IL-17A is produced by breast cancer TILs and promotes chemoresistance and proliferation through ERK1/2.

abstract：:In this study, we report a microfluidic device for the whole-life culture of the nematode Caenorhabditis elegans that allows the scoring of animal survival and health measures. This device referred to as the NemaLife chip features: (1) an optimized micropillar arena in which animals can crawl, (2) sieve channels that ...

journal_title：Scientific reports

authors： Rahman M,Edwards H,Birze N,Gabrilska R,Rumbaugh KP,Blawzdziewicz J,Szewczyk NJ,Driscoll M,Vanapalli SA

更新日期：2020-10-01 00:00:00

abstract：:Pain is a harmful sensation that arises from noxious stimuli. Transient receptor potential ankyrin 1 (TRPA1) is one target for studying pain mechanisms. TRPA1 is activated by various stimuli such as noxious cold, pungent natural products and environmental irritants. Since TRPA1 is an attractive target for pain therapy...

journal_title：Scientific reports

authors： Gupta R,Saito S,Mori Y,Itoh SG,Okumura H,Tominaga M

更新日期：2016-11-22 00:00:00

abstract：:A significant advantage of a graphene biosensor is that it inherently represents a continuum of independent and aligned sensor-units. We demonstrate a nanoscale version of a micro-physiometer - a device that measures cellular metabolic activity from the local acidification rate. Graphene functions as a matrix of indep...

journal_title：Scientific reports

authors： Paulus GL,Nelson JT,Lee KY,Wang QH,Reuel NF,Grassbaugh BR,Kruss S,Landry MP,Kang JW,Vander Ende E,Zhang J,Mu B,Dasari RR,Opel CF,Wittrup KD,Strano MS

更新日期：2014-10-31 00:00:00

abstract：:Increased connectivity with the mainland has led to the arrival of many invasive species to the Galápagos Islands, including novel pathogens, threatening the archipelago's unique fauna. Here we consider the potential role of the mosquito Aedes taeniorhynchus in maintaining the flavivirus West Nile virus [WNV] should i...

journal_title：Scientific reports

authors： Eastwood G,Goodman SJ,Cunningham AA,Kramer LD

更新日期：2013-01-01 00:00:00

abstract：:Convergent-margin basins (CMBs) are commonly associated with active arcs, and hence are rich in detrital zircon (DZ) whose ages closely reflect the timing of deposition. Consequently, maximum depositional ages (MDA) from DZ geochronology can be employed to resolve the stratigraphy and evolution of CMBs. Herein, we use...

journal_title：Scientific reports

authors： Huang C,Dashtgard SE,Kent BAP,Gibson HD,Matthews WA

更新日期：2019-10-25 00:00:00

abstract：:Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-en...

journal_title：Scientific reports

authors： Tervaniemi MH,Katayama S,Skoog T,Siitonen HA,Vuola J,Nuutila K,Sormunen R,Johnsson A,Linnarsson S,Suomela S,Kankuri E,Kere J,Elomaa O

更新日期：2016-03-15 00:00:00

abstract：:The genetic sexing of animals having long gestation periods offers significant benefits in regard to breeding management among their populations living in captivity. In our study, a new increased-sensitivity PCR method for fetal sexing was developed and tested successfully on elephants, from only a small volume of mat...

journal_title：Scientific reports

authors： Vincze B,Gáspárdy A,Biácsi A,Papp EÁ,Garamvölgyi L,Sós E,Cseh S,Kovács G,Pádár Z,Zenke P

更新日期：2019-10-24 00:00:00

abstract：:The development of physiologically active semiochemicals is largely limited by the labor-consuming searching process. How to screen active semiochemicals efficiently is of significance to the extension of behavior regulation in pest control. Here pharmacophore modeling and shape-based virtual screening were combined t...

journal_title：Scientific reports

authors： Liu J,Tian Z,Zhang Y

更新日期：2016-10-06 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Thomas D,Bagiya MS,Sunil PS,Rolland L,Sunil AS,Mikesell TD,Nayak S,Mangalampalli S,Ramesh DS

更新日期：2018-11-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) exhibit broad-spectrum antimicrobial activity, and have promise as new therapeutic agents. While the adult North American bullfrog (Rana [Lithobates] catesbeiana) is a prolific source of high-potency AMPs, the aquatic tadpole represents a relatively untapped source for new AMP discovery. ...

journal_title：Scientific reports

authors： Helbing CC,Hammond SA,Jackman SH,Houston S,Warren RL,Cameron CE,Birol I

更新日期：2019-02-06 00:00:00

abstract：:Liver segmentation is an essential procedure in computer-assisted surgery, radiotherapy, and volume measurement. It is still a challenging task to extract liver tissue from 3D CT images owing to nearby organs with similar intensities. In this paper, an automatic approach integrating multi-dimensional features into gra...

