Discovery of human-like L-asparaginases with potential clinical use by directed evolution.

abstract：:Driven diffusive systems have been a paradigm for modelling many physical, chemical, and biological transport processes. In the systems, spatial correlation plays an important role in the emergence of a variety of nonequilibrium phenomena and exhibits rich features such as pronounced oscillations. However, the lack of...

journal_title：Scientific reports

authors： Hao QY,Jiang R,Hu MB,Jia B,Wang WX

更新日期：2016-01-25 00:00:00

abstract：:During pregnancy several maternal adaptations occur in order to support the growing fetus which are further exacerbated by gestational diabetes mellitus (GDM). Previously we developed a mouse model of GDM, however we did not evaluate alterations to energy and fat metabolism. We have also shown that alterations in lipi...

journal_title：Scientific reports

authors： Pennington KA,Dong Y,Ruano SH,van der Walt N,Sangi-Haghpeykar H,Yallampalli C

更新日期：2020-11-30 00:00:00

abstract：:In the field of correlative microscopy, light and electron microscopy form a powerful combination for morphological analyses in zoology. Due to sample thickness limitations, these imaging techniques often require sectioning to investigate small animals and thereby suffer from various artefacts. A recently introduced n...

journal_title：Scientific reports

authors： Ferstl S,Schwaha T,Ruthensteiner B,Hehn L,Allner S,Müller M,Dierolf M,Achterhold K,Pfeiffer F

更新日期：2020-03-03 00:00:00

abstract：:Nanophotonic circuitry requires an ability to externally control and analyze optical signals tightly confined in subwavelength volumes. Various schemes of surface plasmon (SP) routing have been presented using active and passive metasurfaces. One of the most appealing approaches is the use of plasmonic spin-orbit inte...

journal_title：Scientific reports

authors： Revah M,Yaroshevsky A,Gorodetski Y

更新日期：2019-06-20 00:00:00

abstract：:Directed transport of biological species across the surface of a substrate is essential for realizing lab-on-chip technologies. Approaches that utilize localized magnetic fields to manipulate magnetic particles carrying biological entities are attractive owing to their sensitivity, selectivity, and minimally disruptiv...

journal_title：Scientific reports

authors： Rapoport E,Beach GSD

更新日期：2017-08-31 00:00:00

abstract：:The recent discovery of magnetic skyrmion lattices initiated a surge of interest in the scientific community. Several novel phenomena have been shown to emerge from the interaction of conducting electrons with the skyrmion lattice, such as a topological Hall-effect and a spin-transfer torque at ultra-low current densi...

journal_title：Scientific reports

authors： Levatić I,Popčević P,Šurija V,Kruchkov A,Berger H,Magrez A,White JS,Rønnow HM,Živković I

更新日期：2016-02-19 00:00:00

abstract：:Pantoea sp. IMH is the only bacterium found in genus Pantoea with a high As resistance capacity, but its molecular mechanism is unknown. Herein, the organization, function, and evolution of ars genes in IMH are studied starting with analysis of the whole genome. Two ars systems - ars1 (arsR1B1C1H1) and ars2 (arsR2B2C2...

journal_title：Scientific reports

authors： Wang L,Zhuang X,Zhuang G,Jing C

更新日期：2016-12-14 00:00:00

abstract：:Interleukin (IL)-27, a member of the IL-12 cytokine family, plays an important and diverse role in the function of the immune system. We have previously demonstrated that IL-27 is an anti-viral cytokine which inhibits HIV-1, HIV-2, Influenza virus and herpes simplex virus infection, and enhances the potential of react...

journal_title：Scientific reports

authors： Sowrirajan B,Saito Y,Poudyal D,Chen Q,Sui H,DeRavin SS,Imamichi H,Sato T,Kuhns DB,Noguchi N,Malech HL,Lane HC,Imamichi T

更新日期：2017-02-27 00:00:00

abstract：:The DEAD-box RNA helicase DDX3 plays divergent roles in tumorigenesis, however, its function in mitosis is unclear. Immunofluorescence indicated that DDX3 localized to centrosome throughout the cell cycle and colocalized with centrosome-associated p53 during mitosis in HCT116 and U2OS cells. DDX3 depletion promoted ch...

journal_title：Scientific reports

authors： Chen WJ,Wang WT,Tsai TY,Li HK,Lee YW

更新日期：2017-08-25 00:00:00

abstract：:With the reduction of oil and gas reserves and the increase of mining difficulty in Northern China, the carbonate rocks in Southern North China Basin are becoming a significant exploration target for carbonate reservoirs. However, the development characteristics, formation stages, formation environments and mechanisms...

