Abstract:
:Neonatal mice exhibit natural heart regeneration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by postnatal day 7 (P7). Cardiac biomechanics intricately affect long-term heart function, but whether regenerated cardiac muscle is biomechanically similar to native myocardium remains unknown. We hypothesized that neonatal heart regeneration preserves native left ventricular (LV) biomechanical properties after MI. C57BL/6J mice underwent sham surgery or left anterior descending coronary artery ligation at age P1 or P7. Echocardiography performed 4 weeks post-MI showed that P1 MI and sham mice (n = 22, each) had similar LV wall thickness, diameter, and ejection fraction (59.6% vs 60.7%, p = 0.6514). Compared to P7 shams (n = 20), P7 MI mice (n = 20) had significant LV wall thinning, chamber enlargement, and depressed ejection fraction (32.6% vs 61.8%, p < 0.0001). Afterward, the LV was explanted and pressurized ex vivo, and the multiaxial lenticular stress-strain relationship was tracked. While LV tissue modulus for P1 MI and sham mice were similar (341.9 kPa vs 363.4 kPa, p = 0.6140), the modulus for P7 MI mice was significantly greater than that for P7 shams (691.6 kPa vs 429.2 kPa, p = 0.0194). We conclude that, in neonatal mice, regenerated LV muscle has similar biomechanical properties as native LV myocardium.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang H,Bennett-Kennett R,Paulsen MJ,Hironaka CE,Thakore AD,Farry JM,Eskandari A,Lucian HJ,Shin HS,Wu MA,Imbrie-Moore AM,Steele AN,Stapleton LM,Zhu Y,Dauskardt RH,Woo YJdoi
10.1038/s41598-020-63324-wsubject
Has Abstractpub_date
2020-04-30 00:00:00pages
7319issue
1issn
2045-2322pii
10.1038/s41598-020-63324-wjournal_volume
10pub_type
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