当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling.

mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling.

Abstract：

:Efficient mitochondrial Ca2+ uptake takes place at contact points between the ER and mitochondria, and represents a key regulator of many cell functions. In a previous study with HeLa cells, we showed that ER-to-mitochondria Ca2+ transfer increases during the early phase of ER stress induced by tunicamycin as an adaptive response to stimulate mitochondrial bioenergetics. It remains unknown whether other types of stress signals trigger similar responses. Here we observed that rapamycin, which inhibits the nutrient-sensing complex mTORC1, increased ER-mitochondria coupling in HeLa cells to a similar extent as did tunicamycin. Interestingly, although global responses to both stressors were comparable, there were notable differences in the spatial distribution of such changes. While tunicamycin increased organelle proximity primarily in the perinuclear region, rapamycin increased organelle contacts throughout the entire cell. These differences were paralleled by dissimilar alterations in the distribution of regulatory proteins of the ER-mitochondria interface, heterogeneities in mitochondrial Ca2+ uptake, and the formation of domains within the mitochondrial network with varying mitochondrial transmembrane potential. Collectively, these data suggest that while increasing ER-mitochondria coupling appears to represent a general response to cell stress, the intracellular distribution of the associated responses needs to be tailored to meet specific cellular requirements.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Bravo-Sagua R,López-Crisosto C,Parra V,Rodriguez-Peña M,Rothermel BA,Quest AF,Lavandero S

doi

10.1038/srep36394

subject

Has Abstract

pub_date

2016-11-03 00:00:00

pages

36394

issn

2045-2322

pii

srep36394

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface.

    abstract：:Zolpidem is not a typical GABAA receptor hypnotic. Unlike benzodiazepines, zolpidem modulates tonic GABA currents in the rat dorsal motor nucleus of the vagus, exhibits residual effects in mice lacking the benzodiazepine binding site, and improves speech, cognitive and motor function in human patients with severe brai...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28674

    authors： Che Has AT,Absalom N,van Nieuwenhuijzen PS,Clarkson AN,Ahring PK,Chebib M

    更新日期：2016-06-27 00:00:00

  • Temporal variation in nutrient requirements of tea (Camellia sinensis) in China based on QUEFTS analysis.

    abstract：:Fertilisation datasets collected from field experiments (n = 21) in tea-producing areas from 2016 to 2018 were used to build a quantitative evaluation of the fertility of tropical soils (QUEFTS) model to estimate nutrient uptake of tea plants, and to investigate relationships between tea yield and nutrient accumulatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-57809-x

    authors： Tang S,Liu Y,Zheng N,Li Y,Ma Q,Xiao H,Zhou X,Xu X,Jiang T,He P,Wu L

    更新日期：2020-02-04 00:00:00

  • BioSphincters to treat Fecal Incontinence in Nonhuman Primates.

    abstract：:Loss of anorectal resting pressure due to internal anal sphincter (IAS) dysfunctionality causes uncontrolled fecal soiling and leads to passive fecal incontinence (FI). The study is focused on immediate and long-term safety and potential efficacy of bioengineered IAS BioSphincters to treat passive FI in a clinically r...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54440-3

    authors： Dadhich P,Bohl JL,Tamburrini R,Zakhem E,Scott C,Kock N,Mitchell E,Gilliam J,Bitar KN

    更新日期：2019-12-02 00:00:00

  • The effect of enamel proteins on erosion.

    abstract：:Enamel proteins form a scaffold for growing hydroxyapatite crystals during enamel formation. They are then almost completely degraded during enamel maturation, resulting in a protein content of only 1% (w/v) in mature enamel. Nevertheless, this small amount of remaining proteins has important effects on the mechanical...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15194

    authors： Baumann T,Carvalho TS,Lussi A

    更新日期：2015-10-15 00:00:00

  • Quantum phases in circuit QED with a superconducting qubit array.

    abstract：:Circuit QED on a chip has become a powerful platform for simulating complex many-body physics. In this report, we realize a Dicke-Ising model with an antiferromagnetic nearest-neighbor spin-spin interaction in circuit QED with a superconducting qubit array. We show that this system exhibits a competition between the c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04083

    authors： Zhang Y,Yu L,Liang JQ,Chen G,Jia S,Nori F

    更新日期：2014-02-13 00:00:00

  • Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.

    abstract：:Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without infectious or neuropsychiatric symptoms, lasting at least 6 consecutive months. Its pathogenesis remains incompletely understood. Here, we performed comprehensiv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34990

    authors： Yamano E,Sugimoto M,Hirayama A,Kume S,Yamato M,Jin G,Tajima S,Goda N,Iwai K,Fukuda S,Yamaguti K,Kuratsune H,Soga T,Watanabe Y,Kataoka Y

