Abstract:
:Pyramidal neurons in the rodent hippocampus exhibit spatial tuning during spatial navigation, and they are reactivated in specific temporal order during sharp-wave ripples observed in quiet wakefulness or slow wave sleep. However, analyzing representations of sleep-associated hippocampal ensemble spike activity remains a great challenge. In contrast to wake, during sleep there is a complete absence of animal behavior, and the ensemble spike activity is sparse (low occurrence) and fragmental in time. To examine important issues encountered in sleep data analysis, we constructed synthetic sleep-like hippocampal spike data (short epochs, sparse and sporadic firing, compressed timescale) for detailed investigations. Based upon two Bayesian population-decoding methods (one receptive field-based, and the other not), we systematically investigated their representation power and detection reliability. Notably, the receptive-field-free decoding method was found to be well-tuned for hippocampal ensemble spike data in slow wave sleep (SWS), even in the absence of prior behavioral measure or ground truth. Our results showed that in addition to the sample length, bin size, and firing rate, number of active hippocampal pyramidal neurons are critical for reliable representation of the space as well as for detection of spatiotemporal reactivated patterns in SWS or quiet wakefulness.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen Z,Grosmark AD,Penagos H,Wilson MAdoi
10.1038/srep32193subject
Has Abstractpub_date
2016-08-30 00:00:00pages
32193issn
2045-2322pii
srep32193journal_volume
6pub_type
杂志文章abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-42749-y
更新日期:2019-04-19 00:00:00
abstract::Standard electroporation with pulses in milliseconds has been used as an effective tool to deliver drugs or genetic probes into cells, while irreversible electroporation with nanosecond pulses is explored to alter intracellular activities for pulse-induced apoptosis. A combination treatment, long nanosecond pulses fol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63172-8
更新日期:2020-04-08 00:00:00
abstract::Surface soil moisture plays a crucial role on the terrestrial water, energy, and carbon cycles. Characterizing its variability in space and time is critical to increase our capability to forecast extreme weather events, manage water resources, and optimize agricultural practices. Global estimates of surface soil moist...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52650-3
更新日期:2019-11-06 00:00:00
abstract::Cold-inducible RNA-binding protein (CIRP), released into the circulation during sepsis, causes lung injury via an as yet unknown mechanism. Since endoplasmic reticulum (ER) stress is associated with acute lung injury (ALI), we hypothesized that CIRP causes ALI via induction of ER stress. To test this hypothesis, we st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41363
更新日期:2017-01-27 00:00:00
abstract::The objective was to measure the association between badger culling and bovine tuberculosis (TB) incidents in cattle herds in three areas of England between 2013-2017 (Gloucestershire and Somerset) and 2015-2017 (Dorset). Farming industry-selected licensed culling areas were matched to comparison areas. A TB incident ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49957-6
更新日期:2019-10-11 00:00:00
abstract::Fibroblast growth factor 21 (FGF21) and cytokeratin 18 (CK18) were previously reported to be elevated in nonalcoholic fatty liver disease (NAFLD). We aim to analyze the differential roles of FGF21, cell apoptosis marker CK18 fragment M30 and total cell death marker CK18 M65ED in monitoring the different stages of NAFL...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05257-5
更新日期:2017-07-11 00:00:00
abstract::The most important goals of brain network analyses are to (a) detect pivotal regions and connections that contribute to disproportionate communication flow, (b) integrate global information, and (c) increase the brain network efficiency. Most centrality measures assume that information propagates in networks with the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42322-7
更新日期:2019-04-11 00:00:00
abstract::Serotype-cross-reactive memory T cells responding to secondary dengue virus (DENV) infection are thought to contribute to disease. However, epitope-specific T cell responses have not been thoroughly compared between subjects with primary versus secondary DENV infection. We studied CD8(+) T cells specific for the HLA-A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00051
更新日期:2011-01-01 00:00:00
abstract::Successful establishment of invasive species is often related to the existence of vacant niches. Competition occurs when invaders use the same limiting resources as members of the recipient community, which will be reflected in some overlap of their trophic niches. The concept of isotopic niche has been used to study ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09715
更新日期:2015-05-19 00:00:00
abstract::What is intuitive: pro-social or anti-social behaviour? To answer this fundamental question, recent studies analyse decision times in game theory experiments under the assumption that intuitive decisions are fast and that deliberation is slow. These analyses keep track of the average time taken to make decisions under...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52359-3
更新日期:2019-11-19 00:00:00
abstract::Switching magnetizations with femtosecond circularly polarized lasers may have revolutionary impacts on magnetic data storage and relevant applications. Achievements in ferrimagnetic and ferromagnetic materials of various structures strongly imply a general phenomenon of fundamental atom-laser interaction. Rotating an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41294
更新日期:2017-01-24 00:00:00
abstract::The present study aimed to explore the value of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC). This study included 65 patients with malignant hepatic nodules (55 with HCC, 10 with ICC), and 17 control pati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64804-9
更新日期:2020-05-07 00:00:00
abstract::Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functionally linked to alterations in glutamate levels. Despite the well-documented eff...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80917-7
更新日期:2021-01-14 00:00:00
abstract::Relying on an exact time evolution scheme, we identify a novel transient energy transfer phenomenon in an exactly-solvable quantum microscopic model consisting of a three-level system coupled to two non-Markovian zero-temperature bosonic baths through two separable quantum channels. The dynamics of this model can be s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15332
