Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells.

abstract：:Male moths efficiently recognize conspecific sex pheromones thanks to their highly accurate and specific olfactory system. The Heliothis/Helicoverpa species are regarded as good models for studying the perception of sex pheromones. In this study, we performed a series of experiments to investigate the peripheral mecha...

journal_title：Scientific reports

authors： Chang H,Guo M,Wang B,Liu Y,Dong S,Wang G

更新日期：2016-01-08 00:00:00

abstract：:Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1∆/∆ mice are deaf, Tmc2∆/∆ mice have normal hearing, and double homozygous Tmc1∆/∆; Tmc2∆/∆ mice have deafness and profound vestibular dysfunction. These phenotypes are consistent with their different spatio...

journal_title：Scientific reports

authors： Nakanishi H,Kurima K,Pan B,Wangemann P,Fitzgerald TS,Géléoc GS,Holt JR,Griffith AJ

更新日期：2018-08-14 00:00:00

abstract：:Fatty alcohols have been identified as promising organic phase change materials (PCMs) for thermal energy storage, because of their suitable temperature range, nontoxicity and can be obtained from both natural and synthetic sources. Like all other organic PCMs, octadecanol (OD) as PCM suffers from low thermal conducti...

journal_title：Scientific reports

authors： Al-Ahmed A,Sarı A,Mazumder MAJ,Hekimoğlu G,Al-Sulaiman FA,Inamuddin

更新日期：2020-06-08 00:00:00

abstract：:Visceral adiposity is a risk factor for cardiovascular disorders, type 2 diabetes mellitus (T2D) and associated metabolic diseases. Sub-cutaneous fat is believed to be intrinsically different from visceral fat. To understand molecular mechanisms involved in metabolic advantages of fat transplantation, we studied a rat...

journal_title：Scientific reports

authors： Satoor SN,Puranik AS,Kumar S,Williams MD,Ghale M,Rahalkar A,Karandikar MS,Shouche Y,Patole M,Bhonde R,Yajnik CS,Hardikar AA

更新日期：2011-01-01 00:00:00

abstract：:Heart failure is the most common cause of morbidity and hospitalization in the western civilization. Protein phosphatases play a key role in the basal cardiac contractility and in the responses to β-adrenergic stimulation with type-1 phosphatase (PP-1) being major contributor. We propose here that formation of transie...

journal_title：Scientific reports

authors： Singh S,Lämmle S,Giese H,Kämmerer S,Meyer-Roxlau S,Alfar EA,Dihazi H,Guan K,El-Armouche A,Richter F

更新日期：2018-12-07 00:00:00

abstract：:The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis that the primary care provider must differentiate, in terms of diagnosis and treatment. Effective an...

journal_title：Scientific reports

authors： Chen B,Zhao Y,Li S,Yang L,Wang H,Wang T,Bin Shi,Gai Z,Heng X,Zhang C,Yang J,Zhang L

更新日期：2018-11-20 00:00:00

abstract：:We developed a virus-like particle (VLP)-based therapeutic vaccine against angiotensin II receptor type 1, ATR-AP205-001, which could significantly reduce the blood pressure and protect target organs of hypertensive animals. In this study, we focused on the immunological effect and safety of the VLP-based vaccine. By ...

journal_title：Scientific reports

authors： Hu X,Deng Y,Chen X,Zhou Y,Zhang H,Wu H,Yang S,Chen F,Zhou Z,Wang M,Qiu Z,Liao Y

更新日期：2017-10-03 00:00:00

abstract：:Organic solar cells (OSCs) are promising alternatives to the conventional inorganic solar cells due to their low-cost processing and compatibility with flexible substrates. The development of low band-gap polymer, e.g., poly-[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl] [3-fluoro-2-[(2-ethylhexy...

journal_title：Scientific reports

authors： Moritomo Y,Yonezawa K,Yasuda T

更新日期：2015-09-01 00:00:00

abstract：:Studies focusing on biofilm assembly in deep-sea environments are rarely conducted. To examine the effects of substrate type on microbial community assembly, biofilms were developed on different substrates for different durations at two locations in the Red Sea: in a brine pool and in nearby bottom water (NBW) adjacen...

journal_title：Scientific reports

authors： Zhang WP,Wang Y,Tian RM,Bougouffa S,Yang B,Cao HL,Zhang G,Wong YH,Xu W,Batang Z,Al-Suwailem A,Zhang XX,Qian PY

更新日期：2014-10-17 00:00:00

abstract：:Cartilage loss is a leading cause of disability among adults and effective therapy remains elusive. Neonatal chondrocytes (NChons) are an attractive allogeneic cell source for cartilage repair, but their clinical translation has been hindered by scarce donor availability. Here we examine the potential for catalyzing c...

