Engraftment of human induced pluripotent stem cell-derived hepatocytes in immunocompetent mice via 3D co-aggregation and encapsulation.

abstract：:An important safety concern on cell-based gene therapy is that few methods have been available to control the proliferation and functioning of therapeutic protein-expressing cells after transplantation. We previously reported that the proliferation and functioning of the cells transfected with herpes simplex virus thy...

journal_title：Scientific reports

authors： Tsujimura M,Kusamori K,Katsumi H,Sakane T,Yamamoto A,Nishikawa M

更新日期：2019-12-11 00:00:00

abstract：:Few-layered transition metal dichalcogenides (TMDs) are known as true two-dimensional materials, with excellent semiconducting properties and strong light-matter interaction. Thus, TMDs are attractive materials for semitransparent and flexible solar cells for use in various applications. Hoewver, despite the recent pr...

journal_title：Scientific reports

authors： Akama T,Okita W,Nagai R,Li C,Kaneko T,Kato T

更新日期：2017-09-20 00:00:00

abstract：:Three kinds of Al-TiO2 samples and pure TiO2 samples were synthesized via a modified polyacrylamide gel route using different aluminum salts, including Al2(SO4)3∙18H2O, AlCl3, and Al(NO3)3∙9H2O under identical conditions. The influence of different aluminum salts on the phase purity, morphologies, thermal stability of...

journal_title：Scientific reports

authors： Luo JL,Wang SF,Liu W,Tian CX,Wu JW,Zu XT,Zhou WL,Yuan XD,Xiang X

更新日期：2017-08-14 00:00:00

abstract：:ZnO/SiC heterojunctions show great potential for various optoelectronic applications (e.g., ultraviolet light emitting diodes, photodetectors, and solar cells). However, the lack of a detailed understanding of the ZnO/SiC interface prevents an efficient and rapid optimization of these devices. Here, intrinsic (but inh...

journal_title：Scientific reports

authors： Zhang Y,Lin N,Li Y,Wang X,Wang H,Kang J,Wilks R,Bär M,Mu R

更新日期：2016-03-15 00:00:00

abstract：:Derangement in bone mineral density (BMD) caused by glucocorticoid is well-known. The present study aimed to find key biological pathways associated with low BMD after glucocorticoid treatment in asthmatics using gene expression profiles of peripheral blood cells. We utilized immortalized B cells (IBCs) from 32 childh...

journal_title：Scientific reports

authors： Lee SY,Won HK,Kim BK,Kim SH,Chang YS,Cho SH,Kelly HW,Tantisira KG,Park HW

更新日期：2019-12-27 00:00:00

abstract：:Tumor oxygenation has been correlated with treatment outcome for radiotherapy. In this work, the dependence of tumor oxygenation on tumor vascularity and blood oxygenation was determined quantitatively in a 4D stochastic computational model of head and neck squamous cell carcinoma (HNSCC) tumor growth and angiogenesis...

journal_title：Scientific reports

authors： Forster JC,Douglass MJJ,Harriss-Phillips WM,Bezak E

更新日期：2017-09-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ahmad MN,Karim NU,Normaya E,Piah BM,Iqbal A,Bulat KHK

更新日期：2020-11-05 00:00:00

abstract：:Comparable taxonomic ranks within clades can facilitate more consistent classifications and objective comparisons among taxa. Here we use a temporal approach to identify taxonomic ranks. This is an extension of the temporal banding approach including a Temporal Error Score that finds an objective cut-off for each taxo...

journal_title：Scientific reports

authors： Kraichak E,Crespo A,Divakar PK,Leavitt SD,Lumbsch HT

更新日期：2017-05-23 00:00:00

abstract：:Transparent heaters have attracted increasing attention for their usefulness in vehicle windows, outdoor displays, and periscopes. We present high performance transparent heaters based on Ag nanowires with electron beam irradiation. We obtained an Ag-nanowire thin film with 48 ohm/sq of sheet resistance and 88.8% (sub...

journal_title：Scientific reports

authors： Hong CH,Oh SK,Kim TK,Cha YJ,Kwak JS,Shin JH,Ju BK,Cheong WS

更新日期：2015-12-07 00:00:00

abstract：:In this paper, we propose a strategy for the control of mobile chaotic oscillators by adaptively rewiring connections between nearby agents with local information. In contrast to the dominant adaptive control schemes where coupling strength is adjusted continuously according to the states of the oscillators, our metho...