    更新日期：2016-10-11 00:00:00

  • Top down and bottom up selection drives variations in frequency and form of a visual signal.

    abstract：:The frequency and form of visual signals can be shaped by selection from predators, prey or both. When a signal simultaneously attracts predators and prey selection may favour a strategy that minimizes risks while attracting prey. Accordingly, varying the frequency and form of the silken decorations added to their web...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09543

    authors： Yeh CW,Blamires SJ,Liao CP,Tso IM

    更新日期：2015-03-30 00:00:00

  • Understanding turbulent free-surface vortex flows using a Taylor-Couette flow analogy.

    abstract：:Free-surface vortices have long been studied to develop an understanding of similar rotating flow phenomena observed in nature and technology. However, a complete description of its turbulent three-dimensional flow field still remains elusive. In contrast, the related Taylor-Couette flow system has been well explicate...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16950-w

    authors： Mulligan S,De Cesare G,Casserly J,Sherlock R

    更新日期：2018-01-16 00:00:00

  • Amyloid formation of growth hormone in presence of zinc: Relevance to its storage in secretory granules.

    abstract：:Amyloids are cross-β-sheet fibrillar aggregates, associated with various human diseases and native functions such as protein/peptide hormone storage inside secretory granules of neuroendocrine cells. In the current study, using amyloid detecting agents, we show that growth hormone (GH) could be stored as amyloid in th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23370

    authors： Jacob RS,Das S,Ghosh S,Anoop A,Jha NN,Khan T,Singru P,Kumar A,Maji SK

    更新日期：2016-03-23 00:00:00

  • Methane excess in Arctic surface water-triggered by sea ice formation and melting.

    abstract：:Arctic amplification of global warming has led to increased summer sea ice retreat, which influences gas exchange between the Arctic Ocean and the atmosphere where sea ice previously acted as a physical barrier. Indeed, recently observed enhanced atmospheric methane concentrations in Arctic regions with fractional sea...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16179

    authors： Damm E,Rudels B,Schauer U,Mau S,Dieckmann G

    更新日期：2015-11-10 00:00:00

  • An In Vivo Mouse Model of Pelvic Recurrence of Human Colorectal Cancer.

    abstract：:Pelvic recurrence of colorectal cancer is a crucial problem because radical surgery can lead to excessive invasion. Novel therapeutic strategies are required instead of surgery. However, there are few suitable models because of the difficulty in transplanting and observing tumors in the pelvis. We have established an ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56152-0

    authors： Yamamoto M,Taniguchi K,Masubuchi S,Tominaga T,Inomata Y,Miyamoto A,Ishizuka TA,Murakami T,Osumi W,Hamamoto H,Tanaka K,Okuda J,Uchiyama K

    更新日期：2019-12-23 00:00:00

  • Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents.

    abstract：:In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. Therefore, we investigated the anti-proliferative effect and its possible target in vitro and in vivo. We foun...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08410-2

    authors： Lee JJ,Lee JH,Yim NH,Han JH,Ma JY

    更新日期：2017-08-15 00:00:00

  • Estimating the probability of dengue virus introduction and secondary autochthonous cases in Europe.

    abstract：:Given the speed of air travel, diseases even with a short viremia such as dengue can be easily exported to dengue naïve areas within 24 hours. We set out to estimate the risk of dengue virus introductions via travelers into Europe and number of secondary autochthonous cases as a result of the introduction. We applied ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22590-5

    authors： Massad E,Amaku M,Coutinho FAB,Struchiner CJ,Burattini MN,Khan K,Liu-Helmersson J,Rocklöv J,Kraemer MUG,Wilder-Smith A

    更新日期：2018-03-15 00:00:00

  • Ameliorative effect of Silybin on bisphenol A induced oxidative stress, cell proliferation and steroid hormones oxidation in HepG2 cell cultures.

    abstract：:Bisphenol A (BPA) and silybin are considered xenoestrogens and could interfere with the action of endogenous hormones. It was demonstrated a higher level of BPA in plasma of nonalcoholic steatohepatitis (NASH) patients, compared to those with steatosis (NAFL). We investigated the effect of BPA and silybin, alone or in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40105-8

    authors： Lama S,Vanacore D,Diano N,Nicolucci C,Errico S,Dallio M,Federico A,Loguercio C,Stiuso P

