Abstract：
:Chemotherapy is widely used in cancer treatments. However, non-specific distribution of chemotherapeutic agents to healthy tissues and normal cells in the human body always leads to adverse side effects and disappointing therapeutic outcomes. Therefore, the main aim of this study was to develop a targeted drug delivery system based on the hepatitis B virus-like nanoparticle (VLNP) for specific delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells expressing epithelial growth factor receptor (EGFR). 5-FA was synthesized from 5-fluorouracil (5-FU), and it was found to be less toxic than the latter in cancer cells expressing different levels of EGFR. The cytotoxicity of 5-FA increased significantly after being conjugated on the VLNP. A cell penetrating peptide (CPP) of EGFR was displayed on the VLNP via the nanoglue concept, for targeted delivery of 5-FA to A431, HT29 and HeLa cells. The results showed that the VLNP displaying the CPP and harboring 5-FA internalized the cancer cells and killed them in an EGFR-dependent manner. This study demonstrated that the VLNP can be used to deliver chemically modified 5-FU derivatives to cancer cells overexpressing EGFR, expanding the applications of the VLNP in targeted delivery of chemotherapeutic agents to cancer cells overexpressing this transmembrane receptor.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gan BK,Rullah K,Yong CY,Ho KL,Omar AR,Alitheen NB,Tan WSdoi
10.1038/s41598-020-73967-4subject
Has Abstractpub_date
2020-10-08 00:00:00pages
16867issue
1issn
2045-2322pii
10.1038/s41598-020-73967-4journal_volume
10pub_type
杂志文章abstract：:The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32350
更新日期：2016-08-30 00:00:00
abstract：:Covalent functionalisation of graphene is a continuously progressing field of research. The optical properties of such derivatives attract particular attention. In virtually all optical responses, however, an enhancement in peak intensity with increase of sp3 carbon content, and a vanishing of the peak position shift ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45165
更新日期：2017-03-27 00:00:00
abstract：:Seven new formyl phloroglucinol meroterpenoids (FPMs), namely eucalrobusones J-P (1-7), as well as three known ones (8-10) were isolated from the leaves of Eucalyptus robusta. Their structures were elucidated by spectroscopic data analysis, and their absolute configurations were determined by applications of the Snatz...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39815
更新日期：2016-12-22 00:00:00
abstract：:The gut microbiome is shaped and modified by the polymorphisms of microorganisms in the intestinal tract. Its composition shows strong individual specificity and may play a crucial role in the human digestive system and metabolism. Several factors can affect the composition of the gut microbiome, such as eating habits...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23075
更新日期：2016-03-15 00:00:00
abstract：:Recently, the first-order synchronization transition has been studied in systems of coupled phase oscillators. In this paper, we propose a framework to investigate the synchronization in the frequency-weighted Kuramoto model with all-to-all couplings. A rigorous mean-field analysis is implemented to predict the possib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21926
更新日期：2016-02-23 00:00:00
abstract：:Cesium (Cs) removal from nuclear liquid wastewater has become an emerging issue for safeguarding public health after the accident at the Fukushima Daiichi Nuclear Power Plant. A novel macrocyclic ligand of o-benzo-p-xylyl-22-crown-6-ether (OBPX22C6) was developed and successfully immobilized onto mesoporous silica for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19937
更新日期：2016-01-28 00:00:00
abstract：:Metabolic disorders in T2DM generate multiple sources of free radicals and oxidative stress that accelerate nonenzymatic degenerative protein modifications (DPMs) such as protein oxidation, disrupt redox signaling and physiological function, and remain a major risk factor for clinical diabetic vascular complications. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62341-z
更新日期：2020-04-15 00:00:00
abstract：:Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in hea...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-40343-w
更新日期：2019-03-06 00:00:00
abstract：:Fibroblast growth factor-21 (FGF21) is closely related to various metabolic and cardiovascular disorders. However, the direct targets and mechanisms linking FGF21 to blood pressure control and hypertension are still elusive. Here we demonstrated a novel regulatory function of FGF21 in the baroreflex afferent pathway (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29582
更新日期：2016-07-08 00:00:00
abstract：:Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is now a widely-used modality for glioblastoma (GBM) treatment. However, intratumoral heterogeneity of fluorescence intensity may reflect different onco-metabolic programs. Here, we investigated the metabolic mechanism underlying the heterogeneity of 5-AL...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12557-3
更新日期：2017-09-22 00:00:00
abstract：:To determine levels of change in risk factors for cardiovascular disease among people with and without a previous diagnosis of diabetes from 2007 to 2016 in Iran. Data were obtained from five rounds of the World Health Organization STEPwise approach to Surveillance (STEPS) cross-sectional surveys. Participants were 76...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-020-68640-9
更新日期：2020-07-16 00:00:00
abstract：:Channelrhodopsins are light-gated ion channels of green algae used for the precise temporal and spatial control of transmembrane ion fluxes. The channelrhodopsin Chrimson from Chlamydomonas noctigama allows unprecedented deep tissue penetration due to peak absorption at 590 nm. We demonstrate by electrophysiological r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09600-8
更新日期：2017-08-30 00:00:00
abstract：:Psychological and behavioural interventions may be effective in reducing menopause-related symptoms. This randomized controlled trial aimed to evaluate the effectiveness of Mindfulness-based Stress Reduction (MBSR) in reducing menopause-related symptoms by comparing with an active control group, the menopause educatio...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/s41598-018-24945-4
更新日期：2018-04-26 00:00:00
