Abstract:
:Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang M,Zhang X,Xu K,Teng Q,Liu Q,Li X,Yang J,Xu J,Chen H,Zhang X,Li Zdoi
10.1038/srep34489subject
Has Abstractpub_date
2016-09-28 00:00:00pages
34489issn
2045-2322pii
srep34489journal_volume
6pub_type
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