journal_title：Scientific reports

authors： Lu X,Xie Q,Zha Y,Wang D

更新日期：2018-07-16 00:00:00

abstract：:Since the propagation of plant viruses depends on various host susceptibility factors, deficiency in them can prevent viral infection in cultivated and model plants. Recently, we identified the susceptibility factor Essential for poteXvirus Accumulation 1 (EXA1) in Arabidopsis thaliana, and revealed that EXA1-mediated...

journal_title：Scientific reports

authors： Yusa A,Neriya Y,Hashimoto M,Yoshida T,Fujimoto Y,Hosoe N,Keima T,Tokumaru K,Maejima K,Netsu O,Yamaji Y,Namba S

更新日期：2019-04-11 00:00:00

abstract：:We study the entanglement structure and the topological edge states of the ground state of the spin-1/2 XXZ model with bond alternation. We employ parity-density matrix renormalization group with periodic boundary conditions. The finite-size scaling of Rényi entropies S2 and S∞ are used to construct the phase diagram ...

journal_title：Scientific reports

authors： Tzeng YC,Dai L,Chung MC,Amico L,Kwek LC

更新日期：2016-05-24 00:00:00

abstract：:The aim of this study was to investigate rheumatoid arthritis (RA), and systemic lupus erythematous (SLE) as risk factors for stroke. The study was analyzed by Using the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005), this cohort study investigated patients with a recorded diagnosis of RA (N = 6114), an...

journal_title：Scientific reports

authors： Liou TH,Huang SW,Lin JW,Chang YS,Wu CW,Lin HW

更新日期：2014-06-05 00:00:00

abstract：:Proteus mirabilis forms extensive crystalline biofilms on indwelling urethral catheters that block urine flow and lead to serious clinical complications. The Bcr/CflA efflux system has previously been identified as important for development of P. mirabilis crystalline biofilms, highlighting the potential for efflux pu...

journal_title：Scientific reports

authors： Nzakizwanayo J,Scavone P,Jamshidi S,Hawthorne JA,Pelling H,Dedi C,Salvage JP,Hind CK,Guppy FM,Barnes LM,Patel BA,Rahman KM,Sutton MJ,Jones BV

更新日期：2017-09-22 00:00:00

abstract：:The aim of the current manuscript was to test the applicability of a nanocomposite system of penetration enhancer vesicles (PEVs) within polymeric in situ forming gel network composed of poloxamer and hyaluronic acid for the intranasal delivery of the antiemetic dimenhydrinate (DMH). PEVs were prepared using phospholi...

journal_title：Scientific reports

authors： Barakat SS,Nasr M,Ahmed RF,Badawy SS,Mansour S

更新日期：2017-08-30 00:00:00

abstract：:In this paper, we propose a feasible tool that uses a terahertz (THz) imaging system for identifying wheat grains at different stages of germination. The THz spectra of the main changed components of wheat grains, maltose and starch, which were obtained by THz time spectroscopy, were distinctly different. Used for ori...

journal_title：Scientific reports

authors： Jiang Y,Ge H,Lian F,Zhang Y,Xia S

更新日期：2016-02-19 00:00:00

abstract：:Thermoelectric properties of Graphene nano-ribbons (GNRs) with nanopores (NPs) are explored for a range of pore dimensions in order to achieve a high performance two-dimensional nano-scale thermoelectric device. We reduce thermal conductivity of GNRs by introducing pores in them in order to enhance their thermoelectri...

journal_title：Scientific reports

authors： Hossain MS,Al-Dirini F,Hossain FM,Skafidas E

更新日期：2015-06-17 00:00:00

abstract：:Propolis and Bacopa monnieri (L.) Wettst. (Brahmi) are natural products that contain many active substances and possess anticancer properties. The aim of this study was to investigate the chemical composition of Polish propolis extract (PPE) by gas chromatography-mass spectrometry (GC-MS), B. monnieri extracts (BcH, B...

journal_title：Scientific reports

authors： Moskwa J,Naliwajko SK,Markiewicz-Żukowska R,Gromkowska-Kępka KJ,Nowakowski P,Strawa JW,Borawska MH,Tomczyk M,Socha K

更新日期：2020-12-03 00:00:00

abstract：:The aim of the present study was to evaluate the association between statin use and the risk of age-related macular degeneration (AMD). A systematic search of the PubMed, EMBASE and ISI web of science databases was used to identify eligible published literatures without language restrictions up to April 2015. Summary ...

