Inhibition promotes long-term potentiation at cerebellar excitatory synapses.

abstract：:Mesenchymal stem cells (MSCs) are highly plastic cells that are able to transdifferentiate or dedifferentiate under appropriate conditions. In the present study, we reported here that after in vitro induction of osteogenic differentiation, MSCs could be reverted to a primitive stem cell population (dedifferentiated os...

journal_title：Scientific reports

authors： Rui Y,Xu L,Chen R,Zhang T,Lin S,Hou Y,Liu Y,Meng F,Liu Z,Ni M,Tsang KS,Yang F,Wang C,Chan HC,Jiang X,Li G

更新日期：2015-06-08 00:00:00

abstract：:Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role ...

journal_title：Scientific reports

authors： Chang WM,Lin YF,Su CY,Peng HY,Chang YC,Hsiao JR,Chen CL,Chang JY,Shieh YS,Hsiao M,Shiah SG

更新日期：2017-01-25 00:00:00

abstract：:Drought is one of the major impediments in wheat productivity. Traditional breeding and marker assisted QTL introgression had limited success. Available wheat genomic and RNA-seq data can decipher novel drought tolerance mechanisms with putative candidate gene and marker discovery. Drought is first sensed by root tiss...

journal_title：Scientific reports

authors： Iquebal MA,Sharma P,Jasrotia RS,Jaiswal S,Kaur A,Saroha M,Angadi UB,Sheoran S,Singh R,Singh GP,Rai A,Tiwari R,Kumar D

更新日期：2019-09-26 00:00:00

abstract：:The Na+;HCO3- co-transporter NBCn1 (SLC4A7) is a major regulator of intracellular pH yet its trafficking and turnover are essentially unstudied. Here, we used MDCK-II and MCF-7 cells to investigate these processes in epithelial cells. GFP-NBCn1 membrane localization was abolished by truncation of the full NBCn1 C-term...

journal_title：Scientific reports

authors： Olesen CW,Vogensen J,Axholm I,Severin M,Schnipper J,Pedersen IS,von Stemann JH,Schrøder JM,Christensen DP,Pedersen SF

更新日期：2018-05-09 00:00:00

abstract：:In this study, we have employed graphene oxide as a matrix to simultaneously and directly quantify serum nonesterified and esterified fatty acids (FAs) using matrix-assisted laser/desorption ionization-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS). Twelve serum nonesterified FAs combined...

journal_title：Scientific reports

authors： Ren J,Zhang D,Liu Y,Zhang R,Fang H,Guo S,Zhou D,Zhang M,Xu Y,Qiu L,Li Z

更新日期：2016-09-30 00:00:00

abstract：:Activating transcription factor 4 (ATF4) is constitutively expressed in a variety of tissues, and regulates several pathological features associated with metabolic diseases such as non-alcoholic fatty liver diseases (NAFLD) and obesity. However, the role of ATF4 in animal model systems is poorly understood. To investi...

journal_title：Scientific reports

authors： Yeh KY,Lai CY,Lin CY,Hsu CC,Lo CP,Her GM

更新日期：2017-11-27 00:00:00

abstract：:Chronic lymphocytic leukaemia (CLL) is characterised by a heterogeneous clinical course. Such heterogeneity is associated with a number of markers, including TP53 gene inactivation. While TP53 gene alterations determine resistance to chemotherapy, it is not clear whether they can influence early disease progression. T...

journal_title：Scientific reports

authors： Monti P,Lionetti M,De Luca G,Menichini P,Recchia AG,Matis S,Colombo M,Fabris S,Speciale A,Barbieri M,Gentile M,Zupo S,Dono M,Ibatici A,Neri A,Ferrarini M,Fais F,Fronza G,Cutrona G,Morabito F

更新日期：2020-10-28 00:00:00

abstract：:In this study, we demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function. Presently, skeletal muscle disease and dysfunction at the sarcomere level has been associated with mutatio...

journal_title：Scientific reports

authors： Ow JR,Palanichamy Kala M,Rao VK,Choi MH,Bharathy N,Taneja R

更新日期：2016-09-26 00:00:00

abstract：:Global climate change (GCC) can negatively affect freshwater ecosystems. However, the degree to which freshwater populations can acclimate to long-term warming and the underlying molecular mechanisms are not yet fully understood. We used the cooling water discharge (CWD) area of a power plant as a model for long-term ...

