Chemical composition of Polish propolis and its antiproliferative effect in combination with Bacopa monnieri on glioblastoma cell lines.

abstract：:Functionalized X-Bi bilayers (X = Ga, In, and Tl) with halogens bonded on their both sides have been recently claimed to be the giant topological insulators due to the strong band inversion strengths. Employing the first-principles electronic structure calculation, we find the topological band order transition from th...

journal_title：Scientific reports

authors： Kim Y,Yun WS,Lee JD

更新日期：2016-09-14 00:00:00

abstract：:Selective enhancement of GABAergic inhibition is thought to impact many vital brain functions and interferes with the genesis and/or progression of numerous brain disorders. Here, we show that selectively increasing NMDA receptor activity in inhibitory neurons using an NMDAR positive allosteric modulator (PAM) elevate...

journal_title：Scientific reports

authors： Deng D,Masri S,Yao L,Ma X,Cao X,Yang S,Bao S,Zhou Q

更新日期：2020-07-20 00:00:00

abstract：:Systemic lupus erythematosus (SLE) flares elicit progressive organ damage, leading to disability and early mortality. This study evaluated clinical and immunologic factors associated with impending flare in the Biomarkers of Lupus Disease study. Autoantibodies and 32 soluble mediators were measured by multiplex assays...

journal_title：Scientific reports

authors： Lu R,Guthridge JM,Chen H,Bourn RL,Kamp S,Munroe ME,Macwana SR,Bean K,Sridharan S,Merrill JT,James JA

更新日期：2019-06-13 00:00:00

abstract：:Melanoma is one of the most aggressive skin cancers and is well known for its high metastatic rate. Studies have shown that epithelial mesenchymal transition (EMT) is essential for melanoma cell metastasis. However, the molecular mechanisms underlying EMT are still not fully understood. We have shown that IRGM1, a mem...

journal_title：Scientific reports

authors： Tian L,Li L,Xing W,Li R,Pei C,Dong X,Fu Y,Gu C,Guo X,Jia Y,Wang G,Wang J,Li B,Ren H,Xu H

更新日期：2015-07-23 00:00:00

abstract：:Visual loss caused by retinopathy of prematurity (ROP) will be prevented if treatment-requiring ROP (TR-ROP) can be predicted. In this retrospective study including 418 infants with ≤32 weeks of gestational age (GA) and/or ≤1500 grams of birthweight, we attempted to identify useful predictors. We also examined the eff...

journal_title：Scientific reports

authors： Arima M,Tsukamoto S,Fujiwara K,Murayama M,Fujikawa K,Sonoda KH

更新日期：2017-06-20 00:00:00

abstract：:Antibody based bio-molecular drugs are an exciting, new avenue of drug development as an alternative to the more traditional small chemical compounds. However, the binding mechanism and the effect on the conformational ensembles of a therapeutic antibody to its peptide or protein antigen have not yet been well studied...

journal_title：Scientific reports

authors： Bekker GJ,Fukuda I,Higo J,Kamiya N

更新日期：2020-01-29 00:00:00

abstract：:The clinical presentation of diabetes sometimes overlaps, contributing to ambiguity in the diagnosis. Thus, circulating pancreatic islet-enriched microRNAs (miRNAs) might be useful biomarkers of β-cell injury/dysfunction that would allow more accurate subtyping of diabetes. We measured plasma levels of selected miRNAs...

journal_title：Scientific reports

authors： Seyhan AA,Nunez Lopez YO,Xie H,Yi F,Mathews C,Pasarica M,Pratley RE

更新日期：2016-08-25 00:00:00

abstract：:The development of physiologically active semiochemicals is largely limited by the labor-consuming searching process. How to screen active semiochemicals efficiently is of significance to the extension of behavior regulation in pest control. Here pharmacophore modeling and shape-based virtual screening were combined t...

journal_title：Scientific reports

authors： Liu J,Tian Z,Zhang Y

更新日期：2016-10-06 00:00:00

abstract：:Gram-negative bacteria belonging to the genus Klebsiella are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as Escheric...

journal_title：Scientific reports

authors： Denkovskienė E,Paškevičius Š,Misiūnas A,Stočkūnaitė B,Starkevič U,Vitkauskienė A,Hahn-Löbmann S,Schulz S,Giritch A,Gleba Y,Ražanskienė A

更新日期：2019-10-28 00:00:00

abstract：:The genesis of the hair follicle relies on signals derived from mesenchymal cells in the dermis during skin morphogenesis and regeneration. Multipotent skin-derived precursors (SKPs), which exhibit long term proliferation potential when being cultured in spheroids, have been shown to induce hair genesis and hair folli...

