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Fusion proteins with chromogenic and keratin binding modules.

Abstract：

:The present research relates to a fusion protein comprising a chromogenic blue ultramarine protein (UM) bound to a keratin-based peptide (KP). The KP-UM fusion protein explores UM chromogenic nature together with KP affinity towards hair. For the first time a fusion protein with a chromogenic nature is explored as a hair coloring agent. The KP-UM protein colored overbleached hair, being the color dependent on the formulation polarity. The protein was able to bind to the hair cuticle and even to penetrate throughout the hair fibre. Molecular dynamics studies demonstrated that the interaction between the KP-UM protein and the hair was mediated by the KP sequence. All the formulations recovered the mechanical properties of overbleached hair and KP-UM proved to be safe when tested in human keratinocytes. Although based on a chromogenic non-fluorescent protein, the KP-UM protein presented a photoswitch phenomenon, changing from chromogenic to fluorescent depending on the wavelength selected for excitation. KP-UM protein shows the potential to be incorporated in new eco-friendly cosmetic formulations for hair coloration, decreasing the use of traditional dyes and reducing its environmental impact.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Tinoco A,Antunes E,Martins M,Gonçalves F,Gomes AC,Silva C,Cavaco-Paulo A,Ribeiro A

doi

10.1038/s41598-019-50283-0

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

14044

issue

1

issn

2045-2322

pii

10.1038/s41598-019-50283-0

journal_volume

9

pub_type

杂志文章

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