journal_title：Scientific reports

authors： Falfushynska HI,Phan T,Sokolova IM

更新日期：2016-12-20 00:00:00

abstract：:Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in bra...

journal_title：Scientific reports

authors： Brücken A,Bleilevens C,Berger P,Nolte K,Gaisa NT,Rossaint R,Marx G,Derwall M,Fries M

更新日期：2018-04-30 00:00:00

abstract：:Three dimensional single particle trapping and manipulation is an outstanding challenge in various fields ranging from basic physics to life sciences. By monitoring the response of a trapped particle to a designed environment one can extract its characteristics. In addition, quantum dynamics of a spatially scanned wel...

journal_title：Scientific reports

authors： Kayci M,Radenovic A

更新日期：2015-11-12 00:00:00

abstract：:Diet composition impacts metabolic and cardiovascular health with high caloric diets contributing to obesity related disorders. Dietary interventions such as caloric restriction exert beneficial effects in the cardiovascular system, but alteration of which specific nutrient is responsible is less clear. This study inv...

journal_title：Scientific reports

authors： Hennig M,Ewering L,Pyschny S,Shimoyama S,Olecka M,Ewald D,Magarin M,Uebing A,Thierfelder L,Jux C,Drenckhahn JD

更新日期：2019-10-22 00:00:00

abstract：:The CRISPR/Cas9 system is a powerful method of editing genes by randomly introducing errors into the target sites. Here, we describe a CRISPR-based test for gene essentiality (CRISPR-E test) that allows the identification of essential genes. Specifically, we use sgRNA-mediated CRISPR/Cas9 to target the open reading fr...

journal_title：Scientific reports

authors： You Y,Ramachandra SG,Jin T

更新日期：2020-09-08 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are vital for diverse biological functions, including vision, smell, and aging. They are involved in a wide range of diseases, and are among the most important targets of medicinal drugs. Tools that facilitate GPCR studies or GPCR-based technologies or therapies are thus critical to...

journal_title：Scientific reports

authors： Tegler L,Corin K,Pick H,Brookes J,Skuhersky M,Vogel H,Zhang S

更新日期：2020-12-07 00:00:00

abstract：:Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...

journal_title：Scientific reports

authors： García AC,de Souza LG,Pereira MG,Castro RN,García-Mina JM,Zonta E,Lisboa FJ,Berbara RL

更新日期：2016-02-10 00:00:00

abstract：:The complete plastome sequences of six species were sequenced to better understand the evolutionary relationships and mutation patterns in the chloroplast genome of the genus Colobanthus. The length of the chloroplast genome sequences of C. acicularis, C. affinis, C. lycopodioides, C. nivicola, C. pulvinatus and C. su...

journal_title：Scientific reports

authors： Androsiuk P,Jastrzębski JP,Paukszto Ł,Makowczenko K,Okorski A,Pszczółkowska A,Chwedorzewska KJ,Górecki R,Giełwanowska I

更新日期：2020-07-13 00:00:00

abstract：:Virtual planning of open cranial vault reconstruction is used to simulate and define an pre-operative plan for craniosynostosis surgery. However, virtual planning techniques are subjective and dependent on the experience and preferences of the surgical team. To develop an objective automated 3D pre-operative planning ...

journal_title：Scientific reports

authors： Tolhuisen ML,de Jong GA,van Damme RJM,van der Heijden F,Delye HHK

更新日期：2018-02-20 00:00:00

abstract：:Unlike their wolf ancestors, dogs have unique social skills for communicating and cooperating with humans. Previously, significant heritabilities for human-directed social behaviors have been found in laboratory beagles. Here, a Genome-Wide Association Study identified two genomic regions associated with dog's human-d...

journal_title：Scientific reports

authors： Persson ME,Wright D,Roth LS,Batakis P,Jensen P

更新日期：2016-09-29 00:00:00

abstract：:Gold nanoparticles have particular properties distinct from those of bulk gold crystals, and such nanoparticles are used in various applications in optics, catalysis, and drug delivery. Many reports on microbial synthesis of gold nanoparticles have appeared. However, the molecular details (reduction and dispersion) of...

