Abstract:
:Living organisms employ various mechanisms to escape harm. At the cellular level, mobile cells employ movement to avoid harmful chemicals or repellents. The present study is the first to report that cells move away from the site of injury in response to local wounding. When a migrating Dictyostelium cell was locally wounded at its anterior region by laserporation, the cell retracted its anterior pseudopods, extended a new pseudopod at the posterior region, and migrated in the opposite direction with increasing velocity. When wounded in the posterior region, the cell did not change its polarity and moved away from the site of wounding. Since the cells repair wounds within a short period, we successfully manipulated cell migration by applying multiple wounds. Herein, we discussed the signals that contributed to the wound-induced escape behavior of Dictyostelium cells. Our findings provide important insights into the mechanisms by which cells establish their polarity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pervin MS,Yumura Sdoi
10.1038/s41598-019-39678-1subject
Has Abstractpub_date
2019-03-12 00:00:00pages
4291issue
1issn
2045-2322pii
10.1038/s41598-019-39678-1journal_volume
9pub_type
杂志文章abstract::Refracture of cemented vertebrae occurs commonly after vertebroplasty (VP) for osteoporotic vertebral compression fracture (OVCF). It can result in severe pain or neurological deficit, but no preventive medication is available. Owing to the bone anabolic benefits of teriparatide (TP), this study was aimed to compare t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62869-0
更新日期:2020-04-07 00:00:00
abstract::Embryonic Stem Cells (ESCs) are expected to show a stable euploid karyotype, but in the last decade (sub)chromosomal aberrations have been systematically described in these cell lines when maintained in vitro. Culture conditions and long-term culture have been traditionally proposed as possible factors involved in the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05324
更新日期:2014-06-17 00:00:00
abstract::We have investigated the rotating magnetocaloric effect (R-MCE) of TmB4 - an anisotropic magnetic system with geometrical frustration of Shastry-Sutherland type. The R-MCE was obtained from detailed temperature dependencies of heat capacity in various magnetic fields of a single crystalline sample for crystal axes ori...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29399-2
更新日期:2018-07-19 00:00:00
abstract::Identification of patients with early stage non-small cell lung cancer (NSCLC) with high risk of recurrence could help identify patients who would receive additional benefit from adjuvant therapy. In this work, we present a computational histomorphometric image classifier using nuclear orientation, texture, shape, and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13773-7
更新日期:2017-10-19 00:00:00
abstract::Accumulating of evidence suggests that activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) exacerbates early brain injury (EBI) following subarachnoid hemorrhage (SAH) by provoking pro-inflammatory and pro-apoptotic signaling. Myeloid differentiation primary response protein 88 (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16124-8
更新日期:2017-11-17 00:00:00
abstract::Neonatal mice exhibit natural heart regeneration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by postnatal day 7 (P7). Cardiac biomechanics intricately affect long-term heart function, but whether regenerated cardiac muscle is biomechanically similar to native myocardium remains u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63324-w
更新日期:2020-04-30 00:00:00
abstract::Diagnosing stable ischemic heart disease (IHD) is challenging, especially in females. Currently, no blood test is available. Plasma extracellular vesicles (EV) are emerging as potential biomarker source. We therefore aimed to identify stress induced ischemia due to stable IHD with plasma extracellular vesicle protein ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69297-0
更新日期:2020-07-23 00:00:00
abstract::The dispensing of tiny droplets is a basic and crucial process in a myriad of applications, such as DNA/protein microarray, cell cultures, chemical synthesis of microparticles, and digital microfluidics. This work systematically demonstrates droplet dispensing into immiscible fluids through electric charge concentrati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31901
更新日期:2016-08-18 00:00:00
abstract::Protein kinases are enzymes whose abundance, protein-protein interactions, and posttranslational modifications together determine net signaling activity in cells. Large-scale data on cellular kinase activity are limited, because existing assays are cumbersome, poorly sensitive, low throughput, and restricted to measur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55998-8
更新日期:2019-12-19 00:00:00
abstract::Site conditions and forest management affect dendrometric parameters of chestnut (Castanea sativa Mill.) coppices, but there is modest knowledge on the effect of stand dendrometric characters on physical and mechanical wood characteristics. The aim of this study was to verify these relationships in chestnut coppices t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80558-w
更新日期:2021-01-15 00:00:00
abstract::Gelatin-coupled cellulose (GCC) microgel with whisker-like structure is prepared and used to incorporate into casein (CA) matrix to construct reinforced CA-based composite films by solution casting. The GCC microgel has excellent dispersibility and stability in water, which contributes to the hydrophobicity and signif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37848-1
更新日期:2019-02-04 00:00:00
abstract::Although the glucose lowering effect of dipeptidyl peptidase-4 (DPP4) inhibitors is well established, several potential serious acute safety concerns have been raised including acute kidney injury, respiratory tract infections, and acute pancreatitis. Using the UK-based Clinical Practice Research Datalink (CPRD), we i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33483-y
更新日期:2018-10-11 00:00:00
abstract::Mitochondria are key cellular signaling platforms, affecting fundamental processes such as cell proliferation, differentiation and death. However, it remains unclear how mitochondrial signaling affects other organelles, particularly lysosomes. Here, we demonstrate that mitochondrial respiratory chain (RC) impairments ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45076
更新日期:2017-03-27 00:00:00
