropanolic (2:1, HIET) but not hydro-alcoholic (70% ethanol, HAET) extract dose-dependently (0.1, 0.2, or 0.3 µg/mL) reduced the intra...

journal_title：Scientific reports

authors： Dihingia A,Bordoloi J,Dutta P,Kalita J,Manna P

更新日期：2018-07-03 00:00:00

abstract：:Adverse maternal environments, such as diabetes and obesity, impair placental mitochondrial function, which affects fetal development and offspring long-term health. The underlying mechanisms and effective interventions to abrogate such effect remain unclear. Our previous studies demonstrated impaired mitochondrial bi...

journal_title：Scientific reports

authors： Jiang S,Teague AM,Tryggestad JB,Jensen ME,Chernausek SD

更新日期：2020-05-20 00:00:00

abstract：:We report a new family with autosomal dominant inheritance of a late onset rapidly progressive leukodystrophy in which exome sequencing has revealed a novel mutation p.R782G in the Colony-Stimulating Factor 1 Receptor gene (CSF1R). Neuropathology of two affected family members showed cerebral white matter degeneration...

journal_title：Scientific reports

authors： Foulds N,Pengelly RJ,Hammans SR,Nicoll JA,Ellison DW,Ditchfield A,Beck S,Ennis S

更新日期：2015-05-15 00:00:00