Abstract：
:The role of the actin cytoskeleton in relation to mitochondria function and dynamics is only recently beginning to be recognized. Myo19 is an actin-based motor that is bound to the outer mitochondrial membrane and promotes the localization of mitochondria to filopodia in response to glucose starvation. However, how glucose starvation induces mitochondria localization to filopodia, what are the dynamics of this process and which enzymatic adaptation allows the translocation of mitochondria to filopodia are not known. Here we show that reactive oxygen species (ROS) mimic and mediate the glucose starvation induced phenotype. In addition, time-lapse fluorescent microscopy reveals that ROS-induced Myo19 motility is a highly dynamic process which is coupled to filopodia elongation and retraction. Interestingly, Myo19 motility is inhibited by back-to-consensus-mutation of a unique residue of class XIX myosins in the motor domain. Kinetic analysis of the purified mutant Myo19 motor domain reveals that the duty ratio (time spent strongly bound to actin) is highly compromised in comparison to that of the WT motor domain, indicating that Myo19 unique motor properties are necessary to propel mitochondria to filopodia tips. In summary, our study demonstrates the contribution of actin-based motility to the mitochondrial localization to filopodia by specific cellular cues.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shneyer BI,Ušaj M,Wiesel-Motiuk N,Regev R,Henn Adoi
10.1038/s41598-017-11002-9subject
Has Abstractpub_date
2017-09-14 00:00:00pages
11577issue
1issn
2045-2322pii
10.1038/s41598-017-11002-9journal_volume
7pub_type
杂志文章abstract：:Coriander foliage is a distinctive spice employed on a daily basis in curry and other Indian traditional food preparations mainly for the unique flavour attributes and health benefits. Radical scavenging activity has been demonstrated previously for coriander foliage. However, specific molecules responsible were not i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35836-z
更新日期：2018-11-27 00:00:00
abstract：:In this paper, three plastomes of Mankyua chejuense, Helminthostachys zeylanica, and Botrychium ternatum in Ophioglossaceae were completely sequenced in order to investigate the plastome evolution and phylogeny of eusporangiate ferns. They were similar to each other in terms of length and the gene orders; however, six...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34825-6
更新日期：2018-11-07 00:00:00
abstract：:Atherosclerotic arteries exhibit characteristic constrictions and substantial deviations from cylindrical shape. Therefore, determining the artery's cross-section along the centerline is challenging, although high-resolution isotropic three-dimensional data are available. Herein, we apply high-resolution computed tomo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50711-1
更新日期：2019-10-04 00:00:00
abstract：:Light modulates global features of the important human pathogen Acinetobacter baumannii lifestyle including metabolism, tolerance to antibiotics and virulence, most of which depend on the short BLUF-type photoreceptor BlsA. In this work, we show that the ability to circumvent iron deficiency is also modulated by light...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26127-8
更新日期：2018-05-16 00:00:00
abstract：:Post-glycosylphosphatidylinositol (GPI) attachment to proteins 3, also known as PGAP3 or PERLD1 (PER1-like domain-containing protein 1), participates in the lipid remodeling process of glycosylphosphatidylinositol (GPI) anchor proteins during post-translational modification. Functional defect in PERLD1 was previously ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57592-9
更新日期：2020-01-20 00:00:00
abstract：:We present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, real-time co-evolution of the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22027-z
更新日期：2018-02-23 00:00:00
abstract：:Massive gully land consolidation projects, launched in China's Loess Plateau, aim to restore 2667 [Formula: see text] agricultural lands in total by consolidating 2026 highly eroded gullies. This effort represents a social engineering project where the economic development and livelihood of the farming families are cl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73910-7
更新日期：2020-10-09 00:00:00
abstract：:Cells harboring latent HIV-1 pose a major obstacle to eradication of the virus. The 'shock and kill' strategy has been broadly explored to purge the latent reservoir; however, none of the current latency-reversing agents (LRAs) can safely and effectively activate the latent virus in patients. In this study, we report ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07157-0
更新日期：2017-08-25 00:00:00
abstract：:We report a recent experimental simulation of a controlled-NOT gate operation based on polarization correlation measurements of thermal fields in photon-number fluctuations. The interference between pairs of correlated paths at the very heart of these experiments has the potential for the simulation of correlations be...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30152
更新日期：2016-07-21 00:00:00
abstract：:Attention and saccadic eye movements are critical components of visual perception. Recent studies proposed the hypothesis of a tight coupling between saccadic adaptation (SA) and attention: SA increases the processing speed of unpredictable stimuli, while increased attentional load boosts SA. Moreover, their cortical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70120-z
更新日期：2020-08-10 00:00:00
abstract：:Chinese sturgeon (Acipenser sinensis) has been listed as a critically endangered species on the IUCN Red List and is an endemic fish of China. Five sets of duplex polymerase chain reactions (PCR) assays were developed with 10 tetranucleotide microsatellites for Chinese sturgeon. The size of CS57, ZHX43, ZHX69, AS105, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60401-y
更新日期：2020-02-26 00:00:00
abstract：:Few-layer black phosphorus (BP) is the most promising material among the two-dimensional materials due to its layered structure and the excellent semiconductor properties. Currently, thin BP atomic layers are obtained mostly by mechanical exfoliation of bulk BP, which limits applications in thin-film based electronics...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23736
更新日期：2016-03-30 00:00:00
abstract：:Climate change vulnerability assessment (CCVA) has become a mainstay conservation decision support tool. CCVAs are recommended to incorporate three elements of vulnerability - exposure, sensitivity and adaptive capacity - yet, lack of data frequently leads to the latter being excluded. Further, weighted or unweighted ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13245-y