journal_title：Scientific reports

authors： Lai JH,Kajiyama G,Smith RL,Maloney W,Yang F

更新日期：2013-12-19 00:00:00

abstract：:While molecular-targeted drugs have demonstrated strong therapeutic efficacy against diverse diseases such as cancer and infection, the appearance of drug resistance associated with genetic variations in individual patients or pathogens has severely limited their clinical efficacy. Therefore, precision medicine approa...

journal_title：Scientific reports

authors： Ono F,Chiba S,Isaka Y,Matsumoto S,Ma B,Katayama R,Araki M,Okuno Y

更新日期：2020-02-07 00:00:00

abstract：:Colorectal cancer, the third most commonly diagnosed cancer, is a lifestyle disease where diet and gut microbiome contribute intricately in its initiation and progression. Prophylactic bio-interventions mainly probiotics offer an alternate approach towards reducing or delaying its progression. Therefore, the present s...

journal_title：Scientific reports

authors： Chandel D,Sharma M,Chawla V,Sachdeva N,Shukla G

更新日期：2019-10-14 00:00:00

abstract：:The availability of iron (Fe) can seasonally limit phytoplankton growth in the High Latitude North Atlantic (HLNA), greatly reducing the efficiency of the biological carbon pump. However, the spatial extent of seasonal iron limitation is not yet known. We present autumn nutrient and dissolved Fe measurements, combined...

journal_title：Scientific reports

authors： Birchill AJ,Hartner NT,Kunde K,Siemering B,Daniels C,González-Santana D,Milne A,Ussher SJ,Worsfold PJ,Leopold K,Painter SC,Lohan MC

更新日期：2019-02-05 00:00:00

abstract：:Tract tracing with neuronal tracers not only represents a straightforward approach to identify axonal projection connection between regions of the nervous system at distance but also provides compelling evidence for axonal regeneration. An ideal neuronal tracer meets certain criteria including high labeling efficacy, ...

journal_title：Scientific reports

authors： Mi D,Yuan Y,Zhang Y,Niu J,Wang Y,Yan J,Yang Y,Hu W

更新日期：2019-07-09 00:00:00

abstract：:Two decades ago, a phenomenon resembling Landau damping was described in the synchronization of globally coupled oscillators: the evidence of a regime where the order parameter decays when linear theory predicts neutral stability for the incoherent state. We here show that such an effect is far more generic, as soon a...

journal_title：Scientific reports

authors： Qiu T,Zhang Y,Liu J,Bi H,Boccaletti S,Liu Z,Guan S

更新日期：2015-12-14 00:00:00

abstract：:Elevated nitrogen associated with global change is believed to promote the invasion of many vigorous exotic plants. However, it is unclear how a weak exotic plant will respond to elevated nitrogen in the future. In this study, the competitive outcome of a weak invasive plant (Galinsoga quadriradiata) and two non-invas...

journal_title：Scientific reports

authors： Liu G,Yang YB,Zhu ZH

更新日期：2018-02-16 00:00:00

abstract：:There is no preclinical mouse model to investigate pulmonary Mycobacteroides abscessus (formerly Mycobacterium abscessus) infection in an immunocompetent mouse strain, especially in the context of antibiotic testing and regimen development. We developed a mouse model of pulmonary M. abscessus infection using the aeros...

journal_title：Scientific reports

authors： Maggioncalda EC,Story-Roller E,Mylius J,Illei P,Basaraba RJ,Lamichhane G

更新日期：2020-02-28 00:00:00

abstract：:Memory function deficits induced by Alzheimer's disease (AD) are believed to be one of the causes of an increased risk of tripping in patients. Working memory contributes to accurate stepping over obstacles during locomotion, and AD-induced deficits of this memory function may lead to an increased risk of contact with...

journal_title：Scientific reports

authors： Setogawa S,Yamaura H,Arasaki T,Endo S,Yanagihara D

更新日期：2014-11-27 00:00:00

abstract：:In this paper, we present the first realization of an elastic metamaterial allowing independent tuning of negative density and stiffness for elastic waves propagating along a designated direction. In electromagnetic (or acoustic) metamaterials, it is now possible to tune permittivity (bulk modulus) and permeability (d...

journal_title：Scientific reports

authors： Oh JH,Kwon YE,Lee HJ,Kim YY

更新日期：2016-03-23 00:00:00

abstract：:Bt cotton was genetically modified to produce insecticidal proteins targeting Lepidopteran pests and is therefore only minimally affected by caterpillar damage. This could lead to reduced levels of inherent, systemically inducible defensive compounds in Bt cotton which might benefit other important cotton herbivores s...

