Abstract:
:Altering mechanical compliance in load carriage structures has shown to reduce metabolic cost and accelerative forces of carrying weight. Currently, modifications to load carriage structures have been primarily targeted at vertical motion of the carried mass. No study to date has investigated altering load carriage compliance in the medial-lateral direction. We developed a backpack specifically for allowing a carried mass to oscillate in the horizontal direction, giving us the unique opportunity to understand the effects of lateral mass motion on human gait. Previous modelling work has shown that walking economy can be improved through the interaction of a bipedal model with a laterally oscillating walking surface. To test whether a laterally oscillating mass can experimentally improve walking economy, we systematically varied step width above and below the preferred level and compared the effects of carrying an oscillating and fixed mass. Walking with an oscillating mass was found to reduce the accelerative forces of load carriage in both horizontal and vertical directions. However, load eccentricity caused the vertical force component to create a significant bending moment in the frontal plane. Walking with an oscillating mass led to an increase in the metabolic energy expenditure during walking and an increase in positive hip work during stance. The device's ability to reduce forces experienced by the user, due to load carriage, holds promise. However, the requirement of additional metabolic energy to walk with the device requires future study to improve.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Martin JP,Li Qdoi
10.1038/s41598-018-32175-xsubject
Has Abstractpub_date
2018-09-13 00:00:00pages
13775issue
1issn
2045-2322pii
10.1038/s41598-018-32175-xjournal_volume
8pub_type
杂志文章abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24178-5
更新日期:2018-04-17 00:00:00
abstract::Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). Several lines of evidence suggest that tanycytes may be involved in the regulation of energy homeostasis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03928-x
更新日期:2017-06-16 00:00:00
abstract::Sustainable canola production is essential to meet growing human demands for vegetable oil, biodiesel, and meal for stock feed markets. Blackleg, caused by the fungal pathogen, Leptosphaeria maculans is a devastating disease that can lead to significant yield loss in many canola production regions worldwide. Breakdown...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61211-y
更新日期:2020-03-10 00:00:00
abstract::Highly porous tri-metallic AgxAuyPdz networks with a sub-monolayer bimetallic Au-Pd nanoparticle coating were synthesized via a designed galvanic replacement reaction of Ag nanosponges suspended in mixed solutions of HAuCl4 and K2PdCl4. The resulting networks' ligaments have a rough surface with bimetallic nanoparticl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37092
更新日期:2016-11-15 00:00:00
abstract::The discovery of the insertion of IbT-DNA1 and IbT-DNA2 into the cultivated (hexaploid) sweetpotato [Ipomoea batatas (L.) Lam.] genome constitutes a clear example of an ancient event of Horizontal Gene Transfer (HGT). However, it remains unknown whether the acquisition of both IbT-DNAs by the cultivated sweetpotato oc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48691-3
更新日期:2019-08-29 00:00:00
abstract::Moyamoya disease is an idiopathic human cerebrovascular disorder that is characterized by progressive stenosis and abnormal collateral vessels. We recently identified mysterin/RNF213 as its first susceptibility gene, which encodes a 591-kDa protein containing enzymatically active P-loop ATPase and ubiquitin ligase dom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04442
更新日期:2014-03-24 00:00:00
abstract::The sinusoidal endothelial cells present in the liver (LSECs) are tipically characterized by the presence of pores (fenestrae). During some pathological conditions LSECs undergo "capillarization", a process characterized by loss of fenestrations and acquisition of a vascular phenotype. In chronic liver disease capilla...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-45114-1
更新日期:2019-06-19 00:00:00
abstract::The Y chromosome has high genetic variability with low rates of parallel and back mutations, which make up the most informative haplotyping system. To examine whether Y chromosome haplogroups (Y-hgs) could modify the effects of autosomal variants on non-obstructive azoospermia (NOA), based on our previous genome-wide ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33363
更新日期:2016-09-15 00:00:00
abstract::Anxiety, depression, and insomnia are highly prevalent among migraineurs and are associated with negative health consequences. Anxiety and depression, however, unlike insomnia, are usually underdiagnosed, due to less self-reporting of these two conditions. The aim of the present study was to evaluate the risk of anxie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55928-8
更新日期:2019-12-20 00:00:00
abstract::The physiologic response to tobacco smoke can be measured by gene-expression profiling of the airway epithelium. Temporal resolution of kinetics of gene-expression alterations upon smoking-cessation might delineate distinct biological processes that are activated during recovery from tobacco smoke exposure. Using whol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43295-3
更新日期:2019-05-06 00:00:00
abstract::One quarter of individuals with Preserved Ratio Impaired Spirometry (PRISm) will develop airflow obstruction, but there are no established methods to identify these individuals. We examined the utility of FVC/TLC in identifying features of obstructive lung disease. The ratio of post-bronchodilator FVC and TLCCT from c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61932-0
更新日期:2020-03-20 00:00:00
abstract::Postsynaptic density-95/Discs large/Zonula occludens-1 (PDZ) domain-mediated protein interactions play pivotal roles in various molecular biological events, including protein localisation, assembly, and signal transduction. Although the vertebrate regulator of planar cell polarity Van Gogh-like 2 (Vangl2) was recently...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12916
更新日期:2015-08-10 00:00:00
abstract::Neuroblastoma is the most commonly diagnosed extracranial tumor in the first year of life. Approximately 9% of neuroblastoma patients present germline or somatic aberrations in the gene encoding for anaplastic lymphoma kinase (ALK). This increases in high-risk neuroblastomas, which have a 14% frequency of ALK aberrati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55060-7