journal_title：Scientific reports

authors： Zhou J,Zou Y,Guan S,Liu Z,Xiao G,Boccaletti S

更新日期：2017-11-22 00:00:00

abstract：:Diagnostic testing often assesses the cardiovascular or respiratory systems in isolation, ignoring the major pathophysiologic interactions between the systems in many diseases. When both systems are assessed currently, multiple modalities are utilized in costly fashion with burdensome logistics and decreased accessibi...

journal_title：Scientific reports

authors： Cheng JY,Zhang T,Alley MT,Uecker M,Lustig M,Pauly JM,Vasanawala SS

更新日期：2017-07-13 00:00:00

abstract：:There is a growing desire to integrate the food requirements of predators living in marine ecosystems impacted by humans into sustainable fisheries management. We used non-invasive video-recording, photography and focal observations to build time-energy budget models and to directly estimate the fish mass delivered to...

journal_title：Scientific reports

authors： Gaglio D,Sherley RB,Ryan PG,Cook TR

更新日期：2018-05-29 00:00:00

abstract：:The applications of machine learning/deep learning (ML/DL) methods in meteorology have developed considerably in recent years. Massive amounts of meteorological data are conducive to improving the training effect and model performance of ML/DL, but the establishment of training datasets is often time consuming, especi...

journal_title：Scientific reports

authors： Lu C,Kong Y,Guan Z

更新日期：2020-09-14 00:00:00

abstract：:Serotonin 5-HT2C receptor is a G-protein coupled excitatory receptor that regulates several biochemical pathways and has been implicated in obesity, mental state, sleep cycles, autism, neuropsychiatric disorders and neurodegenerative diseases. The activity of 5-HT2CR is regulated via alternative splicing and A to I ed...

journal_title：Scientific reports

authors： Raabe CA,Voss R,Kummerfeld DM,Brosius J,Galiveti CR,Wolters A,Seggewiss J,Huge A,Skryabin BV,Rozhdestvensky TS

更新日期：2019-03-12 00:00:00

abstract：:Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects...

journal_title：Scientific reports

authors： Mahbub MH,Yamaguchi N,Takahashi H,Hase R,Ishimaru Y,Sunagawa H,Amano H,Kobayashi-Miura M,Kanda H,Fujita Y,Yamamoto H,Yamamoto M,Kikuchi S,Ikeda A,Kageyama N,Nakamura M,Tanabe T

更新日期：2017-12-15 00:00:00

abstract：:The formation and motion features of self interstitial atom (SIA) clusters in tungsten are studied by molecular dynamics (MD) simulations. The static calculations show that the SIA clusters are stable with binding energy over 2 eV. The SIA clusters exhibit a fast one dimensional (1D) motion along 〈111〉. Through analys...

journal_title：Scientific reports

authors： Zhou WH,Zhang CG,Li YG,Zeng Z

更新日期：2014-05-28 00:00:00

abstract：:The impact of environment on individuals is particularly critical. In evolutionary games, adopting the strategy of the neighbor who performs better is nontrivial for the survival and maintenance of cooperation, in that such an action may help the agents to obtain higher benefit and more obvious evolutionary advantages...

journal_title：Scientific reports

authors： Wu Y,Zhang S,Zhang Z

更新日期：2018-10-23 00:00:00

abstract：:Little research on coronaviruses has been conducted on wild animals in Africa. Here, we screened a wide range of wild animals collected in six provinces and five caves of Gabon between 2009 and 2015. We collected a total of 1867 animal samples (cave-dwelling bats, rodents, non-human primates and other wild animals). W...

journal_title：Scientific reports

authors： Maganga GD,Pinto A,Mombo IM,Madjitobaye M,Mbeang Beyeme AM,Boundenga L,Ar Gouilh M,N'Dilimabaka N,Drexler JF,Drosten C,Leroy EM

更新日期：2020-04-30 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Choi S,Rogers DJ,Sandana EV,Bove P,Teherani FH,Nenstiel C,Hoffmann A,McClintock R,Razeghi M,Look D,Gentle A,Phillips MR,Ton-That C

更新日期：2017-11-16 00:00:00

abstract：:Plasmonic metamaterials have overcome fundamental limitations in conventional optics by their capability to engineer material resonances and dispersions at will, holding great promise for sensing applications. Recent demonstrations of metamaterial sensors, however, have mainly relied on their resonant nature for stron...

journal_title：Scientific reports

authors： Ishikawa A,Hara S,Tanaka T,Hayashi Y,Tsuruta K

更新日期：2017-06-09 00:00:00

abstract：:E-mail has become the main carrier of spreading malicious software and been widely used for phishing, even high-level persistent threats. The e-mail accounts with high social reputation are primary targets to be attacked and utilized by attackers, suffering a lot of probing attacks for a long time. In this paper, in o...