journal_title：Scientific reports

authors： Eisenring M,Naranjo SE,Bacher S,Abbott A,Meissle M,Romeis J

更新日期：2019-02-25 00:00:00

abstract：:Biosynthesis of sakuranetin, a flavonoid anti-fungal phytoalexin that occurs in rice, is highly dependent on jasmonic acid (JA) signalling and induced by a variety of environmental stimuli. We previously identified OsNOMT, which encodes naringenin 7-O-methyltransferase (NOMT); NOMT is a key enzyme for sakuranetin prod...

journal_title：Scientific reports

authors： Ogawa S,Miyamoto K,Nemoto K,Sawasaki T,Yamane H,Nojiri H,Okada K

更新日期：2017-01-09 00:00:00

abstract：:Studies have demonstrated that inflammatory bowel disease (IBD) patients are at an increased risk of developing anxiety and/or depression. IBD patients with depression/anxiety have higher rates of hospitalization and increased disease severity than those without. So far, there is a paucity of data concerning the impac...

journal_title：Scientific reports

authors： Gao X,Tang Y,Lei N,Luo Y,Chen P,Liang C,Duan S,Zhang Y

更新日期：2021-01-14 00:00:00

abstract：:The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolu...

journal_title：Scientific reports

authors： Kopp FK,Daerr H,Si-Mohamed S,Sauter AP,Ehn S,Fingerle AA,Brendel B,Pfeiffer F,Roessl E,Rummeny EJ,Pfeiffer D,Proksa R,Douek P,Noël PB

更新日期：2018-11-26 00:00:00

abstract：:Eucalyptus globulus is an aromatic medicinal plant which known for its 1,8-cineole main pharmacological constituent exhibits as natural analgesic agent. Eucalyptus globulus-loaded micellar nanoparticle was developed via spontaneous emulsification technique and further evaluation for its analgesic efficacy study, in vi...

journal_title：Scientific reports

authors： Aziz ZAA,Nasir HM,Ahmad A,Setapar SHM,Ahmad H,Noor MHM,Rafatullah M,Khatoon A,Kausar MA,Ahmad I,Khan S,Al-Shaeri M,Ashraf GM

更新日期：2019-09-23 00:00:00

abstract：:Urban climate is determined by a variety of factors, whose knowledge can help to attenuate heat stress in the context of ongoing urbanization and climate change. We study the influence of city size and urban form on the Urban Heat Island (UHI) phenomenon in Europe and find a complex interplay between UHI intensity and...

journal_title：Scientific reports

authors： Zhou B,Rybski D,Kropp JP

更新日期：2017-07-06 00:00:00

abstract：:The optical gain and spontaneous emission characteristics of low In-content AlInN-delta-GaN quantum wells (QWs) are analyzed for deep ultraviolet (UV) light emitting diodes (LEDs) and lasers. Our analysis shows a large increase in the dominant transverse electric (TE) polarized spontaneous emission rate and optical ga...

journal_title：Scientific reports

authors： Tan CK,Sun W,Borovac D,Tansu N

更新日期：2016-03-10 00:00:00

abstract：:An encapsulated formulation of Bacillus thuringiensis (Bt) was produced by the Pickering emulsion technique to improve its activity and stability under UV-A radiation. In this technique latex particles, GO nanosheets, olive oil, ethanol, and water were used to encapsulate Bt in colloidosomes. The protective efficacy o...

journal_title：Scientific reports

authors： Jalali E,Maghsoudi S,Noroozian E

更新日期：2020-11-26 00:00:00

abstract：:Crossmodal studies have reported not only facilitatory but also inhibitory perceptual interactions. For instance, tactile stimulation to the index finger of a hand leads to the degradation of visual discrimination performance (touch-induced visual suppression, TIVS). It has been suggested that the magnitude of TIVS de...

journal_title：Scientific reports

authors： Hidaka S,Suzuishi Y,Ide M,Wada M

更新日期：2018-11-19 00:00:00

abstract：:An intermediate band in the band gap of semiconductors is fundamental to the development of the intermediate band solar cells, but it is usually produced artificially, which imposes technical challenges on the experimental realization. Here we found that there are natural intermediate bands in the band gaps of the I2-...

journal_title：Scientific reports

authors： Liu Q,Cai Z,Han D,Chen S

更新日期：2018-01-25 00:00:00

abstract：:We report a small molecule tandem organic photovoltaic (OPV) cell with a high power conversion efficiency (PCE) of 7.27%. This cell contains two subcells with an identical mixed active layer of C70:5 wt%TAPC (1,1-bis-(4-bis(4-methyl-phenyl)-amino-phenyl)-cyclohexane). The performance was dramatically improved by simpl...

journal_title：Scientific reports

authors： Gao Y,Jin F,Li W,Su Z,Chu B,Wang J,Zhao H,Wu H,Liu C,Hou F,Lin T,Song Q

更新日期：2016-04-01 00:00:00