    更新日期：2019-03-01 00:00:00

  • Calcium mishandling in absence of primary mitochondrial dysfunction drives cellular pathology in Wolfram Syndrome.

    abstract：:Wolfram syndrome (WS) is a recessive multisystem disorder defined by the association of diabetes mellitus and optic atrophy, reminiscent of mitochondrial diseases. The role played by mitochondria remains elusive, with contradictory results on the occurrence of mitochondrial dysfunction. We evaluated 13 recessive WS pa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61735-3

    authors： La Morgia C,Maresca A,Amore G,Gramegna LL,Carbonelli M,Scimonelli E,Danese A,Patergnani S,Caporali L,Tagliavini F,Del Dotto V,Capristo M,Sadun F,Barboni P,Savini G,Evangelisti S,Bianchini C,Valentino ML,Liguori R,To

    更新日期：2020-03-16 00:00:00

  • The relationship between alertness and spatial attention under simulated shiftwork.

    abstract：:Higher and lower levels of alertness typically lead to a leftward and rightward bias in attention, respectively. This relationship between alertness and spatial attention potentially has major implications for health and safety. The current study examined alertness and spatial attention under simulated shiftworking co...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-020-71800-6

    authors： Chandrakumar D,Dorrian J,Banks S,Keage HAD,Coussens S,Gupta C,Centofanti SA,Stepien JM,Loetscher T

    更新日期：2020-09-11 00:00:00

  • RNA sequencing of cancer reveals novel splicing alterations.

    abstract：:Breast cancer transcriptome acquires a myriad of regulation changes, and splicing is critical for the cell to "tailor-make" specific functional transcripts. We systematically revealed splicing signatures of the three most common types of breast tumors using RNA sequencing: TNBC, non-TNBC and HER2-positive breast cance...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01689

    authors： Eswaran J,Horvath A,Godbole S,Reddy SD,Mudvari P,Ohshiro K,Cyanam D,Nair S,Fuqua SA,Polyak K,Florea LD,Kumar R

    更新日期：2013-01-01 00:00:00

  • The number of key carcinogenic events can be predicted from cancer incidence.

    abstract：:The widely accepted multiple-hit hypothesis of carcinogenesis states that cancers arise after several successive events. However, no consensus has been reached on the quantity and nature of these events, although "driver" mutations or epimutations are considered the most probable candidates. By using the largest publi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12448-7

    authors： Belikov AV

    更新日期：2017-09-22 00:00:00

  • A new ecology-on-a-chip microfluidic platform to study interactions of microbes with a rising oil droplet.

    abstract：:Advances in microfluidics technology has enabled many discoveries on microbial mechanisms and phenotypes owing to its exquisite controls over biological and chemical environments. However, emulating accurate ecologically relevant flow environments (e.g. microbes around a rising oil droplet) in microfluidics remains ch...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50153-9

    authors： White AR,Jalali M,Sheng J

    更新日期：2019-09-24 00:00:00

  • Author Correction: Isolation and identification of two pairs of cytotoxic diterpene tautomers and their tautomerization mechanisms.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-61343-1

    authors： Dai LP,Li XF,Feng QM,Zhang LX,Liu QY,Xu EP,Wu H,Wang ZM

    更新日期：2020-03-04 00:00:00

  • Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo.

    abstract：:Copper (Cu), an essential nutrient, promotes wound healing, however, target of Cu action and underlying mechanisms remain elusive. Cu chaperone Antioxidant-1 (Atox1) in the cytosol supplies Cu to the secretory enzymes such as lysyl oxidase (LOX), while Atox1 in the nucleus functions as a Cu-dependent transcription fac...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33783

    authors： Das A,Sudhahar V,Chen GF,Kim HW,Youn SW,Finney L,Vogt S,Yang J,Kweon J,Surenkhuu B,Ushio-Fukai M,Fukai T

    更新日期：2016-09-26 00:00:00

  • Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes.

    abstract：:The reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) can be achieved by ectopic expression of defined transcription factors (Oct3/4, Sox2, Klf4 and c-Myc). However, to date, some iPSCs have been generated using viral vectors; thus, unexpected insertional mutagenesis in the target cells...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07323

    authors： Dai P,Harada Y,Miyachi H,Tanaka H,Kitano S,Adachi T,Suzuki T,Hino H,Takamatsu T

    更新日期：2014-12-04 00:00:00

  • Fusion proteins with chromogenic and keratin binding modules.

