当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Methylphenidate regulation of osteoclasts in a dose- and sex-dependent manner adversely affects skeletal mechanical integrity.

Methylphenidate regulation of osteoclasts in a dose- and sex-dependent manner adversely affects skeletal mechanical integrity.

Abstract：

:Methylphenidate (MP) is the most prescribed psychostimulant for ADHD patients, with clinically demonstrated detrimental effects on bone quality, potentially leading to early onset osteoporosis and higher fracture risk. The underlying mechanism for the effects of MP on bone remains elusive. This study demonstrates that sex- and dose-dependent effects of MP on bone quality and quantity are mediated by osteoclast activity. Four-week-old male and female rats were treated with low and high dose MP for 13 weeks. Bone quality and quantity were analyzed using microCT, mechanical testing, histomorphometry, and TRAP staining. Male and female rat bone marrow-derived osteoclasts were treated in a dose-dependent manner (0-1000 ng/ml) and osteoclast activity was determined at days 5, 7, and 14 using TRAP staining, as well as a pit formation assay at day 18. Animal studies showed a dose- and a sex-dependent decrease in mechanical integrity in femora and increased TRAP staining in MP-treated rats. Primary cultures revealed that MP had direct dose- and sex-dependent effects on osteoclast activity, as seen by increased differentiation, activity, and resorption. This study demonstrates for the first time that osteoclasts are differentially regulated by MP in adolescent male and female rats, resulting in sex-dependent effects on the skeleton.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Uddin SMZ,Robison LS,Fricke D,Chernoff E,Hadjiargyrou M,Thanos PK,Komatsu DE

doi

10.1038/s41598-018-19894-x

subject

Has Abstract

pub_date

2018-01-24 00:00:00

pages

1515

issue

1

issn

2045-2322

pii

10.1038/s41598-018-19894-x

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Preventing High Fat Diet-induced Obesity and Improving Insulin Sensitivity through Neuregulin 4 Gene Transfer.

    abstract：:Neuregulin 4 (NRG4), an epidermal growth factor-like signaling molecule, plays an important role in cell-to-cell communication during tissue development. Its function to regulate energy metabolism has recently been reported. This current study was designed to assess the preventive and therapeutic effects of NRG4 overe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26242

    authors： Ma Y,Gao M,Liu D

    更新日期：2016-05-17 00:00:00

  • In vitro Studies on The Inhibition of Replication of Zika and Chikungunya Viruses by Dolastane Isolated from Seaweed Canistrocarpus cervicornis.

    abstract：:The lack of vaccines and antiviral treatment, along with the increasing number of cases of Zika virus (ZIKV) and Chikungunya virus (CHIKV) infections, emphasize the need for searching for new therapeutic strategies. In this context, the marine brown seaweed Canistrocarpus cervicornis has been proved to hold great anti...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65357-7

    authors： Cirne-Santos CC,de Souza Barros C,de Oliveira MC,Rabelo VW,Azevedo RC,Teixeira VL,Ferreira DF,de Palmer Paixão ICN

    更新日期：2020-05-19 00:00:00

  • Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration.

    abstract：:This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intravitreal injection of aflibe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28484-w

    authors： Terao N,Koizumi H,Kojima K,Yamagishi T,Yamamoto Y,Yoshii K,Kitazawa K,Hiraga A,Toda M,Kinoshita S,Sotozono C,Hamuro J

    更新日期：2018-07-12 00:00:00

  • Formants provide honest acoustic cues to body size in American alligators.

    abstract：:In many vertebrates, acoustic cues to body size are encoded in resonance frequencies of the vocal tract ("formants"), rather than in the rate of tissue vibration in the sound source ("pitch"). Anatomical constraints on the vocal tract's size render formants honest cues to size in many bird and mammal species, but it i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01948-1

    authors： Reber SA,Janisch J,Torregrosa K,Darlington J,Vliet KA,Fitch WT

    更新日期：2017-05-12 00:00:00

  • CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.

    abstract：:Glucagon is the main counterregulatory hormone in the body. Still, the mechanism involved in the regulation of glucagon secretion from pancreatic alpha cells remains elusive. Dysregulated glucagon secretion is common in patients with Cystic Fibrosis (CF) that develop CF related diabetes (CFRD). CF is caused by a mutat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00098-8

    authors： Edlund A,Pedersen MG,Lindqvist A,Wierup N,Flodström-Tullberg M,Eliasson L

    更新日期：2017-03-07 00:00:00

  • Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains.

