Abstract:
:Plasmonic metamaterials have overcome fundamental limitations in conventional optics by their capability to engineer material resonances and dispersions at will, holding great promise for sensing applications. Recent demonstrations of metamaterial sensors, however, have mainly relied on their resonant nature for strong optical interactions with molecules, but few examples fully exploit their functionality to manipulate the polarization of light. Here, we present cross-polarized surface-enhanced infrared absorption (SEIRA) by the Fano-resonant asymmetric metamaterial allowing for strong background suppression as well as significant field enhancement. The metamaterial is designed to exhibit the controlled Fano resonance with the cross-polarization conversion property at 1730 cm-1, which spectrally overlaps with the C=O vibrational mode. In the cross-polarized SEIRA measurement, the C=O mode of poly(methyl methacrylate) molecules is clearly observed as a distinct dip within a Fano-resonant transmission peak of the metamaterial. The vibrational signal contrast is then improved based on the cross-polarized detection scheme where only the light interacting with the metamaterial-molecular coupled system is detected by totally eliminating the unwanted background light. Our metamaterial approach achieves the zeptomole sensitivity with a large signal-to-noise ratio in the far-field measurement, paving the way toward the realization of ultrasensitive IR inspection technologies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ishikawa A,Hara S,Tanaka T,Hayashi Y,Tsuruta Kdoi
10.1038/s41598-017-03545-8subject
Has Abstractpub_date
2017-06-09 00:00:00pages
3205issue
1issn
2045-2322pii
10.1038/s41598-017-03545-8journal_volume
7pub_type
杂志文章abstract::Although autoantibody detection has been proposed for diagnosis of colorectal cancer, little is known about their initial production and development correlation with cancer progression. Azoxymethane/dextran sodium sulfate (AOM/DSS)-treated mice developed colon adenocarcinoma in the distal colon similar to human sporad...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02938
更新日期:2013-10-15 00:00:00
abstract::Controlling thickness and tightness of surface passivation shells is crucial for many applications of core-shell nanoparticles (NP). Usually, to determine shell thickness, core and core/shell particle are measured individually requiring the availability of both nanoobjects. This is often not fulfilled for functional n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77530-z
更新日期:2020-11-26 00:00:00
abstract::Three-dimensionally (3D) porous morphology of nanostructures can effectively improve their electrocatalytic activity and durability for various electrochemical reactions owing to big surface area and interconnected structure. Cyanogel, a jelly-like inorganic polymer, can be used to synthesize various three-dimensional...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07619
更新日期:2015-01-05 00:00:00
abstract::All-spin logic device (ASLD) has attracted increasing interests as one of the most promising post-CMOS device candidates, thanks to its low power, non-volatility and logic-in-memory structure. Here we investigate the key current-limiting factors and develop a physics-based model of ASLD through nano-magnet switching, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14905
更新日期:2015-10-09 00:00:00
abstract::This study shows that DKK-1, a member of the Dickkopf family and a regulator of the Wnt pathways, represents a novel target of statins which, through the inhibition of HMG-CoA reductase and of non-steroidal isoprenoid intermediates, exert extra-beneficial effect in preventing atherosclerosis beyond their effect on the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35119-7
更新日期:2018-11-12 00:00:00
abstract::Zinc is an essential trace element that plays an important role in differentiation of osteoblasts and bone modeling. This in vitro study aimed to evaluate the osteoblast differentiation of human dental pulp stem cells (DPSCs) on zinc-modified titanium (Zn-Ti) that releases zinc ions from its surface. Based on real-tim...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29462
更新日期:2016-07-08 00:00:00
abstract::The majority of individuals with Down syndrome (DS) do not exhibit accurate accommodation, with the aetiology of this deficit unknown. This study examines the mechanism underlying hypoaccommodation in DS by simultaneously investigating the 'near triad' - accommodation, vergence and pupillary response. An objective pho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20444
更新日期:2016-02-05 00:00:00
abstract::Metabolomics was applied to a C57BL/6N mouse model of chronic unpredictable mild stress (CMS). Such mice were treated with two antidepressants from different categories: fluoxetine and imipramine. Metabolic profiling of the hippocampus was performed using gas chromatography-mass spectrometry analysis on samples prepar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08890
更新日期:2015-03-09 00:00:00
abstract::In cytochrome c oxidase (CytcO) reduction of O2 to water is linked to uptake of eight protons from the negative side of the membrane: four are substrate protons used to form water and four are pumped across the membrane. In bacterial oxidases, the substrate protons are taken up through the K and the D proton pathways,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56648-9
更新日期:2019-12-27 00:00:00
abstract::Ubiquitous in nature, polyamines (PAs) are a class of low-molecular aliphatic amines critically involved in cell growth, survival and differentiation. The polycation behavior is validated as a successful strategy in delivery systems to enhance oligonucleotide loading and cellular uptake. In this study, the chemical fe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77957-4
更新日期:2020-12-03 00:00:00
abstract::Aging is accompanied by a decline in memory and other brain functions. Physical exercise may mitigate this decline through the modulation of factors participating in the crosstalk between skeletal muscle and the brain, such as neurotrophins and oxidative stress parameters. We aimed to determine whether long term exerc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40040-8
更新日期:2019-03-04 00:00:00
abstract::Next generation sequencing has disrupted genetic testing, allowing far more scope in the tests applied. The appropriate sections of the genome to be tested can now be readily selected, from single mutations to whole-genome sequencing. One product offering within this spectrum are focused exomes, targeting ~5,000 genes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60215-y
更新日期:2020-02-24 00:00:00