journal_title：Scientific reports

authors： Kikuchi F,Kato Y,Furihata K,Kogure T,Imura Y,Yoshimura E,Suzuki M

更新日期：2016-10-11 00:00:00

abstract：:The visual magnocellular system is thought to play a crucial role in learning to read. Here therefore, we examined whether magnocellular based training could improve reading in children with visual reading problems. The participants were 24 male primary school students aged between 9-11 (Mean = 9.76, SD = 0.59) with s...

journal_title：Scientific reports

authors： Ebrahimi L,Pouretemad H,Khatibi A,Stein J

更新日期：2019-02-04 00:00:00

abstract：:The acronymously named "ESKAPE" pathogens represent a group of bacteria that continue to pose a serious threat to human health, not only due to their propensity for repeated emergence, but also due to their ability to "eskape" antibiotic treatment. The evolution of multi-drug resistance in these pathogens alone has gr...

journal_title：Scientific reports

authors： Hubick S,Jayaraman A,McKeen A,Reid S,Alcorn J,Stavrinides J,Sterenberg BT

更新日期：2017-02-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Xu X,Zhao J,Wang M,Wang L,Yang J

更新日期：2020-02-06 00:00:00

abstract：:The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We foun...

journal_title：Scientific reports

authors： Liang Y,Zhu F,Zhang H,Chen D,Zhang X,Gao Q,Li Y

更新日期：2016-07-05 00:00:00

abstract：:The early detection of cognitive impairment or dementia is in the focus of current research as the amount of cognitively impaired individuals will rise intensely in the next decades due to aging population worldwide. Currently available diagnostic tools to detect mild cognitive impairment (MCI) or dementia are time-co...

journal_title：Scientific reports

authors： Müller S,Herde L,Preische O,Zeller A,Heymann P,Robens S,Elbing U,Laske C

更新日期：2019-03-05 00:00:00

abstract：:To assess the effectiveness of losartan 50 mg on post dialysis euvolemic hypertensive patients against standard antihypertensive pharmacotherapy. A multicentre, prospective, randomized, single-blind trial was conducted to assess the effect of losartan 50 mg every other day (EOD), once a morning (OM) among post-dialysi...

journal_title：Scientific reports

authors： Aftab RA,Khan AH,Adnan AS,Sulaiman SAS,Khan TM

更新日期：2016-12-06 00:00:00

abstract：:We introduce a setup which realises a tunable engineered environment for experiments in circuit quantum electrodynamics. We illustrate this concept with the specific example of a quantum bit, qubit, in a high-quality-factor cavity which is capacitively coupled to another cavity including a resistor. The temperature of...

journal_title：Scientific reports

authors： Jones PJ,Huhtamäki JA,Salmilehto J,Tan KY,Möttönen M

更新日期：2013-01-01 00:00:00

abstract：:Super-Planckian near-field radiative heat transfer allows effective heat transfer between a hot and a cold body to increase beyond the limits long known for black bodies. Until present, experimental techniques to measure the radiative heat flow relied on steady-state systems. Here, we present a dynamic measurement app...

journal_title：Scientific reports

authors： Lang S,Sharma G,Molesky S,Kränzien PU,Jalas T,Jacob Z,Petrov AY,Eich M

更新日期：2017-10-24 00:00:00

abstract：:Nicotinamide riboside (NR) is a newly discovered nicotinamide adenine dinucleotide (NAD+) precursor vitamin. A crystal form of NR chloride termed NIAGEN is generally recognized as safe (GRAS) for use in foods and the subject of two New Dietary Ingredient Notifications for use in dietary supplements. To evaluate the ki...

journal_title：Scientific reports

authors： Conze D,Brenner C,Kruger CL

更新日期：2019-07-05 00:00:00

abstract：:Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghrelin and related hypothalamic...

journal_title：Scientific reports

authors： Assadi MH,Shknevsky E,Segev Y,Tarasiuk A

更新日期：2017-06-02 00:00:00

abstract：:Environmental DNA (eDNA) metabarcoding has been used increasingly to assess biodiversity of aquatic vertebrates. However, there still remains to be developed a sampling design of eDNA metabarcoding that can ensure high detection rates of species with minimum total survey effort, especially for large-scale surveys of a...

journal_title：Scientific reports

authors： Sato H,Sogo Y,Doi H,Yamanaka H

更新日期：2017-11-01 00:00:00