    abstract：:Human protein tyrosine phosphatase non-receptor type 4 (PTPN4) has been shown to prevent cell death. The active form of human PTPN4 consists of two globular domains, a PDZ (PSD-95/Dlg/ZO-1) domain and a phosphatase domain, tethered by a flexible linker. Targeting its PDZ domain abrogates this protection and triggers a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08193-6

    authors： Caillet-Saguy C,Toto A,Guerois R,Maisonneuve P,di Silvio E,Sawyer K,Gianni S,Wolff N

    更新日期：2017-08-11 00:00:00

  • Evaluating upper limb impairments in multiple sclerosis by exposure to different mechanical environments.

    abstract：:Multiple sclerosis is a chronic, autoimmune and neurodegenerative disease affecting multiple functional systems and resulting in motor impairments associated with muscle weakness and lack of movement coordination. We quantified upper limb motor deficits with a robot-based assessment including behavioral and muscle syn...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20343-y

    authors： Pellegrino L,Coscia M,Muller M,Solaro C,Casadio M

    更新日期：2018-02-01 00:00:00

  • Sedimentary geology of the middle Carboniferous of the Donbas region (Dniepr-Donets Basin, Ukraine).

    abstract：:The Paleozoic Dniepr-Donets Basin in Belarus, Ukraine, and Russia forms a major hydrocarbon province. Although well- and seismic data have established a 20 km thick stratigraphy, field-studies of its sediments are scarce. The inverted Donbas segment (Ukraine) exposes the middle Carboniferous part of the basin's strati...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09099

    authors： van Hinsbergen DJ,Abels HA,Bosch W,Boekhout F,Kitchka A,Hamers M,van der Meer DG,Geluk M,Stephenson RA

    更新日期：2015-03-20 00:00:00

  • Expression of Arabidopsis MYB transcription factor, AtMYB111, in tobacco requires light to modulate flavonol content.

    abstract：:Flavonoids, due to their pharmacological attributes, have recently become target molecules for metabolic engineering in commonly consumed food crops. Strategies including expression of single genes and gene pyramiding have provided only limited success, due principally to the highly branched and complex biosynthetic p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05018

    authors： Pandey A,Misra P,Bhambhani S,Bhatia C,Trivedi PK

    更新日期：2014-05-21 00:00:00

  • Repurposing a platelet aggregation inhibitor ticagrelor as an antimicrobial against Clostridioides difficile.

    abstract：:Drug resistance in Clostridioides difficile becomes a public health concern worldwide, especially as the hypervirulent strains show decreased susceptibility to the first-line antibiotics for C. difficile treatment. Therefore, the simultaneous discovery and development of new compounds to fight this pathogen are urgent...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63199-x

    authors： Phanchana M,Phetruen T,Harnvoravongchai P,Raksat P,Ounjai P,Chankhamhaengdecha S,Janvilisri T

    更新日期：2020-04-16 00:00:00

  • Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations.

    abstract：:Mitochondria are organelles that govern energy supply and control cell death. Mitochondria also express bacterial features, such as the presence of inner membrane cardiolipin and a circular genome rich in hypomethylated CpG motifs. While mitochondrial extrusion by damaged organs or activated cells is thought to trigge...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40900-3

    authors： Becker Y,Loignon RC,Julien AS,Marcoux G,Allaeys I,Lévesque T,Rollet-Labelle E,Benk-Fortin H,Cloutier N,Melki I,Eder L,Wagner É,Pelletier M,Hajj HE,Tremblay MÈ,Belleannée C,Hébert MJ,Dieudé M,Rauch J,Fortin PR,Boil

    更新日期：2019-03-14 00:00:00

  • Craniosynostosis surgery: workflow based on virtual surgical planning, intraoperative navigation and 3D printed patient-specific guides and templates.

    abstract：:Craniosynostosis must often be corrected using surgery, by which the affected bone tissue is remodeled. Nowadays, surgical reconstruction relies mostly on the subjective judgement of the surgeon to best restore normal skull shape, since remodeled bone is manually placed and fixed. Slight variations can compromise the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54148-4

    authors： García-Mato D,Ochandiano S,García-Sevilla M,Navarro-Cuéllar C,Darriba-Allés JV,García-Leal R,Calvo-Haro JA,Pérez-Mañanes R,Salmerón JI,Pascau J

    更新日期：2019-11-27 00:00:00

  • Author Correction: Analysis of sequential hair segments reflects changes in the metabolome across the trimesters of pregnancy.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-60642-x

    authors： Delplancke TDJ,de Seymour JV,Tong C,Sulek K,Xia Y,Zhang H,Han TL,Baker PN

