Abstract：
:Controlling and reducing the formation of pathogenic biofilm on tooth surface is the key to the prevention and treatment of the biofilm-associated oral diseases. Antimicrobial peptides (AMPs), considered as possible future alternatives for conventional antibiotics, have been extensively studied for the control of bacterial infection. Due to the rapid dilution and degradation by human saliva, AMP preparations designed for oral use with longer retention and higher efficacy are in urgent need. To this end, a hydroxyapatite (HAp)-binding antimicrobial peptide (HBAMP), which is based on the fusion of a specific HAp-binding heptapeptide (HBP7) domain and a broad-spectrum antimicrobial peptide (KSLW) domain, has been developed in our laboratory. HBAMP was supposed to form a contact-active antibacterial interface on tooth surface to inhibit the formation of biofilms. In this study, we investigated its binding behaviour, antibacterial activity against bacteria in both planktonic and sessile states, enzymatic stability in human saliva, and cytocompatibility to human gingival fibroblasts (HGFs). Our findings suggest that HBAMP could adsorb on tooth surface to provide effective antibacterial activity with improved retention. This study provides a proof-of-concept on using conjugated molecules to promote antibacterial efficacy by synergistically actions of HBAMP free in solution and bound on tooth surface.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Huang ZB,Shi X,Mao J,Gong SQdoi
10.1038/srep38410subject
Has Abstractpub_date
2016-12-02 00:00:00pages
38410issn
2045-2322pii
srep38410journal_volume
6pub_type
杂志文章abstract：:After active lengthening contractions, a given amount of force can be maintained with less muscle activation compared to pure isometric contractions at the same muscle length and intensity. This increase in neuromuscular efficiency is associated with mechanisms of stretch-induced residual force enhancement. We hypothe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39052
更新日期：2016-12-14 00:00:00
abstract：:Soil erosion due to underground leakage is a major factor causing land degradation in karst regions. Rhizosphere effects (REs) on soil anti-erodibility (SAE) can alleviate this type of soil erosion by improving soil physical processes such as aggregate stability. However, the magnitudes and causes of interspecific var...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58784-z
更新日期：2020-02-12 00:00:00
abstract：:Living organisms employ various mechanisms to escape harm. At the cellular level, mobile cells employ movement to avoid harmful chemicals or repellents. The present study is the first to report that cells move away from the site of injury in response to local wounding. When a migrating Dictyostelium cell was locally w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39678-1
更新日期：2019-03-12 00:00:00
abstract：:Our data about pathogenesis of hepatic steatosis after liver transplantation is scarce. This study aimed to investigate the association between serum adipokines and insulin resistance with hepatic steatosis in liver transplant recipients. We investigated the association between insulin resistance, serum adiponectin, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69571-1
更新日期：2020-07-29 00:00:00
abstract：:Cerebral lateralization is expressed at both the structural and functional levels, and can exist as either a stable characteristic or as a dynamic feature during behavior and development. The anatomically relatively simple olfactory system demonstrates lateralization in both human and non-human animals. Here, we explo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15109-x
更新日期：2017-11-06 00:00:00
abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is thought to be a pure genetic form of subcortical vascular cognitive impairment (SVCI). The aim of this study was to compare white matter integrity and cortical thickness between typical CADASIL, a genetic form, and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36580-0
更新日期：2019-01-28 00:00:00
abstract：:Biochemical remission after transsphenoidal surgery is still unsatisfied in acromegaly patients with macroadenomas, especially with invasive macroadenomas. Concerning the impact of preoperative somatostatin analogues (SSAs) on surgical outcomes, previous studies with limited cases reported conflicting results. To asse...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-50639-6
更新日期：2019-10-01 00:00:00
abstract：:The adipogenic process is characterized by the expression of adipocyte differentiation markers that lead to changes in cell metabolism and to the accumulation of lipid droplets. Moreover, during early adipogenesis, cells undergo a strong downregulation of translational activity with a decrease in cell size, proliferat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42005-3
更新日期：2019-04-04 00:00:00
abstract：:The interplay between orbital, charge, spin, and lattice degrees of freedom is at the core of correlated oxides. This is extensively studied at the interface of heterostructures constituted of two-layer or multilayer oxide films. Here, we demonstrate the interactions between orbital reconstruction and charge transfer ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04206
更新日期：2014-02-26 00:00:00
abstract：:Combining the advantages of structured random measurement matrix and chaotic structure, this paper introduces a color image encryption algorithm based on a structural chaotic measurement matrix and random phase mask. The Chebyshev chaotic sequence is used in the algorithm to generate the flip permutation matrix, the s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75562-z
更新日期：2020-10-29 00:00:00
abstract：:The growth dynamics of Ga(In)N semiconductors by Plasma-Assisted Molecular Beam Epitaxy (PAMBE) at low temperatures (T = 450 °C) is here investigated. The presence of droplets at the growth surface strongly affects the adatom incorporation dynamics, making the growth rate a decreasing function of the metal flux imping...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28984-9
更新日期：2018-07-26 00:00:00
abstract：:This study investigated the effects of 4 aeration levels (varied by injection of air to the soil through subsurface irrigation lines) at two subsurface irrigation line depths (15 and 40 cm) on plant growth, yield and nutritional quality of greenhouse tomato. In all experiments, fruit number, width and length, yield, v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39307
更新日期：2016-12-20 00:00:00
abstract：:Blockage of Delta-like 4 (DLL4)-directed Notch signaling induces excessive tip cell formation and endothelial proliferation resulting in dysfunctional angiogenesis in tumors. MMGZ01, as a murine anti-human DLL4 monoclonal antibody, specifically binds to human DLL4 and blocks Notch pathway. Here, the structure of MMGZ0...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27985
更新日期：2016-06-15 00:00:00