journal_title：Scientific reports

authors： Ma L,Wang Y,Du J,Wang M,Zhang R,Fu Y

更新日期：2015-12-14 00:00:00

abstract：:Nanomedicine development currently suffers from a lack of efficient tools to predict pharmacokinetic behavior without relying upon testing in large numbers of animals, impacting success rates and development costs. This work presents dendPoint, the first in silico model to predict the intravenous pharmacokinetics of d...

journal_title：Scientific reports

authors： Kaminskas LM,Pires DEV,Ascher DB

更新日期：2019-10-29 00:00:00

abstract：:Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the 'honey trap' during an economic exchange. Males tend to cooperate with physicall...

journal_title：Scientific reports

authors： Watabe M,Kato TA,Tsuboi S,Ishikawa K,Hashiya K,Monji A,Utsumi H,Kanba S

更新日期：2013-01-01 00:00:00

abstract：:Dye-sensitised solar cells (DSCs) are a promising substitute for conventional silicon solar cells. A scattering layer of submicrometer pores or particles has been widely introduced to achieve a high light-harvesting efficiency. However, many such fabrication processes require high temperatures and multiple steps to pr...

journal_title：Scientific reports

authors： Ha SJ,Moon JH

更新日期：2014-07-09 00:00:00

abstract：:Nitric oxide (NO)-induced apoptosis in neurons is an important cause of neurodegenerative disease in humans. The cold-inducible protein RBM3 mediates the protective effects of cooling on apoptosis induced by various insults. However, whether RBM3 protects neural cells from NO-induced apoptosis is unclear. This study a...

journal_title：Scientific reports

authors： Yang HJ,Ju F,Guo XX,Ma SP,Wang L,Cheng BF,Zhuang RJ,Zhang BB,Shi X,Feng ZW,Wang M

更新日期：2017-01-30 00:00:00

abstract：:Because of inadequate nutrient and water supply, soils are often unproductive in Northwest China. We studied the effects of manure application at low (LM 7.5  t ha(-1)), medium (MM 15 t ha(-1)), and high (HM 22.5 t ha(-1)) rates combined with fixed levels of chemical fertilizers on maize growth and rainfall use effici...

journal_title：Scientific reports

authors： Wang X,Jia Z,Liang L,Yang B,Ding R,Nie J,Wang J

更新日期：2016-02-12 00:00:00

abstract：:Color vision requires the activity of cone photoreceptors to be compared in post-receptoral circuitry. Decades of psychophysical measurements have quantified the nature of these comparative interactions on a coarse scale. How such findings generalize to a cellular scale remains unclear. To answer that question, we qua...

journal_title：Scientific reports

authors： Schmidt BP,Sabesan R,Tuten WS,Neitz J,Roorda A

更新日期：2018-06-04 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Epeldegui M,Conti DV,Guo Y,Cozen W,Penichet ML,Martínez-Maza O

更新日期：2020-01-15 00:00:00

abstract：:Invasive aspergillosis (IA) is a life-threatening complication among allogeneic hematopoietic stem cell transplant (alloSCT) recipients. Despite well known risk factors and different available assays, diagnosis of invasive aspergillosis remains challenging. 103 clinical variables from patients with hematological malig...

journal_title：Scientific reports

authors： Zoran T,Weber M,Springer J,White PL,Bauer J,Schober A,Löffler C,Seelbinder B,Hünniger K,Kurzai O,Scherag A,Schäuble S,Morton CO,Einsele H,Linde J,Löffler J

更新日期：2019-11-21 00:00:00

abstract：:An aberrant artery (AA) can frequently be observed coursing through the fissure for the ligamentum venosum (FLV) which was termed the "vessel through strait" sign (VTSS) by us. Fundamental data including the incidence, anatomical composition and clinical significance of VTSS and the AAs composing VTSS are still lackin...

journal_title：Scientific reports

authors： Rong G,Wang Z,Wang X,Yu Q,Zhou L,Wang H,Zhang J,Dong J,Ma W,An W,Ren H,Zeng Z,Lu Y,Li Y

更新日期：2016-04-04 00:00:00

abstract：:Up to now, a very few catalysts have been developed approaching the heterogeneous catalytic degradation of Eosin Y and Chromotrope 2R dyes (Acid Red 29). The present study provides a complete perspective of recyclable nanocomposite Au(Salen)@CC for catalytic degradation of hazardous water pollutant dyes viz., Eosin Y ...

journal_title：Scientific reports

authors： Mayani VJ,Mayani SV,Kim SW

更新日期：2017-08-03 00:00:00