    更新日期：2020-02-21 00:00:00

  • Graphene/semi-insulating single crystal CdTe Schottky-type heterojunction X- and γ-Ray Radiation Detectors.

    abstract：:We developed a new concept of X- and γ-ray radiation semiconductor detectors based on a large area graphene/semi-insulating single crystal CdTe Schottky-type heterojunction. These two terminal electronic devices can be easily fabricated by forming a Van der Waals contact between large area chemical vapor deposited gra...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37637-w

    authors： Brus VV,Maslyanchuk OL,Solovan MM,Maryanchuk PD,Fodchuk I,Gnatyuk VA,Vakhnyak ND,Melnychuk SV,Aoki T

    更新日期：2019-01-31 00:00:00

  • The contribution of hormone sensitive lipase to adipose tissue lipolysis and its regulation by insulin in periparturient dairy cows.

    abstract：:Hormone sensitive lipase (HSL) activation is part of the metabolic adaptations to the negative energy balance common to the mammalian periparturient period. This study determined HSL contribution to adipose tissue (AT) lipolysis and how insulin regulates its activity in periparturient dairy cows. Subcutaneous AT (SCAT...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31582-4

    authors： De Koster J,Nelli RK,Strieder-Barboza C,de Souza J,Lock AL,Contreras GA

    更新日期：2018-09-06 00:00:00

  • A Practical Model Evaluating Antiviral Cytokines by Natural Killer Cells in Treatment Naïve Patients with Chronic Hepatitis B Virus Infection.

    abstract：:Natural killer (NK) cells play a major role in anti-viral immunity as first line defense during hepatitis B infection, particularly in untreated patients whose T cells functions are profoundly impaired. Cytokine interferon (IFN)-γ and tumor necrosis factor (TNF)-α produced by NK cells are important anti-viral factors....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06192-1

    authors： Li X,Gu Y,Guo X,Gu L,Zhou L,Wu X,Wang X,Stamataki Z,Huang Y

    更新日期：2017-07-19 00:00:00

  • Caffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune Process.

    abstract：:Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in sepsis due to infection with Gram-negative bacteria but not other microbes. Herein, we provided IκB kinase β (IKKβ) in innate immune process as a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41180

    authors： Choi JH,Park SH,Jung JK,Cho WJ,Ahn B,Yun CY,Choi YP,Yeo JH,Lee H,Hong JT,Han SB,Kim Y

    更新日期：2017-02-01 00:00:00

  • Quantum magnetism in strongly interacting one-dimensional spinor Bose systems.

    abstract：:Strongly interacting one-dimensional quantum systems often behave in a manner that is distinctly different from their higher-dimensional counterparts. When a particle attempts to move in a one-dimensional environment it will unavoidably have to interact and 'push' other particles in order to execute a pattern of motio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10675

    authors： Dehkharghani A,Volosniev A,Lindgren J,Rotureau J,Forssén C,Fedorov D,Jensen A,Zinner N

    更新日期：2015-06-15 00:00:00

  • Prospects of activity limitations among older adults in 23 low and middle income countries.

    abstract：:Increasing life expectancy and a growing share of older people around the world spotlight the issue of health during additional years of life. Research on trends of proportions of older people with activity limitations for low and middle income countries is sparse. We use data from the World Health Survey and the UN W...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67166-4

    authors： Weber D,Scherbov S

    更新日期：2020-06-26 00:00:00

  • Conformational Transitions of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor, a Human Class B GPCR.

    abstract：:The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a potential therapeutic target for endocrine, metabolic and stress-related disorders. However, many questions regarding the protein structure and dynamics of PAC1R remain largely unanswered. Using microsecond-long simulations,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05815-x

    authors： Liao C,Zhao X,Brewer M,May V,Li J

    更新日期：2017-07-14 00:00:00

  • Giant Faraday Rotation in Metal-Fluoride Nanogranular Films.

    abstract：:Magneto-optical Faraday effect is widely applied in optical devices and is indispensable for optical communications and advanced information technology. However, the bismuth garnet Bi-YIG is only the Faraday material since 1972. Here we introduce (Fe, FeCo)-(Al-,Y-fluoride) nanogranular films exhibiting giant Faraday ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23128-5

    authors： Kobayashi N,Ikeda K,Gu B,Takahashi S,Masumoto H,Maekawa S

    更新日期：2018-03-21 00:00:00

  • Author Correction: Linking drug target and pathway activation for effective therapy using multi-task learning.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-43503-0

    authors： Yang M,Simm J,Lam CC,Zakeri P,van Westen GJP,Moreau Y,Saez-Rodriguez J

    更新日期：2019-05-03 00:00:00

  • Biochemical and structural characterization of tomato polyphenol oxidases provide novel insights into their substrate specificity.

