Abstract:
:CD47 is overexpressed in many human cancers, its level positively correlates with tumor invasion and metastasis. However, it is largely unknown whether CD47 overexpression drives metastasis and how CD47 lead to tumor metastasis in non-small cell lung cancer (NSCLC). In this study, we analyzed NSCLC specimens and cell lines, and revealed that CD47 is expressed at a higher level than in tumor-free control samples. Furthermore, increased CD47 expression correlated with clinical staging, lymph node metastasis and distant metastasis. In order to understand the molecular mechanisms underlying CD47 functions, we applied both gain-of-function and loss-of-function approaches in cell lines. The siRNA-mediated downregulation of CD47 inhibited cell invasion and metastasis in vitro, while the overexpression of CD47 by plasmid transfection generated opposite effects. In vivo, CD47-specific shRNA significantly reduced tumor growth and metastasis. On the molecular level, the expression of CD47 correlated with that of Cdc42, both in cell lines and NSCLC specimens. The inhibition of Cdc42 attenuates the invasion and metastasis of CD47-overexpressing cells. These results indicate that Cdc42 is a downstream mediator of CD47-promoted metastasis. Our findings provide first evidence that CD47 is an adverse prognostic factor for disease progression and metastasis, and a promising therapeutic target for NSCLC.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhao H,Wang J,Kong X,Li E,Liu Y,Du X,Kang Z,Tang Y,Kuang Y,Yang Z,Zhou Y,Wang Qdoi
10.1038/srep29719subject
Has Abstractpub_date
2016-07-14 00:00:00pages
29719issn
2045-2322pii
srep29719journal_volume
6pub_type
杂志文章abstract::Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumor carrying poor prognosis and needing new treatment options. The aim of this study was to identify actionable gene mutations that can guide new personalized target-specific therapies in ITAC patients. A series of 48 tumor and 27 corresponding germline DNA s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80242-z
更新日期:2021-01-26 00:00:00
abstract::Across multiple taxa, population structure and dynamics depend on effective signalling between individuals. Among mammals, chemical communication is arguably the most important sense, underpinning mate choice, parental care, territoriality and even disease transmission. There is a growing body of evidence that odours ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12706-8
更新日期:2017-10-19 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-40320-3
更新日期:2019-03-12 00:00:00
abstract::In 2017-2019 a surge of Shispare Glacier, a former tributary of the once larger Hasanabad Glacier (Hunza region), dammed the proglacial river of Muchuhar Glacier, which formed an ice-dammed lake and generated a small Glacial Lake Outburst Flood (GLOF). Surge movement produced the highest recorded Karakoram glacier sur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61277-8
更新日期:2020-03-13 00:00:00
abstract::Strong hydrogen bonds such as F···H···F offer new strategies to fabricate molecular architectures exhibiting novel structures and properties. Along these lines and, to potentially realize hydrogen-bond mediated superexchange interactions in a frustrated material, we synthesized [H2F]2[Ni3F6(Fpy)12][SbF6]2 (Fpy = 3-flu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23054-6
更新日期:2018-03-16 00:00:00
abstract::Methylphenidate (MP) is the most prescribed psychostimulant for ADHD patients, with clinically demonstrated detrimental effects on bone quality, potentially leading to early onset osteoporosis and higher fracture risk. The underlying mechanism for the effects of MP on bone remains elusive. This study demonstrates that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19894-x
更新日期:2018-01-24 00:00:00
abstract::Although rare in the U.S., outbreaks due to Neisseria meningitidis do occur. Rapid, early outbreak detection is important for timely public health response. In this study, we characterized U.S. meningococcal isolates (N = 201) from 15 epidemiologically defined outbreaks (2009-2015) along with temporally and geographic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33622-5
更新日期:2018-10-25 00:00:00
abstract::Pyramidal neurons in the rodent hippocampus exhibit spatial tuning during spatial navigation, and they are reactivated in specific temporal order during sharp-wave ripples observed in quiet wakefulness or slow wave sleep. However, analyzing representations of sleep-associated hippocampal ensemble spike activity remain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32193
更新日期:2016-08-30 00:00:00
abstract::Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, espe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42922
更新日期:2017-02-20 00:00:00
abstract::Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but molecular mechanisms underlying anesthetic action remain debatable. We found that ELIC, a pLGIC from Erwinia chrysanthemi, can be functionally inhibited by isoflurane and other anesthetics. Structures of ELIC co-crystallized with iso...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13833
更新日期:2015-09-08 00:00:00
abstract::The proinflammatory cytokine Interleukin 17A (hereafter named IL-17A) or IL-17A producing cells are elevated in breast tumors environment and correlate with poor prognosis. Increased IL-17A is associated with ER(-) or triple negative tumors and reduced Disease Free Survival. However, the pathophysiological role of IL-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03456
更新日期:2013-12-09 00:00:00
abstract::Beta-glucans are a heterologous group of fibrous glucose polymers that are a major constituent of cell walls in Ascomycetes and Basidiomycetes fungi. Synthesis of β (1,3)- and (1,6)-glucans is coordinated with fungal cell growth and development, thus, is under tight genetic regulation. Here, we report that β-glucan sy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10199
更新日期:2015-05-11 00:00:00
abstract::One of the most exciting areas in lithium ion batteries is engineering structured silicon anodes. These new materials promise to lead the next generation of batteries with significantly higher reversible charge capacity than current technologies. One drawback of these materials is that their production involves costly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00795
更新日期:2012-01-01 00:00:00