abstract：:New mosquito control strategies are vitally needed to address established arthropod-borne infectious diseases such as dengue and yellow fever and emerging diseases such as Zika and chikungunya, all of which are transmitted by the disease vector mosquito Aedes aegypti. In this investigation, Saccharomyces cerevisiae (b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13566-y
更新日期：2017-10-16 00:00:00
abstract：:A subwoofer generates the lowest frequency range in loudspeaker systems. Subwoofers are used in audio systems for live concerts, movie theatres, home theatres, gaming consoles, cars, etc. During the last decades, numerical simulations have emerged as a cost- and time-efficient complement to traditional experiments in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80092-9
更新日期：2021-01-08 00:00:00
abstract：:The metastable-to-stable phase-transition is commonly observed in many fields of science, as an uncontrolled independent process, highly sensitive to microscopic fluctuations. In particular, self-assembled lipid suspensions exhibit phase-transitions, where the underlying driving mechanisms and dynamics are not well un...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09481
更新日期：2015-03-30 00:00:00
abstract：:Dust from grain and feed production may cause adverse health effects in exposed workers. In this study we explored circulating miRNAs as potential biomarkers of occupational grain dust exposure. Twenty-two serum miRNAs were analyzed in 44 grain dust exposed workers and 22 controls. Exposed workers had significantly up...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68296-5
更新日期：2020-07-09 00:00:00
abstract：:The effects of sea salt aerosols (SSA) on cloud microphysical processes, precipitation, and upper troposphere/lower stratosphere water vapour in tropical cyclones were studied with the Weather Research and Forecasting with Chemistry model. Two numerical experiments were conducted: a control experiment (CTL) and an exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51757-x
更新日期：2019-10-22 00:00:00
abstract：:Several studies found that 50-100% serum eye drops provided greater benefits without inducing detrimental effects on the corneal epithelial healing. This study assessed the efficacy of undiluted serum eye drops for the treatment of persistent corneal epithelial defects (PED). A total of 109 eyes received 100% serum ey...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38143
更新日期：2016-12-02 00:00:00
abstract：:Some neural network can be trained by transfer learning, which uses a pre-trained neural network as the source task, for a small target task's dataset. The performance of the transfer learning depends on the knowledge (i.e., layers) selected from the pre-trained network. At present, this knowledge is usually chosen by...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64165-3
更新日期：2020-05-18 00:00:00
abstract：:Objectum-sexuality (OS) is a sexual orientation which has received little attention in the academic literature. Individuals who identify as OS experience emotional, romantic and/or sexual feelings towards inanimate objects (e.g. a bridge, a statue). We tested 34 OS individuals and 88 controls, and provide the first em...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56449-0
更新日期：2019-12-27 00:00:00
abstract：:Organisms possess multiple DNA polymerases (Pols) and use each for a different purpose. One of the five Pols in Escherichia coli, DNA polymerase IV (Pol IV), encoded by the dinB gene, is known to participate in lesion bypass at certain DNA adducts. To understand how cells choose Pols when the replication fork encounte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13080-1
更新日期：2017-10-16 00:00:00
abstract：:Multifunctional nanocarriers harbouring specific targeting moieties and with pH-responsive properties offer great potential for targeted cancer therapy. Several synthetic drug carriers have been studied extensively as drug delivery systems but not much information is available on the application of virus-like nanopart...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37891
更新日期：2016-11-24 00:00:00
abstract：:Herein, we propose an advanced energy-storage system: all-graphene-battery. It operates based on fast surface-reactions in both electrodes, thus delivering a remarkably high power density of 6,450 W kg(-1)(total electrode) while also retaining a high energy density of 225 Wh kg(-1)(total electrode), which is comparabl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05278
更新日期：2014-06-13 00:00:00
abstract：:Photoswitchable fluorescent proteins (PFPs) that can change fluorescence color upon excitation have revolutionized many applications of light such as tracking protein movement, super-resolution imaging, identification of circulating cells, and optical data storage. Nevertheless, the relatively weak fluorescence of PFP...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48335-6
更新日期：2019-08-27 00:00:00
abstract：:This work reports the first study of current-driven magnetization noise in a single, nanometerscale, ferromagnetic (Co) particle, attached to normal metal leads by high-resistance tunneling junctions. As the tunnel current increases at low temperature, the magnetic switching field decreases, its probability distributi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01200
更新日期：2013-01-01 00:00:00
abstract：:We have explored the mechanical properties, electronic structures and phase transition behaviors of three designed new phases for element boron from ambient condition to high-pressure of 120 GPa including (1) a C2/c symmetric structure (m-B₁₆); (2) a symmetric structure (c-B₅₆) and (3) a Pmna symmetric structure (o-B₂...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06786
更新日期：2014-10-27 00:00:00
abstract：:The Fenton-like activity of nanoceria has attracted intensive attention for wastewater treatment in recent years. During the Fenton-like reaction, the adsorption of organic pollutants on catalyst surface plays a key role in their degradation. In this work, the adsorption-degradation of methylene blue (MB) and Congo re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36794-2
更新日期：2019-03-21 00:00:00
abstract：:Angiogenesis is a key restorative process following stroke but has also been linked to increased vascular permeability and blood brain barrier (BBB) disruption. Previous pre-clinical approaches primarily focused on the administration of vascular endothelial growth factor (VEGF) to promote vascular repair after stroke....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56634-1
更新日期：2019-12-27 00:00:00
abstract：:A major challenge in nanofabrication is to pattern unconventional substrates that cannot be processed for a variety of reasons, such as incompatibility with spin coating, electron beam lithography, optical lithography, or wet chemical steps. Here, we present a versatile nanofabrication method based on re-usable silico...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07802
更新日期：2015-01-15 00:00:00