更新日期:2019-12-18 00:00:00
abstract::Harmful algal blooms caused by Phaeocystis globosa have resulted in staggering losses to coastal countries because of their world-wide distribution. Bacteria have been studied for years to control the blooms of harmful alga, however, the action mechanism of them against harmful algal cells is still not well defined. H...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17002
更新日期:2015-11-25 00:00:00
abstract::Potato (Solanum tuberosum L.) is the fourth most important crop worldwide. Potato virus A (PVA) is one of the most harmful viruses infecting potatoes. However, the molecular mechanisms governing the responses to PVA infection in potato at the transcriptional and post-transcriptional levels are not well understood. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17059-w
更新日期:2017-12-05 00:00:00
abstract::Transposition mutagenesis is a powerful tool to identify the function of genes, reveal essential genes and generally to unravel the genetic basis of living organisms. However, transposon-mediated mutagenesis has only been successfully applied to a limited number of archaeal species and has never been reported in Therm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36711
更新日期:2016-11-08 00:00:00
abstract::A three dimensional (3D) numerical solution of unsteady, Ag-MgO hybrid nanoliquid flow with heat and mass transmission caused by upward/downward moving of wavy spinning disk has been scrutinized. The magnetic field has been also considered. The hybrid nanoliquid has been synthesized in the presence of Ag-MgO nanoparti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75905-w
更新日期:2020-11-02 00:00:00
abstract::Quantum coherence and quantum correlations are important quantum resources for quantum computation and quantum information. In this paper, using entropy-based measures, we investigate the relationships between quantum correlated coherence, which is the coherence between subsystems, and two main kinds of quantum correl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09332-9
更新日期:2017-09-21 00:00:00
abstract::SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukaryotes and is essential for the regulation of processes such as DNA damage repair, transcription, DNA replication and mitosis. UbL modification of proteins occurs via a specific enzymatic cascade formed by the crosstalk b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41998
更新日期:2017-02-06 00:00:00
abstract::Three main surveillance systems (laboratory-confirmed, influenza-like illness (ILI) and nationwide Notifiable Infectious Diseases Reporting Information System (NIDRIS)) have been used for influenza surveillance in China. However, it is unclear which surveillance system is more reliable in developing influenza early wa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21059-9
更新日期:2018-02-12 00:00:00
abstract::This study was to evaluate the effect of Epigallocatechin-3-gallate (EGCG) on the bond strength of two adhesive systems to the Sodium hypochlorite (NaOCl) treated intraradicular dentin. The roots were accepted regular root canal treatments and post space preparations, and further divided into eight groups according to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04107-8
更新日期:2017-06-26 00:00:00
abstract::Human corneal endothelial cells (HCECs) easily become fibroblastic-like when cultured, rendering them unsuitable for tissue engineering of the cornea. Transforming growth factor β (TGF-β) could be a key factor in this phenomenon; however, TGF-β is also known to maintain the endothelium in a quiescent state in vivo. Th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22821-9
更新日期:2018-03-13 00:00:00
abstract::The CoCrMo matrix composites with nano-TiO2 particle (2 wt.%, 4 wt.% and 6 wt.%) were fabricated by using a powder metallurgy technique (P/M), and the nano-TiO2 content was optimized in matrix. The microstructures, mechanical and high-temperature tribological properties of the synthesized composites were systematicall...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63918-4
更新日期:2020-04-22 00:00:00
abstract::Engineered Terahertz (THz) metamaterials presented an unique characteristics for biosensing application due to their accurately tunable resonance frequency, which is in accord with vibrational frequency of some important biomolecules such as cancer biomarker. However, water absorption in THz regime is an obstacle to e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16762-y
更新日期:2017-11-27 00:00:00
abstract::M2BP (also called 90K) is an interferon-stimulated gene product that is upregulated in HIV-1 infection. A recent study revealed that M2BP reduces the infectivity of HIV-1 by inhibiting the processing of the viral envelope protein. Here we report that in addition to reducing viral infectivity, M2BP inhibits HIV-1 virio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32736
更新日期:2016-09-08 00:00:00
abstract::The performance of most error-correction (EC) algorithms that operate on genomics reads is dependent on the proper choice of its configuration parameters, such as the value of k in k-mer based techniques. In this work, we target the problem of finding the best values of these configuration parameters to optimize error...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52196-4
更新日期:2019-11-06 00:00:00
abstract::Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-11852-3
更新日期:2017-11-10 00:00:00
abstract::Here we investigated the feasibility of using microwave spectroscopy for characterization of normal and breast cancer cell lines cultured in vitro. Healthy non-tumorigenic, MCF-10A and breast cancer, MDA-MB-231, Hs578T, T47D and MCF-7 cell lines were electrically characterized using the open-ended coaxial probe techni...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41124-1
更新日期:2019-03-18 00:00:00
abstract::We describe a spin wave modulator - spintronic device aimed to control spin wave propagation by an electric field. The modulator consists of a ferromagnetic film serving as a spin wave bus combined with a synthetic multiferroic comprising piezoelectric and magnetostrictive materials. Its operation is based on the stre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28878-w
更新日期:2018-07-18 00:00:00
abstract::Measurements of volcanic tephra fallout deposits provide useful information about the magnitude and intensity of explosive volcanic eruptions and potential for remobilization of deposits as dangerous volcanic flows. However, gathering information in the vicinity of erupting craters is extremely dangerous, and moreover...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71902-1
更新日期:2020-09-09 00:00:00