journal_title：Scientific reports

authors： Zhang H,Xu G,Liu M,Wang M

更新日期：2021-01-12 00:00:00

abstract：:Nitrogen (N) deposition is a key factor that affects terrestrial biogeochemical cycles with a growing trend, especially in the southeast region of China, where shortage of available phosphorus (P) is particularly acute and P has become a major factor limiting plant growth and productivity. Arbuscular mycorrhizal fungi...

journal_title：Scientific reports

authors： Lin C,Wang Y,Liu M,Li Q,Xiao W,Song X

更新日期：2020-07-23 00:00:00

abstract：:Red mud as a waste material is produced in large quantities by the aluminum industry. Heat activation has been used to enhance sorption capacity of red mud for its beneficial reuse as an effective sorbent. In this study, heat-activated red mud (HARM) was investigated for its Cd(II) sorption capacity under various proc...

journal_title：Scientific reports

authors： Yang T,Sheng L,Wang Y,Wyckoff KN,He C,He Q

更新日期：2018-09-10 00:00:00

abstract：:Data on post stroke outcomes in developing countries are scarce due to uncoordinated healthcare delivery systems. In Malaysia, the national stroke clinical practice guideline does not address transfer of care and longer term post stroke care beyond tertiary care. Hence, post stroke care delivery may be delivered at ei...

journal_title：Scientific reports

authors： Abdul Aziz AF,Ali MF,Yusof MF,Che' Man Z,Sulong S,Aljunid SM

更新日期：2018-12-19 00:00:00

abstract：:APOBEC3G (A3G) belongs to the family of cytosine deaminases that play an important role in the innate immune response. Similar to other, two-domain members of the APOBEC family, A3G is prone to concentration-dependent oligomerization, which is an integral for its function in the cell. It is shown that oligomerization ...

journal_title：Scientific reports

authors： Pan Y,Zagorski K,Shlyakhtenko LS,Lyubchenko YL

更新日期：2018-12-18 00:00:00

abstract：:Post-transcriptional gene regulation by microRNAs (miRNAs) is involved in memory formation. However, the roles of individual miRNAs in these processes remain largely unknown. In this study, we want to clarify the role of miR-181a in hippocampus-dependent memory formation. A transient increase in miR-181a expression wa...

journal_title：Scientific reports

authors： Zhang SF,Chen JC,Zhang J,Xu JG

更新日期：2017-08-16 00:00:00

abstract：:Spherical radioactive caesium (Cs)-bearing microparticles (CsMPs) were emitted during the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident in March, 2011. The emission source (timing) and formation process of these particles remain unclear. In this study, the isotopic ratios of uranium (235U and 238U) and caesi...

journal_title：Scientific reports

authors： Kurihara Y,Takahata N,Yokoyama TD,Miura H,Kon Y,Takagi T,Higaki S,Yamaguchi N,Sano Y,Takahashi Y

更新日期：2020-02-24 00:00:00

abstract：:Difficulties in the production of lignin from rice straw because of high silica content in the recovered lignin reduce its recovery yield and applications as bio-fuel and aromatic chemicals. Therefore, the objective of this study is to develop a novel method to reduce the silica content in lignin from rice straw more ...

journal_title：Scientific reports

authors： Do NH,Pham HH,Le TM,Lauwaert J,Diels L,Verberckmoes A,Do NHN,Tran VT,Le PK

更新日期：2020-12-04 00:00:00

abstract：:The phytohormone auxin is a major determinant and regulatory component important for plant development. Auxin transport between cells is mediated by a complex system of transporters such as AUX1/LAX, PIN, and ABCB proteins, and their localization and activity is thought to be influenced by phosphatases and kinases. Fl...

journal_title：Scientific reports

authors： Kuhn BM,Nodzyński T,Errafi S,Bucher R,Gupta S,Aryal B,Dobrev P,Bigler L,Geisler M,Zažímalová E,Friml J,Ringli C

更新日期：2017-02-06 00:00:00

abstract：:Previous results regarding the associations between esophageal squamous-cell carcinoma (ESCC) risk and smoking/alcohol drinking in high-risk areas are inconsistent. We performed a large population-based case-control study from 2010 to 2013 in a high-incidence area of China, and enrolled 1353 ESCC cases and 1961 contro...

journal_title：Scientific reports

authors： Yang X,Chen X,Zhuang M,Yuan Z,Nie S,Lu M,Jin L,Ye W

更新日期：2017-12-08 00:00:00

abstract：:Loss of stromal Caveolin-1 (CAV1) expression is associated with poor prognosis in various cancers. We evaluated the prognostic value of CAV1 expression of both cancer cells and stromal cells in colorectal liver metastases (CRLM) in patients undergoing hepatectomy. In this retrospective study, 109 patients were enrolle...