abstract::The Asian citrus psyllid (ACP; Diaphorina citri) is the vector of Candidatus Liberibacter asiaticus (CLas) that is associated with the devastating Huanglongbing (HLB; citrus greening disease). This pest of Asian origin has spread into the Americas and more recently into a few countries in East Africa. During recent su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66380-4
更新日期:2020-06-10 00:00:00
abstract::Due to the globalization and computerization of financial and economic activities, numerous repetitive leveraged investments have become possible in stock markets and currency exchanges. In reality, repeated leveraged investments up to 100 times/day are possible via online access. With computer-aided programs, this re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50237-6
更新日期:2019-09-24 00:00:00
abstract::We analysed the ligand-based activation mechanism of the prostate-specific G-protein coupled receptor (PSGR), which is an olfactory receptor that mediates cellular growth in prostate cancer cells. Furthermore, it is an olfactory receptor with a known chemically near identic antagonist/agonist pair, α- and β-ionone. Us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16001-4
更新日期:2017-11-22 00:00:00
abstract::Irreversible electroporation (IRE) is a non-thermal ablation modality that has been shown to be safe and effective in its application to tumors that are close to risky areas. This study aims to assess the safety and efficacy of IRE for unresectable hilar cholangiocarcinoma. Nine patients from two medical centers in As...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67772-2
更新日期:2020-07-02 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) in the 3'-untranslated regions targeted by putative mircoRNA can change its binding strength, affecting the susceptibility and prognosis of cancer. We aimed to investigate the associations between SNPs within miR-148a binding sites and gastric cancer (GC) risk and prognosis. Usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07080
更新日期:2014-11-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-67554-w
更新日期:2020-06-25 00:00:00
abstract::This study proposes a new method of visualizing the ambient dose rate distribution using artificial neural networks (ANNs) from airborne radiation monitoring results. The method was applied to the results of the airborne radiation monitoring which was conducted around the Fukushima Daiichi Nuclear Power Plant by an un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81546-4
更新日期:2021-01-20 00:00:00
abstract::Previous studies reported that boreal winter precipitation in southeastern China (SEC) tends to increase during El Niño. In this study, however, we find that most weak El Niño events are accompanied by below-normal precipitation in SEC, although strong El Niño events are accompanied by above-normal precipitation in SE...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53496-5
更新日期:2019-11-22 00:00:00
abstract::We describe a new species of an ornithischian dinosaur, Isaberrysaura mollensis gen. et sp. nov. The specimen, consisting in an almost complete skull and incomplete postcranium was collected from the marine-deltaic deposits of the Los Molles Formation (Toarcian-Bajocian), being the first reported dinosaur for this uni...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42778
更新日期:2017-02-16 00:00:00
abstract::The roles of CD4 + T cells and CD8 + T cells in hepatitis B virus (HBV) infection have been well documented. However, the role of innate immunity in HBV infection remains obscure. Here we examined the effect of activation of innate immunity by polyinosinic: polycytidylic acid (PolyI:C) on HBV infection. A chronic HBV ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00387-2
更新日期:2017-03-22 00:00:00
abstract::Spin injection, manipulation and detection are the integral parts of spintronics devices and have attracted tremendous attention in the last decade. It is necessary to judiciously choose the right combination of materials to have compatibility with the existing semiconductor technology. Conventional metallic magnets w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05588
更新日期:2014-07-07 00:00:00
abstract::Breast cancer is the most common cancer in women. However, it remains unproven whether psychological factors have an influence on breast cancer incidence. In our earlier study, subjects possessing two personality traits, decisiveness and "ikigai" (a Japanese word meaning something that makes one's life worth living), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32559
更新日期:2016-09-02 00:00:00
abstract::Previous studies have shown that it is possible to nutritionally program gilthead seabream offspring through fish oil (FO) replacement by vegetable oils (VO) in the broodstock diet, to improve their ability to grow fast when fed low fish meal (FM) and FO diets during grow-out phase. However, in those studies broodstoc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72166-5
更新日期:2020-09-23 00:00:00
abstract::The p38 MAPKs play important roles in the regulation of balance between cell survival and cell death on the development of various cancers. However, the roles of p38 MAPKs regulating apoptotic effects on Leydig tumor cells remain unclear. In the present study, we showed that cordycepin (3'-deoxyadenosine) selectively ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13372
更新日期:2015-08-25 00:00:00
abstract::The spatio-temporal distribution soil pH is critical for understanding the productivity and long-term sustainability of our agri-ecosystem. This study quantified the spatio-temporal distribution of paddy soil pH in Jiangxi province, China, and the potential driver of the change between 1980 and 2010. Data from the Soi...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-018-20873-5
更新日期:2018-02-09 00:00:00
abstract::The high theoretical capacity and low discharge potential of silicon have attracted much attention on Si-based anodes. Herein, hollow porous SiO2 nanocubes have been prepared via a two-step hard-template process and evaluated as electrode materials for lithium-ion batteries. The hollow porous SiO2 nanocubes exhibited ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01568
更新日期:2013-01-01 00:00:00
abstract::Salts containing radical cations of 1,2,4,5-tetrakis(isopropylthio)benzene (TPB) and 1,2,4,5-tetrakis(ethylthio) benzene (TEB) have been successfully synthesized with . These newly synthesized salts have been characterized by UV-Vis absorption, EPR spectroscopy, conductivity measurement, single crystal X-ray diffracti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29314
更新日期:2016-07-11 00:00:00