journal_title：Scientific reports

authors： Wen Y,Chen X,Zeng X,Wang W

更新日期：2020-04-29 00:00:00

abstract：:Abscisic acid (ABA) is a phytohormone that is necessary for stress adaptation. Recent studies have reported that attenuated levels of ABA improved grain yield and seedling growth under low temperature in cereals. To improve plant growth under low temperature, we attempted to generate ABA-insensitive transgenic rice by...

journal_title：Scientific reports

authors： Endo A,Egawa C,Oohashi M,Meguro-Maoka A,Shimosaka E,Sato Y

更新日期：2018-08-17 00:00:00

abstract：:Rheumatoid Arthritis (RA) causes chronic inflammation of joints. The cytokines TNFα and IFNγ are central players in RA, however their source has not been fully elucidated. Natural Killer (NK) cells are best known for their role in elimination of viral-infected and transformed cells, and they secrete pro-inflammatory c...

journal_title：Scientific reports

authors： Yamin R,Berhani O,Peleg H,Aamar S,Stein N,Gamliel M,Hindi I,Scheiman-Elazary A,Gur C

更新日期：2019-02-04 00:00:00

abstract：:Chemotherapy is widely used in cancer treatments. However, non-specific distribution of chemotherapeutic agents to healthy tissues and normal cells in the human body always leads to adverse side effects and disappointing therapeutic outcomes. Therefore, the main aim of this study was to develop a targeted drug deliver...

journal_title：Scientific reports

authors： Gan BK,Rullah K,Yong CY,Ho KL,Omar AR,Alitheen NB,Tan WS

更新日期：2020-10-08 00:00:00

abstract：:Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs). USP45 is a ubiquitin specific protease about which little is known, aside from roles in DNA damage repair and differentiation of the vertebrate retina. Here, by ...

journal_title：Scientific reports

authors： Conte C,Griffis ER,Hickson I,Perez-Oliva AB

更新日期：2018-09-26 00:00:00

abstract：:Mammalian sperm are unable to fertilize the egg immediately after ejaculation. To gain fertilization competence, they need to undergo a series of modifications inside the female reproductive tract, known as capacitation. Capacitation involves several molecular events such as phosphorylation cascades, hyperpolarization...

journal_title：Scientific reports

authors： Ritagliati C,Luque GM,Stival C,Baro Graf C,Buffone MG,Krapf D

更新日期：2018-09-06 00:00:00

abstract：:Solitons are of fundamental importance in photonics due to applications in optical data transmission and also as a tool for investigating novel phenomena ranging from light generation at new frequencies and wave-trapping to rogue waves. Solitons are also moving scatterers: they generate refractive index perturbations ...

journal_title：Scientific reports

authors： Rubino E,Lotti A,Belgiorno F,Cacciatori SL,Couairon A,Leonhardt U,Faccio D

更新日期：2012-01-01 00:00:00

abstract：:The bacterial second messenger cyclic di-3',5'-guanosine monophosphate (c-di-GMP) is a key regulator of bacterial motility and virulence. As high levels of c-di-GMP are associated with the biofilm lifestyle, c-di-GMP hydrolysing phosphodiesterases (PDEs) have been identified as key targets to aid development of novel ...

journal_title：Scientific reports

authors： Bellini D,Horrell S,Hutchin A,Phippen CW,Strange RW,Cai Y,Wagner A,Webb JS,Tews I,Walsh MA

更新日期：2017-02-10 00:00:00

abstract：:Analyzing heart rate variability (HRV) in preterm infants can help track maturational changes and subclinical signatures of disease. We conducted an observational study to characterize the effect of demographic and cardiorespiratory factors on three features of HRV using a linear mixed-effects model. HRV-features were...

journal_title：Scientific reports

authors： Joshi R,Kommers D,Guo C,Bikker JW,Feijs L,van Pul C,Andriessen P

更新日期：2019-05-22 00:00:00

abstract：:Human fetuin-B plays a key physiological role in human fertility through its inhibitory action on ovastacin, a member of the astacin family of metallopeptidases. The inhibitor consists of tandem cystatin-like domains (CY1 and CY2), which are connected by a linker containing a "CPDCP-trunk" and followed by a C-terminal...

journal_title：Scientific reports

authors： Guevara T,Körschgen H,Cuppari A,Schmitz C,Kuske M,Yiallouros I,Floehr J,Jahnen-Dechent W,Stöcker W,Gomis-Rüth FX

更新日期：2019-10-11 00:00:00