abstract：:Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several conformational changes, however the functional significance of these changes to cellular processes are largely unexplored. Here, we pre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19729
更新日期：2016-01-28 00:00:00
abstract：:In order to foster animal welfare as well as high quality of research, many countries regulate by law that the severity of animal experiments must be evaluated and considered when performing biomedical research. It is well accepted that multiple parameters rather than a single readout parameter should be applied to de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76391-w
更新日期：2020-11-13 00:00:00
abstract：:Surfaces with reversible wettability have broad applications but remain challenging since the switching process is usually energy intensive and complex. In this paper, a pyramid shaped Cu2S film with hierarchical micro/nanostructures is formed on a commercial copper mesh. This film is formed by a spontaneous redox sul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48952-1
更新日期：2019-08-28 00:00:00
abstract：:Heteroplasmy is the existence of more than one mitochondrial DNA (mtDNA) variant within a cell. The evolutionary mechanisms of heteroplasmy are not fully understood, despite being a very common phenomenon. Here we combined heteroplasmy measurements using high throughput sequencing on green turtles (Chelonia mydas) wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56918-6
更新日期：2020-01-14 00:00:00
abstract：:Infestation of phosphine (PH3) resistant insects threatens global grain reserves. PH3 fumigation controls rice weevil (Sitophilus oryzae) but not highly resistant insect pests. Here, we investigated naturally occurring strains of S. oryzae that were moderately resistant (MR), strongly resistant (SR), or susceptible (w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50972-w
更新日期：2019-10-10 00:00:00
abstract：:Enterovirus 71 (EV71) is a human pathogen that causes hand, foot, mouth disease and neurological complications. Although EV71, as well as other enteroviruses, initiates a remodeling of intracellular membrane for genomic replication, the regulatory mechanism remains elusive. By screening human cDNA library, we uncover ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44592
更新日期：2017-03-17 00:00:00
abstract：:Cattleyak are interspecific hybrids between cattle and yak, exhibiting the same prominent adaptability as yak and much higher performances than yak. However, male infertility of cattleyak resulted from spermatogenic arrest has greatly restricted their effective utilization in yak breeding. In past decades, much work h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18607-0
更新日期：2018-01-12 00:00:00
abstract：:Influenza A and B viruses cause seasonal flu epidemics. The M2 protein of influenza B (BM2) is a membrane-embedded tetrameric proton channel that is essential for the viral lifecycle. BM2 is a functional analog of AM2 but shares only 24% sequence identity for the transmembrane (TM) domain. The structure and function o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40217-1
更新日期：2019-03-06 00:00:00
abstract：:In recent decades Madagascar has experienced significant habitat loss and modification, with minimal understanding of how human land use practices have impacted the evolution of its flora and fauna. In light of ongoing and intensifying anthropogenic pressures, we seek new insight into mechanisms driving genetic variab...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52689-2
更新日期：2019-11-07 00:00:00
abstract：:Carbon nanotubes (CNTs) are among the most versatile nanomaterials, but their exploitation is hindered by limited dispersibility, especially in aqueous solvents. Here, we show that AP-LYS, a highly cationic soluble derivative of denatured hen egg lysozyme, is a very effective tool for the unbundling and solubilisation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52701-9
更新日期：2019-11-12 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62443-8
更新日期：2020-03-24 00:00:00
abstract：:Computational predictions of double gene knockout effects by flux balance analysis (FBA) have been used to characterized genome-wide patterns of epistasis in microorganisms. However, it is unclear how in silico predictions are related to in vivo epistasis, as FBA predicted only a minority of experimentally observed ge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47935-6
更新日期：2019-08-14 00:00:00
abstract：:FTY-720 (Fingolimod) was one of the first compounds authorized for the treatment of multiple sclerosis. Among its other activities, this sphingosine analogue enhances exocytosis in neuroendocrine chromaffin cells, altering the quantal release of catecholamines. Surprisingly, the size of chromaffin granules is reduced ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55106-w
更新日期：2019-12-05 00:00:00
abstract：:Zinc oxy-selenide Zn(O,Se) is a novel material, that can replace the toxic CdS buffer layer in thin film solar cells and other optoelectronic devices. In this paper a systematic study of the structural, optical and electrical properties of Zn(O,Se) layers, grown by pulsed laser deposition under 50 mTorr of nitrogen ba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54008-1
更新日期：2019-11-25 00:00:00
abstract：:The mechanism by which chronic metabolic acidosis (CMA) regulates sodium (Na(+))-chloride (Cl(-)) cotransporter (NCC) in the renal distal convoluted tubules remains unexplored. We examined the role of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and with-no-lysine kinase 4 (WNK4) on expression of NCC in mouse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18360
更新日期：2016-01-05 00:00:00
abstract：:The Coronavirus Disease 2019 (COVID-19) pandemic continues to have a devastating effect on the health and well-being of the global population. A critical step in the fight against COVID-19 is effective screening of infected patients, with one of the key screening approaches being radiology examination using chest radi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76550-z
更新日期：2020-11-11 00:00:00
abstract：:We report a theoretical and experimental study of the aggregation kinetics of oppositely charged nanoparticles. Kinetic Monte Carlo simulations are performed for symmetric, charge-asymmetric and size-asymmetric systems of oppositely charged nanoparticles. Simulation results show that both the weight and number average...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40379-y
更新日期：2019-03-06 00:00:00