    abstract：:Polyphenol oxidases (PPOs) contain the structurally similar enzymes tyrosinases (TYRs) and catechol oxidases (COs). Two cDNAs encoding pro-PPOs from tomato (Solanum lycopersicum) were cloned and heterologously expressed in Escherichia coli. The two pro-PPOs (SlPPO1-2) differ remarkably in their activity as SlPPO1 reac...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39687-0

    authors： Kampatsikas I,Bijelic A,Rompel A

    更新日期：2019-03-11 00:00:00

  • Genetic Variations of NLR family genes in Behcet's Disease.

    abstract：:This study aimed to investigate whether single nucleotide polymorphisms (SNPs) of five NLR family genes (NOD1, NOD2, NLRP1, NLRP3 and CIITA) are associated with Behcet's disease (BD) in a Chinese Han population. The study was carried out in 950 BD patients and 1440 controls for 19 SNPs in the selected NLR genes. In th...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1038/srep20098

    authors： Li L,Yu H,Jiang Y,Deng B,Bai L,Kijlstra A,Yang P

    更新日期：2016-02-01 00:00:00

  • Non-vitamin K antagonist oral anticoagulation usage according to age among patients with atrial fibrillation: Temporal trends 2011-2015 in Denmark.

    abstract：:Among atrial fibrillation (AF) patients, Danish nationwide registries (2011-2015) were used to examine temporal trends of initiation patterns of oral anticoagulation (OAC) treatment according to age. Overall, 43,299 AF patients initiating vitamin K antagonists (VKA) (42%), dabigatran (29%), rivaroxaban (13%), or apixa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31477

    authors： Staerk L,Fosbøl EL,Gadsbøll K,Sindet-Pedersen C,Pallisgaard JL,Lamberts M,Lip GY,Torp-Pedersen C,Gislason GH,Olesen JB

    更新日期：2016-08-11 00:00:00

  • Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest.

    abstract：:Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a cl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01770

    authors： Kavanagh JN,Currell FJ,Timson DJ,Savage KI,Richard DJ,McMahon SJ,Hartley O,Cirrone GA,Romano F,Prise KM,Bassler N,Holzscheiter MH,Schettino G

    更新日期：2013-01-01 00:00:00

  • Mechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter.

    abstract：:The serotonin transporter (SERT) is an integral membrane protein that exploits preexisting sodium-, chloride-, and potassium ion gradients to catalyze the thermodynamically unfavorable movement of synaptic serotonin into the presynaptic neuron. SERT has garnered significant clinical attention partly because it is the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23789

    authors： Davis BA,Nagarajan A,Forrest LR,Singh SK

    更新日期：2016-04-01 00:00:00

  • Blurring of ancient wall paintings caused by binder decay in the pigment layer.

    abstract：:In this paper, the effect of binder decay rather than a change in the pigments on the blurring of ancient wall paintings was researched. The simulated wall paintings were prepared by brushing an aqueous solution containing gelatine and ochre grains on the surface of cylindrical compressed soil samples. Then, the dried...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78117-4

    authors： Zheng L,Wang Z,Shen S,Xia Y,Li Y,Hu D

    更新日期：2020-12-03 00:00:00

  • IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM.

    abstract：:Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49923-2

    authors： Catanzaro JR,Strauss JD,Bielecka A,Porto AF,Lobo FM,Urban A,Schofield WB,Palm NW

    更新日期：2019-09-19 00:00:00

  • Homogeneous nucleation of corundum nanocrystallites by rapid heating of aluminum formate hydroxide-based precursor powder.

    abstract：:The high density nucleation of α-Al2O3 nanocrystallites was observed by rapid heating of the aluminum formate hydroxide-based precursor powder at 1200 °C for 50 s. The nucleation of α-Al2O3 nanocrystallites with less 10 nm in size from high purity aluminum oxide matrix has not been observed to our knowledge. Based on ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51156-2

    authors： Yoshida M,Kato Y,Oumi Y,Sakurada O,Tanaka M,Wada M,Kitaoka S

    更新日期：2019-10-17 00:00:00