abstract::Ethoxyquin was recently identified as a neuroprotective compound against toxic neuropathies and efficacy was demonstrated against paclitaxel-induced neurotoxicity in vivo. In this study we examined the efficacy of ethoxyquin in preventing neurotoxicity of cisplatin in rodent models of chemotherapy-induced peripheral n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28861
更新日期:2016-06-28 00:00:00
abstract::The metal-free nitrogen-doped graphitic-carbon@graphene (Ng-C@G) is prepared from a composite of polyaniline and graphene by a facile polymerization following by pyrolysis for electrochemical oxygen reduction reaction (ORR). Pyrolysis creates a sponge-like with ant-cave-architecture in the polyaniline derived nitrogen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68260-3
更新日期:2020-07-24 00:00:00
abstract::A comprehensive identification of sphingoid bases and ceramides in wild Cordyceps was performed by integrating a sequential chromatographic enrichment procedure and an UHPLC-ultrahigh definition-Q-TOF-MS based sphingolipidomic approach. A total of 43 sphingoid bases and 303 ceramides were identified from wild Cordycep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38641
更新日期:2016-12-14 00:00:00
abstract::The use of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) as a positron emission tomography (PET) tracer for brain tumor imaging might have some limitations because of the relatively low affinity for the L-type amino acid transporter 1 (LAT1). To assess the stereospecificity and evaluate the influence of aromatic ring m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40013-x
更新日期:2019-02-27 00:00:00
abstract::Recent studies have discovered an intriguing nonstationary relationship between El Ninõ-Southern Oscillation (ENSO) and the Western Pacific (WP) teleconnection pattern, one of the most prominent winter atmospheric circulation patterns in the North Pacific, with a regime-dependent interdecadal modulation of significant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27906-z
更新日期:2018-06-22 00:00:00
abstract::Ferromagnetism can occur in wide-band gap semiconductors as well as in carbon-based materials when specific defects are introduced. It is thus desirable to establish a direct relation between the defects and the resulting ferromagnetism. Here, we contribute to revealing the origin of defect-induced ferromagnetism usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08999
更新日期:2015-03-11 00:00:00
abstract::The integrity of the corticospinal tract (CST) is significantly affected following basal ganglia haemorrhage. We aimed to assess the local features of CST and to effectively predict motor function by diffusion characteristics of CST in patients with motor injury following acute haemorrhage in the acute basal ganglia r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73305-8
更新日期:2020-10-01 00:00:00
abstract::Energy storage devices that provide high specific power without compromising on specific energy are highly desirable for many electric-powered applications. Here, we demonstrate that polymer organic radical gel materials support fast bulk-redox charge storage, commensurate to surface double layer ion exchange at carbo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22194
更新日期:2016-02-26 00:00:00
abstract::Massive gully land consolidation projects, launched in China's Loess Plateau, aim to restore 2667 [Formula: see text] agricultural lands in total by consolidating 2026 highly eroded gullies. This effort represents a social engineering project where the economic development and livelihood of the farming families are cl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73910-7
更新日期:2020-10-09 00:00:00
abstract::Although TRAIL can directly induce cell death in some cancer cells, it appears that TRAIL resistance exists in many cancers. This study focuses on anti-cancer drugs for TRAIL-resistant head and neck cancer (HNC) to provide further progress toward effective cancer therapy. Results indicate in TRAIL-resistant HNC cells,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31039-8
更新日期:2018-08-21 00:00:00
abstract::Relying on an exact time evolution scheme, we identify a novel transient energy transfer phenomenon in an exactly-solvable quantum microscopic model consisting of a three-level system coupled to two non-Markovian zero-temperature bosonic baths through two separable quantum channels. The dynamics of this model can be s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15332
更新日期:2015-10-19 00:00:00
abstract::The interaction of light with biological tissues has been considered for various therapeutic applications. Light-induced neurite growth has the potential to be a clinically useful technique for neuron repair. However, most previous studies used either a large illumination area to accelerate overall neurite growth or e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54687-w
更新日期:2019-12-03 00:00:00
abstract::Pesticides are the main tactics for pest control because they reduce the pest population very fast and their efficiency does not depend on abiotic factors. However, the indiscriminate use of these substances can speed up the development of resistant populations and causing environmental contamination. Therefore, alter...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26043-x
更新日期:2018-05-16 00:00:00
abstract::Detection of sedimentary cycles is difficult in fine-grained or homogenous sediments but is a prerequisite for the interpretation of depositional environments. Here we use a new autocorrelation analysis to detect cycles in a homogenous sediment core, E602, from the northern shelf of the South China Sea. Autocorrelatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01653
更新日期:2013-01-01 00:00:00
abstract::Stemborers (Busseola fusca, Sesamia calamistis and Chilo partellus), the fall armyworm (Spodoptera frugiperda) and associated parasitoids constitute an interacting system in maize fields in Kenya. This work aims at developing and evaluating models that represent the evolution of those interactions by applying system t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79553-y
更新日期:2021-01-14 00:00:00
abstract::Conventional anatomically contoured plates do not adequately fit most tibiae. This emphasizes the need for a more thorough morphological study. Statistical shape models are promising tools to display anatomical variations within a population. Herein, we aim to provide a better insight into the anatomical variations of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44092-8
更新日期:2019-05-21 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-27850-y
更新日期:2018-06-22 00:00:00