Abstract：
:Inhibitor of kappa B (IκB)-ζ transcription is rapidly induced by stimulation with TLR ligands and IL-1. Despite high IκBζ expression in inflammation sites, the association of IκBζ with host defence via systemic immune responses against bacterial infection remains unclear. Oral immunisation with a recombinant attenuated Salmonella vaccine (RASV) strain did not protect IκBζ-deficient mice against a lethal Salmonella challenge. IκBζ-deficient mice failed to produce Salmonella LPS-specific IgG, especially IgG2a, although inflammatory cytokine production and immune cell infiltration into the liver increased after oral RASV administration. Moreover, IκBζ-deficient mice exhibited enhanced splenic germinal centre reactions followed by increased total IgG production, despite IκBζ-deficient B cells having an intrinsic antibody class switching defect. IκBζ-deficient CD4+ T cells poorly differentiated into Th1 cells. IFN-γ production by CD4+ T cells from IκBζ-deficient mice immunised with RASV significantly decreased after restimulation with heat-killed RASV in vitro, suggesting that IκBζ-deficient mice failed to mount protective immune responses against Salmonella infection because of insufficient Th1 and IgG production. Therefore, IκBζ is crucial in protecting against Salmonella infection by inducing Th1 differentiation followed by IgG production.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ahn JH,Cho J,Kwon BE,Lee GS,Yoon SI,Kang SG,Kim PH,Kweon MN,Yang H,Vallance BA,Kim YI,Chang SY,Ko HJdoi
10.1038/s41598-019-44019-3subject
Has Abstractpub_date
2019-06-10 00:00:00pages
8397issue
1issn
2045-2322pii
10.1038/s41598-019-44019-3journal_volume
9pub_type
杂志文章abstract：:We investigate temperature smearing effects on the electron-boson spectral density function (I(2)χ(ω)) obtained from optical data using a maximum entropy inversion method. We start with two simple model input I(2)χ(ω), calculate the optical scattering rates at selected temperatures using the model input spectral densi...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-03-31 00:00:00
abstract：:p53 and aldehyde dehydrogenase (ALDH) have been implicated in key tumorigenesis processes including cancer initiating cell (CIC) maintenance; however, the relationship between these two mediators remains poorly defined. In this study, ALDH isoform expression diversity was revealed in CICs with disparate p53 functional...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-01-23 00:00:00
abstract：:Synthetic fertilizer production is associated with a high environmental footprint, as compounds typically dissolve rapidly leaching emissions to the atmosphere or surface waters. We tested two recovered nutrients with slower release patterns, as promising alternatives for synthetic fertilizers: struvite and a commerci...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-07-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-09-29 00:00:00
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journal_title：Scientific reports
pub_type： 历史文章,杂志文章
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更新日期：2019-11-28 00:00:00
abstract：:Drosophila melanogaster is a promiscuous species that inhabits a large range of harsh environments including flooded habitats and varying temperature changes. To survive these environments, fruit flies have adapted mechanisms of tolerance that allow them to thrive. During exposure to anoxic stress, fruit flies and oth...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-03-17 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2021-01-12 00:00:00
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更新日期：2018-01-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2014-06-19 00:00:00
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