journal_title：Scientific reports

authors： Neofytou K,Pikoulis E,Petrou A,Agrogiannis G,Petrides C,Papakonstandinou I,Papalambros A,Aggelou A,Kavatzas N,Liakakos T,Felekouras E

更新日期：2017-05-17 00:00:00

abstract：:Anisotropic Fe3O4 nanoparticle and a series of its graphene composites have been successfully prepared as high-frequency absorbers. The crystal structure, morphology and magnetic property of the samples were detailed characterized through X-ray diffractometer (XRD), transmission electron microscopy (TEM) and vibrating...

journal_title：Scientific reports

authors： Yin Y,Zeng M,Liu J,Tang W,Dong H,Xia R,Yu R

更新日期：2016-05-04 00:00:00

abstract：:The consumption of bovine milk and meat is considered a risk factor for colon- and breast cancer formation, and milk consumption has also been implicated in an increased risk for developing Multiple Sclerosis (MS). A number of highly related virus-like DNAs have been recently isolated from bovine milk and sera and fro...

journal_title：Scientific reports

authors： Eilebrecht S,Hotz-Wagenblatt A,Sarachaga V,Burk A,Falida K,Chakraborty D,Nikitina E,Tessmer C,Whitley C,Sauerland C,Gunst K,Grewe I,Bund T

更新日期：2018-02-12 00:00:00

abstract：:Often ignored and regarded as mere transcriptional noise, long noncoding RNAs (lncRNAs) are starting to be considered key regulators of gene expression across the Eukarya domain of life. In the model diatom Phaeodactylum tricornutum, we have previously reported the occurrence of 1,510 intergenic lncRNAs (lincRNAs), ma...

journal_title：Scientific reports

authors： Cruz de Carvalho MH,Bowler C

更新日期：2020-08-24 00:00:00

abstract：:The order Chlamydiales are biphasic intracellular bacterial pathogens infecting humans and domesticated animals. Wildlife infections have also been reported, with the most studied example being Chlamydia pecorum infections in the koala, an iconic Australian marsupial. In koalas, molecular evidence suggests that spill-...

journal_title：Scientific reports

authors： Burnard D,Huston WM,Webb JK,Jelocnik M,Reiss A,Gillett A,Fitzgibbon S,Carver S,Carrucan J,Flanagan C,Timms P,Polkinghorne A

更新日期：2017-10-09 00:00:00

abstract：:The ideal type of stent utilized at index endoscopic retrograde cholangiopancreatography (ERCP) in management of malignant hilar obstruction (MHO) remains unclear. We aimed to determine the ideal stent choice in patients with MHO. In this retrospective study, patients with unresectable MHO were separated into the plas...

journal_title：Scientific reports

authors： Choi JH,Lee SH,You MS,Shin BS,Choi YH,Kang J,Jang S,Paik WH,Ryu JK,Kim YT

更新日期：2019-09-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Arntzen JW,van Belkom J

更新日期：2020-04-24 00:00:00

abstract：:Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full ...

journal_title：Scientific reports

authors： Zhang M,Zhang X,Xu K,Teng Q,Liu Q,Li X,Yang J,Xu J,Chen H,Zhang X,Li Z

更新日期：2016-09-28 00:00:00

abstract：:Soils - constituting the largest terrestrial carbon pool - are vulnerable to climatic warming. Currently existing uncertainties regarding carbon fluxes within terrestrial systems can be addressed by studies of past carbon cycle dynamics and related climate change recorded in sedimentary successions. Here we show an ex...

journal_title：Scientific reports

authors： Pieńkowski G,Hodbod M,Ullmann CV

更新日期：2016-08-24 00:00:00

abstract：:The mechanisms contributing to collective attention in humans remain unclear. Research indicates that pedestrians utilise the gaze direction of others nearby to acquire environmentally relevant information, but it is not known which, if any, additional social cues influence this transmission. Extending upon previous f...

journal_title：Scientific reports

authors： Gallup AC,Chong A,Kacelnik A,Krebs JR,Couzin ID

更新日期：2014-07-23 00:00:00

abstract：:Associated with global warming, drought has destructive influences on agriculture and ecosystems, especially in the fragile Qinghai-Tibet Plateau (QTP). This study investigated spatial-temporal patterns of meteorological drought in the QTP and its surrounding areas and made an attempt to explore the relationship betwe...

journal_title：Scientific reports

authors： Feng W,Lu H,Yao T,Yu Q

更新日期：2020-08-31 00:00:00