journal_title：Scientific reports

authors： Guo L,Wang X,Yuan J,Zhu M,Fu X,Xu RH,Wu C,Wu Y

更新日期：2019-02-27 00:00:00

abstract：:To effectively manage a watershed and successfully restore a river system, it is very important to assess the toxicity of sediments and identify the substances causing the toxicity. Seventy-six sediments collected in the Haihe River Basin (HRB) in China were screened for acute toxicity using Chironomus dilutus. We fou...

journal_title：Scientific reports

authors： Zhu X,Shan B,Tang W,Zhang C

更新日期：2017-05-03 00:00:00

abstract：:Reef coral assemblages are highly dynamic and subject to repeated disturbances, which are predicted to increase in response to climate change. Consequently there is an urgent need to improve our understanding of the mechanisms underlying different recovery scenarios. Recent work has demonstrated that reef structural c...

journal_title：Scientific reports

authors： Hata T,Madin JS,Cumbo VR,Denny M,Figueiredo J,Harii S,Thomas CJ,Baird AH

更新日期：2017-05-22 00:00:00

abstract：:Breaking Continuous Flash Suppression (bCFS) has been adopted as an appealing means to study human visual awareness, but the literature is beclouded by inconsistent and contradictory results. Although previous reviews have focused chiefly on design pitfalls and instances of false reasoning, we show in this study that ...

journal_title：Scientific reports

authors： Kerr JA,Hesselmann G,Räling R,Wartenburger I,Sterzer P

更新日期：2017-06-07 00:00:00

abstract：:Covalent functionalisation of graphene is a continuously progressing field of research. The optical properties of such derivatives attract particular attention. In virtually all optical responses, however, an enhancement in peak intensity with increase of sp3 carbon content, and a vanishing of the peak position shift ...

journal_title：Scientific reports

authors： Vecera P,Eigler S,Koleśnik-Gray M,Krstić V,Vierck A,Maultzsch J,Schäfer RA,Hauke F,Hirsch A

更新日期：2017-03-27 00:00:00

abstract：:The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required. In order to identify new candidates as potential drug targets, we combined large-scale transposon mutagenesis data analysis and bioinforma...

journal_title：Scientific reports

authors： Fernández-Piñar R,Lo Sciuto A,Rossi A,Ranucci S,Bragonzi A,Imperi F

更新日期：2015-12-01 00:00:00

abstract：:The diversity of DNA sequencing methods and algorithms for genome assemblies presents scientists with a bewildering array of choices. Here, we construct and compare eight candidate assemblies combining overlapping shotgun read data, mate-pair and Chicago libraries and four different genome assemblers to produce a high...

journal_title：Scientific reports

authors： Fernandez-Silva I,Henderson JB,Rocha LA,Simison WB

更新日期：2018-01-24 00:00:00

abstract：:DNA focused panel sequencing has been rapidly adopted to assess therapeutic targets in advanced/refractory cancer. Integrated Genomic Profiling (IGP) utilising DNA/RNA with tumour/normal comparisons in a Clinical Laboratory Improvement Amendments (CLIA) compliant setting enables a single assay to provide: therapeutic ...

journal_title：Scientific reports

authors： Borad MJ,Egan JB,Condjella RM,Liang WS,Fonseca R,Ritacca NR,McCullough AE,Barrett MT,Hunt KS,Champion MD,Patel MD,Young SW,Silva AC,Ho TH,Halfdanarson TR,McWilliams RR,Lazaridis KN,Ramanathan RK,Baker A,Aldrich J,

更新日期：2016-12-23 00:00:00

abstract：:Almost half of the groundwater in the Pearl River Delta (PRD) contains salt water originally derived from paleo-seawater due to the Holocene transgression, which then generates intense physicochemical gradients in the mixing zone between freshwater and saltwater. Although some studies have been conducted on the hydrol...

journal_title：Scientific reports

authors： Sang S,Zhang X,Dai H,Hu BX,Ou H,Sun L

更新日期：2018-11-23 00:00:00

abstract：:The 170 National Forests and Grasslands (NFs) in the conterminous United States are public lands that provide important ecosystem services such as clean water and timber supply to the American people. This study investigates the potential impacts of climate change on two key ecosystem functions (i.e., water yield and ...

journal_title：Scientific reports

authors： Duan K,Sun G,Sun S,Caldwell PV,Cohen EC,McNulty SG,Aldridge HD,Zhang Y

更新日期：2016-04-21 00:00:00

abstract：:Yield-phenology relation is a critical issue affecting rainfed maize field productivity in semiarid east African Plateau (EAP). We first introduced Chinese ridge-furrow mulching (RFM) system to EAP, using three maize cultivars with early-, mid- and late-maturing traits as test materials. A two-year field experiment wa...

journal_title：Scientific reports

authors： Mo F,Wang JY,Li FM,Nguluu SN,Ren HX,Zhou H,Zhang J,Kariuki CW,Gicheru P,Kavagi L,Cheruiyot WK,Xiong YC