abstract::Extracellular vesicles are selectively enriched in RNA that has potential as disease biomarkers. To systemically characterize circulating extracellular RNA (exRNA) profiles, we performed RNA sequencing analysis on plasma extracellular vesicles derived from 50 healthy individuals and 142 cancer patients. Of ~12.6 milli...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19413
更新日期:2016-01-20 00:00:00
abstract:ABSTARCT:The relationship between chronic kidney disease (CKD), which is defined by declined estimated glomerular filtration rate (eGFR) and/or proteinuria, and asymptomatic intracranial arterial stenosis (ICAS) is largely unknown. We conducted a population-based, cross-sectional study by recruiting 5209 participants f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04549-0
更新日期:2017-07-04 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating from undifferentiated iPSCs contaminating the graft is a critical concern for clinical application. Here, we hypothesized that brentuximab vedotin, which target...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21923-8
更新日期:2018-02-27 00:00:00
abstract::We developed an optimized Dipheylthiocarbazone or Dithizone (DTZ) with improved physical and chemical properties to characterize human islets and insulin-producing cells differentiated from embryonic stem cells. Application of the newly formulated iDTZ (i stands for islet) over a range of temperatures, time intervals ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45678-y
更新日期:2019-06-26 00:00:00
abstract::Alzheimer's disease (AD) is a lethal progressive neurological disorder affecting the memory. Recently, US Food and Drug Administration mitigated the standard for drug approval, allowing symptomatic drugs that only improve cognitive deficits to be allowed to accelerate on to clinical trials. Our study focuses on taurin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07467
更新日期:2014-12-12 00:00:00
abstract::Impulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the inf...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35537-7
更新日期:2018-12-05 00:00:00
abstract::Biclustering algorithms, which aim to provide an effective and efficient way to analyze gene expression data by finding a group of genes with trend-preserving expression patterns under certain conditions, have been widely developed since Morgan et al. pioneered a work about partitioning a data matrix into submatrices ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23466
更新日期:2016-03-22 00:00:00
abstract::Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation is detectable in both brain and blood. We examined free mono-ubiquitin, ubiquitinated proteins, catalytic ubiquitination, and proteasome activities in frozen postmortem OFC tissue from 76 (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38490-1
更新日期:2019-02-19 00:00:00
abstract::Targeting epigenetic reader proteins by small molecule inhibitors represents a new therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although inhibitors targeting bromodomain protein 1 (BRD1) are in development, the function of BRD1 has hardly been studied. We investigated the therapeutic p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29127-w
更新日期:2018-07-24 00:00:00
abstract::Techniques that manipulate DNA, a biomolecule with electrical properties, are in demand in various medical fields. This study fabricated a nanochannel with a conductive/semi-conductive interface using focused ion beams (FIBs) and introduced a nanochip technology to freely align, attach, and detach lambda DNAs in the i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39444-3
更新日期:2019-02-26 00:00:00
abstract::The aim of this study was to evaluate the impact of lymph node status from neck dissection pathological specimens on the survival for isolated regional nodal recurrence or persistence after primary treatment of nasopharyngeal carcinoma. Through a retrospective cohort study performed in an academic tertiary referral ho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62625-4
更新日期:2020-03-27 00:00:00
abstract::Precision Medicine in Oncology requires tailoring of therapeutic strategies to individual cancer patients. Due to the limited quantity of tumor samples, this proves to be difficult, especially for early stage cancer patients whose tumors are small. In this study, we exploited a 2.4 × 2.4 centimeters polydimethylsiloxa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08831-z
更新日期:2017-08-22 00:00:00
abstract::This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabol...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/s41598-018-33843-8
更新日期:2018-10-31 00:00:00
abstract::We report an integrated system for accelerating assays with concentrators in a standard 12-well plate (ISAAC-12) and demonstrate its versatility for rapid detection of matrix metalloproteinase (MMP)-9 expression in the cell culture supernatant of breast cancer cell line MDA-MB-231 by accelerating the enzymatic reactio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29065-7
更新日期:2018-07-17 00:00:00
abstract::The bald eagle (Haliaeetus leucocephalus) once experienced near-extinction but has since rebounded. For decades, bald eagles near the Wisconsin River, USA, have experienced a lethal syndrome with characteristic clinical and pathological features but unknown etiology. Here, we describe a novel hepacivirus-like virus (F...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50580-8
更新日期:2019-10-18 00:00:00
abstract::Photosynthesis is sensitive to environmental stress and must be efficiently modulated in response to abiotic stress. However, the underlying mechanisms are not well understood. Here we report that ARABIDOPSIS THALIANA HOMEOBOX 17 (ATHB17), an Arabidopsis HD-Zip transcription factor, regulated the expression of a numbe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45492
更新日期:2017-03-30 00:00:00
abstract::Angiopoietin-like protein 8 (ANGPTL8) has a role in lipid metabolism, beta-cell proliferation and diabetes progression, however, the association between different variants in the ANGPTL8 gene and metabolic syndrome (MetS) components has not been studied widely especially in Arab ethnic groups. In this study, the assoc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63850-7
更新日期:2020-04-21 00:00:00
abstract::Congenital ptosis may be associated with abnormalities of visual development and function, including amblyopia, strabismus and refractive errors. However, the prevalence estimates of these abnormalities vary widely. We performed a systematic review and meta-analysis to estimate the prevalence of amblyopia, strabismus ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-26671-3
更新日期:2018-05-29 00:00:00