更新日期：2017-10-11 00:00:00
abstract：:The Turin Shroud is traditionally considered to be the burial cloth in which the body of Jesus Christ was wrapped after his death approximately 2000 years ago. Here, we report the main findings from the analysis of genomic DNA extracted from dust particles vacuumed from parts of the body image and the lateral edge use...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14484
更新日期：2015-10-05 00:00:00
abstract：:Living organisms employ various mechanisms to escape harm. At the cellular level, mobile cells employ movement to avoid harmful chemicals or repellents. The present study is the first to report that cells move away from the site of injury in response to local wounding. When a migrating Dictyostelium cell was locally w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39678-1
更新日期：2019-03-12 00:00:00
abstract：:Delay embedding-a method for reconstructing dynamical systems by delay coordinates-is widely used to forecast nonlinear time series as a model-free approach. When multivariate time series are observed, several existing frameworks can be applied to yield a single forecast combining multiple forecasts derived from vario...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57255-4
更新日期：2020-01-20 00:00:00
abstract：:Glyoxalase pathway plays an important role in stress adaptation and many clinical disorders. The first enzyme of this pathway, glyoxalase I (GlxI), uses methylglyoxal as a substrate and requires either Ni(II)/Co(II) or Zn(II) for activity. Here we have investigated the origin of different metal ion specificities of Gl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03076
更新日期：2013-11-13 00:00:00
abstract：:The current economics of the fish protein industry demand rapid, accurate and expressive prediction algorithms at every step of protein production especially with the challenge of global climate change. This help to predict and analyze functional and nutritional quality then consequently control food allergies in hype...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10890-1
更新日期：2017-09-07 00:00:00
abstract：:L-asparaginase is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL). The main prerequisite for clinical efficacy of L-asparaginases is micromolar KM for asparagine to allow for complete depletion of this amino acid in the blood. Since currently approved L-asparaginases are of bacterial origin, immun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10758-4
更新日期：2017-08-31 00:00:00
abstract：:This work demonstrates the first application of direct broadband (1 GHz-30 GHz) quality (Q) factor measurements of the uniform precession mode in magnetised garnet spheres for the accurate determination of the room-temperature intrinsic ferromagnetic linewidth (ΔH). The spheres were enclosed in a subwavelength cavity,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45699-7
更新日期：2019-07-01 00:00:00
abstract：:The fluorination of p-type metal phthalocyanines produces n-type semiconductors, allowing the design of organic electronic circuits that contain inexpensive heterojunctions made from chemically and thermally stable p- and n-type organic semiconductors. For the evaluation of close to intrinsic transport properties, hig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07573
更新日期：2014-12-19 00:00:00
abstract：:Hypoplastic left heart syndrome (HLHS) is a fatal congenital heart disease in which the left side of the heart is underdeveloped, impairing the systemic circulation. Underdeveloped left ventricle exerts biomechanical stress on the right ventricle that can progress into heart failure. Genome-wide transcriptome changes ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30896
更新日期：2016-08-03 00:00:00
abstract：:Meishan boars are known for their early sexual maturity. However, they exhibit a significantly smaller testicular size and a reduced proportion of Sertoli cells and daily sperm production compared with Duroc boars. The testes of Duroc and Meishan boars at 20, 75 and 270 days of age were used for histological and trans...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20758
更新日期：2016-02-11 00:00:00
abstract：:The development of new anode materials having high electrochemical performances and interesting reaction mechanisms is highly required to satisfy the need for long-lasting mobile electronic devices and electric vehicles. Here, we report a layer crystalline structured SnP3 and its unique electrochemical behaviors with ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35980
更新日期：2016-10-24 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is a hyperglycaemic imbalance first recognized during pregnancy, and affects up to 22% of pregnancies worldwide, bringing negative maternal-fetal consequences in the short- and long-term. In order to better characterize GDM in pregnant women, 100 blood plasma samples (50 GDM and 50 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75539-y
更新日期：2020-11-06 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-36016-9
更新日期：2018-11-23 00:00:00
abstract：:Two yellow luminescence bands related to different defects have been revealed in undoped GaN grown by hydride vapor phase epitaxy (HVPE). One of them, labeled YL1, has the zero-phonon line (ZPL) at 2.57 eV and the band maximum at 2.20 eV at low temperature. This luminescence band is the ubiquitous yellow band observed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26354-z
更新日期：2018-05-25 00:00:00
abstract：:Rassf1A/5 tumor suppressors serve as adaptor proteins possessing a modular architecture with the C-terminal consisting of a coiled-coil SARAH (Salvador-Rassf-Hippo) domain and the central portion being composed of Ras associated (RA) domain. Here, we investigate the effect of Rassf effectors on Mst1 function by mappin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45020
更新日期：2017-03-22 00:00:00
abstract：:Lariatin A, an 18-residue lasso peptide encoded by the five-gene cluster larABCDE, displays potent and selective anti-mycobacterial activity. The structural feature is an N-terminal macrolactam ring, through which the C-terminal passed to form the rigid lariat-protoknot structure. In the present study, we established ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30375
更新日期：2016-07-26 00:00:00
abstract：:Diets high in advanced glycation end products (AGEs) are thought to be detrimental to cardiovascular health. However, there remains uncertainty about the beneficial effect of a low AGE diet on cardiovascular risk factors and inflammatory markers in overweight individuals. We thus performed a randomised, double blind, ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/s41598-017-04214-6
更新日期：2017-06-23 00:00:00