更新日期：2017-06-12 00:00:00

abstract：:FAS rs2234767 (-1377 G>A), rs1800682 (-670 A>G) and FASLG rs763110 (-844 C>T) promoter polymorphisms can influence transcriptional activities of the genes and thus multiple tumors susceptibility. To investigate their association with risk of colorectal cancer (CRC), the three SNPs were genotyped in 878 cases and 884 c...

journal_title：Scientific reports

authors： Wang S,Wu S,Meng Q,Li X,Zhang J,Chen R,Wang M

更新日期：2016-01-13 00:00:00

abstract：:Pertussis is a highly contagious disease for which prompt, point-of-care diagnosis remains an unmet clinical need. Results from conventional test modalities (nucleic acid detection, serology, and culture) take hours to days. To overcome this challenge, we identified a new biomarker (tracheal colonization factor A, Tcf...

journal_title：Scientific reports

authors： Burnham-Marusich AR,Olsen RK,Scarbrough J,Kvam A,Yang W,Zimmerman L,Dunn JJ,Merkel T,Kozel TR

更新日期：2020-09-14 00:00:00

abstract：:Antimicrobial peptides (AMPs) are peptide antibiotics with a broad spectrum of antimicrobial activities. Activity prediction of AMPs from their amino acid sequences is of great therapeutic importance but imposes challenges on prediction methods due to label interactions. In this paper we propose a novel multi-label le...

journal_title：Scientific reports

authors： Wang P,Ge R,Liu L,Xiao X,Li Y,Cai Y

更新日期：2017-05-19 00:00:00

abstract：:A new concept in the formulation of hybrid nanostructured materials combining high quality graphene 3D supported by Nickel foam and polyporphyrins for visible light photocatalytic application is here reported. Our innovative approach involves the development of a freestanding device able to: i) offer a high surface ar...

journal_title：Scientific reports

authors： Ussia M,Bruno E,Spina E,Vitalini D,Pellegrino G,Ruffino F,Privitera V,Carroccio SC

更新日期：2018-03-22 00:00:00

abstract：:Recent experimental work in the field of synthetic protocell biology has shown that prebiotic vesicles are able to 'steal' lipids from each other. This phenomenon is driven purely by asymmetries in the physical state or composition of the vesicle membranes, and, when lipid resource is limited, translates directly into...

journal_title：Scientific reports

authors： Shirt-Ediss B,Ruiz-Mirazo K,Mavelli F,Solé RV

更新日期：2014-07-14 00:00:00

abstract：:Adaptation of visual responses enhances visual information processing mainly by preserving the full dynamic range of neuronal responses during changing light conditions and is found throughout the whole visual system. Although adaptation in the primate superior colliculus neurons has received much attention little is ...

journal_title：Scientific reports

authors： Bytautiene J,Baranauskas G

更新日期：2018-06-12 00:00:00

abstract：:Helicobacter pylori is presumed to infect gastric tissue via the oral cavity in childhood, whereas risk factors for H. pylori infection in the oral cavity are unknown. In this study, we analysed the effects of Streptococcus mutans, a major cariogenic bacterial species, on H. pylori colonisation in the oral cavity, as ...

journal_title：Scientific reports

authors： Nomura R,Kadota T,Ogaya Y,Matayoshi S,Iwashita N,Okawa R,Nakano K

更新日期：2020-07-27 00:00:00

abstract：:The influence of an auroral substorm on the total electron content (TEC) jumps and cycle slips on Global Positioning System (GPS) at high-latitudes is studied. For the first time, optical data from the all-sky imager, as well as interplanetary magnetic field and magnetometer data are used to complete the analysis of t...

journal_title：Scientific reports

authors： Chernyshov AA,Miloch WJ,Jin Y,Zakharov VI

更新日期：2020-04-14 00:00:00

abstract：:Hepatic steatosis (HS) can exacerbate acute pancreatitis (AP). This study aimed to investigate the relation between α1-antitrypsin (AAT) and acute pancreatitis when patients have HS. Using proteomic profiling, we identified 18 differently expressed proteins pots in the serum of rats with or without HS after surgical e...

journal_title：Scientific reports

authors： Wang Q,Du J,Yu P,Bai B,Zhao Z,Wang S,Zhu J,Feng Q,Gao Y,Zhao Q,Liu C

更新日期：2015-12-04 00:00:00

abstract：:Salvia miltiorrhiza is one of the most widely-used medicinal plants. Here, we systematically analyzed the RNA editing events in its mitochondria. We developed a pipeline using REDItools to predict RNA editing events from stand-specific RNA-Seq data. The predictions were validated using reverse transcription, RT-PCR am...

journal_title：Scientific reports

authors： Wu B,Chen H,Shao J,Zhang H,Wu K,Liu C

更新日期：2017-02-10 00:00:00