    abstract：:The present research relates to a fusion protein comprising a chromogenic blue ultramarine protein (UM) bound to a keratin-based peptide (KP). The KP-UM fusion protein explores UM chromogenic nature together with KP affinity towards hair. For the first time a fusion protein with a chromogenic nature is explored as a h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50283-0

    authors： Tinoco A,Antunes E,Martins M,Gonçalves F,Gomes AC,Silva C,Cavaco-Paulo A,Ribeiro A

    更新日期：2019-10-01 00:00:00

  • Low brain endocannabinoids associated with persistent non-goal directed nighttime hyperactivity after traumatic brain injury in mice.

    abstract：:Traumatic brain injury (TBI) is a frequent cause of chronic headache, fatigue, insomnia, hyperactivity, memory deficits, irritability and posttraumatic stress disorder. Recent evidence suggests beneficial effects of pro-cannabinoid treatments. We assessed in mice levels of endocannabinoids in association with the occu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71879-x

    authors： Vogel A,Wilken-Schmitz A,Hummel R,Lang M,Gurke R,Schreiber Y,Schäfer MKE,Tegeder I

    更新日期：2020-09-10 00:00:00

  • Metastability in lipid based particles exhibits temporally deterministic and controllable behavior.

    abstract：:The metastable-to-stable phase-transition is commonly observed in many fields of science, as an uncontrolled independent process, highly sensitive to microscopic fluctuations. In particular, self-assembled lipid suspensions exhibit phase-transitions, where the underlying driving mechanisms and dynamics are not well un...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09481

    authors： Jacoby G,Cohen K,Barkan K,Talmon Y,Peer D,Beck R

    更新日期：2015-03-30 00:00:00

  • Zinc depletion promotes apoptosis-like death in drug-sensitive and antimony-resistance Leishmania donovani.

    abstract：:Micronutrients are essential for survival and growth for all the organisms including pathogens. In this manuscript, we report that zinc (Zn) chelator N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethylenediamine (TPEN) affects growth and viability of intracellular pathogen Leishmania donovani (LD) by a concentration and t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10041-6

    authors： Saini S,Bharati K,Shaha C,Mukhopadhyay CK

    更新日期：2017-09-05 00:00:00

  • Paternal obesity modifies the effect of an antenatal lifestyle intervention in women who are overweight or obese on newborn anthropometry.

    abstract：:The contribution of paternal obesity to pregnancy outcomes has been little described. Our aims were to determine whether the effect of an antenatal maternal dietary and lifestyle intervention among women who are overweight or obese on newborn adiposity, was modified by paternal obesity. We conducted a secondary analys...

    journal_title：Scientific reports

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/s41598-017-01672-w

    authors： Dodd JM,Du Plessis LE,Deussen AR,Grivell RM,Yelland LN,Louise J,Mcphee AJ,Robinson JS,Owens JA

    更新日期：2017-05-08 00:00:00

  • Improving the electron spin properties of nitrogen-vacancy centres in nanodiamonds by near-field etching.

    abstract：:The nitrogen-vacancy (NV) centre in diamond is a promising candidate for quantum computing applications and magnetic sensing applications, because it is an atomic-scale defect with stable coherence time (T2) and reliable accessibility at room temperature. We demonstrated a method for improving the NV spin properties (...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34158-4

    authors： Brandenburg F,Nagumo R,Saichi K,Tahara K,Iwasaki T,Hatano M,Jelezko F,Igarashi R,Yatsui T

    更新日期：2018-10-26 00:00:00

  • IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production.

    abstract：:Inhibitor of kappa B (IκB)-ζ transcription is rapidly induced by stimulation with TLR ligands and IL-1. Despite high IκBζ expression in inflammation sites, the association of IκBζ with host defence via systemic immune responses against bacterial infection remains unclear. Oral immunisation with a recombinant attenuate...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44019-3

    authors： Ahn JH,Cho J,Kwon BE,Lee GS,Yoon SI,Kang SG,Kim PH,Kweon MN,Yang H,Vallance BA,Kim YI,Chang SY,Ko HJ

    更新日期：2019-06-10 00:00:00

  • Vitellogenin induction in caudal fin of guppy (Poecilia reticulata) as a less invasive and sensitive biomarker for environmental estrogens.

    abstract：:Guppy (Poecilia reticulata) is an ideal model for studying environmental estrogens, and its large caudal fin has a high capacity to regenerate. This study analyzed the feasibility of caudal fin for detecting vitellogenin (Vtg), the most commonly used biomarker of environmental estrogens. Firstly, a sandwich ELISA for ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06670-6

    authors： Wang J,Ma S,Zhang Z,Zheng M,Dong Y,Ru S

    更新日期：2017-08-09 00:00:00