更新日期:2015-10-19 00:00:00
abstract::Acquisition of nutrients during intra-vacuolar growth of L. pneumophila within macrophages or amoebae is poorly understood. Since many genes of L. pneumophila are acquired by inter-kingdom horizontal gene transfer from eukaryotic hosts, we examined the presence of human solute carrier (SLC)-like transporters in the L....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26782-x
更新日期:2018-05-29 00:00:00
abstract::The purpose of the study was to assess both anatomic and functional outcomes between short-pulse continuous wavelength and infrared micropulse lasers in the treatment of DME. This was a prospective interventional study from tertiary care eye hospital-King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia). Patients...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79699-9
更新日期:2021-01-08 00:00:00
abstract::The identification of genome-wide selection signatures can provide insights on the mechanisms of natural and/or artificial selection and uncover genes related to biological functions and/or phenotypes. Tibetan sheep are an important livestock in Tibet, providing meat and wool for Tibetans who are renown for breeding l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81932-y
更新日期:2021-01-28 00:00:00
abstract::The prevalence of a macrophage phenotype in atherosclerotic plaque may drive its progression and/or instability. Macrophages from coronary plaques are not available, and monocyte-derived macrophages (MDMs) are usually considered as a surrogate. We compared the MDM profile obtained from coronary artery disease (CAD) pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44847-3
更新日期:2019-06-18 00:00:00
abstract::Characterizing a high-dimensional entanglement is fundamental in quantum information applications. Here, we propose a theoretical scheme to analyze and characterize the angular momentum hyperentanglement that two photons are entangled simultaneously in spin and orbital angular momentum. Based on the electro-optic samp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21856
更新日期:2016-02-25 00:00:00
abstract::Next generation sequencing (NGS) together with protein expression analysis is back bone of molecularly targeted therapy in precision medicine. Our retrospective study shows our experience with NGS of 324 genes in combination with protein expression in patients with advanced breast cancer (aBC). The primary purpose was...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67393-9
更新日期:2020-06-26 00:00:00
abstract::Insulin gene mutations have been identified to cause monogenic diabetes, and most of which developed permanent neonatal diabetes at young ages before 6 months of age in humans. To establish an animal model of permanent diabetes, we performed genome editing using the CRISPR/Cas9 system. We generated a novel Kuma mutant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68987-z
更新日期:2020-07-22 00:00:00
abstract::Two related models for T cell signalling initiation suggest either that T cell receptor (TCR) engagement leads to its recruitment to ordered membrane domains, often referred to as lipid rafts, where signalling molecules are enriched or that ordered TCR-containing membrane nanodomains coalesce upon TCR engagement. That...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10082
更新日期:2015-05-08 00:00:00
abstract::Giant spin Hall effect (GSHE) has received significant attention for its potential in future spintronic applications. Spin current via GSHE-based thin films provides an effective and promising means to manipulate magnetization. However, an external in-plane magnetic field is required to consistently switch the perpend...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26586-z
更新日期:2018-05-25 00:00:00
abstract::For translocated animals, behavioral competence may be key to post-release survival. However, monitoring behavior is typically limited to tracking movements or inferring behavior at a gross scale via collar-mounted sensors. Animal-bourne acoustic monitoring may provide a unique opportunity to monitor behavior at a fin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41455-z
更新日期:2019-03-26 00:00:00
abstract::There are still lot of controversies whether aberrant left hepatic artery (ALHA) originating from left gastric artery should be ligated or preserved during gastric cancer (GC) surgery. We aimed to investigate this issue. We reviewed ALHA cases who had laparoscopic gastrectomy for gastric cancer at Seoul National Unive...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62587-7
更新日期:2020-04-03 00:00:00
abstract::The arrival of the Longobards in Northern Italy in 568 CE marked a period of renewed political stability in the Peninsula after the collapse of the Western Roman Empire. The trajectory of the spread of Longobards in Italy across the Alps and into the South is known from many literary sources. However, their mobility a...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-020-67480-x
更新日期:2020-07-15 00:00:00
abstract::We study the spin and valley dependent transport in a silicene superlattice under the influence of a magnetic exchange field, a perpendicular electric field and a voltage potential. It is found that a gate-voltage-controllable fully spin and valley polarized current can be obtained in the proposed device, and the spin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33701
更新日期:2016-09-20 00:00:00
abstract::We report here the design and multiple functions of a new hierarchical nanotheronostic platform consisting of an upconversion nanoparticle (UCNP) core: shell with an additional mesoporous silica (mSiO2) matrix load shell containing sealed, high concentration of ICG molecules. We demonstrate that this UCNP@mSiO2-ICG na...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16016-x
更新日期:2017-11-16 00:00:00
abstract::The Sinorhizobium meliloti (S. meliloti) strain CCNWSX0020 displayed tolerance to high levels exposures of multiple metals and growth promotion of legume plants grown in metal-contaminated soil. However, the mechanism of metal-resistant strain remains unknown. We used five P1B-ATPases deletions by designating as ∆copA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29355
更新日期:2016-07-05 00:00:00
abstract::The toxicological mechanisms of liver injury caused by most traditional Chinese medicine (TCM) remain largely unknown. Due to the unique features, exosomal microRNAs (miRNAs) are currently attracting major interests to provide further insights into toxicological mechanisms. Thus, taking Fructus Meliae Toosendan as an ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21113-6
更新日期:2018-02-12 00:00:00